count source_label source_id relationship target_label target_id entity_type solr_id publication_id sentences 8 MESH:D004202 activates MBEC_ECOLX UNIPROT:P13657 Phenotype 06e8b618-375d-11e8-a51f-001a4a160176 24815513 Thus, when all of the factors are at their SOP values, as the disinfectant is increased up a single row of the MBEC device (e.g., going from row E to row D, corresponding to DisConc increasing by 1), then it is predicted that the LR will increase by 0.7866. 4 MBEC_ECOLX UNIPROT:P13657 inhibits MESH:D003091 Phenotype a097c912-3748-11e8-a34b-001a4a160175 26004353 MBEC/MBC values showed that transition from planktonic toward sessile phenotype caused a significant reduction of colistin activity for all strains tested, with comparable extent for both conditions tested (MBEC/MBC: 166±182.7 versus 137.7±146.1, for “standard” and “CF-like” settings, respectively;P>0.05, pairedt-test) (Tables 2 and 3). 4 MBEC_ECOLX UNIPROT:P13657 activates FPLX:TGFBR ProteinFamily 77286ad4-cb28-11e5-b419-001a4ae51246 PMC1891905 TGF-β signaling also increases expression of TGF-β receptor II.36Therefore, we next examined cyclosporine-treated mBECs for evidence of TGF-β-mediated signaling using immunoblotting for TGF-β receptor II expression and phosphorylation of SMAD-2.Figure 6Ashows that cyclosporine treatment of mBEC increases TGF-β receptor II protein expression, compared to mBEC kept in tacrolimus-supplemented media; there is also increased SMAD-2 phosphorylation (Figure 6B) in the cyclosporine-treated, but not in the tacrolimus-treated mBECs. 4 MESH:D048271 inhibits MBEC_ECOLX UNIPROT:P13657 Phenotype 1fdb28e6-340a-11e8-8636-001a4a160175 27851985 mesenteroidesbiofilms were unaffected by the change in incubation temperature, and both the chitosan-coated and the uncoated emulsion encapsulation lowered the MBEC. 2 MBEC_ECOLX UNIPROT:P13657 activates CHEBI:37923 Chemical 06e8b618-375d-11e8-a51f-001a4a160176 24815513 The MBEC method To initiate the standardized MBEC method (ASTM E2799), the wells of an MBEC device (Innovotech Inc., Edmonton, Ab. 2 MBEC_ECOLX UNIPROT:P13657 activates GO:0001525 Phenotype 940706a4-bc3e-11e5-9b9d-001a4ae51247 PMC2597046 DETA-NONOate co-cultured with the conditioned medium from BMSCs increases angiogenesis and capillary tube formation To test whether DETA-NONOate in combination with BMSCs upregulates angiogenesis via the Ang1/Tie2 system, MBEC capillary tube-like formation assays were performedin vitro. 2 MBEC_ECOLX UNIPROT:P13657 activates GO:0007155 Phenotype 95b9ca7a-bc54-11e5-ac4e-001a4ae51246 10.1016/S0165-5728(01)00348-4 VCAM-1 has been reported to be elevated early in HIV and SIV neuropathogenesis(Persidsky et al., 1997a; Sasseville et al., 1995), and so it was important to determine if MBEC could be induced to express this adhesion molecule on the cell surface in response to cytokines of neurological importance. 2 UNIPROT:P01375 activates MBEC_ECOLX UNIPROT:P13657 Protein 9d91949e-bc54-11e5-ac4e-001a4ae51246 10.1016/S0165-5728(02)00256-4 We have previously shown that MBEC in culture are activated by addition of TNF-α to the culture medium bathing the cells. 2 CHEBI:40968 activates MBEC_ECOLX UNIPROT:P13657 Chemical 3490b592-374a-11e8-87fd-001a4a160176 26141761 It suggested that astaxanthin promoted proliferation and migration of MBEC and VSMC, and might play synergistic role in angiogenesis. 2 UNIPROT:P96471 inhibits MBEC_ECOLX UNIPROT:P13657 Protein 3f0b7538-88ba-11e6-a316-001a4ae51247 PMC5039596 Streptokinase Treatment Lowers the MBEC to Clinically Relevant Levels The addition of streptokinase during antibiotic treatment dramatically increased the susceptibility of biofilms to antibiotics, resulting in lower MBEC values (Table 1).|||The combination of streptokinase and two antibiotics lowered the MBEC to a level that can safely be obtained in vivo (Table 1). 1 MBEC_ECOLX UNIPROT:P13657 increases UNIPROT:Q96PE1 Protein 9b664f96-351c-11e8-9fbf-001a4a160176 28523566 Here, treatment of MBEC with RG-CM greatly induced the expression of GPR124 mRNA, suggesting that RG-secreted factors might increase angiogenic response of endothelial cells to RG cells. 1 MBEC_ECOLX UNIPROT:P13657 inhibits UNIPROT:Q40565 Protein 47783d8e-5c93-11e7-8c5f-001a4ae51246 PMC5293564 In conclusion, we report the establishment of anin vitroculture system that mimics the barrier function of the BBB via an MBEC monolayer on Transwell inserts, and demonstrate that ATP promotes MBEC barrier disruption and paracellular transmigration of Ra2 microglia. 1 MBEC_ECOLX UNIPROT:P13657 activates CHEBI:78337 Chemical 0acf4756-c8ec-11e5-8b47-001a4ae51246 PMC2650528 "The MBEC system also allows the determination of the MIC of the test agent for planktonic cells shed from the biofilm as well as the minimum biofilm eradication concentration (MBEC), the concentration of antimicrobial agent required to sterilize the biofilm after 24 h of exposure." 1 MBEC_ECOLX UNIPROT:P13657 activates GO:0001525 Phenotype a90198b2-bc3e-11e5-9b9d-001a4ae51247 PMC3505259 Mouse brain EC (MBEC) culture and capillary-like tube formation assay To investigate whether combination treatment increases angiogenesis, and to further elucidate whether the combination treatment-induced angiogenesis is related to the Ang1 signaling pathway, MBEC capillary-like tube formation assay was employedin vitro. 1 MBEC_ECOLX UNIPROT:P13657 activates GO:0065003 Phenotype b3115a4e-bc17-11e5-8abe-001a4ae51246 PMC2025667 These results show that MBEC can allow DNA-protein complex formation to be monitored under equilibrium conditions with high sensitivity and reproducibility using currently available fluorimeters and plate readers. 1 MBEC_ECOLX UNIPROT:P13657 inhibits GO:0042710 Phenotype b5c79e62-c47b-11e5-8491-001a4ae51247 PMC3165298 "We therefore examined the activity of ABC-1 to inhibit biofilm formation by five human pathogens and one plant pathogen in the MBEC static biofilm assay." 1 MBEC_ECOLX UNIPROT:P13657 activates GO:0035148 Phenotype 940706a4-bc3e-11e5-9b9d-001a4ae51247 PMC2597046 DETA-NONOate co-cultured with the conditioned medium from BMSCs increases angiogenesis and capillary tube formation To test whether DETA-NONOate in combination with BMSCs upregulates angiogenesis via the Ang1/Tie2 system, MBEC capillary tube-like formation assays were performedin vitro. 1 MBEC_ECOLX UNIPROT:P13657 activates PF:PF03432 ProteinFamily 3c9c0364-c8ec-11e5-9faa-001a4ae51247 PMC2648203 "By comparison to other accessory proteins, we propose that MbeC induces DNA bending, helping the MbeA relaxase to melt the DNA around thenicsite and cleave the phosphodiester bond." 1 FPLX:Protease inhibits MBEC_ECOLX UNIPROT:P13657 ProteinFamily 47783d8e-5c93-11e7-8c5f-001a4ae51246 PMC5293564 It has been reported that ATP increases MMP-9 activity [17], and it is therefore possible that ATP induced MMP-9 secretion and the subsequent protease disruption of MBEC junctions, which decreased the TEER. 1 UNIPROT:P01584 activates MBEC_ECOLX UNIPROT:P13657 Protein 03db12f6-c480-11e5-91a7-001a4ae51247 20200351 We used neutralizing antibodies to IL-1α or IL-1β to determine the relative contributions of IL-1α and IL-1β to platelet-induced MBEC activation. 1 PF:PF00683 inhibits MBEC_ECOLX UNIPROT:P13657 ProteinFamily eb1562d0-3c8e-11f0-afc2-0050569a791b 10.1016/j.phymed.2022.154179 " Recently, Sans-Serramitjana et al. reported that despite having the same efficacy against planktonic bacteria, TB-loaded NLC decreases MBEC against established P. aeruginosa biofilms compared to free TB (Sans-Serramitjana et al., 2017)." 1 MESH:D000255 inhibits MBEC_ECOLX UNIPROT:P13657 Phenotype 47783d8e-5c93-11e7-8c5f-001a4ae51246 PMC5293564 In conclusion, we report the establishment of anin vitroculture system that mimics the barrier function of the BBB via an MBEC monolayer on Transwell inserts, and demonstrate that ATP promotes MBEC barrier disruption and paracellular transmigration of Ra2 microglia. 1 UNIPROT:P26447 activates MBEC_ECOLX UNIPROT:P13657 Protein a0e81c28-bc3e-11e5-8d2d-001a4ae51247 10.1016/j.neuroscience.2011.05.044 Treatment with 1000 and 2000 ng/ml of S100A4 for 12 h significantly increased the permeability coefficients of MBEC for Na-F by 115% and 130% of control, respectively (Fig. 2A).