count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
4	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D050500	Phenotype	d5095e3e-3362-11e8-a34b-001a4a160175	16627019	An investigation in 263 patients with abdominal pain, acute recurrent pancreatitis or chronic pancreatitis suggested that sphincter of Oddi dysfunction increases intrapancreatic ductal pressure in chronic pancreatitis.
3	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D003085	Phenotype	3ea8f48a-3778-11e8-87fd-001a4a160176	15044885	Sphincter of Oddi dysfunction is one cause of persistent biliary colic in patients with or without previous cholecystectomy.|||Sphincter of Oddi dysfunction (SOD) is an important cause of post-cholecystectomy biliary colic and idiopathic recurrent pancreatitis.
2	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D010195	Phenotype	b61959da-bbd1-11e5-956b-001a4ae51247	10.1016/j.acthis.2008.05.005	Sphincter of Oddi dysfunction often causes a chronic biliary duct pain or recurrent pancreatitis, but the underlying mechanism remains unclear.
2	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D010146	Phenotype	b61959da-bbd1-11e5-956b-001a4ae51247	10.1016/j.acthis.2008.05.005	Sphincter of Oddi dysfunction often causes a chronic biliary duct pain or recurrent pancreatitis, but the underlying mechanism remains unclear.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		UNIPROT:P00450	Protein	17cf760a-394b-11ef-b466-0050569a791b	10.1016/j.mpsur.2019.03.002	There is ongoing debate as to whether pancreas divisum and sphincter of Oddi dysfunction can cause CP.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		CHEBI:155848	Chemical	1f9b0178-3548-11e8-9192-001a4a160175	18853839	One theory suggests that persistent obstruction of the pancreatic duct due to pancreas divisum, choledochocele, duodenal diverticula, ampullary or pancreatic tumors, and sphincter of Oddi dysfunction causes elevation of the pancreatic ductal pressure with ensuing pancreatitis.4 Alcohol is the most common toxin and the second leading cause of AP, accounting for about 30 to 35% of all cases.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D002779	Phenotype	4ef6be42-ab1c-11e6-807f-001a4ae51247	PMC5047970	Patients with Billroth II gastrectomy have a higher incidence of biliary diseases, mainly due to the following: 1) injuries of the pneumogastric nerve at the lesser curvature during the gastroenterostomy – in particular the block of hepatic plexus, celiac branches, and pyloric plexus – lead to impairment of gallbladder contractibility, and the cholestasis induced by sphincter of Oddi dysfunction, bile duct infection, and the change of bile composition also contribute to the formation of bile duct stones.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D002779	Phenotype	660b6d50-5c22-11e7-b441-001a4ae51247	PMC5386428	The cause of biliary colic in patients with an absent gall bladder is attributed to sphincter of Oddi dysfunction and biliary dyskinesia, which in turn promotes biliary stasis, infection, and choledocholithiasis [12–14].
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D042882	Phenotype	bd14659e-bc31-11e5-8d2d-001a4ae51247	PMC3728185	Bacteria colonized in the stomach and small intestine in patients with sphincterotomy and biliary enteric anastomoses, recurrent cholangitis and sphincter of Oddi dysfunction might be the cause of secondary gallstones and cholecystitis.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D015746	Phenotype	9f72861c-3ab3-11e8-b868-001a4a160176	18995213	Sphincter of Oddi Dysfunction SOD dysfunction is another potential cause of upper abdominal pain.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D015746	Phenotype	623b3f40-c478-11e5-9cc6-001a4ae51246	PMC3123682	Sphincter of Oddi dysfunction is a rare cause of abdominal pain after gastric bypass.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D002764	Phenotype	bd14659e-bc31-11e5-8d2d-001a4ae51247	PMC3728185	Bacteria colonized in the stomach and small intestine in patients with sphincterotomy and biliary enteric anastomoses, recurrent cholangitis and sphincter of Oddi dysfunction might be the cause of secondary gallstones and cholecystitis.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D003085	Phenotype	39a95ab0-bc0f-11e5-8abe-001a4ae51246	PMC3250652	Some postulate that an associated sphincter of Oddi dysfunction may be the cause of biliary colic in these patients [7].
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D003085	Phenotype	b3bb2d10-3548-11e8-bf76-001a4a160175	18722735	Sphincter of Oddi dysfunction can cause biliary colic, jaundice, pancreatitis, and abnormal hepatic transaminases (1,2).
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D042883	Phenotype	660b6d50-5c22-11e7-b441-001a4ae51247	PMC5386428	The cause of biliary colic in patients with an absent gall bladder is attributed to sphincter of Oddi dysfunction and biliary dyskinesia, which in turn promotes biliary stasis, infection, and choledocholithiasis [12–14].
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D010195	Phenotype	5847032e-5c30-11e7-b441-001a4ae51247	PMC5307753	Lacking any of the above evidence or other direct causes, any unexplained pancreatitis, such as sphincter of Oddi dysfunction, pregnancy associated, ampullary obstruction, hyper-calcemia, drugs related and autoimmune, were defined as idiopathic AP in this study [29].
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D010195	Phenotype	4540fa5e-375f-11e8-a34b-001a4a160175	21840110	Pancreas divisum and sphincter of Oddi dysfunction may also cause acute pancreatitis in non-pregnant population[6,7].
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D010195	Phenotype	3ea8f48a-3778-11e8-87fd-001a4a160176	15044885	Sphincter of Oddi dysfunction (SOD) is an important cause of post-cholecystectomy biliary colic and idiopathic recurrent pancreatitis.
1	Sphincter of Oddi Dysfunction	MESH:D046628	inhibits		MESH:D010195	Phenotype	129770a8-d649-11ee-b346-0050569a791b	10.1016/j.cgh.2008.02.029	■ Pancreatic Ductal Stenting May Prevent Pancreatitis in High Risk Patients Saad AM, Fogel EL, McHenry L, et al. Pancreatic duct stent placement prevents post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction but normal manometry results.Gastrointest Endosc 2008;67:255–261 Summary Pancreatic ductal stenting in patients undergoing sphincter of Oddi manometry after sphincter ablation has been shown to reduce the rate of post-ERCP pancreatitis.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D010195	Phenotype	42274fcc-3556-11e8-9fbf-001a4a160176	14520278	Sphincter of Oddi dysfunction (SOD) may cause chronic disabling “pancreatobiliary-type” pain or recurrent episodes of unexplained pancreatitis.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D010195	Phenotype	54f48402-377d-11e8-bf76-001a4a160175	19187899	There remain substantial controversy and disagreement as to whether pancreas divisum and sphincter of Oddi dysfunction are causes of pancreatitis.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D010195	Phenotype	b57e4eca-3533-11e9-ab56-001a4a160175	PMC5984920	Thus, the patient’s pancreatitis was likely caused by sphincter of Oddi dysfunction, with possible contributions from NSAIDs use; meloxicam can cause pancreatic duct constriction through prostaglandin inhibition [10,11].
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D010195	Phenotype	b3bb2d10-3548-11e8-bf76-001a4a160175	18722735	Sphincter of Oddi dysfunction can cause biliary colic, jaundice, pancreatitis, and abnormal hepatic transaminases (1,2).
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D050500	Phenotype	7694bdbe-1eca-11e8-bcd1-001a4a160175	PMC5851771	In such cases, recurrent pain may be attributable to a lack of papillary muscles or to simultaneous acute or chronic pancreatitis,[5]which may itself be caused by sphincter of Oddi dysfunction, compensatory enzyme hypersecretion, remaining ventral gland hypertrophy, and elevated pancreatic intra-ductal pressure.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D007239	Phenotype	4ef6be42-ab1c-11e6-807f-001a4ae51247	PMC5047970	Patients with Billroth II gastrectomy have a higher incidence of biliary diseases, mainly due to the following: 1) injuries of the pneumogastric nerve at the lesser curvature during the gastroenterostomy – in particular the block of hepatic plexus, celiac branches, and pyloric plexus – lead to impairment of gallbladder contractibility, and the cholestasis induced by sphincter of Oddi dysfunction, bile duct infection, and the change of bile composition also contribute to the formation of bile duct stones.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D007239	Phenotype	660b6d50-5c22-11e7-b441-001a4ae51247	PMC5386428	The cause of biliary colic in patients with an absent gall bladder is attributed to sphincter of Oddi dysfunction and biliary dyskinesia, which in turn promotes biliary stasis, infection, and choledocholithiasis [12–14].
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D007565	Phenotype	b3bb2d10-3548-11e8-bf76-001a4a160175	18722735	Sphincter of Oddi dysfunction can cause biliary colic, jaundice, pancreatitis, and abnormal hepatic transaminases (1,2).
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D013035	Phenotype	04ab9882-c863-11ee-b346-0050569a791b	10.1016/j.hbpd.2022.08.010	Functional obstruction or intermittent spasms caused by sphincter of Oddi dysfunction facilitates the occurrence of OPR[34–38].
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		MESH:D010146	Phenotype	42274fcc-3556-11e8-9fbf-001a4a160176	14520278	Sphincter of Oddi dysfunction (SOD) may cause chronic disabling “pancreatobiliary-type” pain or recurrent episodes of unexplained pancreatitis.
1	Sphincter of Oddi Dysfunction	MESH:D046628	activates		FPLX:SOD	ProteinFamily	caec601e-ab2c-11e6-ab72-001a4ae51246	PMC4989410	Occasionally, benign causes like chronic pancreatitis or sphincter of Oddi dysfunction (SOD) may cause double duct sign.
1		MESH:D004240	activates	Sphincter of Oddi Dysfunction	MESH:D046628	Phenotype	d277c82e-ae95-11ec-8f68-0050569a1f61	PMCPMC8418959	The duodenal diverticulum can also cause sphincter of Oddi dysfunction, leading to pancreatitis and cholangitis.
1		MESH:D004240	activates	Sphincter of Oddi Dysfunction	MESH:D046628	Phenotype	04ab9882-c863-11ee-b346-0050569a791b	10.1016/j.hbpd.2022.08.010	The changes in the sphincter tension and frequency and rhythm of sphincter contractions caused by diverticulum lead to sphincter of Oddi dysfunction and may explain the presence of OPR.
1		MESH:D000431	activates	Sphincter of Oddi Dysfunction	MESH:D046628	Phenotype	df048d80-c47b-11e5-85e4-001a4ae51246	PMC3077610	Ethanol exposure has been linked to abnormal blood flow, leading to ischemic changes, and increased sphincter of Oddi dysfunction, resulting in pancreatic duct hypertension (2).
1		UNIPROT:P09466	inhibits	Sphincter of Oddi Dysfunction	MESH:D046628	Protein	808aba56-7934-11ee-9572-0050569a1f61	10.1007/s00384-023-04427-4	The risk factors for PEP include female gender, normal bilirubin, decreased patient age, sphincter of Oddi dysfunction, and previous occurrences of PEP [2].
1		FPLX:SOD	activates	Sphincter of Oddi Dysfunction	MESH:D046628	ProteinFamily	caec601e-ab2c-11e6-ab72-001a4ae51246	PMC4989410	Occasionally, benign causes like chronic pancreatitis or sphincter of Oddi dysfunction (SOD) may cause double duct sign.
1		MESH:D010195	activates	Sphincter of Oddi Dysfunction	MESH:D046628	Phenotype	b73495b2-3958-11e8-8636-001a4a160175	11818916	Microlithiasis is also thought to be an important cause of idiopathic pancreatitis, implying that biliary crystals may cause sphincter of Oddi obstruction.12-14 Sphincter of Oddi dysfunction (SOD) is also a source of biliary-type pain after cholecystectomy.
1		MESH:D010195	activates	Sphincter of Oddi Dysfunction	MESH:D046628	Phenotype	5847032e-5c30-11e7-b441-001a4ae51247	PMC5307753	Lacking any of the above evidence or other direct causes, any unexplained pancreatitis, such as sphincter of Oddi dysfunction, pregnancy associated, ampullary obstruction, hyper-calcemia, drugs related and autoimmune, were defined as idiopathic AP in this study [29].
1		MESH:D001663	inhibits	Sphincter of Oddi Dysfunction	MESH:D046628	Phenotype	808aba56-7934-11ee-9572-0050569a1f61	10.1007/s00384-023-04427-4	The risk factors for PEP include female gender, normal bilirubin, decreased patient age, sphincter of Oddi dysfunction, and previous occurrences of PEP [2].
1		MESH:D000074607	activates	Sphincter of Oddi Dysfunction	MESH:D046628	Phenotype	37078456-da8f-11ee-8b99-0050569a1f61	10.1007/s12664-018-0831-3	Adverse effects of opium addiction on gastrointestinal (GI) tract like opioid-induced bowel dysfunction (OBD), sphincter of Oddi dysfunction, and narcotic bowel syndrome (NBS) have been described.