count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
8	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P54253	Protein	5bcf731a-ee08-11e5-9b35-001a4ae51246	PMC4383046	Consistent with the finding that Pum1 negatively regulates Atxn1,Pum1heterozygous (Pum1+/−) mice showed increased levels of both Atxn1 protein (Figure 2B) and mRNA (Figure 2C)—approximately 30% in the cerebrum and 50% in the cerebellum—andPum1−/−mice showed even more pronounced increases (Figures 2B and 2C).|||Given that the promoter sequences of theATXN1-3′ UTR constructs carrying either WT or Mut binding sites are exactly the same and that transfection of neither construct affected PUM1 protein levels, we conclude that PUM1 promotes degradation of ATXN1 by binding its 3′ UTR (Figures 3E, bottom panel andS3I).
8	PUM1	UNIPROT:Q14671	increases		UNIPROT:P54253	Protein	5bcf731a-ee08-11e5-9b35-001a4ae51246	PMC4383046	These data demonstrate that Pum1 directly regulates Atxn1 levels in the mouse brain.|||PUM1 thus increases ATXN1 levels by directly regulating the stability ofATXN1mRNA.
4	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:Q13363	Protein	e228e8fe-ab1a-11e6-81c1-001a4ae51246	27732849	Indeed, PUM1 overexpression alone reduced reporter activity to ∼0.5 relative light units (RLU), which was reverted back to ∼1.0 as expected in PBE2 mutants (Figure 6B, orange bars).
4	PUM1	UNIPROT:Q14671	activates		UNIPROT:P42574	Protein	e228e8fe-ab1a-11e6-81c1-001a4ae51246	27732849	PUM1 regulatesATAXIN1mRNA levels in the mouse brain causing a Spinocerebellar ataxia type 1 (SCA1)-like neurodegeneration phenotype (Gennarino et al., 2015).
4	PUM1	UNIPROT:Q14671	activates		GO:0010467	Phenotype	c2c047ba-5ca3-11e7-af4d-001a4ae51247	PMC4715682	Furthermore, PUM1 or PUM2 overexpression produced a gene expression signature that was similar to that observed uponNORADinactivation, with genes that were down- or upregulated inNORAD−/−cells showing a similar pattern of expression in PUM1/2 overexpressing cells (Figure S7D).
4	PUM1	UNIPROT:Q14671	activates		MESH:D020754	Phenotype	e228e8fe-ab1a-11e6-81c1-001a4ae51246	27732849	PUM1 regulatesATAXIN1mRNA levels in the mouse brain causing a Spinocerebellar ataxia type 1 (SCA1)-like neurodegeneration phenotype (Gennarino et al., 2015).
4	PUM1	UNIPROT:Q14671	inhibits		GO:0006412	Phenotype	172882ec-351e-11e8-bf76-001a4a160175	28965817	Other validated RNA-binding proteins included the endogenous translation repressor PUM1 and the related PUM2, EGFP-STAU2L, and ILF3 (Figures S2B and S2C).
4	PUM1	UNIPROT:Q14671	activates		MESH:D000782	Phenotype	c2c047ba-5ca3-11e7-af4d-001a4ae51247	PMC4715682	Accordingly, PUM2 and, to a lesser extent, PUM1 overexpression was sufficient to induce significant levels of aneuploidy (Figure 5D).
4	PUM1	UNIPROT:Q14671	activates		UNIPROT:P54253	Protein	f0212ac4-bc3d-11e5-8abe-001a4ae51246	PMC3420947	MED15 and Pum1 directly modulate polyQ-mediated ATXN1 aggregation in cell-free assays We next investigated whether MED15 and Pum1 directly influence polyQ-mediated ATXN1 aggregation in cell-free assays.|||We also examined whether a hybrid Pum1 protein with an N-terminal MED15CC fragment can promote ATXN1 aggregation in cell-based assays.
4	PUM1	UNIPROT:Q14671	activates		GO:0030154	Phenotype	5bcf731a-ee08-11e5-9b35-001a4ae51246	PMC4383046	Pum1 Mutant Mice Develop Progressive Motor Dysfunction and Neurodegeneration Recent studies have shown that Pum1 is an essential regulator of spermatogenesis in mice and promotes differentiation of embryonic stem cells (Chen et al., 2012; Leeb et al., 2014), but its role in the mammalian nervous system has not been investigated.|||Recent studies have shown that Pum1 is an essential regulator of spermatogenesis in mice and promotes differentiation of embryonic stem cells (Chen et al., 2012; Leeb et al., 2014), but its role in the mammalian nervous system has not been investigated.
4	PUM1	UNIPROT:Q14671	inhibits		MESH:D009369	Phenotype	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	PUM1 reduction enhances T cell killing of tumors Cytotoxic CD8+T are the main tumor killing cell type.|||These results supported that PUM1 reduction enhanced T cell killing in tumors.|||Notably, in both groups injected with T cells, PUM1 deficiency significantly enhanced the tumor-killing effect of T cells (Fig. 3B and C).|||PUM1 reduction also enhanced T cell killing of tumors.
4		UNIPROT:P01308	phosphorylatesProtein	PUM1	UNIPROT:Q14671	Protein	04a31498-055f-11f0-bd9d-0050569a1f61	10.1016/j.celrep.2024.114491	These include hnRNPA1, an RBP that binds to an AU-rich motif (UAAUU) and is increased in phosphorylation at Ser199 by over 8-fold following acute insulin stimulation (p= 2.2 × 10−9) and ∼2-fold after chronic stimulation (p= 2.6 × 10−12); PUM1 and PUM2, which also bind AU-rich sequences and are phosphorylated by insulin at Ser209 and Ser82; and KHSRP, which is phosphorylated at Ser194, a residue within the RNA-binding motif (Table 1).
3		UNIPROT:P01189	activates	PUM1	UNIPROT:Q14671	Protein	f3e0865e-d3fe-11e5-90d3-001a4ae51247	PMC4872080	We classified the transcripts into five groups:those that do not have any PUM1(2) or miRNA sites (None)those that contain at least one CLIP-supported PUM1(2) site but do not contain any site of an interacting miRNA (Only PUM1(2))those that contain at least one interacting miRNA site but do not contain any PUM1(2) sites (Only miRNA)those that contain at least one CLIP-supported PUM1(2) site and at least one site of an interacting miRNA (Both (not stem-loop))those that contain at least one CLIP-supported PUM1(2) site and at least one site of an interacting miRNA with the additional constraint that the PUM1(2) site forms a stem-loop with the miRNA site (Both (stem-loop)) (See ‘Materials and Methods’ for details on how we predict stem-loops).
2	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P54253	Protein	0ccd40b2-3910-11e8-a51f-001a4a160176	PMC5758885	Mouse and human PUM1 repress the Ataxin1 (ATXN1) mRNA, encoded by the Spinocerebellar Ataxia Type 1 (SCA-1)-associated gene in neurons and cultured cells (54).
2	PUM1	UNIPROT:Q14671	decreases		UNIPROT:P54253	Protein	2afd0b87-dc61-11ea-a377-001a4a160175	PMC6217844	Meanwhile, ATXN1 expression level is negatively regulated by PUMILIO1 (PUM1), which is also an RBP, by modulatingATXN1RNA stability [165].
2	PUM1	UNIPROT:Q14671	activates		UNIPROT:P46527	Protein	d681ca80-ab46-11e6-90f5-001a4ae51247	PMC4926514	For example, Pumilio1 (PUM1) enhances miR-221 and miR-222 accessibility on the 3′ UTR of p27 mRNA.
2	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P04637	Protein	db833db0-bbf1-11e5-9b9d-001a4ae51247	PMC3449084	Here, we show that Pumilio 1 (Pum1), through coordinated posttranscriptional regulation of multiple factors in the p53 pathway, represses p53 activation and apoptosis after spermatogonial division.
2	PUM1	UNIPROT:Q14671	increases		UNIPROT:Q14565	Protein	30a76e44-383c-11e6-b56c-001a4ae51246	PMC4344436	Pum1 temporally up-regulates expression of Dmc1, a meiotic recombinase required for sporulation, during mating (Fig. 2) (Wang et al., 2014).
2	PUM1	UNIPROT:Q14671	activates		UNIPROT:P01574	Protein	dc09c9b4-bc52-11e5-ac4e-001a4ae51246	PMC4207803	Full-length PUM1 and PUM2 but neither dC nor dN enhanced NDV-induced IFN-β reporter activity, indicating that both PUM-HD and the N-terminal portion are necessary for transactivation.
2	PUM1	UNIPROT:Q14671	inhibits		GO:0007049	Phenotype	9e5cf97a-8cc3-11ee-add2-0050569a791b	10.1007/s00018-022-04254-w	What is remarkable is that opposite effects of PUM1 on the cell cycle regulator translation appears well-coordinated based on the nature of cell cycle regulators, so that PUM1 promote translation of positive cell cycle regulators yet repress negative cell cycle regulators.
2	PUM1	UNIPROT:Q14671	inhibits		GO:0006402	Phenotype	0ccd40b2-3910-11e8-a51f-001a4a160176	PMC5758885	Moreover, depletion of PUM1 was found to stabilize three PUM1-bound mRNAs, consistent with PUM1-mediated mRNA degradation (Supplementary Table S1) (12).
2	PUM1	UNIPROT:Q14671	inhibits		GO:0006915	Phenotype	db833db0-bbf1-11e5-9b9d-001a4ae51247	PMC3449084	Here, we show that Pumilio 1 (Pum1), through coordinated posttranscriptional regulation of multiple factors in the p53 pathway, represses p53 activation and apoptosis after spermatogonial division.
2	PUM1	UNIPROT:Q14671	inhibits		GO:0006915	Phenotype	0f5fa6c6-351e-11e8-87fd-001a4a160176	PMC5580656	"This finding echoes our laboratory's previous study of Pum1 in mouse spermatogenesis, where Pum1 suppresses apoptosis of
                         spermatocytes (Chen et al. 2012)."
2	PUM1	UNIPROT:Q14671	increases		PF:PF07508	ProteinFamily	30a76e44-383c-11e6-b56c-001a4ae51246	PMC4344436	Pum1 temporally up-regulates expression of Dmc1, a meiotic recombinase required for sporulation, during mating (Fig. 2) (Wang et al., 2014).
2	PUM1	UNIPROT:Q14671	increases		UNIPROT:Q9NZQ7	Protein	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	We found that PUM1 expression is associated with poor CD8+T cell infiltration in GC, and that PUM1 positively regulates PD-L1 expression.|||These data indicate that PUM1 deficiency reduced the expression of PD-L1 in GC.
2	PUM1	UNIPROT:Q14671	decreases		UNIPROT:P54253	Protein	0f5fa6c6-351e-11e8-87fd-001a4a160176	PMC5580656	"Recent works have shown that
                   Pum1 is important in both male (Chen et al. 2012) and female (Mak et al. 2016) germline development and in preventing neurodegeneration by repressing Ataxin1 expression (Gennarino et al. 2015), whereas Pum2 plays multiple roles in neuronal function (Vessey et al. 2006,2010;Siemen et al. 2011;Driscoll et al. 2013).|||Gennarino et al. (2015)discovered that Pum1 directly represses ATAXIN1 expression and thus plays an important role in motor function and in preventing
                         neurodegeneration."
2	PUM1	UNIPROT:Q14671	decreases		UNIPROT:P46527	Protein	0ccd40b2-3910-11e8-a51f-001a4a160176	PMC5758885	The results demonstrate that PUM1 and PUM2 directly repress CDKN1B expression through two PRE elements located in the 3′ UTR of its mRNA.|||In cell culture studies, depletion of PUMs was shown to promote cell proliferation and PUM1 repressed expression of the CDKN1B/p27 tumor suppressor (18).
2	PUM1	UNIPROT:Q14671	activates		UNIPROT:P02774	Protein	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	Compared with the control group, the tumor volume in the PUM1 knockdown group was reduced, indicating that PUM1 could promote GC cell proliferation (Fig. 3B and C), which was consistent with our previous findings [12].|||In this study, we thoroughly investigated the role of PUM1 on PD-L1 expression in GC and found that PUM1 can potentially promote the immune escape of GC cells.
2	PUM1	UNIPROT:Q14671	activates		GO:0006351	Phenotype	dc09c9b4-bc52-11e5-ac4e-001a4ae51246	PMC4207803	Furthermore, PUM1 and PUM2 accelerated the activation of IRFs and NF-κB transcription factors, suggesting their action in signal transduction, rather than post-transcriptional steps.|||PUM1 and PUM2 augmented p-55C1BLuc activity (Figure 1C), as well as p-55A2Luc activity (Figure 1D), suggesting that PUM1 and PUM2 mediate the activation of both IRFs and NF-κB transcription factors.
2	PUM1	UNIPROT:Q14671	activates		GO:0008283	Phenotype	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	Compared with the control group, the tumor volume in the PUM1 knockdown group was reduced, indicating that PUM1 could promote GC cell proliferation (Fig. 3B and C), which was consistent with our previous findings [12].|||Recently, we reported that PUM1 could promote gastric cancer (GC) cell proliferation, metastasis, and glycolytic metabolism through posttranscriptional regulation of DEP domain-containing mTOR-interacting protein (DEPTOR) [12].
2	PUM1	UNIPROT:Q14671	activates		GO:0030154	Phenotype	17bfbb08-bbe0-11e5-9b9d-001a4ae51247	PMC3995090	Pum1 depletion reduced differentiation inTbx3fl/flESCs but had no effect onTbx3−/−cells (Figure 3I).|||Pum1 Promotes ESC Differentiation by Posttranscriptional Downregulation of the Naive Pluripotency Circuit Gene trap insertions in thePum1gene were identified in four independent screens (Table S2) and validated by siRNA (Figures 3A and 3B).
2	PUM1	UNIPROT:Q14671	activates		PF:PF00806	ProteinFamily	2dd4fb0a-bc27-11e5-8abe-001a4ae51246	10.1016/j.ymeth.2013.04.020	The protocol is based on our work analyzing PUF mediated mRNA regulation by human PUM1 and PUM2 in human HEK293 cells[16].|||Protocol: reporter activity analysis using dual reporter assay The following protocol is based on our work analyzing PUF mediated mRNA regulation by human PUM1 and PUM2 in human cells and is a continuation of the protocol outlined in Section 2.3.3[16].1.48h after transfection, measure luciferase activity with the Dual-Glo® Luciferase Assay System (Promega) using a GloMax®-Multi+ plate-reading luminometer (Promega) according to the manufacturer’s instructions.2.Analyze the data:a.Average the firefly and Renilla RLUs from the mock transfected wells.
2		UNIPROT:P54253	inhibits	PUM1	UNIPROT:Q14671	Protein	5bcf731a-ee08-11e5-9b35-001a4ae51246	PMC4383046	Genetic Reduction of Atxn1 Levels Rescued the Pum1 Mutant Phenotype To test our hypothesis that the neurological deficits ofPum1mutant mice resulted from an increase in Atxn1 levels due to loss of Pum1 regulation, we crossedPum1+/−withAtxn1+/−mice and characterized the offspring.
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:Q9BVP2	Protein	39c1b9fc-cd40-11ee-9aaa-0050569a1f61	10.1007/s10811-018-1538-7	Pum1 still produces NS in lab culture, but less copiously than Pum2, and the difference could relate to Pum1’s treatment with penicillin and streptomycin for the genome project.
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:O00233	Protein	c65c6174-c6a0-11ee-b22c-0050569a1f61	10.1016/j.ijbiomac.2023.127593	The direct binding of miR-221 to the p27 3′ UTR was diminished by specific silencing of PUM1, which thereby eliminated miR-221-triggered inhibition of P27.
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:O00233	Protein	aabee22c-bbf3-11e5-8abe-001a4ae51246	PMC4253089	For instance, the binding of RBPs, PUM1 and PUM2, induce a conformational change in the 3′UTR of P27 mRNA, thus making a target sequence accessible to an miRNA.46Currently, little computational methodology exists to detect and model these phenomena.
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:Q9NZQ7	Protein	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	PUM1 positively regulates PD-L1 in GC To further understand how PUM1 regulates PD-L1 expression, we selected SNU-719 and SGC-7901 cells to construct cell lines stably knocked down for PUM1.
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:Q969H0	Protein	25767f0d-f53c-11eb-acde-001a4a160175	29273203	In a cooperative interaction, Pum1 binding on the 3′ UTR of p27 mRNA elevates miR221/222 accessibility, causing more Ago/miRNA-mediated repression[35].
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:Q15431	Protein	965cbd8c-1b65-11e6-bd85-001a4ae51247	PMC4946805	PUM1 Down-Regulates the SYCP1 Protein from the SC During Late Meiotic Prophase I Meiosis requires the normal assembly and disassembly of the SCs that contain SYCP1, SYCP2, and SYCP3 proteins.
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:Q9BZB8	Protein	ea5ee952-f5d2-11eb-a857-001a4a160176	29427077	As inXenopus, PUM1 can be phosphorylated during oocyte maturation and may induce a conformational change in the complex consisting of PUM1 and cytoplasmic polyadenylation element (CPE)-binding protein (CPEB) that targets CPEB for dissociation, which is required for the translational activation ofcyclin B1mRNA [37,38].
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:Q9BSG1	Protein	dab1bae0-bc52-11e5-9b9d-001a4ae51247	PMC4047104	We discovered that Pum1, a RNA-binding protein, acts in concert with Cfl1 to direct Znf2-dependent filamentation.
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:O75607	Protein	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	We investigated whether PUM1 can positively regulate NPM3 and found that the mRNA expression and protein levels of NPM3 were reduced in PUM1 knockdown cells (Fig. 4A–D).
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P42574	Protein	0c4cc17c-f591-11eb-9684-001a4a160176	31643042	The loss of Pum1 led to progressive motor dysfunction and SCA1-like neurodegeneration, highlighting the importance of Pum function in normal maintenance of nervous system [76].
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:O00716	Protein	88b9cfcc-bc19-11e5-8abe-001a4ae51246	PMC3794589	The human PUM1 has been shown to be required for the repression that is mediated by miR-221/222 on p27 mRNA and to enhance the activity of multiple E2F3 targeting miRNAs (11,16,17).
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:O00716	Protein	c193120a-3800-11e6-b56c-001a4ae51246	PMC4904894	Therefore, the miR-340–PUM1/2 axis might control cell cycle progression by targeting multiple transcripts in addition toCDKN1B, which encodes p27KIP1.7For example, PUM1/2 have also been implicated in the miRNA-mediated control of the cell cycle regulator E2F3 in bladder cancer cells.8 PUM1 belongs to a growing list of RNA-binding proteins including HuR, Dnd1, CRD-BP, and PTB that are implicated in the modulation of miRNA targeting in mammalian cells.
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:O00716	Protein	bcaf06b2-bc50-11e5-8d2d-001a4ae51247	PMC4693235	Likewise, a RBP-induced structural switch modulating miRNA-mediated gene expression by PUM proteins has also been described on mRNAs coding for oncogene E2F transcription factor 3 (E2F3), which is strongly repressed by the cooperative action of miR-506 and PUM1 in bladder carcinoma cells [42].
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P15172	Protein	de091a60-c483-11e5-85e4-001a4ae51246	PMC3476303	Depletion of both PUM1 and PUM2 together substantially reduced PUM repression to only 15% (Fig. 2B,PUM1+PUM2).
1	PUM1	UNIPROT:Q14671	decreases		UNIPROT:Q12778	Protein	89a9e1f0-8dd3-11e7-97d2-001a4ae51247	PMC5553310	siRNA-mediated knockdown of PUM1 or PUM2 in MDA-MB-231 cells increased the protein levels of PTEN, NRAS, and FOXO1 but not c-JUN (Fig. 3B).
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P01111	Protein	89a9e1f0-8dd3-11e7-97d2-001a4ae51247	PMC5553310	In support of this, depletion of PUM1 or PUM2 increased the stability of the NRAS full-length 3′ UTR (Supplementary Fig. S5A).
1	PUM1	UNIPROT:Q14671	decreases		UNIPROT:P01111	Protein	89a9e1f0-8dd3-11e7-97d2-001a4ae51247	PMC5553310	siRNA-mediated knockdown of PUM1 or PUM2 in MDA-MB-231 cells increased the protein levels of PTEN, NRAS, and FOXO1 but not c-JUN (Fig. 3B).
1	PUM1	UNIPROT:Q14671	decreases		UNIPROT:O43490	Protein	df25e152-c83b-11ee-9133-0050569a1f61	10.1016/j.prmcm.2023.100264	A recent study found that morin inhibits colon cancer stem cells by inhibiting PUM1 protein expression, which reduces colon spheroid formation and CD133 expression in colon cancer cell lines.
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P69891	Protein	b4ac329a-c9b3-11ee-b346-0050569a791b	PMC9699939	We observed this after either a short 24-hour chase or a longer 3-day chase, suggesting that PUM1 specifically mediates HBG1 mRNA degradation (Figure 2B;supplemental Figure 8A).
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:Q8TB45	Protein	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	Recently, we reported that PUM1 could promote gastric cancer (GC) cell proliferation, metastasis, and glycolytic metabolism through posttranscriptional regulation of DEP domain-containing mTOR-interacting protein (DEPTOR) [12].
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:P46527	Protein	c193120a-3800-11e6-b56c-001a4ae51246	PMC4904894	Our results show that miRNA-mediated downregulation of PUM1 and PUM2 antagonizes the miR-221/222–mediated inhibition of p27KIP1.
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P46527	Protein	ac41cf3a-ab4c-11e6-9646-001a4ae51246	PMC4902075	PUM1 and PUM2 inhibit p27 at the translational level, by rendering the p27 transcript available to interact with two oncomiRs (miR-221 and miR-222), while the oncoprotein SKP2 inhibits the CDK inhibitor at the post-translational level by triggering the proteasomal degradation of p27, showing that miR-340 affected not only the synthesis but also the decay of p27.
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P46527	Protein	8be05cb4-c8d7-11e5-9cb8-001a4ae51247	PMC4724947	While PUM1 and PUM2 inhibit p27 at the translational level, by rendering the p27 transcript available to interact with two oncomiRs (miR-221 and miR-222) overexpressed in lung and glioblastoma tumor cells, SKP2 inhibits the CDK inhibitor at the posttranslational level, by triggering the proteasomal degradation of p27 (summarized inFigure 8).
1	PUM1	UNIPROT:Q14671	increases		UNIPROT:P46527	Protein	0ccd40b2-3910-11e8-a51f-001a4a160176	PMC5758885	In cell culture studies, depletion of PUMs was shown to promote cell proliferation and PUM1 repressed expression of the CDKN1B/p27 tumor suppressor (18).
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:P46527	Protein	da91a86e-3ad8-11ef-908f-0050569a1f61	10.1016/j.dnarep.2018.07.008	MiR-340-mediated inhibition of PUM1 and PUM2, therefore, antagonizes the miRNA-dependent downregulation of p27 [40].
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P46527	Protein	7385acba-3909-11e8-bf76-001a4a160175	25516298	PUM1 and PUM2 also known as PUMILIO proteins have been shown to cause repression of p27 mRNA through microRNA dependent gene silencing in rapidly proliferating cells[107].
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P04637	Protein	cd57541f-dcb7-11ea-a606-001a4a160175	PMC5949103	While Pum1 can suppress multiple activators of p53 to safeguard spermatogenesis in male mice [5], the subfertility of knockout female mice was attributed to a decrease in ovarian reserve because the significant proportion of oocytes were arrested at pachytene stage without the disassembly of SYCP1 protein in meiosis I [11].
1	PUM1	UNIPROT:Q14671	decreases		UNIPROT:P60484	Protein	89a9e1f0-8dd3-11e7-97d2-001a4ae51247	PMC5553310	siRNA-mediated knockdown of PUM1 or PUM2 in MDA-MB-231 cells increased the protein levels of PTEN, NRAS, and FOXO1 but not c-JUN (Fig. 3B).
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:Q937N9	Protein	45721ad2-ae96-11ec-a61d-0050569a1f61	PMC8575309	Besides clarifying the molecular mechanism by which PUM1 modulates PrPC, these data provide direct evidence for the validity of the regulators identified in our screen.
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:Q14565	Protein	dab1bae0-bc52-11e5-9b9d-001a4ae51247	PMC4047104	Again, the loss of Pum1 increased the stochasticity of Dmc1 dynamics in basidia (Figure 7B) as observed for Fas1 in filaments (Figure 5G).
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P14635	Protein	9e5cf97a-8cc3-11ee-add2-0050569a791b	10.1007/s00018-022-04254-w	In the late S phase and early M phase, the translational repression of PUM1 along with ubiquitination degradation would cause a reduction of CCNA and CCNB proteins to facilitate G2/M progression.
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:O14818	Protein	8884466c-5c2d-11e7-8b40-001a4ae51247	PMC5429137	We first demonstrate that PUM1 and PUM2 RBPs are both required to maintain human and murine HSPC growth in vitro and also in vivo: loss of either PUM1 or PUM2 induces loss of HSPC survival, expansion, and clonogenic properties in vitro and renders them unable to reconstitute hematopoiesis in vivo after myeloablation.
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:O14818	Protein	8884466c-5c2d-11e7-8b40-001a4ae51247	PMC5429137	PUM1 or PUM2 KD strongly inhibited CD34+HSPC expansion in vitro (Figure 1C; supplemental Figure 1B).
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P51608	Protein	9ae6f420-2db0-11eb-82e4-001a4a160176	PMC7530521	PUM1 overexpression in human iPSC-derived neurons decreased MECP2 long 3′UTR isoform levels and caused dendrite complexity and soma size reductions (8).
1	PUM1	UNIPROT:Q14671	activates		UNIPROT:Q96C10	Protein	dc09c9b4-bc52-11e5-ac4e-001a4ae51246	PMC4207803	LGP2 knockdown diminishedIFNBgene induction augmented by PUM1 and PUM2 (Figure 3B), suggesting that PUM1 and PUM2 augment viral RNA sensing mediated by LGP2.
1	PUM1	UNIPROT:Q14671	increases		UNIPROT:Q96C10	Protein	30a4d928-374e-11e8-87fd-001a4a160176	PMC5565464	1Bthe PUM1 siRNAs 1777 and 2652 activated the transcription of LGP2, whereas the PUM1 siRNA 412 and the NT siRNA had no effect.
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:Q96C10	Protein	41aa8452-3536-11e9-9b28-001a4a160176	PMC5889655	However, as previously reported, PUM1 siRNA up-regulates LGP2 and indirectly up-regulates a network of genes.
1	PUM1	UNIPROT:Q14671	decreases		UNIPROT:Q96C10	Protein	30a4d928-374e-11e8-87fd-001a4a160176	PMC5565464	The results also show that the increase in the expression of genes in both phase 1 and phase 2 were dependent on the increase in the expression of LGP2 following depletion of PUM1.
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:Q96C10	Protein	0c4cc17c-f591-11eb-9684-001a4a160176	31643042	In HEp-2 cells, human Pum1 caused suppression of LGP-2 activity (a master regulator of innate immunity genes), thereby influencing innate immunity system [61].
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:Q96C10	Protein	30a4d928-374e-11e8-87fd-001a4a160176	PMC5565464	In preliminary studies we noted that depletion of PUM1 by siRNA induces the synthesis LGP2.
1	PUM1	UNIPROT:Q14671	inhibits		UNIPROT:P46094	Protein	1b5e5602-c478-11e5-85e4-001a4ae51246	21344644	Recently, it has been shown inXenopusembryo vegetal cells that the Pumilio 1 protein represses the translation of the maternal determinant xCR1 that is required for A/P patterning duringXenopusembryogenesis (Zhang et al.,2009).
1	PUM1	UNIPROT:Q14671	activates		MESH:D012640	Phenotype	9ae6f420-2db0-11eb-82e4-001a4a160176	PMC7530521	Mutations in PUM1 are associated with adult-onset ataxia, and PUM1 haploinsufficiency leads to developmental delay and seizures (92,93).
1	PUM1	UNIPROT:Q14671	activates		GO:0007283	Phenotype	fa9298aa-fdc7-11e5-8bba-001a4ae51247	PMC4821617	Conclusions conclusions This study revealed a key gene,Pum1, which promotes both spermatogenesis and germline stem cell development.
1	PUM1	UNIPROT:Q14671	inhibits		GO:0039703	Phenotype	dc09c9b4-bc52-11e5-ac4e-001a4ae51246	PMC4207803	In accord with the increased IFN promoter activity, NDV RNA replication was suppressed by the overexpression of PUM1 and PUM2 24 h after NDV infection, suggesting that PUM1 and PUM2 share antiviral potential (Figure 1E).
1	PUM1	UNIPROT:Q14671	activates		GO:0000747	Phenotype	dab1bae0-bc52-11e5-9b9d-001a4ae51247	PMC4047104	Pum1 promotes yeast-to-hypha transition in a mating colony through its regulation of hypha-specific proteins (e.g.
1	PUM1	UNIPROT:Q14671	inhibits		GO:0010467	Phenotype	2421b8aa-3407-11e8-87fd-001a4a160176	PMC5677592	PUM1 or PUM2 overexpression reversed the effects ofNORADon target gene expression (Lee et al.67; Tichon et al.133).
1	PUM1	UNIPROT:Q14671	inhibits		GO:0009058	Phenotype	30a4d928-374e-11e8-87fd-001a4a160176	PMC5565464	In preliminary studies we noted that depletion of PUM1 by siRNA induces the synthesis LGP2.
1	PUM1	UNIPROT:Q14671	inhibits		GO:0022008	Phenotype	b0ca1494-ae94-11ec-8b2e-0050569a1f61	PMCPMC8595405	Loss of both Pum1 and Pum2 also disrupts neurogenesis in mice (Zhang et al., 2017).
1	PUM1	UNIPROT:Q14671	inhibits		GO:0009994	Phenotype	b0ca1494-ae94-11ec-8b2e-0050569a1f61	PMCPMC8595405	Importantly, stabilization of PUM1 aggregates blocks oocyte differentiation, indicating that the dissolution of these aggregates at a particular point in oocyte differentiation is important for their continued maturation.In related findings, mammalian PUM proteins may also play important roles in the proliferation and differentiation of embryonic stem cells (Uyhazi et al., 2020).
1	PUM1	UNIPROT:Q14671	activates		GO:0008283	Phenotype	0c4cc17c-f591-11eb-9684-001a4a160176	31643042	Silencing Pum1 in ovarian cancer cell line reduced the proliferation, migration and invasion efficiency, while increasing the cell apoptosis [72].
1	PUM1	UNIPROT:Q14671	activates		GO:0008283	Phenotype	9e5cf97a-8cc3-11ee-add2-0050569a791b	10.1007/s00018-022-04254-w	We further explored whether PCCR proteins expression were changed accordingly in ovarian cancer, indeed CDKN1B and WEE1 protein were significantly downregulated in ovarian cancer cohort where PUM1 protein was upregulated (Fig.6E, F), supporting that PUM1-mediated translational control of PCCR network plays a conserved role in human ovarian cell proliferation and contributed to cancer progression [46].
1	PUM1	UNIPROT:Q14671	activates		GO:0008283	Phenotype	8884466c-5c2d-11e7-8b40-001a4ae51247	PMC5429137	Again, loss of PUM1 or PUM2 inhibited proliferation of every AML cell (Figure 3F).
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006412	Phenotype	0f5fa6c6-351e-11e8-87fd-001a4a160176	PMC5580656	"All
                         of the examined targets showed up-regulation in P1KO, P2KO, and Ndcko (Fig. 6L,M;Supplemental Fig. S6G), indicating that Pum1 and Pum2 (either alone or together) repress the translation of these targets."
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006412	Phenotype	17bfbb08-bbe0-11e5-9b9d-001a4ae51247	PMC3995090	Pum1 inhibits translation and promotes degradation of target mRNAs.
1	PUM1	UNIPROT:Q14671	activates		GO:0006412	Phenotype	0bee4c1c-c47e-11e5-9cc6-001a4ae51246	PMC3024781	It is therefore likely that Pum1 and Pum2 contribute to oocyte maturation by controlling the translation of different target mRNAs.
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006412	Phenotype	1b5e5602-c478-11e5-85e4-001a4ae51246	21344644	Recently, it has been shown inXenopusembryo vegetal cells that the Pumilio 1 protein represses the translation of the maternal determinant xCR1 that is required for A/P patterning duringXenopusembryogenesis (Zhang et al.,2009).
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006412	Phenotype	627499b0-dbc4-11ea-853d-001a4a160176	PMC7241771	In addition, many of the mRNAs associated with PUM1 belong to a relatively small number of functional groups, which suggests the existence of an RNA regulon model [21] in which PUM1 inhibits translation and promotes the degradation of its target mRNAs [22].
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006412	Phenotype	9e5cf97a-8cc3-11ee-add2-0050569a791b	10.1007/s00018-022-04254-w	What is remarkable is that opposite effects of PUM1 on the cell cycle regulator translation appears well-coordinated based on the nature of cell cycle regulators, so that PUM1 promote translation of positive cell cycle regulators yet repress negative cell cycle regulators.
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006412	Phenotype	bf9e5194-bc40-11e5-8d2d-001a4ae51247	PMC4216463	Thus, Pum1 most probably directly promotes their degradation upon 2i withdrawal and potentially also inhibits translation.
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006402	Phenotype	b4ac329a-c9b3-11ee-b346-0050569a791b	PMC9699939	We observed this after either a short 24-hour chase or a longer 3-day chase, suggesting that PUM1 specifically mediates HBG1 mRNA degradation (Figure 2B;supplemental Figure 8A).
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006402	Phenotype	bf9e5194-bc40-11e5-8d2d-001a4ae51247	PMC4216463	In either case, it seems that Pum1-mediated mRNA degradation is a further mechanism that ensures rapid dissolution of the naive pluripotency network.
1	PUM1	UNIPROT:Q14671	activates		MESH:D000782	Phenotype	105a299a-ae94-11ec-89b1-0050569a791b	PMCPMC8249382	NORAD KO cells exhibit chromosomal instability and aneuploidy by down-regulating its target PUMILIO, pum1 (Pumilio homolog 1) haploinsufficiency in mice causes neurodegeneration  .
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006281	Phenotype	dc1be18c-ae93-11ec-ae7b-0050569a1f61	PMCPMC8037018	In the absence of NORAD, PUMILIO proteins, PUM1 and PUM2, drive chromosomal instability by hyperactively repressing mitotic, DNA repair, and DNA replication factors.
1	PUM1	UNIPROT:Q14671	inhibits		MESH:D009362	Phenotype	0c4cc17c-f591-11eb-9684-001a4a160176	31643042	Further, in vitro and in vivo analyses showed that Pum1 knock-down could reduce the cell-growth, invasion and metastasis while promoting apoptosis [71].
1	PUM1	UNIPROT:Q14671	activates		MESH:D009362	Phenotype	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	Recently, we reported that PUM1 could promote gastric cancer (GC) cell proliferation, metastasis, and glycolytic metabolism through posttranscriptional regulation of DEP domain-containing mTOR-interacting protein (DEPTOR) [12].
1	PUM1	UNIPROT:Q14671	activates		GO:0044770	Phenotype	9e5cf97a-8cc3-11ee-add2-0050569a791b	10.1007/s00018-022-04254-w	As matter of fact, most of the key regulators of cell phase transition from G1-S-G2-M, including both positive and negative regulators, were bound by PUM1, prompting us to investigate if PUM1 promotes cell cycle phase transition through co-ordinated regulation of key regulators of cell phase transition at posttranscriptional level.
1	PUM1	UNIPROT:Q14671	activates		MESH:D009361	Phenotype	0c4cc17c-f591-11eb-9684-001a4a160176	31643042	Silencing Pum1 in ovarian cancer cell line reduced the proliferation, migration and invasion efficiency, while increasing the cell apoptosis [72].
1	PUM1	UNIPROT:Q14671	inhibits		MESH:D009361	Phenotype	0c4cc17c-f591-11eb-9684-001a4a160176	31643042	Further, in vitro and in vivo analyses showed that Pum1 knock-down could reduce the cell-growth, invasion and metastasis while promoting apoptosis [71].
1	PUM1	UNIPROT:Q14671	activates		GO:0051726	Phenotype	c193120a-3800-11e6-b56c-001a4ae51246	PMC4904894	Therefore, the miR-340–PUM1/2 axis might control cell cycle progression by targeting multiple transcripts in addition toCDKN1B, which encodes p27KIP1.7For example, PUM1/2 have also been implicated in the miRNA-mediated control of the cell cycle regulator E2F3 in bladder cancer cells.8 PUM1 belongs to a growing list of RNA-binding proteins including HuR, Dnd1, CRD-BP, and PTB that are implicated in the modulation of miRNA targeting in mammalian cells.
1	PUM1	UNIPROT:Q14671	activates		GO:0008152	Phenotype	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	Recently, we reported that PUM1 could promote gastric cancer (GC) cell proliferation, metastasis, and glycolytic metabolism through posttranscriptional regulation of DEP domain-containing mTOR-interacting protein (DEPTOR) [12].
1	PUM1	UNIPROT:Q14671	activates		GO:0042113	Phenotype	f56812c6-bc34-11e5-ac4e-001a4ae51246	PMC2522278	PANTHER pathway analysis of PUM1 targets revealed significant enrichment of components that regulate angiogenesis (p<8×10−7) or that mediate inflammatory/immune responses (T and B cell activation,p<5×10−4andp<10−2, respectively).
1	PUM1	UNIPROT:Q14671	inhibits		MESH:D010455	Phenotype	ab03aca0-c8ea-11e5-a801-001a4ae51246	PMC2423135	"Pum1 and Ddx6
                         antibodies and Pum1 blocking peptide were from Bethyl Labs, and HuR antibody was supernatant from hybridoma 3A2 cells."
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006260	Phenotype	dc1be18c-ae93-11ec-ae7b-0050569a1f61	PMCPMC8037018	In the absence of NORAD, PUMILIO proteins, PUM1 and PUM2, drive chromosomal instability by hyperactively repressing mitotic, DNA repair, and DNA replication factors.
1	PUM1	UNIPROT:Q14671	inhibits		MESH:D051379	Phenotype	b0ca1494-ae94-11ec-8b2e-0050569a1f61	PMCPMC8595405	Loss of Pum1 also leads to subfertility in female mice (Mak et al., 2016), and defects in the maternal phase of embryogenesis (Mak et al., 2018).
1	PUM1	UNIPROT:Q14671	activates		MESH:D051379	Phenotype	b0ca1494-ae94-11ec-8b2e-0050569a1f61	PMCPMC8595405	Loss of both Pum1 and Pum2 also disrupts neurogenesis in mice (Zhang et al., 2017).
1	PUM1	UNIPROT:Q14671	activates		GO:0006915	Phenotype	6a4e4fd1-f543-11eb-bcd4-001a4a160176	29428722	Downregulation of PUM1 induces cell apoptosis Flow cytometry revealed a higher apoptosis rate in the cells after silencingPUM1(Fig. 3A, p 
1	PUM1	UNIPROT:Q14671	inhibits		GO:0006915	Phenotype	0ccd40b2-3910-11e8-a51f-001a4a160176	PMC5758885	In male mice, knockout of PUM1 reduced fertility substantially and increased apoptosis of developing sperm as a result of increases in p53 pathway components, some of which are bound and regulated by PUM1 (25) (Supplementary Table S1).
1	PUM1	UNIPROT:Q14671	activates		GO:0008219	Phenotype	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	To exclude cell death caused by transfection PUM1, we used a control group without T cells.
1	PUM1	UNIPROT:Q14671	activates		GO:0001556	Phenotype	0bee4c1c-c47e-11e5-9cc6-001a4ae51246	PMC3024781	It is therefore likely that Pum1 and Pum2 contribute to oocyte maturation by controlling the translation of different target mRNAs.
1	PUM1	UNIPROT:Q14671	activates		GO:0016049	Phenotype	8884466c-5c2d-11e7-8b40-001a4ae51247	PMC5429137	PUM1 and PUM2 promote leukemic cell growth Having established the major role of PUM1/2 in normal HSPCs, we investigated PUM1 and PUM2 activities in myeloid leukemia.
1	PUM1	UNIPROT:Q14671	activates		GO:0045087	Phenotype	0c4cc17c-f591-11eb-9684-001a4a160176	31643042	In HEp-2 cells, human Pum1 caused suppression of LGP-2 activity (a master regulator of innate immunity genes), thereby influencing innate immunity system [61].
1	PUM1	UNIPROT:Q14671	activates		MESH:D042822	Phenotype	b0ca1494-ae94-11ec-8b2e-0050569a1f61	PMCPMC8595405	Over-expression and increased availability of PUM1 and PUM2 leads to genomic instability in somatic cells, and loss of NORAD in mice results in a striking premature aging phenotype (Kopp et al., 2019).
1	PUM1	UNIPROT:Q14671	activates		MESH:D043171	Phenotype	105a299a-ae94-11ec-89b1-0050569a791b	PMCPMC8249382	NORAD KO cells exhibit chromosomal instability and aneuploidy by down-regulating its target PUMILIO, pum1 (Pumilio homolog 1) haploinsufficiency in mice causes neurodegeneration  .
1	PUM1	UNIPROT:Q14671	activates		PF:PF01877	ProteinFamily	c193120a-3800-11e6-b56c-001a4ae51246	PMC4904894	Growth factor-induced phosphorylation of PUM1 Ser714 increases its RNA-binding activity, suggesting a role of PUM1 post-translational modification in the control of cell cycle re-entry.6 ThePUM1andPUM2transcripts share miR-340 target elements in their otherwise divergent 3′-UTRs.
1	PUM1	UNIPROT:Q14671	activates		PF:PF01877	ProteinFamily	430ef08c-c485-11e5-85e4-001a4ae51246	PMC3317963	In response to growth factors, Pumilio 1 becomes phosphorylated, which in turn increases its RNA binding activity.
1	PUM1	UNIPROT:Q14671	inhibits		PF:PF01877	ProteinFamily	76e45aca-3759-11e8-b868-001a4a160176	27157388	Given the high abundance of NORAD, and the presence of multiple binding sites on each transcript, Lee and colleagues propose that NORAD functions as a PUM2/PUM1 decoy, preventing these RNA-binding proteins from interacting with and destabilizing their targets (Figure 1).
1	PUM1	UNIPROT:Q14671	inhibits		FPLX:Cyclin:A	ProteinFamily	9e5cf97a-8cc3-11ee-add2-0050569a791b	10.1007/s00018-022-04254-w	In the late S phase and early M phase, the translational repression of PUM1 along with ubiquitination degradation would cause a reduction of CCNA and CCNB proteins to facilitate G2/M progression.
1	PUM1	UNIPROT:Q14671	inhibits		FPLX:Interferon	ProteinFamily	3e82dca0-c895-11ee-b346-0050569a791b	10.1016/j.dci.2023.104656	Further mechanistic studies have shown that ADAR and PUM1 might target LGP2, a RLR receptor (Gong et al., 2022), to downregulate IFN response in human cells (Liu et al., 2017;Stok et al., 2022).
1	PUM1	UNIPROT:Q14671	inhibits		FPLX:Interferon	ProteinFamily	30a4d928-374e-11e8-87fd-001a4a160176	PMC5565464	The activation of genes associated with innate immunity and reductions in viral yields and viral gene products raised the question of whether depletion of PUM1 results in production of IFN.
1	PUM1	UNIPROT:Q14671	increases		FPLX:Interferon	ProteinFamily	dc09c9b4-bc52-11e5-ac4e-001a4ae51246	PMC4207803	PUM1 and PUM2 Augment dsRNA Binding Activity of LGP2 Finally, to elucidate the mechanism of the enhancement of IFN gene expression by PUM1 and PUM2, we examined dsRNA binding activity of LGP2 in the presence or absence of PUM1 and PUM2.
1	PUM1	UNIPROT:Q14671	activates		FPLX:Cyclin	ProteinFamily	9e5cf97a-8cc3-11ee-add2-0050569a791b	10.1007/s00018-022-04254-w	Our study indicated that CDKN1B and WEE1 are post-transcriptionally regulated by PUM1, such that PUM1 indirectly upregulates cyclin–CDK kinase complexes through repression of CDKN1B and WEE1 translation.
1		CHEBI:90348	activates	PUM1	UNIPROT:Q14671	Chemical	ab03aca0-c8ea-11e5-a801-001a4ae51246	PMC2423135	"GMM allowed us to make a more sophisticated,
                         probabilistic determination of which probes were Pum1 associated and which represented background."
1		UNIPROT:O23717	inhibits	PUM1	UNIPROT:Q14671	Protein	358f8700-bc47-11e5-8abe-001a4ae51246	PMC3787373	CPEB was associated with the probes (Fig. 6 B) and reporter mRNAs (Fig. S4 B) irrespective of the mutation in PBE1, indicating that the mutation in PBE1 disrupts binding of Pum1 without affecting that of CPEB.
1		MESH:D004317	inhibits	PUM1	UNIPROT:Q14671	Phenotype	4ba74924-c774-11ee-b346-0050569a791b	PMC10480464	The presence of doxorubicin was shown to significantly decrease the presence of Pumilio 1 proteins independently ofNORADin cancer cells.
1		UNIPROT:Q9H334	activates	PUM1	UNIPROT:Q14671	Protein	8884466c-5c2d-11e7-8b40-001a4ae51247	PMC5429137	Taken together, our results demonstrate that FOXP1 supports HSPC and leukemic cell expansion and mediates PUM1- and PUM2-dependent growth activities in both normal progenitors and leukemic cells.
1		MESH:D007239	increases	PUM1	UNIPROT:Q14671	Phenotype	dc09c9b4-bc52-11e5-ac4e-001a4ae51246	PMC4207803	Overexpression of PUM1 and PUM2 augmentedIFNBpromoter activity induced by NDV infection (Figure 1B).
1		MESH:D051379	activates	PUM1	UNIPROT:Q14671	Phenotype	0f5fa6c6-351e-11e8-87fd-001a4a160176	PMC5580656	"Because our conditional knockout mice depleted Pum1 and Pum2 from the nervous system since the beginning of neurogenesis,
                         the observed defects in the DG as the most obvious phenotype in the Ndcko mutant mice represent a major function of Pum1 and
                         Pum2 in hippocampal neurogenesis and perhaps the most important function of Pum1 and Pum2 in the brain."
1		UNIPROT:P04637	activates	PUM1	UNIPROT:Q14671	Protein	db833db0-bbf1-11e5-9b9d-001a4ae51247	PMC3449084	p53 Is Overactivated in Spermatocytes inPum1Null Testes Pum1 represses at least two factors, Map2k3 and Map3k1, that activate p53 by activating the p38 MAPK (Figures2E,3A, and 3B).
1		UNIPROT:P54084	decreases	PUM1	UNIPROT:Q14671	Protein	68a5a580-f581-11eb-91e7-001a4a160176	33128584	As displayed in Fig.1c, d, linear PUM1 expression was greatly reduced after digestion by RNase R, but circ_0000043 expression was not affected, suggesting the cyclic structure of circ_0000043.
1		CHEBI:75092	decreases	PUM1	UNIPROT:Q14671	Chemical	df25e152-c83b-11ee-9133-0050569a1f61	10.1016/j.prmcm.2023.100264	A recent study found that morin inhibits colon cancer stem cells by inhibiting PUM1 protein expression, which reduces colon spheroid formation and CD133 expression in colon cancer cell lines.
1		UNIPROT:P02774	activates	PUM1	UNIPROT:Q14671	Protein	2d59652e-c675-11ee-b22c-0050569a1f61	10.1016/j.canlet.2023.216498	Meanwhile, the immune checkpoint PD-L1/PD-1 was the main receptor ligand pair for the interaction between PUM1 overexpression GC cells and CD8+T cells (Supplementary Fig. S2D).
1		UNIPROT:O00453	inhibits	PUM1	UNIPROT:Q14671	Protein	8998d4d2-e17f-11e7-a331-001a4a160176	PMC5741267	A tantalizing future direction is to ask if similar counterparts of SYGL-1 or LST-1 exist in other vertebrate stem cell models to enhance the repressive activity of PUF proteins, Pum1 and Pum2.
1		UNIPROT:Q56P42	inhibits	PUM1	UNIPROT:Q14671	Protein	de091a60-c483-11e5-85e4-001a4ae51246	PMC3476303	RNAi knockdown of CCR4 did not reduce PUM1 repression (Fig. 6D,CCR4, 58% repression), whereas PUM1 repression was significantly abrogated by knockdown of POP2 (Fig. 6D,POP2, 39% repression).