count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
8	LE418_CAEEL	UNIPROT:G5EBZ4	inhibits		GO:0030154	Phenotype	e51d4976-bbd6-11e5-8abe-001a4ae51246	10.1016/S0092-8674(02)01202-3	Thus, just as embryonic somatic cells require MEP-1 and LET-418 to stably inactivate germline potential, we propose that the activities of MEP-1 and LET-418 and, by extension, other synMuvB proteins including HDA-1 are required during larval development for VPCs to stably inactivate the potential to undergo vulval differentiation.|||When the gonad signals the VPCs to initiate vulval differentiation, synMuvB components, including MEP-1, LET-418, and HDA-1, are either downregulated in the three VPCs nearest the gonadal signal or are activated in more distal VPCs.
6	LE418_CAEEL	UNIPROT:G5EBZ4	inhibits		GO:0006338	Phenotype	e51d4976-bbd6-11e5-8abe-001a4ae51246	10.1016/S0092-8674(02)01202-3	Our findings instead support a model in which PIE-1 transiently inhibits MEP-1, LET-418, and HDA-1 activities to prevent chromatin remodeling in the germline and to thus insure the proper activation of germline gene expression during later development.|||Our findings support a model in which PIE-1 inhibits the activities of MEP-1, LET-418, and HDA-1 to prevent chromatin remodeling and to preserve MES-protein-dependent germline pluripotency during the early embryonic phase of somatic cell-fate specification.
6		UNIPROT:Q7X9V2	inhibits	LE418_CAEEL	UNIPROT:G5EBZ4	Protein	e51d4976-bbd6-11e5-8abe-001a4ae51246	10.1016/S0092-8674(02)01202-3	PIE-1 Inhibits the Histone Deacetylase Activity of HDA-1 The studies described above suggest that PIE-1 inhibits the function of MEP-1 and LET-418.|||The studies described above suggest that PIE-1 inhibits the function of MEP-1 and LET-418.|||Our findings support a model in which PIE-1 inhibits the activities of MEP-1, LET-418, and HDA-1 to prevent chromatin remodeling and to preserve MES-protein-dependent germline pluripotency during the early embryonic phase of somatic cell-fate specification.
4		UNIPROT:Q7X9V2	activates	LE418_CAEEL	UNIPROT:G5EBZ4	Protein	e51d4976-bbd6-11e5-8abe-001a4ae51246	10.1016/S0092-8674(02)01202-3	We next asked if ectopic expression of PIE-1 can induce the synMuv phenotype characteristic of MEP-1, LET-418, and HDA-1 inhibition.
4		UNIPROT:Q7X9V2	decreases	LE418_CAEEL	UNIPROT:G5EBZ4	Protein	e51d4976-bbd6-11e5-8abe-001a4ae51246	10.1016/S0092-8674(02)01202-3	We did not observe any change in the abundance or localization of the MEP-1 or LET-418 proteins inhsp::pie-1embryos and larvae (data not shown), suggesting that ectopic PIE-1 expression inhibits the activity of, rather than the expression of, MEP-1 and LET-418.
2	LE418_CAEEL	UNIPROT:G5EBZ4	inhibits		UNIPROT:G5EBZ4	Protein	fc8324f6-bbe4-11e5-8abe-001a4ae51246	10.1016/j.ydbio.2007.03.026	LET-418 suppresseslin-39transcription by LIN-1/ETS mediated promoter binding By performing ChIP experiments we found that LET-418 specifically associated with thelin-39promoter fragments III and IV (seeFig.
2	LE418_CAEEL	UNIPROT:G5EBZ4	activates		GO:0000747	Phenotype	fc8324f6-bbe4-11e5-8abe-001a4ae51246	10.1016/j.ydbio.2007.03.026	LET-418 promotes Pn.p cell fusion and represses vulval induction by negatively controllinglin-39activity In wild-type animals, all VPCs P(4–8).
2	LE418_CAEEL	UNIPROT:G5EBZ4	inhibits		GO:0040025	Phenotype	5fad2a64-c46d-11e5-9cc6-001a4ae51246	PMC4200253	elegansas a model system, we found that RBR-2/KDM5 and LET-418/CHD4 functioned in the same pathway to negatively regulate vulval development.
2		FPLX:HDAC	inhibits	LE418_CAEEL	UNIPROT:G5EBZ4	ProteinFamily	e51d4976-bbd6-11e5-8abe-001a4ae51246	10.1016/S0092-8674(02)01202-3	PIE-1 Inhibits the Histone Deacetylase Activity of HDA-1 The studies described above suggest that PIE-1 inhibits the function of MEP-1 and LET-418.
2		UNIPROT:O22446	inhibits	LE418_CAEEL	UNIPROT:G5EBZ4	Protein	e51d4976-bbd6-11e5-8abe-001a4ae51246	10.1016/S0092-8674(02)01202-3	PIE-1 Inhibits the Histone Deacetylase Activity of HDA-1 The studies described above suggest that PIE-1 inhibits the function of MEP-1 and LET-418.
2		UNIPROT:G5EBZ4	inhibits	LE418_CAEEL	UNIPROT:G5EBZ4	Protein	fc8324f6-bbe4-11e5-8abe-001a4ae51246	10.1016/j.ydbio.2007.03.026	LET-418 suppresseslin-39transcription by LIN-1/ETS mediated promoter binding By performing ChIP experiments we found that LET-418 specifically associated with thelin-39promoter fragments III and IV (seeFig.
1	LE418_CAEEL	UNIPROT:G5EBZ4	activates		CHEBI:85045	Chemical	e53b4a1e-8270-11e6-b946-001a4ae51247	PMC5024519	In addition our results suggest that the proposed mechanism of H3K27me3 modulation by LET-418 and CHD-3 might not be only restricted to the four target genes studied in this assay, but could concern a larger gene population.Fig.
1	LE418_CAEEL	UNIPROT:G5EBZ4	inhibits		CHEBI:85045	Chemical	e53b4a1e-8270-11e6-b946-001a4ae51247	PMC5024519	Our data suggest that LET-418 promotes the deposition of the negative H3K27me3 marks at its target genes, directly or indirectly, whereas CHD-3 acts as a modulator of this deposition.
1	LE418_CAEEL	UNIPROT:G5EBZ4	activates		MESH:D013724	Phenotype	9a7932c8-ae95-11ec-89b1-0050569a791b	PMCPMC8678065	Suppression of the evolutionary conserved chromatin regulators SPR-5 and LET-418 (the worm homologs of Lysine-specific histone demethylase (LSD-1) and Mi2 respectively) causes C. elegans germ cells to display teratoma-like characteristics (Käser-Pébernard et al., 2014).
1	LE418_CAEEL	UNIPROT:G5EBZ4	inhibits		GO:0008406	Phenotype	93400814-bbf4-11e5-8abe-001a4ae51246	PMC3986580	Concomitant loss of SPR-5 and LET-418 leads to immediate sterility, aberrant gonad development, and germline teratoma incidence.
1	LE418_CAEEL	UNIPROT:G5EBZ4	inhibits		GO:0030336	Phenotype	0e3c168a-9ecc-11ee-a9a2-0050569a1f61	PMC8110489	elegans(Dufourcq et al.11; Zinovyeva et al.51), here we show that the related repressor complexes of LET-418, SIN-3, SPR-1 likely modulate the negative regulation of cell migration during embryonic development.