guanyl-nucleotide exchange factor activity

Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

• Code: GO:0005085
• Source: Gene Ontology
• Alternative labels: guanyl-nucleotide releasing factor GDS GDP-dissociation stimulator activity Rho guanine nucleotide exchange factor ARF guanyl-nucleotide exchange factor activity Rac guanyl-nucleotide exchange factor activity Ran guanyl-nucleotide exchange factor activity Rap guanyl-nucleotide exchange factor activity cAMP-dependent guanyl-nucleotide exchange factor activity Sar guanyl-nucleotide exchange factor activity GNRP Ras guanyl-nucleotide exchange factor activity Ral guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity RhoGEF guanyl-nucleotide release factor activity Rab guanyl-nucleotide exchange factor activity GEF