count source_label source_id relationship target_label target_id entity_type solr_id publication_id sentences 4 PUBCHEM:65154 PUBCHEM:65154 activates MESH:D009369 Phenotype 0fdcfb50-3413-11e8-a51f-001a4a160176 9672660 Initial studies using gas chromatography-mass spectrophotometry revealed that levels of 8-hydroxyadenine, 8-hydroxyguanine, and their derivatives 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-foramido-pyrimidine (FapyGua) were elevated in liver tumors of adult English sole from contaminated Eagle Harbor, WA compared to that of normal liver tissue from sole from cleaner reference locales in Puget Sound[108, 109]. 4 PUBCHEM:65154 PUBCHEM:65154 activates MESH:D006147 Phenotype 62601e10-c477-11e5-a92e-001a4ae51246 26452301 The oxidation product of guanine, 8-hydroxyguanine, preferentially pairs up adenine rather than cytosine, thus generating transversion mutations (Kasai and Nishimura, 1984; Shibutani et al., 1991). 4 CHEBI:16234 activates PUBCHEM:65154 PUBCHEM:65154 Chemical d1671a6e-3745-11e8-9fbf-001a4a160176 26674130 Formation of 8-hydroxyguanine catalyzed by hydroxyl radicals was considered a major mutagenic base lesion in living cells[34]. 2 PUBCHEM:65154 PUBCHEM:65154 activates UNIPROT:P02774 Protein eff9ce68-bbff-11e5-8abe-001a4ae51246 10.1016/j.bbrc.2007.07.175 It has been reported that 8-hydroxyguanine, a representative feature of oxidative DNA damage, is generated by the CDAA diet[4], and it is well-established that 8-hydroxyguanine induces G/C to T/A or A/T to C/G transversions inEscherichia coli[22]. 2 PUBCHEM:65154 PUBCHEM:65154 activates UNIPROT:P02774 Protein 92c5f4b0-bbff-11e5-8abe-001a4ae51246 10.1016/j.bbrc.2008.11.044 It is well-established that 8-hydroxyguanine induces G/C to T/A or A/T to C/G transversions inEscherichia coli[28]. 2 PUBCHEM:65154 PUBCHEM:65154 activates GO:0008219 Phenotype 46eb2190-3944-11e8-bf76-001a4a160175 15755676 Expression of mutant α-synuclein cells produces increased levels of 8-hydroxyguanine, protein carbonyls, lipid peroxidation, and 3-nitrotyrosine, and markedly accelerated cell death in response to oxidative insult (Lee et al., 2001). 2 MESH:D063646 activates PUBCHEM:65154 PUBCHEM:65154 Phenotype d2fa54a0-3ab4-11e8-8636-001a4a160175 17590295 Free radicals also participate in carcinogenesis as measured by BP-induced hepatic 8-hydroxyguanine production (Urios and Blanco, 1996; Garcon et al., 2001). 2 MESH:D017382 activates PUBCHEM:65154 PUBCHEM:65154 Phenotype a7fa14f6-bc45-11e5-ac4e-001a4ae51246 10.1016/j.mrfmmm.2004.05.013 8-Hydroxyguanine (8-OH-G) induced by reactive oxygen species (ROS) is one of the stable oxidative DNA damages and is thought to be involved in oxidative mutagenesis and carcinogenesis[3,4]. 2 CHEBI:15430 activates PUBCHEM:65154 PUBCHEM:65154 Chemical 774ecc76-bbea-11e5-8abe-001a4ae51246 10.1016/S1568-7864(02)00186-6 The reaction of protoporphyrin via single oxygen or hydroxyl radicals may induce oxidative DNA modification, form 8-hydroxyguanine, a main oxidation product of the bases, and 5-hydroxy pyrimidine derivatives and apurinic sites that are strong lethal and potentially mutagenic lesions. 1 PUBCHEM:65154 PUBCHEM:65154 activates UNIPROT:P49585 Protein 14b90750-ca01-11e5-be63-001a4ae51246 16106417 If left unrepaired by hOGG1, 8-hydroxyguanine can produce G:CT:A transversions. 1 PUBCHEM:65154 PUBCHEM:65154 activates UNIPROT:O42567 Protein 90b8b6b4-cf0d-11e5-888a-001a4ae51246 1710166 All of the secondary nitroalkanes and cyclopentanone oxime significantly increased levels of 8-hydroxyguanine in both DNA and RNA and caused the appearance of DX1, RX1 and RX2. 1 PUBCHEM:65154 PUBCHEM:65154 phosphorylatesProtein UNIPROT:P84022 Protein f6941354-c8b8-11ee-b346-0050569a791b PMC10068496 Concomitant administration of naringin (a SMAD3 inhibitor) and cumulinic acid (a SMAD7 agonist) in mice provided additional protection against renal fibrosis.26Compound bitter ginseng injection stabilized the binding between SMAD7 and TGFβR1, thereby reducing SMAD3 phosphorylation and extracellular matrix fibrosis in hepatic stellate cells.27In bleomycin-induced pulmonary fibrosis, 8-hydroxyguanine DNA glycosidase-1 promoted mesenchymal transdifferentiation of pulmonary glandular epithelial cells by activating SMAD2/3 by binding to SMAD7.28These studies suggest that Smad7 upregulation may be utilized to further maintain the SMAD3/SMAD7 balance in the future. 1 PUBCHEM:65154 PUBCHEM:65154 activates UNIPROT:O42201 Protein 90b8b6b4-cf0d-11e5-888a-001a4ae51246 1710166 All of the secondary nitroalkanes and cyclopentanone oxime significantly increased levels of 8-hydroxyguanine in both DNA and RNA and caused the appearance of DX1, RX1 and RX2. 1 PUBCHEM:65154 PUBCHEM:65154 activates UNIPROT:P02774 Protein c7a443ce-bc51-11e5-ac4e-001a4ae51246 PMC3234590 "It is well established that 8-hydroxyguanine induces G/C to T/A or A/T to C/G transversions inEscherichia coli35." 1 PUBCHEM:65154 PUBCHEM:65154 activates UNIPROT:P02774 Protein a6895b40-bc45-11e5-8d2d-001a4ae51247 10.1016/j.mrfmmm.2008.10.005 It is well-established that 8-hydroxyguanine induces G/C to T/A or A/T to C/G transversions inEscherichia coli[27]. 1 PUBCHEM:65154 PUBCHEM:65154 activates UNIPROT:P08922 Protein 5d0377ac-bbd8-11e5-956b-001a4ae51247 10.1016/j.brainresbull.2010.06.014 GPs attenuated MPP+-induced oxidative stress Significantly increased ROS, oxidative injury products such as protein carbonyls and 8-hydroxyguanine, and lipid peroxidation product such as MDA were detected in MPP+/vehicle group compared with control group. 1 PUBCHEM:65154 PUBCHEM:65154 activates MESH:D000375 Phenotype dc6cb234-c97f-11ee-b346-0050569a791b PMC9837651 Elevated levels of 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine seem to be promising serum biomarkers of oxidative damage in nucleic acids and accelerated cellular aging. 1 PUBCHEM:65154 PUBCHEM:65154 activates GO:0006281 Phenotype 3efd6c28-bc40-11e5-8d2d-001a4ae51247 10.1016/j.freeradbiomed.2012.08.592 In thalassemic patients the presence of 8-hydroxyguanine as well as other single-base modifications stimulates DNA repair systems. 1 PUBCHEM:65154 PUBCHEM:65154 activates MESH:D063646 Phenotype dd595b0c-bc54-11e5-8abe-001a4ae51246 10.1016/j.etp.2008.01.010 It has been reported that after its biotransformation, DEN produces the promutagenic adductsO6-ethyldeoxyguanosine andO4- andO6-ethyldeoxythymidine and 8-hydroxyguanine (8-OHG) that may initiate liver carcinogenesis (Verna et al., 1996;Nakae et al., 1997). 1 PUBCHEM:65154 PUBCHEM:65154 increases MESH:D017382 Phenotype 2dce4232-ea19-11ee-b346-0050569a791b PMC9552032 This damage includes elevated levels of intracellular reactive oxygen species/reactive nitrogen species, protein carbonyls, and 3-nitrotyrosine, increased lipid peroxidation, significant DNA damage as 8-hydroxy-deoxyguanosine produced by reactive oxygen species/reactive nitrogen species, and 8-hydroxyguanine in RNA. 1 PUBCHEM:65154 PUBCHEM:65154 activates MESH:D004249 Phenotype f3ee0158-bbdf-11e5-9b9d-001a4ae51247 PMC4506808 In addition, oxygen radicals also react with DNA, causing oxidative damage; 8-hydroxyguanine (8-OHGua) is a product of oxidative DNA damage [6]. 1 PUBCHEM:65154 PUBCHEM:65154 inhibits MESH:D013577 Phenotype 1029bdf8-cb2b-11e5-9aa0-001a4ae51247 PMC122169 "Recent findings that guanine and 8-hydroxyguanine inhibit GTPCHI activity in a GTPCHI feedback regulatory protein (GFRP)-dependent manner raise the possibility that a BH4deficiency occurs in Lesch–Nyhan syndrome and Parkinson's disease (11)." 1 PUBCHEM:65154 PUBCHEM:65154 inhibits MESH:D009696 Phenotype 02b10a2a-7864-11ee-add2-0050569a791b 10.1007/s11033-023-08424-2 Additionally, DNA damage causes the production of compounds from the breakdown of sugars such as erythrose, base-free sites, and modified bases such as thymine 5,6-dihydroxycytosine, glycol, and 8-hydroxyguanine, which together cause nucleic acid loss [59]. 1 PUBCHEM:65154 PUBCHEM:65154 inhibits MESH:D010300 Phenotype 1029bdf8-cb2b-11e5-9aa0-001a4ae51247 PMC122169 "Recent findings that guanine and 8-hydroxyguanine inhibit GTPCHI activity in a GTPCHI feedback regulatory protein (GFRP)-dependent manner raise the possibility that a BH4deficiency occurs in Lesch–Nyhan syndrome and Parkinson's disease (11)." 1 UNIPROT:P02144 activates PUBCHEM:65154 PUBCHEM:65154 Protein 21814d22-bc40-11e5-8abe-001a4ae51246 PMC2683184 Methylene blue photoinactivation of RNA viruses In June 1986, we began a series of experiments that rather rapidly led to two original findings, namely: (A) that methylene blue (MB) in the presence of light mediates the formation of 8-hydroxyguanine in DNA and RNA and (B) that MB photoinactivates RNA viruses very effectively. 1 MESH:D010696 inhibits PUBCHEM:65154 PUBCHEM:65154 Phenotype d11ce9c6-bc31-11e5-8d2d-001a4ae51247 PMC3748069 We found that phloroglucinol pre-treatment significantly attenuated the increase in 8-hydroxyguanine induced by 6-OHDA treatment for 48 h (Figure 5C). 1 MESH:D004052 activates PUBCHEM:65154 PUBCHEM:65154 Phenotype dd595b0c-bc54-11e5-8abe-001a4ae51246 10.1016/j.etp.2008.01.010 It has been reported that after its biotransformation, DEN produces the promutagenic adductsO6-ethyldeoxyguanosine andO4- andO6-ethyldeoxythymidine and 8-hydroxyguanine (8-OHG) that may initiate liver carcinogenesis (Verna et al., 1996;Nakae et al., 1997). 1 MESH:D004317 activates PUBCHEM:65154 PUBCHEM:65154 Phenotype 824b27cc-3416-11e8-bf76-001a4a160175 18513847 It is known that the adriamycin-induced DNA injuries included oxidized pyrimidines and 8-hydroxyguanine. 1 MESH:D016627 activates PUBCHEM:65154 PUBCHEM:65154 Phenotype d11ce9c6-bc31-11e5-8d2d-001a4ae51247 PMC3748069 We found that phloroglucinol pre-treatment significantly attenuated the increase in 8-hydroxyguanine induced by 6-OHDA treatment for 48 h (Figure 5C). 1 MESH:D004249 inhibits PUBCHEM:65154 PUBCHEM:65154 Phenotype cb0bbd0a-0b23-11e6-918a-001a4ae51246 PMC4931535 In a study of ischemia/reperfusion induced injury in rat liver tissues, nimesulide was shown to effectively inhibit COX-2 activity and diminish oxidative stress as evident from increased GSH-levels and decreased levels of MDA, myeloperoxidase and DNA damage product 8-hydroxyguanine suggesting a benefit of nimesulide treatment in this pathology [169]. 1 MESH:D012256 increases PUBCHEM:65154 PUBCHEM:65154 Phenotype 21da737c-bbda-11e5-9b9d-001a4ae51247 10.1016/S1011-1344(01)00132-4 Treatment with Fpg protein and comparison with exonuclease III digested profiles revealed no further loss of the supercoiled population, indicating that dry riboflavin produced very low amounts of 8-hydroxyguanine and formamidopyrimidine moieties. 1 CHEBI:16486 increases PUBCHEM:65154 PUBCHEM:65154 Chemical 90b8b6b4-cf0d-11e5-888a-001a4ae51246 1710166 All of the secondary nitroalkanes and cyclopentanone oxime significantly increased levels of 8-hydroxyguanine in both DNA and RNA and caused the appearance of DX1, RX1 and RX2. 1 UNIPROT:Q8TCS8 activates PUBCHEM:65154 PUBCHEM:65154 Protein 3ee5a27c-88ba-11e6-9c3b-001a4ae51246 PMC5118650 Similarly, PNPase might produce 8-hydroxyguanine from 8-hydroxyguanosine or 8-hydroxy-2′-deoxyguanosine. 1 CHEBI:25750 increases PUBCHEM:65154 PUBCHEM:65154 Chemical 90b8b6b4-cf0d-11e5-888a-001a4ae51246 1710166 All of the secondary nitroalkanes and cyclopentanone oxime significantly increased levels of 8-hydroxyguanine in both DNA and RNA and caused the appearance of DX1, RX1 and RX2. 1 UNIPROT:P08922 activates PUBCHEM:65154 PUBCHEM:65154 Protein 40a5591c-bc38-11e5-8abe-001a4ae51246 PMC3518474 Whereas the higher energetic UVB irradiation causes mainly direct mutations (especially cyclobutane pyrimidine dimers, CPDs), UVA acts indirectly by increasing intracellular levels of reactive oxygene species (ROS), which in turn lead to 8-hydroxyguanine and finally to G-T transversion[33],[34]. 1 MESH:D006147 activates PUBCHEM:65154 PUBCHEM:65154 Phenotype e0dd9196-cff9-11ee-9aaa-0050569a1f61 10.1016/j.apcatb.2011.11.006 The main product generated by the OHattack upon DNA deoxyribose bases is 8-hydroxyguanine produced by the oxidation of guanine bases. 1 MESH:D002104 decreases PUBCHEM:65154 PUBCHEM:65154 Phenotype 760d2e58-374d-11e8-8f56-001a4a160175 22192840 It has been shown that Cd reduces the expression and activity of 8-hydroxyguanine glycosylase (OGG1), the enzyme responsible for excision repair of 8-oxodG in DNA, which releases 8-oxoGua (Potts et al., 2003). 1 CHEBI:16234 activates PUBCHEM:65154 PUBCHEM:65154 Chemical 542a4c6e-ca01-11e5-ab20-001a4ae51246 16306135 In addition to this,•OH radicals can attack DNA bases and produce thymine glycol, 8-hydroxyguanine or 2,6-diamino-4-hydroxy-5-formamidopyrimidine.