ERAD pathway

The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
  • Code: GO:0036503
  • Source: Gene Ontology
  • Alternative labels: endoplasmic reticulum-associated protein degradation pathway ER-associated degradation pathway protein degradation by ERAD endoplasmic reticulum-associated degradation

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  • Number of publications: 234
  • Number of sentences: 266

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