ERK1 and ERK2 cascade

An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.

• Code: GO:0070371
• Source: Gene Ontology
• Alternative labels: ERK2 cascade ERK1 and ERK2 signalling pathway extracellular signal-regulated kinase 1/2 (ERK1/2) cascade ERK1/2 cascade ERK1 cascade MAPK1 cascade ERK1 and ERK2 signaling pathway ERK cascade MAPK3 cascade extracellular signal-regulated kinase 1/2 cascade