count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
26	PTFC_BACAM	UNIPROT:P41029	inhibits		GO:0042710	Phenotype	b2e9a8de-3904-11e8-bf76-001a4a160175	28729051	FruA inhibited the biofilm formation of wild type until similar level to the biofilm formation inhibited by FruA in UA159.comCand UA159.comDmutants.|||Biofilm formation was significantly inhibited by FruA in cultures with TSB, TSBs, and TSBg, but not with TSBf (Fig. 2C).|||Interestingly, biofilm formation was also significantly inhibited by FruA when cultured with TSB.|||Taken together, we suggested that FruA had multiple functions to inhibit both glucan-dependent biofilm formation in the presence of sucrose, and glucan-independent biofilm formation related to the Com-dependent and -independent QS systems in the presence of sugars.|||Furthermore, biofilm formation was significantly inhibited by FruA in cultures with TSBs and TSBg, but not with TSBf (Fig. 2A).|||In cultures with TSB and TSBs, biofilm formation was significantly inhibited by FruA.|||In the present study, FruA inhibited biofilm formation in not only cultures with TSBs, and but also those with TSBg and TSBf, which do not produce glucan.
8	PTFC_BACAM	UNIPROT:P41029	inhibits		MESH:D001430	Phenotype	b2e9a8de-3904-11e8-bf76-001a4a160175	28729051	FruA treatment to CSP inhibited bacteriocin production inS. mutansGS5.comC-in a dose-dependent manner (Fig. 4C and D).|||The present study is the first to show that FruA inhibits production of bacteriocin in the QS system, and may also depress eDNA-dependent initial attachment, early biofilm formation, and biofilm maturity formation in a glucan-independent system.|||Thus, CSP may be a target for inhibition of bacteriocin production by FruA in the QS system.
8		UNIPROT:O31713	decreases	PTFC_BACAM	UNIPROT:P41029	Protein	fdf51720-bbd7-11e5-956b-001a4ae51247	10.1016/j.jbiotec.2007.07.508	Hence, the knockout of fruR is anticipated to increase transcription of fruB, fruA and fruK.
7		CHEBI:17234	activates	PTFC_BACAM	UNIPROT:P41029	Chemical	2ab128d6-bc45-11e5-8d2d-001a4ae51247	PMC4232747	We found that elevation of basolateral fructose or glucose concentration promoted the apical growth of JE2 but only glucose effectively promoted the growth of NE768(fruA).|||Viable counts confirmed 10 mM glucose-induced similar growth of JE2 and NE768(fruA) (p> 0.05,n= 5, Fig.1d), while viable counts of JE2 in fructose at 8 h were significantly higher than NE768(fruA) (Log10CFU was 8.14 ± 0.06 and 7.05 ± 0.20, respectively;p< 0.0001,n= 5, Fig.1f).
5	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006351	Phenotype	608b439a-c8e0-11e5-9624-001a4ae51246	PMC1539954	"This suggests that FruA directly activates transcription from the Ω4400 promoter incsgAnull mutant cells, accounting for moderate Ω4400 expression.|||Mutations between bp −86 and −77 impair DNA binding in vitro, suggesting
                   that FruA binds near bp −80 and activates Ω4400 transcription in response to C-signal duringM.|||The results support a model in which FruA directly activates
                   transcription from the Ω4400 promoter both before and after C-signaling.|||Taken together, these results suggest that (i) FruA binds near bp −80 and activates Ω4400 transcription in response to
                      C-signal duringM.|||Therefore, PD2behaved more like the Ω4400 promoter with respect to C-signal dependence, suggesting that FruA can activate transcription
                      in response to C-signal from positions ranging at least from about 80 to 160 bp upstream of the transcriptional start site."
4	PTFC_BACAM	UNIPROT:P41029	inhibits		UNIPROT:P54081	Protein	b2e9a8de-3904-11e8-bf76-001a4a160175	28729051	Interestingly, biofilm formation was also significantly inhibited by FruA when cultured with TSB.
4	PTFC_BACAM	UNIPROT:P41029	inhibits		MESH:D005936	Phenotype	b2e9a8de-3904-11e8-bf76-001a4a160175	28729051	Taken together, we suggested that FruA had multiple functions to inhibit both glucan-dependent biofilm formation in the presence of sucrose, and glucan-independent biofilm formation related to the Com-dependent and -independent QS systems in the presence of sugars.
3	PTFC_BACAM	UNIPROT:P41029	phosphorylatesProtein		MESH:D005632	Phenotype	41f1a6ec-c8de-11e5-9ad8-001a4ae51247	PMC1796965	"FruA phosphorylates fructose at C-6.The expression of thefru-gusAfusion and the results of the heterocomplementation experiments suggested that FruA transports fructose.|||In the presence of fructose (and in the absence of glucose), FruA preferentially phosphorylates the
                         incoming sugar (fructose) rather than the PRDI domain of FruT.|||Determination of the site of FruA-mediated fructose phosphorylation.To carry out FruA-mediated fructose phosphorylation, we prepared membrane fragments fromE."
3		MESH:D005632	activates	PTFC_BACAM	UNIPROT:P41029	Phenotype	2ab128d6-bc45-11e5-8d2d-001a4ae51247	PMC4232747	We found that elevation of basolateral fructose or glucose concentration promoted the apical growth of JE2 but only glucose effectively promoted the growth of NE768(fruA).
2	PTFC_BACAM	UNIPROT:P41029	inhibits		UNIPROT:P01308	Protein	b2e9a8de-3904-11e8-bf76-001a4a160175	28729051	Thus, CSP may not be a target factor for inhibition of genetic competency by FruA in the response of bacterial cell surface components, though we concluded that FruA is an inhibitor of the Com-dependent QS system inS.
2	PTFC_BACAM	UNIPROT:P41029	activates		UNIPROT:P31759	Protein	a349118a-bc01-11e5-8abe-001a4ae51246	10.1016/j.tim.2005.04.002	Specifically, they suggest that FruA-P stimulates the conversion of the inactive form of FrzF to an active form, denoted FrzF*, which induces FrzCD methylation.
2	PTFC_BACAM	UNIPROT:P41029	methylatesProtein		UNIPROT:P15529	Protein	a349118a-bc01-11e5-8abe-001a4ae51246	10.1016/j.tim.2005.04.002	Second, the C-signal dependent activation of the response regulator FruA, which presumably involves phosphorylation of FruA, stimulates the Frz chemosensory system by inducing methylation of the MCP homologue, FrzCD, in a manner that depends on the FrzF methyltransferase (for a review of the Frz system, see Ref.
2	PTFC_BACAM	UNIPROT:P41029	inhibits		UNIPROT:Q9H3Z4	Protein	b2e9a8de-3904-11e8-bf76-001a4a160175	28729051	It is considered that CSP activities are inhibited by FruA before CSP induces the signal activities of the two-component ComDE system, and bacteriocin production is inhibited by inactivation of CSP.
2	PTFC_BACAM	UNIPROT:P41029	methylatesProtein		UNIPROT:P43500	Protein	a349118a-bc01-11e5-8abe-001a4ae51246	10.1016/j.tim.2005.04.002	Second, the C-signal dependent activation of the response regulator FruA, which presumably involves phosphorylation of FruA, stimulates the Frz chemosensory system by inducing methylation of the MCP homologue, FrzCD, in a manner that depends on the FrzF methyltransferase (for a review of the Frz system, see Ref.
2	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006810	Phenotype	b0bc3347-0eb0-11ea-b13c-001a4a160176	PMC6872149	Overexpression of fruA in the TM genetic background increased apparent Mtl and NAG transport rates 4-5-fold, but increased apparent αMG and 2DG transport rates 7 and 11-fold, respectively, compared to the control strain bearing the empty pMAL plasmid (Fig 3A).
2	PTFC_BACAM	UNIPROT:P41029	inhibits		MESH:D013395	Phenotype	b2e9a8de-3904-11e8-bf76-001a4a160175	28729051	Taken together, we suggested that FruA had multiple functions to inhibit both glucan-dependent biofilm formation in the presence of sucrose, and glucan-independent biofilm formation related to the Com-dependent and -independent QS systems in the presence of sugars.
2	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006935	Phenotype	4768643c-3955-11e8-8f56-001a4a160175	14662352	Aggregation also depends on phosphorylated FruA and is initiated by the C-signal and FruA-dependent stimulation of the Frz chemotaxis-like system.
2	PTFC_BACAM	UNIPROT:P41029	inhibits		GO:0042710	Phenotype	0d1650ac-c47a-11e5-91a7-001a4ae51247	PMC3067281	FruA inhibited biofilm formation early in the biofilm formation assay (Fig.5B).|||salivariusincluding FruA may inhibit CSP-dependent competency, bacteriocin production, and biofilm formation.
2	PTFC_BACAM	UNIPROT:P41029	activates		IP:IPR003406	ProteinFamily	a1e8fff8-c8ea-11e5-a801-001a4ae51246	PMC2446797	"It
                   is then proposed that the higher levels of activated FruA induce the sporulation branch of the developmental pathway.|||In a current model (reviewed in references13and52), FruA activated in response to C-signaling stimulates development through a branched pathway, with one branch leading to
                   aggregation and a second branch leading to sporulation."
2		UNIPROT:P38586	activates	PTFC_BACAM	UNIPROT:P41029	Protein	b93c27c8-cb2b-11e5-a6cd-001a4ae51247	PMC134883	We show here that DevT stimulates FruA synthesis.|||Thus, DevT stimulates accumulation of FruA during development.
2		UNIPROT:Q0Q2J8	activates	PTFC_BACAM	UNIPROT:P41029	Protein	8a422fd8-bbd8-11e5-8abe-001a4ae51246	PMC4320627	In these cases, bound MrpC2 appeared to enhance the binding of FruA.|||This pattern is similar to the first pattern, in which bound MrpC2 appears to enhance the binding of FruA.
1	PTFC_BACAM	UNIPROT:P41029	increases		UNIPROT:P41029	Protein	fda86520-c482-11e5-9da3-001a4ae51247	PMC3370845	"Increased activation
                      of FruA is proposed to induce FruA-dependent transcription of several target genes."
1	PTFC_BACAM	UNIPROT:P41029	inhibits		UNIPROT:Q9H3Z4	Protein	0d1650ac-c47a-11e5-91a7-001a4ae51247	PMC3067281	salivariusincluding FruA may inhibit CSP-dependent competency, bacteriocin production, and biofilm formation.
1	PTFC_BACAM	UNIPROT:P41029	activates		UNIPROT:A2RRP1	Protein	b0bc3347-0eb0-11ea-b13c-001a4a160176	PMC6872149	Overexpression of fruA in the TM genetic background increased apparent Mtl and NAG transport rates 4-5-fold, but increased apparent αMG and 2DG transport rates 7 and 11-fold, respectively, compared to the control strain bearing the empty pMAL plasmid (Fig 3A).
1	PTFC_BACAM	UNIPROT:P41029	activates		UNIPROT:P18583	Protein	65940a5e-c46a-11e5-9da3-001a4ae51247	PMC4135671	MrpC and FruA cooperatively bind in the promoter region of thedevoperon and appear to directly activate transcription (53; A. Campbell, P. Viswanathan, B. Son, T. Barrett, and L. Kroos, unpublished data).
1	PTFC_BACAM	UNIPROT:P41029	methylatesProtein		UNIPROT:P43500	Protein	9e125f96-bc01-11e5-9b9d-001a4ae51247	10.1016/S0966-842X(01)02166-7	Both the C-signal and FruA are required for increased methylation of FrzCD, a cytoplasmic methyl-accepting chemotaxis protein, during development12.
1	PTFC_BACAM	UNIPROT:P41029	activates		CHEBI:78737	Chemical	e120f1be-ca00-11e5-b88f-001a4ae51247	PMC1112048	"In this regulatory process, FruA, encoding a potential EIIABCFruPTS unit, is necessary to produce fructose-1-phosphate, while FruC, encoding a putative 1-phosphofructokinase, plays an indirect
                   role in fructose operon regulation even in the absence of fructose in the culture medium."
1	PTFC_BACAM	UNIPROT:P41029	phosphorylatesProtein		CHEBI:29864	Chemical	b0bc3347-0eb0-11ea-b13c-001a4a160176	PMC6872149	The results, presented in Table 5, show that purified FruB had a FruA-dependent activating effect on [  C]mannitol phosphorylation in vitro when PEP was the phosphoryl donor, regardless of whether membrane pellets were used from the WT or ΔfruBKA strain, or whether a crude extract was used from the mutant lacking the fru operon.
1	PTFC_BACAM	UNIPROT:P41029	methylatesProtein		CHEBI:29309	Chemical	a1e8fff8-c8ea-11e5-a801-001a4ae51246	PMC2446797	"FruA is proposed to induce the aggregation branch by, in an unknown
                   mechanism, stimulating methylation of the FrzCD methyl-accepting chemotaxis protein, which directs cells to aggregate into
                   mounds (2,30,31,48,53)."
1	PTFC_BACAM	UNIPROT:P41029	activates		CHEBI:29309	Chemical	fda86520-c482-11e5-9da3-001a4ae51247	PMC3370845	"Low levels of activated FruA are proposed to stimulate the methylation state of
                      the methyl-accepting chemosensory protein (MCP), FrzCD."
1	PTFC_BACAM	UNIPROT:P41029	phosphorylatesProtein		MESH:D013395	Phenotype	41f1a6ec-c8de-11e5-9ad8-001a4ae51247	PMC1796965	"In the presence of fructose (and in the absence of glucose), FruA preferentially phosphorylates the
                         incoming sugar (fructose) rather than the PRDI domain of FruT."
1	PTFC_BACAM	UNIPROT:P41029	activates		MESH:D008274	Phenotype	b0bc3347-0eb0-11ea-b13c-001a4a160176	PMC6872149	Overexpression of fruA in the TM genetic background increased apparent Mtl and NAG transport rates 4-5-fold, but increased apparent αMG and 2DG transport rates 7 and 11-fold, respectively, compared to the control strain bearing the empty pMAL plasmid (Fig 3A).
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006351	Phenotype	a4d5bbc4-3405-11e8-b868-001a4a160176	PMC5405206	"FruA appears to activate transcription of theexooperon, whose products are required for sporulation, and FruA and MrpC regulate many other genes important for sporulation
                         that are not shown inFig."
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006351	Phenotype	a1e8fff8-c8ea-11e5-a801-001a4ae51246	PMC2446797	"It has
                   been demonstrated that FruA activates transcription of thedevlocus (63), which in turn is necessary for expression of Tn5 lacZΩ7536 (27), which resides in Mxan_3227 (J. Jakobsen, personal communication)."
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006351	Phenotype	1578679a-c47e-11e5-9cc6-001a4ae51246	21037205	FruA in combination with LadA (Viswanathan et al. 2007b) stimulates transcription of thedevTRSoperon (Viswanathan et al. 2007b), which encodes three clustered, regularly interspaced short palindromic repeat proteins-associated proteins (Viswanathan et al. 2007a), and alone induces transcription offdgA(Ueki and Inouye 2005).
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006351	Phenotype	1aa09994-c470-11e5-85e4-001a4ae51246	PMC2668394	We propose that the N-terminal regulatory domain of FruA interacts with MrpC2 at thefmgBCpromoter region, mediating cooperative binding of the two transcription factors and subjectingfmgBCexpression to combinatorial control similar to that observed forfmgA.
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006351	Phenotype	8a422fd8-bbd8-11e5-8abe-001a4ae51246	PMC4320627	MrpC has not been reported to act as a repressor of transcription, although it has been suggested to delay transcription offmgDby competing with FruA for binding to a site from which FruA appears to activate transcription [45].
1	PTFC_BACAM	UNIPROT:P41029	inhibits		GO:0006351	Phenotype	1578679a-c47e-11e5-9cc6-001a4ae51246	21037205	FruA in combination with LadA (Viswanathan et al. 2007b) stimulates transcription of thedevTRSoperon (Viswanathan et al. 2007b), which encodes three clustered, regularly interspaced short palindromic repeat proteins-associated proteins (Viswanathan et al. 2007a), and alone induces transcription offdgA(Ueki and Inouye 2005).
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006351	Phenotype	99825e2c-c8e5-11e5-9cb8-001a4ae51247	PMC1876556	Discussion Our results support a model in which transcription of thedevoperon is activated by FruA and LadA binding to sites centered at about −90 and +350, respectively.
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006351	Phenotype	f5583422-c8e7-11e5-9624-001a4ae51246	PMC1913320	By analogy, we speculate that FruA (possibly phosphorylated in response to C-signaling) binds upstream of thedevpromoter and activates its transcription.
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006351	Phenotype	4fce20c8-3506-11e9-87c2-001a4a160175	30193985	xanthuscells results in proteolysis of the transcription factors MrpC and FruA that activate the transcription of thedevoperon and, accordingly, halts the production of Dev proteins and sporulation[79,80].
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0006351	Phenotype	65940a5e-c46a-11e5-9da3-001a4ae51247	PMC4135671	MrpC and FruA cooperatively bind in the promoter region of thedevoperon and appear to directly activate transcription (53; A. Campbell, P. Viswanathan, B. Son, T. Barrett, and L. Kroos, unpublished data).
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0007619	Phenotype	7ad0d146-ab4f-11e6-9ac8-001a4ae51246	PMC4868454	"This result indicates that PSI binding may affect U1 snRNP targeting to different 5′SS infruitlesspre-mRNA and affect interactions of U1 snRNP with the three alternative 3′SS to control AS of the fru-A, -B, and -C isoforms
                                  that are known to modulate fly courtship behavior."
1	PTFC_BACAM	UNIPROT:P41029	inhibits		MESH:D007444	Phenotype	1009a6c4-c47a-11e5-9da3-001a4ae51247	PMC3067331	Since inulin is a polymer of fructose, the induction effect onfruAandlevDlikely results from degradation of inulin by FruA and release of free fructose, which serves as the inducing signal.
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0043934	Phenotype	a1e8fff8-c8ea-11e5-a801-001a4ae51246	PMC2446797	"This result is to be expected if premature FruA expression requires FrzCD to promote normal aggregation, but can still
                      promote sporulation through thedevand Mxan_3227 loci."
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0043934	Phenotype	be593d7c-c9ff-11e5-b88f-001a4ae51247	PMC384728	"With repeated signaling several hundred molecules of C-signal accumulate on the cell surface; the responding cell phosphorylates
                               most of its FruA, which in turn induces expression of sporulation genes and eventually sporulation itself (13,23)."
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0043934	Phenotype	fda86520-c482-11e5-9da3-001a4ae51247	PMC3370845	"FruA is proposed to induce aggregation and then sporulation in proportion to the degree of activation by C-signal, a 17-kDa
                         proteolytic fragment of the CsgA protein (12,24,43,46)."
1	PTFC_BACAM	UNIPROT:P41029	activates		GO:0043934	Phenotype	4aabcce4-c8e9-11e5-9cb8-001a4ae51247	PMC2446785	This in turn causes premature accumulation of FruA, which accelerates sporulation.
1	PTFC_BACAM	UNIPROT:P41029	inhibits		MESH:D001430	Phenotype	0d1650ac-c47a-11e5-91a7-001a4ae51247	PMC3067281	salivariusincluding FruA may inhibit CSP-dependent competency, bacteriocin production, and biofilm formation.
1	PTFC_BACAM	UNIPROT:P41029	activates		MESH:D002470	Phenotype	d8d9486c-ca00-11e5-9b70-001a4ae51247	PMC1111851	FruA may thus enhance cell survival during periods of nutrient starvation by degrading fructans.
1	PTFC_BACAM	UNIPROT:P41029	activates		MESH:D005632	Phenotype	34a3de54-ae94-11ec-8b2e-0050569a1f61	PMCPMC8704671	When fructose was used as carbon source, the expression levels of FOS and sucrose metabolism genes sacA, sacR1, pts1BCA, agl2 and pts26BCA did not change significantly, while the expression levels of sacK1, agl4 and sacR2 were increased.The expressions of fruA, fruA1, pst9D and pts10AB were increased after adding fructose.
1	PTFC_BACAM	UNIPROT:P41029	inhibits		GO:0010147	Phenotype	a9bb0f66-c6f5-11ee-b346-0050569a791b	10.1016/j.fhfh.2023.100117	Addition of FruA, an extracellular fructosidase identified in L.crispatusDSM29598, caused further fructan degradation when added to the bread dough making step (Li et al., 2020).
1	PTFC_BACAM	UNIPROT:P41029	activates		IP:IPR003406	ProteinFamily	b93c27c8-cb2b-11e5-a6cd-001a4ae51247	PMC134883	"In this branch, FruA and the C-signal interact to induce transcription
                   of the essential sporulation operondevRSafter 6 to 9 h of development (5,19)."
1		UNIPROT:P41029	increases	PTFC_BACAM	UNIPROT:P41029	Protein	fda86520-c482-11e5-9da3-001a4ae51247	PMC3370845	"Increased activation
                      of FruA is proposed to induce FruA-dependent transcription of several target genes."
1		UNIPROT:Q9RGZ3	activates	PTFC_BACAM	UNIPROT:P41029	Protein	a1e8fff8-c8ea-11e5-a801-001a4ae51246	PMC2446797	Second, premature expression of MrpC induces premature transcription offruAand consequent production of FruA (Fig.4Cand5A).
1		UNIPROT:Q9RGZ3	activates	PTFC_BACAM	UNIPROT:P41029	Protein	50c68f5e-ae95-11ec-a61d-0050569a1f61	PMCPMC8561891	It is generally assumed that FruA is activated by MrpC to aid in activating the developmental pathway, and recent work suggests that MrpC is transcribed proportionally to nutrient availability [57].
1		UNIPROT:Q9RGZ3	activates	PTFC_BACAM	UNIPROT:P41029	Protein	8a422fd8-bbd8-11e5-8abe-001a4ae51246	PMC4320627	It is possible that cooperative interactions with MrpC allow FruA to bind to sequences dissimilar to the proposed consensus.
1		UNIPROT:Q9RGZ3	activates	PTFC_BACAM	UNIPROT:P41029	Protein	02b9085c-ae93-11ec-8b2e-0050569a1f61	PMCPMC8844925	It is also a possibility that the promoter with a TSS at −53 is activated by MrpC together with FruA as described for several developmentally regulated promoters (46–51).
1		UNIPROT:Q3IZ91	decreases	PTFC_BACAM	UNIPROT:P41029	Protein	aa54fb2c-c8dd-11e5-a1fd-001a4ae51246	PMC1482907	"It is of interest
                      that EIIGlcimpacts the expression of fructanase (fruA), which is known to be induced by the presence of its substrates, levans and inulins, but also to be negatively regulated
                      by CCR and the fructose-PTS (51)."
1		UNIPROT:Q8A1A0	activates	PTFC_BACAM	UNIPROT:P41029	Protein	db4f4100-c474-11e5-a92e-001a4ae51246	PMC4475891	"For example, RhaD
                      could synthesized-sorbose andd-psicose simultaneously fromd-glyceraldehyde, FucA generatedl-tagatose andl-fructose together froml-glyceraldehyde (6,7), and FruA and TagA producedl-sorbose andl-psicose froml-glyceraldehyde."
1		PF:PF15323	activates	PTFC_BACAM	UNIPROT:P41029	ProteinFamily	98e5cc00-cb2a-11e5-b419-001a4ae51246	PMC135454	In the course of 2D gel analysis of developmental protein synthesis in the wild-type,fruA::Tc, andcsgA731strains,dofAexpression andtpsexpression were found to be FruA dependent but CsgA independent (20).
1		CHEBI:44800	activates	PTFC_BACAM	UNIPROT:P41029	Chemical	05d072bc-85b7-11ee-add2-0050569a791b	10.1007/s00253-022-12150-3	Wang et al. (155) found that the exogenous addition of AI-2 can increase the transcription ofspaP,fruA,gtfB,gtfC, andgtfDgenes, all of which are related to adhesion biofilm inS.
1		UNIPROT:P54707	phosphorylatesProtein	PTFC_BACAM	UNIPROT:P41029	Protein	3c56ab48-352d-11e8-a51f-001a4a160176	27430596	FruA is an “orphan” RR, and the HK responsible for phosphorylation of FruA is currently unknown, although genetic evidence suggests that phosphorylation of FruA is induced by the C-signal[187].
1		UNIPROT:Q6H321	phosphorylatesProtein	PTFC_BACAM	UNIPROT:P41029	Protein	9e125f96-bc01-11e5-9b9d-001a4ae51247	10.1016/S0966-842X(01)02166-7	It has been proposed that the receptor is the unknown histidine protein kinase (HPK) that phosphorylates FruA (Ref.
1		MESH:D013217	inhibits	PTFC_BACAM	UNIPROT:P41029	Phenotype	a4d5bbc4-3405-11e8-b868-001a4a160176	PMC5405206	"Briefly, starvation and C-signal enhance MrpC and FruA activity, respectively, and MrpC positively autoregulates and stimulates
                         C-signal production (Fig. 8)."
1		MESH:D005632	decreases	PTFC_BACAM	UNIPROT:P41029	Phenotype	c3de3324-c47d-11e5-8491-001a4ae51247	PMC2944538	"The expression of PTS3 Lev and FruA is repressed by fructose-specific PTS1 and PTS2 through carbon
                         catabolite repression, which allows bacteria to metabolize the readily used sugars instead of nonpreferred ones (72,73,74)."
1		MESH:D005632	increases	PTFC_BACAM	UNIPROT:P41029	Phenotype	b0bc3347-0eb0-11ea-b13c-001a4a160176	PMC6872149	To explain these results, we must consider that the overexpression of fruA and fruB caused by fructose induction was dissimilar from that obtained using the two compatible plasmids, pMAL and pZA31-PtetM2, which have different copy numbers.
1		MESH:D005632	increases	PTFC_BACAM	UNIPROT:P41029	Phenotype	ffb1fd4c-c471-11e5-91a7-001a4ae51247	19965476	Fructose adaptation resulted in overexpression of fruA and fruK (>3 log2), and mannose-adapted cells overexpressed the mannitol importer (>5 log2) (tables S19 and S20).
1		UNIPROT:Q0Q2J8	activates	PTFC_BACAM	UNIPROT:P41029	Protein	1ce1c9a6-c47c-11e5-a92e-001a4ae51246	PMC3133106	"It was proposed that binding of MrpC2 to the downstream site repressesfmgDtranscription until C-signaling causes the concentration of active FruA to increase sufficiently to outcompete the downstream
                      MrpC2 for cooperative binding with the upstream MrpC2."
1		UNIPROT:Q0Q2J8	activates	PTFC_BACAM	UNIPROT:P41029	Protein	a1e8fff8-c8ea-11e5-a801-001a4ae51246	PMC2446797	"MrpC2 binds to the promoter and is thought to induce transcriptional
                   upregulation of the key developmental transcriptional regulator gene,fruA(60)."