necroptotic process

A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.

• Code: GO:0070266
• Source: Gene Ontology
• Alternative labels: RIPK1-mediated regulated necrosis TNF-induced necroptosis necroptosis programmed necrosis activation of necroptosis PARP-dependent cell death parthanatos programmed necrotic cell death activation of necroptosis of activated-T cells induction of necroptosis of activated-T cells establishment of necroptosis of activated-T cells activation of necroptosis by extracellular signals activation of necroptosis in response to extracellular signals extracellular signal-induced necroptosis induction of necroptosis by extracellular signals induction of necroptosis establishment of necroptosis