count source_label source_id relationship target_label target_id entity_type solr_id publication_id sentences 3 PF:PF07465 PF:PF07465 decreases UNIPROT:P01100 Protein 094c3a9c-ae96-11ec-a61d-0050569a1f61 PMCPMC8024007 Given the proposed role of PSAM -GlyR activation in silencing neurons (Magnus et al., 2011; Magnus et al., 2019), we initially hypothesized that activating PSAM -GlyR in vivo will suppress D1-MSNs activity and reduce c-fos expression.|||PSAM 4 -GlyR enhances rather than suppresses c-fos expression in D1-MSNs in vivo.|||These results support the rejection of the initial hypothesis that PSAM -GlyR activation reduces c-fos expression in D1-MSNs. 2 PF:PF07465 PF:PF07465 activates CHEBI:29108 Chemical 094c3a9c-ae96-11ec-a61d-0050569a1f61 PMCPMC8024007 Thus, increased c-fos expression in D1-MSNs following in vivo activation of PSAM -GlyR is likely caused by PSAM -GlyR-induced depolarization and firing in addition to loss of GABAergic inhibition, and reflects increased neuronal activity of D1-MSNs in vivo.Finally, PSAM -GlyR-induced depolarization may allow robust calcium influx via voltage-gated calcium channels and NMDA receptors relieved from voltage-dependent magnesium pore-block (Mayer and Westbrook, 1987; Mayer et al., 1984). 2 PF:PF07465 PF:PF07465 inhibits MESH:D045888 Phenotype ba748729-dc82-11ea-8b3e-001a4a160176 30001511 PSEM/PSAM-induced changes fall into six categories (Figure 1), enhancing or suppressing ganglion cell responses early or late during ON or OFF stimuli. 2 PF:PF07465 PF:PF07465 activates MESH:D005680 Phenotype 094c3a9c-ae96-11ec-a61d-0050569a1f61 PMCPMC8024007 The results also show that PSAM -GlyR activation results in ‘apparent cross-desensitization’ of GABA synaptic currents, producing a rightward shift in the GABA reversal potential and a profound reduction of inhibitory GABA synaptic currents onto D1-MSNs, likely attributed to electrical shunting since the reduction was observed at all potentials. 2 PF:PF07465 PF:PF07465 activates PF:PF01437 ProteinFamily 3c13a6b8-bc44-11e5-8d2d-001a4ae51247 10.1016/j.bbabio.2007.09.004 tricornutumplastome contains subunit PsaM, which is supposed to enable trimerisation of PSI in cyanobacteria, but sequence identity is only 50%. 2 PF:PF07465 PF:PF07465 activates GO:0099610 Phenotype 094c3a9c-ae96-11ec-a61d-0050569a1f61 PMCPMC8024007 The cell-attached data show that activation of PSAM -GlyR triggers action potential firing when the neurons are depolarized to subthreshold potentials by increasing extracellular potassium.|||PSAM 4 -GlyR induces action potential firing in D1-MSNs in cell-attached recordings. 1 PF:PF07465 PF:PF07465 inhibits UNIPROT:P02724 Protein f69503f4-ea9b-11ee-b346-0050569a791b 10.1016/j.neuroscience.2022.06.035 Indeed, this is the case when SOD1 MN intrinsic excitability is decreased via the anion-permeable PSAM–glycine receptor, reducing MN firing but not affecting the already reduced integrity of synaptic or disease markers (Bączyk et al., 2020a). 1 PF:PF07465 PF:PF07465 inhibits UNIPROT:P07288 Protein 1a990b78-7072-11ee-add2-0050569a791b 10.1007/s00432-023-05008-2 Studies have shown that PSAM and PSAMR can reduce the effects of blood dilution (Lee et al.2014) and prostate volume on serum PSA. 1 PF:PF07465 PF:PF07465 activates UNIPROT:O24821 Protein 8d3fcae4-3906-11e8-b868-001a4a160176 28110170 Evaluation of micelle-mediated cargo delivery into cells DiD-loaded PEG-PE micelle (PPM), PSA micelle (PSAM) or HMs were prepared by film hydration and then added to cultures of DC 2.4 cells in the absence of serum. 1 PF:PF07465 PF:PF07465 increases UNIPROT:P01100 Protein 094c3a9c-ae96-11ec-a61d-0050569a1f61 PMCPMC8024007 These results show that activation of PSAM -GlyR increased c-fos expression in transduced cells and therefore activated rather than inhibited D1-MSNs in vivo. 1 PF:PF07465 PF:PF07465 decreases CHEBI:29108 Chemical 6d34073a-351b-11e9-9b28-001a4a160176 PMC6101199 Second, PSAM/PSEM slightly decreased the baseline calcium levels of cones (Figure S8F), which is consistent with a slightly depolarized horizontal cell potential (Liu et al., 2013). 1 PF:PF07465 PF:PF07465 decreases CHEBI:29108 Chemical ba748729-dc82-11ea-8b3e-001a4a160176 30001511 Two-photon imaging reveals that PSEM application in PSAM-expressing retinas (1) reduces baseline calcium levels in cone terminals, (2) makes light-evoked calcium transients more sustained, and (3) eliminates the preference of cones for small stimuli. 1 PF:PF07465 PF:PF07465 inhibits CHEBI:49470 Chemical b5e0a06f-f53a-11eb-ac74-001a4a160175 29627208 " 2,3,5 The newly developed subtractive manufacturing PSAM method allows the production of metal frameworks by milling porous soft alloy blocks." 1 PF:PF07465 PF:PF07465 activates MESH:D015658 Phenotype 4bc87426-5c93-11e7-86a3-001a4ae51246 PMC4934021 These results showed that HM-ELISA+PSAM allows one to detect HIV infection approximately 5days earlier than conventional HM-ELISA, and more seroconversion panel members were identified as positives by HM-ELISA+PSAM than by conventional HM-ELISA and commercially available ELISA tests (seeTable 7). 1 PF:PF07465 PF:PF07465 activates GO:0046331 Phenotype 6d34073a-351b-11e9-9b28-001a4a160176 PMC6101199 First, we show that PSAM/PSEM efficiently blocks the lateral inhibition from horizontal cells to cones (Figure 2), indicating that PSAM/PSEM prevents horizontal cells from responding to light. 1 PF:PF07465 PF:PF07465 activates MESH:D014025 Phenotype 3a95af1a-c71d-11ee-b22c-0050569a1f61 10.1016/j.bioorg.2023.106828 So far, the development of PSAM has greatly promoted the direct TI of bioactive compounds. 1 PF:PF07465 PF:PF07465 activates GO:0051899 Phenotype 094c3a9c-ae96-11ec-a61d-0050569a1f61 PMCPMC8024007 Therefore, to determine if the membrane depolarization induced by PSAM -GlyR activation is capable of triggering action potential firing when the membrane potential is closer to firing threshold, the cell-attached experiment was repeated after depolarizing the neurons to subthreshold potentials by increasing the extracellular potassium concentration from 4.5 mM to ~11.5 mM (10–13 mM). 1 PF:PF07465 PF:PF07465 activates FPLX:Histone ProteinFamily 8a99bbc8-739e-11ee-ae93-0050569a1f61 10.1007/s00210-023-02674-4 Psam A selectively induced the histones in the cells to become hyperacetylated, which increased the transcriptional activity of the HDAC target gene gelsolin. 1 PF:PF07465 PF:PF07465 inhibits FPLX:HDAC ProteinFamily 8a99bbc8-739e-11ee-ae93-0050569a1f61 10.1007/s00210-023-02674-4 It has been proved that Psam A inhibited HDAC 1 about 300 times more than HDAC6 and about 1000 times less selective for HDAC7 and HDAC8 (Baud et al.2012). 1 MESH:D008024 activates PF:PF07465 PF:PF07465 Phenotype 094c3a9c-ae96-11ec-a61d-0050569a1f61 PMCPMC8024007 PSAM -GlyR was activated by application of the ligand uPSEM . 1 CHEBI:17996 activates PF:PF07465 PF:PF07465 Chemical 094c3a9c-ae96-11ec-a61d-0050569a1f61 PMCPMC8024007 Instability of chloride equilibrium underlies PSAM 4 -GlyR-mediated depolarization.