intrinsic apoptotic signaling pathway

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).

• Code: GO:0097193
• Source: Gene Ontology
• Alternative labels: intrinsic apoptotic signalling pathway mitochondrial-mediated apoptotic pathway intrinsic apoptosis intrinsic apoptotic pathway induction of apoptosis by intracellular signals