count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
50		UNIPROT:P56693	activates	Polonium	MESH:D011059	Protein	5b611ba4-ca5e-11e5-9bd2-001a4ae51247	12643284	Likewise, transfection of Sox10 into the F10.9 melanoma stimulated the Po promoter transcriptional activation in a dose-dependent manner in the absence of IL6RIL6 (Fig.3B).|||The induction of Po promoter activity by ectopic Sox10 was, as expected, abrogated by mutations of the Sox10 sites B and C or mutation of site C′ (Fig.6A).|||The combination of Sox10 with ZBP-99 produced a 10.2-fold stimulation of the Po promoter, above the additional effect of each factor alone, and similar to that seen following IL6RIL6 treatment of the cells (Fig.7B).|||Although Sox10 activates the transcriptional activity of the Po and MBP promoters in the F10.9 melanoma cells, as it does in N2A neuroblastoma cells (16,50), Sox10 fails to activate MBP promoters in HeLa cells (58).
32	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	007586f4-1adf-11f0-85c3-0050569a1f61	10.1016/j.freeradbiomed.2024.09.023	To ascertain the essential role AMPK activation plays in bilirubin-regulated uric acid levels, mice were randomly allocated into 5 groups: 1) CON group (n = 7); 2) PO group (n = 7); 3) PO + high dose bilirubin (10 mg/kg/day) group (n = 7); 4) PO + Metformin group (n = 6): PO induced mice were orally administered with AMPK agonist metformin (Cat#M813341, Macklin) at a dose of 10 mg/kg/day; 5) PO + Hemin group (n = 7): PO induced mice were intraperitoneally injected with HO-1 agonist hemin (Cat#H811002, Macklin) at a dose of 10 mg/kg/2 days.|||PO + bilirubin model in mice with hepatocyte-specificAMPKαknockdown generatedviaAAV8-TBG-shAMPKαinjection To ascertain the essential role AMPK activation plays in bilirubin-regulated uric acid levels, mice were randomly allocated into 5 groups: 1) CON group (n = 7); 2) PO group (n = 7); 3) PO + high dose bilirubin (10 mg/kg/day) group (n = 7); 4) PO + Metformin group (n = 6): PO induced mice were orally administered with AMPK agonist metformin (Cat#M813341, Macklin) at a dose of 10 mg/kg/day; 5) PO + Hemin group (n = 7): PO induced mice were intraperitoneally injected with HO-1 agonist hemin (Cat#H811002, Macklin) at a dose of 10 mg/kg/2 days.|||To investigate the protection effects exerted by bilirubin (Cat#B802201, Macklin) through 2-week successive oral administration in PO model, mice were randomly divided into 8 groups: 1) CON group (n = 7); 2) Bilirubin group (n = 7): mice were orally administered with bilirubin (10 mg/kg/day); 3) PO group (n = 7); 4) PO + low dose bilirubin (2.5 mg/kg/day) group (n = 7); 5) PO + middle dose bilirubin (5 mg/kg/day) group (n = 7); 6) PO + high dose bilirubin (10 mg/kg/day) group (n = 7); 7) PO + bilirubin + DMP group (n = 7): PO induced mice were orally administered with bilirubin (10 mg/kg/day) and intraperitoneally injected with AMPK phosphorylation blocker dorsomorphin (0.3 mg/kg/day; DMP, Cat#D833087, Macklin); 8) PO + bilirubin + 3-MA group (n = 6): PO induced mice were orally administered with bilirubin (10 mg/kg/day) and intraperitoneally injected with autophagosome inhibitor 3-methyladenine (20 mg/kg/2 days; 3-MA, Cat#5142-23-4, Sigma-Aldrich).|||PO + bilirubin mouse model To investigate the protection effects exerted by bilirubin (Cat#B802201, Macklin) through 2-week successive oral administration in PO model, mice were randomly divided into 8 groups: 1) CON group (n = 7); 2) Bilirubin group (n = 7): mice were orally administered with bilirubin (10 mg/kg/day); 3) PO group (n = 7); 4) PO + low dose bilirubin (2.5 mg/kg/day) group (n = 7); 5) PO + middle dose bilirubin (5 mg/kg/day) group (n = 7); 6) PO + high dose bilirubin (10 mg/kg/day) group (n = 7); 7) PO + bilirubin + DMP group (n = 7): PO induced mice were orally administered with bilirubin (10 mg/kg/day) and intraperitoneally injected with AMPK phosphorylation blocker dorsomorphin (0.3 mg/kg/day; DMP, Cat#D833087, Macklin); 8) PO + bilirubin + 3-MA group (n = 6): PO induced mice were orally administered with bilirubin (10 mg/kg/day) and intraperitoneally injected with autophagosome inhibitor 3-methyladenine (20 mg/kg/2 days; 3-MA, Cat#5142-23-4, Sigma-Aldrich).
32		CHEBI:28054	increases	Polonium	MESH:D011059	Chemical	8419f514-cbf0-11e5-b7d4-001a4ae51246	10542286	Phenol and 2-methylphenol elicit a maximum plateau level of Po transcription of about 6000–7000 luciferase units/A600(Fig.1,AandB).
32		MESH:D019800	increases	Polonium	MESH:D011059	Phenotype	8419f514-cbf0-11e5-b7d4-001a4ae51246	10542286	Phenol and 2-methylphenol elicit a maximum plateau level of Po transcription of about 6000–7000 luciferase units/A600(Fig.1,AandB).
32		FPLX:PRKG	activates	Polonium	MESH:D011059	ProteinFamily	4e03cbbc-cb28-11e5-9aa0-001a4ae51247	11303020	In the continuous presence of ATP and cGMP, PKG (5 units/μl) enhanced the channel activity (Po= 0.122).|||The application of exogenous PP2A inhibited the PKG-mediated KATPchannel activity (Po= 0.032).
32		MESH:D000584	inhibits	Polonium	MESH:D011059	Phenotype	01d6ad62-cbf1-11e5-b0dd-001a4ae51247	10608827	Furthermore, amiloride inhibited single channel activity (N·Po) by acting as an open channel blocker (39).|||In order to determine whether the efficacy of amiloride was changed by any of these truncation mutations, we constructed dose-response curves for amiloride inhibition of channel activity (N·Po) in these outside-out patches (Fig. 6B).
32		FPLX:AMPK	activates	Polonium	MESH:D011059	ProteinFamily	451a9d50-abb0-11e6-9646-001a4ae51246	PMC4505442	These results demonstrate that AMPK partially mediates the anti-inflammatory effects of PO on BMDM.|||However, AMPK inhibition diminished the ability of PO to prevent PA-induced IκBα degradation (Fig. 7C).
24	Polonium	MESH:D011059	activates		UNIPROT:Q15717	Protein	007586f4-1adf-11f0-85c3-0050569a1f61	10.1016/j.freeradbiomed.2024.09.023	Mice were divided into four groups : 1) CON group (n = 7); 2) SnMP group (n = 5); 3) PO induced HUA group (n = 7); 4) PO + SnMP group (n = 5).|||The PO induced HUA model (n = 9) was established by intragastric administration of a mixture of potassium oxonate (PO, Cat#P831461, Macklin) and hypoxanthine (Cat#H811076, Macklin) at a dose of 250 mg/kg/day respectively in 0.5 % CMC-Na (Cat#419311, Sigma-Aldrich) for 2 weeks.|||Bilirubin treatment attenuated PO induced HUA symptoms by decreasing circulating uric acid (Fig. 3A), XO activity (Fig. 3B) and BUN (Fig. 3C) levels.|||PO + SnMP mouse model For potassium oxonate (PO; a murine uricase [17] inhibitor) induced HUA model, mice were acclimatized for at least 1 week prior to the experiments before they were randomly allocated into groups.
24	Polonium	MESH:D011059	decreases		UNIPROT:P01584	Protein	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	Supplementation of PO significantly decreases the levels of IL-1β release into the culture media in both 200 and 400 μM of PA + LPS-treated BMDMs.|||However, treatment of PO decreased the levels of pro-IL-1β and mature IL-1β levels in BMDMs (Fig. 6B, lane 5 and 6).|||Pretreatment of PO for 16 h followed by LPS and ATP exposure significantly decreased the protein levels of IL-1β in the culture supernatant (Fig. 1D).|||Pretreatment of PO followed by TNFα exposure significantly decreased the mRNA levels of IL-1β, IL-6, and TNFα (Fig. 1E) Together, these data suggest that supplementation of PO prevents the activation of LPS or TNFα-induced inflammatory responses in BMDMs and PO also prevents LPS/ATP-induced NLRP3 inflammasome activation in both mouse and human macrophages.
24	Polonium	MESH:D011059	inhibits		MESH:D051379	Phenotype	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	4E-G, PO, LO, KO or FO supplementation notably reduced the elevated serum levels of fasting glucose and insulin, as well as HOMA-IR in the HFD-fed mice.|||PO, LO, KO or FO supplementation notably reversed the earlier observations in the HFD-fed mice, suggesting their actions on regulating HFD-induced lipid metabolism disorder.|||Dietary PO, LO, KO or FO significantly inhibited HFD-induced the infiltration of macrophages into eWAT and liver in mice.|||Additionally, the ratio ofFirmicutesandBacteroidetes(F/B) was dramatically elevated in the HFD-fed mice, whereas PO or LO supplementation prominently reduced HFD-induced the increase of F/B ratio in the feces of mice (Fig. 6D).|||Dietary PO and FO attenuated low-grade chronic inflammation in the HFD-fed mice As depicted inTable 1, compared to the LFD group, the serum levels of TNF-α, IL-1βand IL-6 were significantly elevated in the HFD-fed mice.|||Dietary PO and LO reduced body weight gain and fat accumulation in the HFD-fed mice As demonstrated inSupplementary Table S5, after 14 weeks of feeding, although the food intake of HFD-fed mice was lower than that in the LFD group, the final body weights, eWAT weights, and liver weights of HFD-fed mice were much higher than that in the LFD group.|||Moreover, PO or LO supplementation also notably enhanced the glucose tolerance and insulin sensitivity, and reduced the elevated serum levels of fasting glucose and insulin, as well as HOMA-IR in the HFD-fed mice.|||In line with the previous studies, a higher F/B ratio was observed in the feces of HFD-fed mice in the present study, while PO or LO supplementation significantly reduced HFD-induced high F/B ratio in mice.
20		UNIPROT:P11161	activates	Polonium	MESH:D011059	Protein	5b611ba4-ca5e-11e5-9bd2-001a4ae51247	12643284	Krox20 Also Synergizes with Sox10 to Activate the Myelin Po Promoter but Does Not Act through the −168/−161 Element In addition to ZBP-99, which is positively involved in the activity of the Po promoter and increases after IL6RIL6 treatment, other proteins appear to bind to the −175/−171 probe and contribute to the three DNA-protein complexes observed.|||Activation of the Po promoter by Krox20 was seen in SC (18) but not in neuroblastoma (16), and synergism of Krox20 and Sox10 was reported on the Connexin-32 promoter (57).|||In the F10.9 cell system, Krox20 expression activates the Po promoter and exhibits a strong synergism with Sox10.
18		MESH:D010457	activates	Polonium	MESH:D011059	Phenotype	63a532de-cb29-11e5-a6cd-001a4ae51247	11585829	The PO-inducing activity of Gram-positive bacteria, or peptidoglycan digested with lysozyme or coelomic fluid proteins,2and of muramyl dipeptide, disaccharide dipeptide, and muramic acid (Fig.2) was abolished in CCF-depleted coelomic fluid and reconstituted by adding recombinant CCF.|||Hence, it can be suggested that recognition of peptidoglycan saccharide moieties rather than recognition of amino acid determinants by earthworm defense molecule(s) is required to elicit pro-PO activation.
16	Polonium	MESH:D011059	inhibits		UNIPROT:O94856	Protein	451a9d50-abb0-11e6-9646-001a4ae51246	PMC4505442	Each of the proinflammatory genes analyzed above are under transcriptional regulation by NFκB. Therefore, we examined whether PO would inhibit activation of the NFκB pathway in BMDM.
16	Polonium	MESH:D011059	inhibits		UNIPROT:Q99217	Protein	00a0e1d8-1bbf-11f0-b759-0050569a791b	10.1016/j.foodcont.2023.110211	Poór et al. (2023) found that the modified toxin alternariol-3-glucoside (AG) forms highly stable complex with sugammadex and decrease the content of AG and alternariol-9-monomethylether-3-glucoside (AMG) moderately.
16	Polonium	MESH:D011059	inhibits		UNIPROT:P35228	Protein	451a9d50-abb0-11e6-9646-001a4ae51246	PMC4505442	In BMDM coincubated with both fatty acids, PO reduced the PA-induced increases in the classical M1 markerNos2/iNOS in a dose-dependent fashion at both 6 and 18 h of coincubation, and this response was completely ablated by 0.5 mmPO (Fig. 3A).
16	Polonium	MESH:D011059	activates		CHEBI:28118	Chemical	63a532de-cb29-11e5-a6cd-001a4ae51247	11585829	Peptides E1 and E4 containing polysaccharide-binding and glucanase motifs reconstituted the pro-PO cascade only in the presence of LPS and laminarin, whereas E5 covering the C-terminal part of ECCF restored the PO activity triggered byN,N′-diacetylchitobiose and muramic acid.
16	Polonium	MESH:D011059	inhibits		CHEBI:49468	Chemical	00a0e1d8-1bbf-11f0-b759-0050569a791b	10.1016/j.foodcont.2023.110211	Poór et al. (2023) found that the modified toxin alternariol-3-glucoside (AG) forms highly stable complex with sugammadex and decrease the content of AG and alternariol-9-monomethylether-3-glucoside (AMG) moderately.
16	Polonium	MESH:D011059	activates		MESH:D006859	Phenotype	eae31270-e9fb-11ef-b449-0050569a791b	10.1016/j.jcou.2024.102999	Adding a small amount of chair-structured, linear, or cyclic biomass additives to the catalysts used for the cycloaddition reaction can markedly improve the reaction efficiency because the rich hydrogen-bonding network accelerates PO activation and promotes PO ring opening by the hydroxyl groups.
16	Polonium	MESH:D011059	activates		MESH:D009569	Phenotype	451a9d50-abb0-11e6-9646-001a4ae51246	PMC4505442	Accordingly, the PO-induced prevention of PA-inducedNos2expression (Fig. 7D) and NO production (Fig. 7F) were voided when AMPK was inhibited using Compound C. Furthermore, a similar trend is seen in AMPKβ1 knockout macrophages (Fig. 7E), which lack the β1 subunit essential for assembling the AMPK heterotrimer, resulting in AMPKα degradation (29).
16	Polonium	MESH:D011059	inhibits		MESH:D010712	Phenotype	451a9d50-abb0-11e6-9646-001a4ae51246	PMC4505442	In addition toNos2, PO (0.5 mm) prevented PA-induced expression ofIl6andCxcl1(Fig. 4,A–C).
16	Polonium	MESH:D011059	activates		MESH:D010712	Phenotype	26dce096-cbf0-11e5-b7d4-001a4ae51246	10037710	The change inJas the concentration [Po[ of profilin was increased reflected the increase in the contribution of PA to barbed end assembly as G-actin was gradually saturated by profilin.
16	Polonium	MESH:D011059	activates		FPLX:AMPK	ProteinFamily	451a9d50-abb0-11e6-9646-001a4ae51246	PMC4505442	The nucleotide levels did not change at 30 min of incubation with palmitoleate, when AMPKα phosphorylation is clearly observed (Fig. 7B), nor at earlier time points (data not shown), suggesting that AMPK may be activated by PO through an ATP-independent mechanism.
16	Polonium	MESH:D011059	decreases		UNIPROT:P01375	Protein	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	We also observed, LPS exposure (1 μg/ml) for 4 h to JEG-3 cells, another trophoblast showed an increase in the mRNA expression of TNF-α and pretreatment of PO followed by LPS exposure decreased the expression of TNF-α mRNA expression relative to 18S compared to LPS alone in JEG-3 cells (Fig. 2B).|||However, pretreatment of PO for 16 h followed by LPS exposure only prevented the mRNA expression of TNF-α (Fig. 2A).|||Pretreatment of PO followed by TNFα exposure significantly decreased the mRNA levels of IL-1β, IL-6, and TNFα (Fig. 1E) Together, these data suggest that supplementation of PO prevents the activation of LPS or TNFα-induced inflammatory responses in BMDMs and PO also prevents LPS/ATP-induced NLRP3 inflammasome activation in both mouse and human macrophages.
16	Polonium	MESH:D011059	activates		MESH:D007980	Phenotype	5609bcf4-352a-11e8-bf76-001a4a160175	25542379	Phenol oxidase (PO) activity was measured spectrophotometrically, following a method modified from Hernandez-Lopez et al.[46]by recording the formation of dopachrome produced froml-dihydroxyphenylalanine (l-DOPA).|||Phenol oxidase activity Phenol oxidase (PO) activity was measured spectrophotometrically, following a method modified from Hernandez-Lopez et al.[46]by recording the formation of dopachrome produced froml-dihydroxyphenylalanine (l-DOPA).
16		CHEBI:28118	activates	Polonium	MESH:D011059	Chemical	63a532de-cb29-11e5-a6cd-001a4ae51247	11585829	The PO-inducing activity of Gram-positive bacteria, or peptidoglycan digested with lysozyme or coelomic fluid proteins,2and of muramyl dipeptide, disaccharide dipeptide, and muramic acid (Fig.2) was abolished in CCF-depleted coelomic fluid and reconstituted by adding recombinant CCF.
16		MESH:D014357	activates	Polonium	MESH:D011059	Phenotype	2598b42a-ee1a-11e5-872c-001a4ae51246	PMC4358281	Furthermore, the addition of trypsin (exogenous proteinase) into the PO reaction of the WSSV-infected and PBS-injected shrimp hemolymph restored the PO activity of the WSSV-infected shrimp, and no significant difference in the PO activity was then observed between the infected and uninfected shrimp (Fig. 3B).
16		FPLX:PPP2	inhibits	Polonium	MESH:D011059	ProteinFamily	4e03cbbc-cb28-11e5-9aa0-001a4ae51247	11303020	The application of exogenous PP2A inhibited the PKG-mediated KATPchannel activity (Po= 0.032).
16		CHEBI:47040	activates	Polonium	MESH:D011059	Chemical	adedb9e6-20ca-11e6-8d81-001a4ae51247	10.1074/jbc.273.38.24948	Lipid A is also unable to activate the pro-PO cascade.
16		MESH:D002120	activates	Polonium	MESH:D011059	Phenotype	5968abd6-cb2c-11e5-8189-001a4ae51246	12114507	To distinguish among these possibilities, we first examined the effect of the calcium channel agonist FPL64176, which is known to enhance the Po.
16		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	2598b42a-ee1a-11e5-872c-001a4ae51246	PMC4358281	Furthermore, the addition of trypsin (exogenous proteinase) into the PO reaction of the WSSV-infected and PBS-injected shrimp hemolymph restored the PO activity of the WSSV-infected shrimp, and no significant difference in the PO activity was then observed between the infected and uninfected shrimp (Fig. 3B).
16		PF:PF04942	activates	Polonium	MESH:D011059	ProteinFamily	3d8a947c-1b1f-11f0-bb75-0050569a1f61	10.1016/j.psep.2024.04.040	The production of -COOH, -OH, CC, aromatic structures is promoted by reaction between biochar and H3PO4and the development of PO or P-OOH functional groups is also promoted (Liu et al., 2019).
16		MESH:D006632	activates	Polonium	MESH:D011059	Phenotype	9d1e3852-ca5d-11e5-9088-001a4ae51247	12529366	However, after the respective mitochondrial domain moved approximately 4 μm from the patch location (Fig.3A,right panel), a further histamine stimulation induced strong BKCachannel activation (Po, 0.252 ± 0.073,n= 4;p< 0.05versuspreviousL2position; Fig.3,BandC,tracings c).
16		MESH:D000242	inhibits	Polonium	MESH:D011059	Phenotype	6b7d36a8-cc20-11e5-b0dd-001a4ae51247	9593688	Using ATPγS as the phosphate donor in place of ATP in patches from dexamethasone-treated cells, cAMP inhibited Po to the same extent as that observed in control cells (percentage of change in Po, −60.8 ± 12.3%, Fig.3C).
16		MESH:D000255	activates	Polonium	MESH:D011059	Phenotype	9884aa7e-c463-11e5-85e4-001a4ae51246	PMC4777821	More recently, using the on-nucleus patch clamp technique, our group showed that the open probability (Po) of R1R2 heterodimers was only enhanced by ATP at low [IP3], comparable with the properties exhibited by R2R2 (39).
16		MESH:D010455	inhibits	Polonium	MESH:D011059	Phenotype	01d6ad62-cbf1-11e5-b0dd-001a4ae51247	10608827	Our data show that the αβTγT-rENaC number per patch,Po, and thus overall channel activity (N·Po) were inhibited to wild-type levels by the peptide mixture, similar to that seen in the macroscopic experiments.
16		UNIPROT:P20132	activates	Polonium	MESH:D011059	Protein	48bd664a-3a8e-11e8-a51f-001a4a160176	28465179	Proteolytic cleavage by enzyme trypsin activated PO activity in MrHc2 by 109%, MrHc1 84% (p<0.05) whereas in MrHc3 and 4, 48 and 55% respectively and was very close to PO activation observed in hemocyanin and plasma, SDS activated PO activity by 1100% in MrHc3, 960% in MrHc1, 781.81% in MrHc2 and 175% in MrHc4 (p<0.05).
16		UNIPROT:O14638	activates	Polonium	MESH:D011059	Protein	9483c9f2-cbf0-11e5-a19a-001a4ae51247	10551814	Addition of B10 (4.5 μmcis) rapidly restored channel activity (Po= 0.75).
16		MESH:D004187	activates	Polonium	MESH:D011059	Phenotype	63a532de-cb29-11e5-a6cd-001a4ae51247	11585829	The PO-inducing activity of Gram-positive bacteria, or peptidoglycan digested with lysozyme or coelomic fluid proteins,2and of muramyl dipeptide, disaccharide dipeptide, and muramic acid (Fig.2) was abolished in CCF-depleted coelomic fluid and reconstituted by adding recombinant CCF.
16		MESH:D000119	activates	Polonium	MESH:D011059	Phenotype	63a532de-cb29-11e5-a6cd-001a4ae51247	11585829	The PO-inducing activity of Gram-positive bacteria, or peptidoglycan digested with lysozyme or coelomic fluid proteins,2and of muramyl dipeptide, disaccharide dipeptide, and muramic acid (Fig.2) was abolished in CCF-depleted coelomic fluid and reconstituted by adding recombinant CCF.
16		MESH:D007239	inhibits	Polonium	MESH:D011059	Phenotype	2598b42a-ee1a-11e5-872c-001a4ae51246	PMC4358281	Determination of the Proteinase Activity in PmPPAE2-silenced and WSSV-infected Shrimp The proteinase activity ofPmPPAE2-silenced and WSSV-infected shrimp was compared so as to investigate the corresponding serine proteinase activity and thus whether WSSV infection suppresses the PO activation via inhibition ofPmPPAE2 in the shrimp proPO system.|||The proteinase activity ofPmPPAE2-silenced and WSSV-infected shrimp was compared so as to investigate the corresponding serine proteinase activity and thus whether WSSV infection suppresses the PO activation via inhibition ofPmPPAE2 in the shrimp proPO system.
16		UNIPROT:P20132	activates	Polonium	MESH:D011059	Protein	6c5a9f30-1b52-11f0-bb75-0050569a1f61	10.1016/j.ijbiomac.2024.132041	In vitro, the sodium dodecyl sulfate (SDS) has been extensively used to promote the PO activity of hemocyanin.|||Although a large amount of SDS temporarily elevated the Hc-d PO activity, it would denature the protein over time.
16		MESH:D005308	activates	Polonium	MESH:D011059	Phenotype	993a5fa4-3757-11e8-b868-001a4a160176	27300290	High fertilizer N input in the MSN treatment significantly lowered the proportion of total Pi in Pt in 0–30 cm depth soil and increased total Po in 60–90 cm depth soil compared with those in the MS treatment.|||Moreover, both the sequential fractionation and31P-NMR results showed that application of N fertilizer tended to increase the relative distribution of Po in the soil and remarkably increased soil Po in 60–90 cm depth soil (Table S1andTable 7).|||Yang et al. (2010)also reported that the long-term application of N fertilizer increased Po in topsoil in vegetable greenhouse but decreased Pt and Pi.
16		CHEBI:16234	activates	Polonium	MESH:D011059	Chemical	eae31270-e9fb-11ef-b449-0050569a791b	10.1016/j.jcou.2024.102999	Adding a small amount of chair-structured, linear, or cyclic biomass additives to the catalysts used for the cycloaddition reaction can markedly improve the reaction efficiency because the rich hydrogen-bonding network accelerates PO activation and promotes PO ring opening by the hydroxyl groups.|||When the hydroxyl group attached with a group with small steric hindrance, enough hydroxyl groups can interact with PO and promote the ring-opening of PO, increasing the rate of cycloaddition reaction.
14	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	Compared to the LFD group, the relative abundance ofFirmicuteswas obviously boosted in the HFD-fed mice, whereas only PO supplementation significantly inhibited HFD-induced the increase of relative abundance ofFirmicutesin the feces of mice (Fig. 6B).|||In this study, PO or LO supplementation notably decreased the relative abundance ofFaecalibaculumbut increased the relative abundance ofDubosiellain the feces of HFD-fed mice.|||Dietary PO and LO increased the production of SCFAs in the HFD-fed mice Finally, the contents of SCFAs including acetic acid, propionate acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid and hexanoic acid in the feces of mice were determined by GC–MS.
14	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	91a1f7d4-3527-11e8-a51f-001a4a160176	25614106	Effectiveness of the SQ gout capsule on kidney function in non-induced and PO-induced mice (n=10) In the non-induced group there were no significant differences between normal and treatment groups.|||SQ gout capsule regulated the renal transporters in PO-induced mice In the regulation of m GLUT9, mOCT1, mOCT2 and the mOAT1 proteins, SQ at 450mg/kg significantly up-regulated the down-regulated protein levels and down regulated the mGLUT9 protein level (p<0.05 andp<0.01 respectively for OCT1, OCT2, OAT1 and GLUT9).|||SQ gout capsule regulated the renal transporters in PO-induced mice PO- induced hyperuricemia significantly elevated the renal protein levels of mURAT1 (p<0.05).|||In the present study, SQ attenuated the PO-induced SCr, BUN and UCr levels to the normal level without regulating any of the biochemical parameters in the non-induced mice implying the renoprotective ability of SQ.
14		MESH:D012433	activates	Polonium	MESH:D011059	Phenotype	ea858634-cb27-11e5-a6cd-001a4ae51247	11507100	Ryanodine-modified Single RyR2 Channels Were Sensitive to Modulation Early single-channel studies showed that ryanodine increased the open probability (Po) of the RyR channel to near unity and that, at micromolar activating Ca2+concentrations, the ryanodine-modified channels were inhibited only partially by Mg2+and ruthenium red (22).
12	Polonium	MESH:D011059	activates		UNIPROT:Q15717	Protein	e4a4c9e6-45a2-11f0-afc2-0050569a791b	10.1016/j.tifs.2022.03.002	Flavanones Orally administered orange juice (5 mL/kg) or hesperetin (5 mg/kg) to PO-induced HUA rats for 2 weeks resulted in inhibition of hepatic XO and XDH activity and reduction of serum UA from 214.36 μM to 169.98 μM or 185.81 μM, respectively (Haidari et al., 2009).|||Orally administered orange juice (5 mL/kg) or hesperetin (5 mg/kg) to PO-induced HUA rats for 2 weeks resulted in inhibition of hepatic XO and XDH activity and reduction of serum UA from 214.36 μM to 169.98 μM or 185.81 μM, respectively (Haidari et al., 2009).|||Intragastric administration of caffeic acid (100 mg/kg) to PO-induced HUA rats for 7 days significantly reduced serum UA and XOR activity and modulated GLUT9, OAT1, ABCG2, URAT1 and UAT (Wan et al., 2019).|||Phenolic acids Intragastric administration of caffeic acid (100 mg/kg) to PO-induced HUA rats for 7 days significantly reduced serum UA and XOR activity and modulated GLUT9, OAT1, ABCG2, URAT1 and UAT (Wan et al., 2019).
12		CHEBI:39867	inhibits	Polonium	MESH:D011059	Chemical	463a7512-bc54-11e5-8abe-001a4ae51246	10.1016/j.cca.2006.09.001	The inhibition of PO by valproic acid was surprising, since PO inhibitors reversed the action of valproic acid on growth cones, so valproic acid was expected to activate rather than inhibit PO.|||In 2005 Cheng and collaborators[90]reported that valproic acid directly inhibits recombinant PO with a Kiof about 1 mM, close to the therapeutic blood levels of 0.3 to 0.7 mM.
12		CHEBI:2150	increases	Polonium	MESH:D011059	Chemical	0d3072ce-0d5f-11f0-b759-0050569a791b	10.1016/S0169-328X(99)00124-2	5, panel A, T treatment was ineffective at any time considered (2, 6 and 24 h); DHT did not change Po mRNA levels after short exposures (2 and 6 h), but stimulated Po gene expression at 24 h.|||It is apparent from panel A, which shows a representative Northern blot, that both T and DHT treatments appear to increase Po mRNA levels vs. control (castrated animals treated with the vehicle only).|||Due to the absence of AR mRNA in cultured Schwann cells, we have tested the hypothesis that DHT might be able to activate Po gene expression by acting through another steroid receptor.
12		CHEBI:6364	activates	Polonium	MESH:D011059	Chemical	48bd664a-3a8e-11e8-a51f-001a4a160176	28465179	Laminarin enhanced PO activity of plasma devoid of hemocytes by 37% (p<0.05) and recognition was speculated by humoral PRP for activation of PO (Fig. 5A)[95,96].|||In dimeric MrHc2 PO activation induced by laminarin or trypsin (109%) appeared same and indicated recognition followed by proteolytic cleavage for elicitation of PO, however failed with LPS of tested bacteria.|||Laminarin serving as a PAMP activated PO activity in MrHc2 by 109%, MrHc3 by 32% and in MrHc4 by 36% (p<0.05), whereas MrHc1 showed no response.
10	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	d4159aa6-3402-11e8-87fd-001a4a160176	26344851	4, compared with Control group mice, PO administration induced a significant elevation of XOD expression by more than 2 folds in mice liver (p<0.01).|||In this study, PO was used to induce HUA in mice as previously described (Wang et al., 2011).|||Induction of hyperuricemia and drugs treatment In this study, PO was used to induce HUA in mice as previously described (Wang et al., 2011).|||PO-induced HUA models have some characters such as short time and cost less, hence, we use the PO-induced hyperuricemic mice in this study.
10	Polonium	MESH:D011059	inhibits		GO:0006954	Phenotype	46ba9108-e9e9-11ef-b5b7-0050569a1f61	10.1016/j.jep.2024.118737	Here, PO treatment was sufficient to suppress inflammation and alleviate the pathogenesis of DSS-induced UC in the established mouse model system.|||These data thus suggest that PO can reduce the severity of colonic inflammation and engage effective anti-inflammatory responses in DSS-induced colitis, although further research will be necessary to elucidate the underlying mechanisms of action.|||Based on the above results, 11 bioactive components that play a role in PEO's anti-UC mechanism were screened using network pharmacology, and the results of animal experiments verified that PO can reduce the severity of colonic inflammation and engage effective anti-inflammatory responses in DSS-induced colitis.
10		MESH:D017830	activates	Polonium	MESH:D011059	Phenotype	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	All three concentrations of Triton X-100 caused a significant increase (p<0.05) in PO activity compared to negative controls.|||Similar patterns were evident for hemocyte suspension tested with dopamine as a substrate, and Triton X-100 was also able to enhance the PO activities of hemolymph lysates in a dose dependent fashion (data not shown).|||In contrast, PO activities were enhanced by Triton X-100 in both hemocyte suspensions and hemolymph lysates.
8	Polonium	MESH:D011059	activates		UNIPROT:P0C0P6	Protein	3458b9fe-1a72-11f0-a2ca-0050569a1f61	10.1016/j.scitotenv.2024.176487	In both the NPs and the MPs group, the PO activity significantly increased, demonstrating a marked contrast to the Control group (P< 0.05).
8	Polonium	MESH:D011059	inhibits		UNIPROT:Q13505	Protein	22723a42-bc2d-11e5-9b9d-001a4ae51247	10.1016/j.coph.2007.06.002	In an RDBPCT specific for psoriasis patients, FA supplementation of 5mg PO daily reduced the efficacy of MTX therapy over 12 weeks in 22 adult patients [6].
8	Polonium	MESH:D011059	inhibits		UNIPROT:P20396	Protein	463a7512-bc54-11e5-8abe-001a4ae51246	10.1016/j.cca.2006.09.001	The PO inhibitor, JTP-4819, exhibiting a concentration-dependent inhibition of the PO-induced degradation of TRHin vitro, was shown to restore the TRH-like immunoreactivity in the hippocampus and the cerebral cortex of aged rats following single as well as repeated oral administration[61].
8	Polonium	MESH:D011059	activates		UNIPROT:P47989	Protein	e4a4c9e6-45a2-11f0-afc2-0050569a791b	10.1016/j.tifs.2022.03.002	Alcoholic extracts ofRhizoma Alpiniae Officinarum(mainly galangin, kaempferide and 3-methoxy-galangin, accounting for 70.1%), administered orally at 100 and 250 mg/kg for 30 days to HUA rats, significantly attenuated PO-induced hepatic XOR activity (Lin et al., 2018b).
8	Polonium	MESH:D011059	activates		UNIPROT:P30990	Protein	463a7512-bc54-11e5-8abe-001a4ae51246	10.1016/j.cca.2006.09.001	Bai et al.[71]reported that Z-Gly-Pro-methylcoumarylamide, a specific PO substrate, significantly inhibited the degradation of neurotensin and acetylneurotensin(8–13) by the cytosol of enterocytes.
8	Polonium	MESH:D011059	decreases		UNIPROT:Q93070	Protein	750bbdba-04a7-11f0-bd9d-0050569a1f61	10.1016/j.scitotenv.2024.174608	In comparison to the extreme scenarios lacking solar radiation, on-site research demonstrated comparable outcomes wherein the presence of floating discs resulted in lower algae concentrations, decreased DO levels by 36 %, and elevated concentrations of NO₃−-N, NH4+, and PO₄3−-P by 30 %, 27 %, and 95 % respectively in the covered reservoir (Bakhtiar et al., 2022).
8	Polonium	MESH:D011059	activates		UNIPROT:O00592	Protein	9b009e0e-04e4-11f0-bb39-0050569a791b	10.1016/j.jclepro.2024.143387	PO and CO2are used to produce PPC and PC via BP technology under certain temperature, pressure and catalyst conditions.
8	Polonium	MESH:D011059	activates		CHEBI:35223	Chemical	9b009e0e-04e4-11f0-bb39-0050569a791b	10.1016/j.jclepro.2024.143387	PO and its byproducts (propylene glycol monomethyl ether, propylene glycol isomethyl ether, and propylene glycol) are produced by reaction of propylene and H2O2in the presence of a catalyst.
8	Polonium	MESH:D011059	inhibits		CHEBI:29036	Chemical	3ee5dace-04aa-11f0-9c9e-0050569a1f61	10.1016/j.scitotenv.2024.174263	Interestingly, PO decreased the bioavailability of Cu, but not the sediment-to-water release.
8	Polonium	MESH:D011059	activates		CHEBI:26020	Chemical	f8e4d316-04e7-11f0-baad-0050569a1f61	10.1016/j.envres.2024.119250	Even though increased phosphate was produced by Po mineralization, the two pathways for its entry into microbial cells for energy metabolism were both inhibited by the addition of MPs.
8	Polonium	MESH:D011059	inhibits		CHEBI:32988	Chemical	5dff1aec-87bd-11f0-afc2-0050569a791b	10.1016/j.cej.2020.125766	However, PO reduced the concentration of aldehyde and ketonic compounds instead of amide I & II functional group compounds, and it might be due to different structural properties (e.g.
8	Polonium	MESH:D011059	activates		CHEBI:75682	Chemical	360dd118-86af-11f0-86f5-0050569a1f61	10.1016/j.lwt.2020.110416	A higher PO extent could lead to a shorter T21, which means the capillary force of the muscle tissue was elevated to hold immobilized water.
8	Polonium	MESH:D011059	activates		MESH:D011059	Phenotype	5b611ba4-ca5e-11e5-9bd2-001a4ae51247	12643284	Modulation of the Concentrations of Pax3 and Sox10 in Stably Transfected F10.9 Cells Regulates the Level of Cellular Myelin Po mRNA To further evaluate the contributions of Pax3 and Sox10 on the induction of Po mRNA, the F10.9 cells were permanently transformed with vectors containing Pax3 and Sox10 cDNAs placed under the control of a tetracycline-regulated element.
8	Polonium	MESH:D011059	increases		MESH:D011059	Phenotype	5b611ba4-ca5e-11e5-9bd2-001a4ae51247	12643284	The rat Po promoter sequence mediating tissue-specific expression of Po contains a number of binding sites for known transcription factors (8,16), some of which are indicated in Fig.5A.
8	Polonium	MESH:D011059	activates		MESH:D006859	Phenotype	7a18b0c8-1bc3-11f0-aa93-0050569a1f61	10.1016/j.foodchem.2023.137913	The PO stretching vibration peak on the phosphate group of CD-PL shifted from 1236 cm−1to 1245 cm−1, mainly due to the interaction between the hydroxyl group of CD and the upper chain/glycerol/head base region of the phospholipid bilayer, and the addition of CD increased the number of hydrogen bonds in this region (Gharib, et al., 2018).
8	Polonium	MESH:D011059	activates		MESH:D009569	Phenotype	574f9d30-bc2e-11e5-ac4e-001a4ae51246	10.1016/j.bmc.2007.10.066	The magnitude of the PO-elicited inflammatory macrophage response was measured 3days later by macrophage counts of peritoneal lavage specimens as well as in vitro TNFα and NO production by the harvested peritoneal macrophages.
8	Polonium	MESH:D011059	activates		MESH:D002725	Phenotype	1f7f81fe-1a4d-11f0-b40b-0050569a1f61	10.1016/j.cej.2024.157771	However, with the addition of KH2PO4, the rate of PO, PO3, and KO radicals to participate in the H-O chain reaction increases with the increment ofc,weakening the H-O cycle reaction R20 and promoting a decrease in reaction temperature.
8	Polonium	MESH:D011059	inhibits		GO:0042710	Phenotype	7b222a14-352d-11e8-a51f-001a4a160176	29028485	Amongst, PO reaction product effectively inhibited the biofilm formation in both bacteria.
8	Polonium	MESH:D011059	activates		MESH:D060467	Phenotype	1715f49e-1ad4-11f0-b759-0050569a791b	10.1016/j.pmpp.2024.102441	Disease resistance is primarily caused by PAL and PO, two essential plant defensive enzymes involved in the manufacture of phytoalexins and phenolics [98].
8	Polonium	MESH:D011059	activates		MESH:D048271	Phenotype	7ef920f4-4590-11f0-afc2-0050569a791b	10.1016/j.foodchem.2021.132012	PO and PO groups of TPP have induced differences in the bands of chitosan in the range of 1076 to 902 cm−1, particularly, 1030 cm−1seemed sharpened in the formulated particles.
8	Polonium	MESH:D011059	increases		MESH:D008903	Phenotype	d86a38a2-d8be-11ee-b346-0050569a791b	10.1016/j.atmosenv.2006.05.041	It should be noted that the fertilizer distribution in the PO plot might not be very uniform which might induce a high level of mineral N content around the potato roots and a low level elsewhere.
8	Polonium	MESH:D011059	inhibits		MESH:D000447	Phenotype	5dff1aec-87bd-11f0-afc2-0050569a791b	10.1016/j.cej.2020.125766	However, PO reduced the concentration of aldehyde and ketonic compounds instead of amide I & II functional group compounds, and it might be due to different structural properties (e.g.
8	Polonium	MESH:D011059	activates		IP:IPR001664	ProteinFamily	360dd118-86af-11f0-86f5-0050569a1f61	10.1016/j.lwt.2020.110416	A latest review suggested that there was a balance between promoting factors and opposing factors: protein cross-linking could reduce the water holding capacity as described above, while increased net filament induced by PO could elevate the water holding capacity (Bao & Ertbjerg, 2018).
8	Polonium	MESH:D011059	activates		PF:PF00421	ProteinFamily	df24f766-47e6-11f0-afc2-0050569a791b	10.1016/j.scienta.2017.01.039	The φPo, φEoand ψEo(Fig. 4A–C) decreased, thereby reducing the activity of PSII; consequently, an enhanced transformation of active PSII centres to non-QAcentres or PSI can be presumed in the leaves under LL.
8	Polonium	MESH:D011059	activates		PF:PF04151	ProteinFamily	9b009e0e-04e4-11f0-bb39-0050569a791b	10.1016/j.jclepro.2024.143387	PO and CO2are used to produce PPC and PC via BP technology under certain temperature, pressure and catalyst conditions.
8	Polonium	MESH:D011059	increases		UNIPROT:Q16236	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	In this study, we also examined whether PO induces the expression of Nrf2 target genes, such as NQO-1, HO-1, and GCLC.|||8, PO induced the expression of Nrf2-dependent genes, and in the same time, the expression of NF-κB target genes were suppressed by the pretreatment of PO.
8	Polonium	MESH:D011059	inhibits		UNIPROT:P24752	Protein	6f331804-87fe-11f0-b8fe-0050569a1f61	10.1016/j.agee.2020.107050	At each depth, the percentages of total Po and residue P within Psumboth exponentially or linearly increased with decreasing MAT (Fig. 4b, c).|||The increased Po contents with decreasing MAT in the upper 80 cm of soil (Fig. 3c) echoed the increased root and microbial P stored in low- relative to high-temperature areas (Fig. 2).
8	Polonium	MESH:D011059	decreases		UNIPROT:P05231	Protein	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	PO, LO, KO or FO supplementation notably reduced the elevated serum levels of TNF-α, IL-1βand IL-6 in the HFD-fed mice.|||In addition, compared to the LFD group, the mRNA levels of pro-inflammatory cytokines such as TNF-α, IL-1βand IL-6 were dramatically elevated in the eWAT and liver of HFD-fed mice, whereas PO, LO, KO or FO supplementation notably blocked HFD-induced the up-regulation of TNF-α, IL-1βand IL-6 mRNA expression in the eWAT and liver of mice.
8	Polonium	MESH:D011059	inhibits		UNIPROT:P05164	Protein	38f07ece-374f-11e8-8636-001a4a160175	28013186	Pre-treatment with PO or PT significantly lowered the ethanol-induced gross gastric lesion score, ulcer lesion area, and myeloperoxidase activity in the gastric mucosa.|||Treatment with PO or PT suppressed ethanol-induced activity of myeloperoxidase.
8	Polonium	MESH:D011059	activates		CHEBI:30751	Chemical	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	The present results demonstrated that PO or LO supplementation elevated the relative abundance of SCFA-producing microbiota includingLachnospiraceae,Lactobacillaceae,BifidobacteriaceaeandBifidobacteriumin the feces of HFD-fed mice, and accompanied by the increase of SCFAs production, such as acetic acid, butyric acid and valeric acid.|||The present study manifested that the relative abundance ofBifidobacteriaceae,Lachnospiraceae, andLactobacillaceaewere much lower in the HFD-fed mice, whereas PO or LO supplementation dramatically increased the relative abundance of these SCFAs-producing microbiota in the feces of HFD-fed mice.|||Additionally, PO and LO supplementation also selectively increased the relative abundance of SCFAs-producing bacteria, subsequently elevated the production of SCFAs in the feces of HFD-fed mice.|||Dietary PO and LO increased the production of SCFAs in the HFD-fed mice Finally, the contents of SCFAs including acetic acid, propionate acid, isobutyric acid, butyric acid, isovaleric acid, valeric acid and hexanoic acid in the feces of mice were determined by GC–MS.
8		PF:PF00089	activates	Polonium	MESH:D011059	ProteinFamily	842ca890-3402-11e8-b868-001a4a160176	26899630	The PO activity was also induced by Laminarin, Trypsin, and α-chymotrypsin when the concentration of these substances was increased (Fig. 6).
8		MESH:D008550	activates	Polonium	MESH:D011059	Phenotype	52bd8f9a-bc31-11e5-8d2d-001a4ae51247	10.1016/S0003-9861(02)00689-6	Melatonin (N-acetyl-5-methoxytryptamine) is activating the PO reaction and promoting oscillations.
8		UNIPROT:P26038	activates	Polonium	MESH:D011059	Protein	993a5fa4-3757-11e8-b868-001a4a160176	27300290	High fertilizer N input in the MSN treatment significantly lowered the proportion of total Pi in Pt in 0–30 cm depth soil and increased total Po in 60–90 cm depth soil compared with those in the MS treatment.
8		CHEBI:17924	activates	Polonium	MESH:D011059	Chemical	eae31270-e9fb-11ef-b449-0050569a791b	10.1016/j.jcou.2024.102999	The mixed catalytic systems composed of NEt3(HE)Br and sorbitol, xylitol, and glucose largely promoted the cycloaddition reaction of CO2and PO, achieving PC yields of 92.10 %, 92.16 %, and 95.00 % respectively, after 1 h of reaction at 110 °C, with corresponding TOF values being 61.40, 61.44, and 63.34 h⁻1, respectively.
8		MESH:D011059	increases	Polonium	MESH:D011059	Phenotype	5b611ba4-ca5e-11e5-9bd2-001a4ae51247	12643284	The rat Po promoter sequence mediating tissue-specific expression of Po contains a number of binding sites for known transcription factors (8,16), some of which are indicated in Fig.5A.
8		MESH:D011059	activates	Polonium	MESH:D011059	Phenotype	5b611ba4-ca5e-11e5-9bd2-001a4ae51247	12643284	Modulation of the Concentrations of Pax3 and Sox10 in Stably Transfected F10.9 Cells Regulates the Level of Cellular Myelin Po mRNA To further evaluate the contributions of Pax3 and Sox10 on the induction of Po mRNA, the F10.9 cells were permanently transformed with vectors containing Pax3 and Sox10 cDNAs placed under the control of a tetracycline-regulated element.
8		CHEBI:16761	activates	Polonium	MESH:D011059	Chemical	b8dba174-00a4-11f0-8027-0050569a1f61	10.1016/j.indcrop.2024.119221	A portion of ADP was able to delocalize alkyl groups (Lou et al., 2023) and then produce PO·
8		UNIPROT:Q69YU5	activates	Polonium	MESH:D011059	Protein	eae31270-e9fb-11ef-b449-0050569a791b	10.1016/j.jcou.2024.102999	The mixed catalytic systems composed of NEt3(HE)Br and sorbitol, xylitol, and glucose largely promoted the cycloaddition reaction of CO2and PO, achieving PC yields of 92.10 %, 92.16 %, and 95.00 % respectively, after 1 h of reaction at 110 °C, with corresponding TOF values being 61.40, 61.44, and 63.34 h⁻1, respectively.
8		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	9524d6a0-390b-11e8-bf76-001a4a160175	25449703	After degranulation in the hemolymph, proPO is activated by proteolytic cleavage by serine proteases, yielding active PO[22].
8		MESH:D006886	inhibits	Polonium	MESH:D011059	Phenotype	0eabb190-04b3-11f0-ac21-0050569a1f61	10.1016/j.jbc.2024.107733	In the presence of 1 mM 2-APB, TRPV3 channel Po reached 0.89 ± 0.06, 50 μM HCQ significantly decreased Po to 0.50 ± 0.03, and 100 μM HCQ significantly decreased Po to 0.13 ± 0.04 (Fig. 2L).
8		UNIPROT:Q9BTX1	activates	Polonium	MESH:D011059	Protein	eae31270-e9fb-11ef-b449-0050569a791b	10.1016/j.jcou.2024.102999	The mixed catalytic systems composed of NEt3(HE)Br and sorbitol, xylitol, and glucose largely promoted the cycloaddition reaction of CO2and PO, achieving PC yields of 92.10 %, 92.16 %, and 95.00 % respectively, after 1 h of reaction at 110 °C, with corresponding TOF values being 61.40, 61.44, and 63.34 h⁻1, respectively.
8		CHEBI:6364	activates	Polonium	MESH:D011059	Chemical	842ca890-3402-11e8-b868-001a4a160176	26899630	The PO activity was also induced by Laminarin, Trypsin, and α-chymotrypsin when the concentration of these substances was increased (Fig. 6).
8		UNIPROT:P62158	inhibits	Polonium	MESH:D011059	Protein	0339faa6-bc1f-11e5-9b9d-001a4ae51247	10.1016/j.ceca.2005.07.001	More precisely, CaM (400nM) was shown to reduce the open probability (Po) of RyR1 channels.
8		MESH:D000255	activates	Polonium	MESH:D011059	Phenotype	4488b0b8-abe0-11e6-9ac8-001a4ae51246	PMC4465056	Using “on-nucleus” patch clamp single channel recordings of both endogenousXenopusIP3R1 or rat IP3R1 expressed in DT40 TKO cells, elevating ATP levels increased the channel open probability (Po) by modulating the sensitivity of the channel to both activating and inhibitory [Ca2+], essentially left-shifting the bell-shaped [Ca2+] versus Porelationship at a given [IP3][78,79].
8		CHEBI:34856	activates	Polonium	MESH:D011059	Chemical	34500b70-04fa-11f0-bb39-0050569a791b	10.1016/j.bmc.2024.117847	To further reduce its intrinsic clearance, authors swapped out C6 on the phthalazine nucleus with nitrogen as well as displaced the basic piperazine group with a neutral morpholine group, which brought a decreased clearance (Cl = 17 mL/min/kg) and increased PO exposure (AUC0‑last= 130318 ng·
8		UNIPROT:P84241	activates	Polonium	MESH:D011059	Protein	7a4d3cb0-3757-11e8-b868-001a4a160176	27296493	AKH enhances PO activity and antioxidant defense (Goldsworthy et al., 2005) but decreases the antimicrobial peptides.
8		CHEBI:16052	activates	Polonium	MESH:D011059	Chemical	9b009e0e-04e4-11f0-bb39-0050569a791b	10.1016/j.jclepro.2024.143387	PO and its byproducts (propylene glycol monomethyl ether, propylene glycol isomethyl ether, and propylene glycol) are produced by reaction of propylene and H2O2in the presence of a catalyst.
8		MESH:D007239	activates	Polonium	MESH:D011059	Phenotype	2fab04d8-3c65-11f0-86f5-0050569a1f61	10.1016/j.jinsphys.2022.104425	Microbial infections lead to activation of PPO into PO via a serine protease cascade (Kim and Stanley, 2021).
8		MESH:D007239	decreases	Polonium	MESH:D011059	Phenotype	9ec81e78-0d7b-11f0-aa93-0050569a1f61	10.1016/S0022-1910(98)00144-9	We have determined thatCsPDV infection reduces levels of PO activity in the plasma of parasitizedH.
8		CHEBI:58339	activates	Polonium	MESH:D011059	Chemical	595eab1e-002d-11f0-9c09-0050569a791b	10.1016/j.ibmb.2024.104254	The SPHs in hemolymph can function as cofactors with CLIP proteases known as PAPs, which activate the PO zymogen, to remarkably increase the efficiency of PO activation (Kwon et al., 2000;Wang and Jiang, 2004;Kan et al., 2008;Wang et al., 2020;Ji et al., 2022;Jin et al., 2022,2023, and 2024).
8		UNIPROT:P02812	activates	Polonium	MESH:D011059	Protein	6c5a9f30-1b52-11f0-bb75-0050569a1f61	10.1016/j.ijbiomac.2024.132041	Additionally, phosphatidyl serine (PS), a type of phospholipids, has been found to induce hemocyanin's PO activity since phospholipids share similar structural and electrostatic characteristics with SDS micelles [51].
8		UNIPROT:P02812	decreases	Polonium	MESH:D011059	Protein	3324d31a-1c0c-11f0-b759-0050569a791b	10.1016/j.envpol.2023.123144	By contrast, in W9, PCZ + W9, W9+Ps and PCZ + W9+Ps treated plant GPx and PO expression level were reduced as compared to control plant.
8		UNIPROT:Q8TDD2	activates	Polonium	MESH:D011059	Protein	3a0363c0-bc00-11e5-9b9d-001a4ae51247	10.1016/j.bbrc.2005.10.042	Depletion of Sp7 using the LZ driver reduces the PO reaction to similar levels obtained with ubiquitous drivers (Fig. 5), indicating that depletion of Sp7 in crystal cell precursors is sufficient to impair the PO reaction.
8		UNIPROT:Q7RTV0	activates	Polonium	MESH:D011059	Protein	3723bb32-8630-11f0-afc2-0050569a791b	10.1016/j.bbadis.2021.166075	Furthermore, INI administration increased the diabetic channel Po from 0.4 ± 0.01 (n = 6) at +50 mV and 0.1 ± 0.01 (n = 6) at −50 mV to 0.9 ± 0.05 at +50 mV and 0.38 ± 0.01 at −50 mV, respectively (Fig. 1E).
8		UNIPROT:P12272	activates	Polonium	MESH:D011059	Protein	f749957c-5cd5-11e7-bcb7-001a4ae51246	PMC4641003	It is clear that PTHrP induction of PO osteoclasts mediates the sculpting aspects of PO modeling, but it is unknown if PTHrP regulates osteoblastic induction in the PO or any other site.
8		MESH:D012967	activates	Polonium	MESH:D011059	Phenotype	6c5a9f30-1b52-11f0-bb75-0050569a1f61	10.1016/j.ijbiomac.2024.132041	In vitro, the sodium dodecyl sulfate (SDS) has been extensively used to promote the PO activity of hemocyanin.
8		CHEBI:43572	inhibits	Polonium	MESH:D011059	Chemical	6c5a9f30-1b52-11f0-bb75-0050569a1f61	10.1016/j.ijbiomac.2024.132041	japonicushad its PO activity suppressed by kojic acid, 4-hexylresorcinol (4-HR), and PTU [57].
8		MESH:D013654	activates	Polonium	MESH:D011059	Phenotype	820bd034-3c59-11ef-9c6b-0050569a1f61	10.1016/S0306-3623(97)00309-1	The open probability (Po) of unitary Ba2+(Ca2+) current increased from 0.21±0.04 to 0.48±0.07 by 20 mM taurine at 0.9 mM [Ca]o. Poat 5.4 mM [Ca]odecreased from 0.63±0.06 to 0.39±0.09 by 20 mM taurine.
8		PF:PF00089	activates	Polonium	MESH:D011059	ProteinFamily	4fa1681c-bbf6-11e5-9b9d-001a4ae51247	10.1016/S1096-4959(03)00120-9	Trypsin significantly (P<0.001) enhanced PO activity in hemocytes from band 2 and 5, respectively (Fig. 1b).|||Trypsin also activated PO activity of band 5 (P<0.05).
8		CHEBI:29033	activates	Polonium	MESH:D011059	Chemical	d4086096-3aa3-11e8-b868-001a4a160176	25700784	It is noteworthy that Fe2+could greatly enhance the PO-like activity of skHbs, and 20 mM Fe2+were found to restore the PO-like activity after pre-inhibition by EDTA.|||The PO-like activities of two skHbs were found to be further activated by Fe2+, and the EDTA-inhibited PO-like activities of skHbI and skHbII were found to be restored by 20 mM Fe2+(Table 1), while the other metal ions could not restore function (Table S2).
8		CHEBI:46295	activates	Polonium	MESH:D011059	Chemical	9b6b847e-3748-11e8-8f56-001a4a160175	26027948	These results show that vardenafil was able to fully restore object discrimination when given PO within 2 min or ICV within 4 min after T1.|||These results show that, identical to the 10-min retention experiment, vardenafil fully restored object discrimination when given PO within 2 min after T1.
8		MESH:D014357	activates	Polonium	MESH:D011059	Phenotype	48bd664a-3a8e-11e8-a51f-001a4a160176	28465179	In dimeric MrHc2 PO activation induced by laminarin or trypsin (109%) appeared same and indicated recognition followed by proteolytic cleavage for elicitation of PO, however failed with LPS of tested bacteria.|||Proteolytic cleavage by enzyme trypsin activated PO activity in MrHc2 by 109%, MrHc1 84% (p<0.05) whereas in MrHc3 and 4, 48 and 55% respectively and was very close to PO activation observed in hemocyanin and plasma, SDS activated PO activity by 1100% in MrHc3, 960% in MrHc1, 781.81% in MrHc2 and 175% in MrHc4 (p<0.05).
8		CHEBI:50114	activates	Polonium	MESH:D011059	Chemical	2ffb7dd4-bbee-11e5-9b9d-001a4ae51247	10.1016/j.brainres.2006.07.100	The estrogen-induced increase in the total number of mast cells in the thalamus as well as the number of degranulated mast cells was most evident in the lateral intralaminar (CL, PC, CM), VPL and Po nuclei (Fig. 7).|||In support of such a possibility, stabilization of mast cells by the central injection of cromolyn inhibited mast cell degranulation and prevented the estrogen-induced increase in mast cell populations in the whole thalamus, lateral intralaminar, VPL and Po nuclei.
8		MESH:D048271	activates	Polonium	MESH:D011059	Phenotype	2d556980-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2003.12.004	The RA (Relative Average) PO activity showed that chitosan elicited the highest PO activity with RA value of 3.15±0.70unitmg−1protein (Table 1).|||Phenoloxidase activity The prawn haemocyte lysate supernatant (HLS) showed PO activity induced by chitosan, Gram-positive and Gram-negative bacterial cells, and the activities were significantly different (P<0.05) from haemocyte lysate supernatant (HLS) that contained no elicitor.|||The prawn haemocyte lysate supernatant (HLS) showed PO activity induced by chitosan, Gram-positive and Gram-negative bacterial cells, and the activities were significantly different (P<0.05) from haemocyte lysate supernatant (HLS) that contained no elicitor.
8		UNIPROT:P84241	activates	Polonium	MESH:D011059	Protein	650105d0-3757-11e8-8f56-001a4a160175	27288849	OA increases phagocytosis in the beet army wormSpodoptera exigua(Kim et al., 2009) and AKH increases the duration of PO activity in locusts (Locusta migratoria) (Goldsworthy et al., 2002).|||For example, AKH enhances PO activity (Goldsworthy et al., 2002) and antioxidant defense (Kodrik, 2008; Vecera et al., 2012; Bednarova et al., 2015).
8		UNIPROT:O00482	inhibits	Polonium	MESH:D011059	Protein	913a5170-390e-11e8-87fd-001a4a160176	27476426	Exposure to CPF reduced the PO activity only in males of edge populations when they were subsequently challenged with an implant (Population type × CPF × Implant interaction, F1, 168= 4.17,P= 0.043,Fig. 5C).|||For example,Janssens et al. (2014)showed that larval exposure to 2 μg/l CPF reduced PO activity in adults of the damselflyIschnura elegans.A reduction in PO activity was also found in the damselflyCoenagrion puellaexposed to 30 μg/l of endosulfan (Campero et al., 2008a).
8		UNIPROT:O14686	activates	Polonium	MESH:D011059	Protein	bc88796c-04b1-11f0-baad-0050569a1f61	10.1016/j.yexcr.2024.114265	LDH kit measurement revealed that the death rate of cells was substantially increased upon PO treatment, which was decreased by KMT2D silencing but then increased again after further IDI1 overexpression (Fig. 6A).|||Then, Nile red staining revealed that the lipid accumulation was significantly increased in cells after PO treatment, which was decreased by KMT2D silencing but aggravated by IDI1 overexpression (Fig. 5C).
8		UNIPROT:O75030	activates	Polonium	MESH:D011059	Protein	8d316b7c-bc15-11e5-8abe-001a4ae51246	PMC3025927	Analysis of absolute and relative EDL muscle Po demonstrated a statistically significant lower Po in MI vehicle treated rats when compared to sham vehicle treated rats; absolute and relative EDL Po was significantly greater with PG873637 treatment in both sham (17% increase in absolute Po and 13% increase in relative Po) and MI (28% increase in absolute Po and 27% increase in relative Po) rats when compared to vehicle treatment.|||Analysis of absolute and relative soleus Po demonstrated a significantly greater absolute Po in MI vehicle treated rats compared to sham vehicle treated rats; treatment with PG873637 resulted in a significantly greater absolute and relative sham (19% increase in absolute Po and 14% increase in relative Po) and MI (12% increase in absolute Po and 12% increase in relative Po) soleus muscle Po compared to vehicle treated rats.
8		CHEBI:16234	activates	Polonium	MESH:D011059	Chemical	cc146f32-1a30-11f0-a2ca-0050569a1f61	10.1016/j.scitotenv.2024.177810	Hydroxyl groups on biochar surfaces also contribute to adsorption via ligand exchange, where they replace water molecules or hydroxide ions bound to metal oxides, allowing PO₄3−or AsO₄3−to form direct bonds with the metal surface.|||In contrast, under neutral to alkaline conditions, deprotonated hydroxyl groups become more reactive, enhancing PO₄3−adsorption through electrostatic interactions, although competition with arsenate remains significant (Ahmed et al., 2024b).
8		UNIPROT:Q9UQ90	activates	Polonium	MESH:D011059	Protein	c9cdc1c2-c8de-11e5-9624-001a4ae51246	16421099	6B, both the native Tm-PGRP and r-Tm-PGRP specifically induced PO activity in the presence of soluble Lys-PGN and the pass-through fraction from the T-4P2-coupled column (columns 3and7), suggesting that the native Tm-PGRP and r-Tm-PGRP can recognize soluble Lys-PGN and induce Lys-PGN-dependent PO activity in the presence of the pass-through fraction.|||aureussoluble Lys-PGN strongly induced the PO activities and melanin syntheses (columns 2and5inFig.|||Furthermore, to explore whether PO activity and melanin synthesis induced by natural Lys-PGN also could be inhibited by T-4P2in a dose-dependent manner, we examined the PO activity and melanin synthesis potency with different amounts of T-4P2in the presence of soluble Lys-PGN.|||The PO activity and melanin synthesis are induced by 10 ng of natural Lys-PGN were completely inhibited by 1.5 μg of T-4P2(Fig. 3,CandD).
6	Polonium	MESH:D011059	activates		UNIPROT:P01308	Protein	c8153296-3913-11e8-9192-001a4a160175	24246938	diversicolorexposed to both forms of Ag (nanoparticulate or ionic) and laccase type PO was increased inS.|||In addition, laccase-type PO and lysozyme activity were increased inS.
6	Polonium	MESH:D011059	decreases		UNIPROT:Q04206	Protein	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	Interestingly, treatment of PO followed by LPS to BMDMs decreased the nuclear levels of NF-κB p65 subunit compared to LPS alone treated cells (Fig. 4B), and the nuclear levels of histone deacetylase 1 were unchanged in vehicle, PO, LPS alone, or LPS + PO treatment conditions (Fig. 4B).|||However, we did observe changes in the nuclear activation of NF-κB p65 subunit with LPS, and supplementation of PO decreased the nuclear levels of p65 subunit.
6	Polonium	MESH:D011059	activates		UNIPROT:O95139	Protein	47cdb9fe-3905-11e8-8f56-001a4a160175	PMC5568115	Changes in PO deaths in combination with other substances The proportion of all PO deaths in combination with any of the five psychoactive substances increased 1.3 times (95% CI=1.3–1.3), from 44.3% in 2002–03 to 57.9% in 2014–15 (Table 1).|||The proportion of all PO deaths in combination with any of the five psychoactive substances increased 1.3 times (95% CI=1.3–1.3), from 44.3% in 2002–03 to 57.9% in 2014–15 (Table 1).
6	Polonium	MESH:D011059	activates		UNIPROT:P01266	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	The results exhibited that PO diet significantly induced liver TG, TC and LDL-C contents (P< 0.01,Fig. 4A-4C) in croakers, compared with FO diet.|||Simultaneously, by analyzing the indicators of lipid content in serum and liver, we observed dietary PO diet significantly increased the TG, TC and LDL-C contents in serum and liver of croakers, compared with FO diet.
6	Polonium	MESH:D011059	activates		CHEBI:47774	Chemical	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	The results exhibited that PO diet significantly induced liver TG, TC and LDL-C contents (P< 0.01,Fig. 4A-4C) in croakers, compared with FO diet.|||Simultaneously, by analyzing the indicators of lipid content in serum and liver, we observed dietary PO diet significantly increased the TG, TC and LDL-C contents in serum and liver of croakers, compared with FO diet.
6	Polonium	MESH:D011059	decreases		MESH:D008315	Phenotype	da3bba62-3512-11e8-8f56-001a4a160175	26800098	But, these elevated levels of MPO and MDA were strikingly attenuated by PO.|||The level of MDA, a lipid-peroxidation product which is commonly used as a marker to manifest the level of oxidative stress and antioxidant status[33], was remarkably decreased in lung tissue by the pretreatment with PO.
6	Polonium	MESH:D011059	activates		MESH:D019066	Phenotype	5e9fcb94-00a0-11f0-9c09-0050569a791b	10.1016/j.quascirev.2024.109005	Along-dip facies shifts driven by sea-level changes were enhanced by the low gradients of the Po Plain and of the Adriatic shelf.|||Along-dip facies shifts for tens of km reflect the increased amplitude of glacio-eustatic oscillations after the Early/Middle Pleistocene Transition (Head and Gibbard, 2005,2015), and were enhanced by the low gradients of the Po Plain and of the Adriatic shelf.
6	Polonium	MESH:D011059	activates		UNIPROT:Q15717	Protein	d4159aa6-3402-11e8-87fd-001a4a160176	26344851	Induction of hyperuricemia and drugs treatment In this study, PO was used to induce HUA in mice as previously described (Wang et al., 2011).|||In this study, PO was used to induce HUA in mice as previously described (Wang et al., 2011).|||PO-induced HUA models have some characters such as short time and cost less, hence, we use the PO-induced hyperuricemic mice in this study.
6		UNIPROT:P07204	activates	Polonium	MESH:D011059	Protein	c9cdc1c2-c8de-11e5-9624-001a4ae51246	16421099	6B, both the native Tm-PGRP and r-Tm-PGRP specifically induced PO activity in the presence of soluble Lys-PGN and the pass-through fraction from the T-4P2-coupled column (columns 3and7), suggesting that the native Tm-PGRP and r-Tm-PGRP can recognize soluble Lys-PGN and induce Lys-PGN-dependent PO activity in the presence of the pass-through fraction.
6		UNIPROT:Q9XXV0	inhibits	Polonium	MESH:D011059	Protein	9f362270-f58a-11eb-94a6-001a4a160176	30765061	When infected with vBmPPO1 and vBmPPO2, comparing with the control, overexpression of PPAE enhanced PO activity and interference of PPAE mRNA reduced PO activity in cells, which demonstrated that the detection system is available.
6		MESH:D006859	activates	Polonium	MESH:D011059	Phenotype	eae31270-e9fb-11ef-b449-0050569a791b	10.1016/j.jcou.2024.102999	This phenomenon indicates that hydroxyl groups in the catalyst structure provided hydrogen bonds that substantially reduced the activation energy of the reaction and synergistically promoted the ring-opening reaction of PO with Br−.|||The strong hydrogen bonds provided by EG during the reaction quickly activated PO and stabilized intermediates and transition states.
6		MESH:D015054	activates	Polonium	MESH:D011059	Phenotype	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	1B shows the PO activities induced by different zymosan concentrations (10, 20, 40, 80 and160 μg/mL).|||Activation with LPS and zymosan Both LPS and zymosan significantly (p<0.05) increased PO activity relative to negative controls prepared without these PAMPs (Fig. 1).
6		CHEBI:15843	activates	Polonium	MESH:D011059	Chemical	0ed69292-bbdf-11e5-9b9d-001a4ae51247	10.1016/j.jinsphys.2003.11.002	Fig. 2Cdemonstrates that arachidonic acid injection significantly increased the PO activity at 1, 2 and 3 days post-infection in previously dexamethasone-treated insects inoculated withT.|||Indeed, arachidonic acid application significantly increased both hemocyte microaggregation and PO activity in the hemolymph of insects previously treated with dexamethasone and challenged with parasites.
6		CHEBI:6364	activates	Polonium	MESH:D011059	Chemical	97c74c86-374d-11e8-9fbf-001a4a160176	28668255	Laminarin, a non-self molecule, appeared to enhance the PO activity in the acellular plasma to 0.066±0.012 (164% increase) and in serum to 0.265±0.009 (136% increase), whereas in HLS, a difference of 58% was obtained (p<0.05).|||Denaturation induced by SDS enhanced the PO activity in HLS, whereas the recognition of non-self molecule laminarin and tryptic cleavage enhanced the PO activity to a maximum in the serum and plasma.
6		MESH:D001640	inhibits	Polonium	MESH:D011059	Phenotype	82a3e454-bbee-11e5-8abe-001a4ae51246	10.1016/S0006-8993(02)04203-8	Bicuculline injection into the RPa suppressed the effect of PO warming onTbatrise in response to VMH stimulation.Fig.|||The fact that bicuculline injection into the RPa antagonized the effect of PO warming suggests that the inhibition occurs at least in the RPa.
6		MESH:D019840	activates	Polonium	MESH:D011059	Phenotype	d4086096-3aa3-11e8-b868-001a4a160176	25700784	Results showed that the PO-like activity of skHbs was significantly activated by isopropanol (Fig. 3A).|||Results showed that isopropanol, a potent activator of oxidase, could significantly activate the PO-like activity of skHbs, but SDS, the most efficient Hc activator, inhibited the activity instead[7–14].
6		UNIPROT:Q14117	increases	Polonium	MESH:D011059	Protein	0d3072ce-0d5f-11f0-b759-0050569a791b	10.1016/S0169-328X(99)00124-2	Because of our previous studies indicating that DHP, a steroid which interacts with the PR, may activate Po gene expression[19], we have tested whether DHT might interact with the PR.|||In particular, the addition of P or DHP to cultures of Schwann cells significantly increases Po mRNA levels; in these `in vitro' experiments, treatment with tetrahydroprogesterone (THP), the 3α-reduced metabolite of DHP, proved to be even more effective than the other two steroids[19].
6		CHEBI:131488	activates	Polonium	MESH:D011059	Chemical	ee246096-f07e-11ee-b346-0050569a791b	10.1016/S0006-2952(03)00456-8	As described above, H89 elevated the benzamil-sensitiveIscby increasing the Po and No of the NSC channel.|||These reports indicate that the NSC channel reported in the present study is composed of four α subunits of ENaC, and that H89 stimulates translocation of α subunit of ENaC to the apical membrane of the alveolar type II epithelium, and that H89 also increases the Po of the NSC channel composed of α subunit of ENaC by translocating a protein activating α subunit of ENaC.
6		UNIPROT:P41235	activates	Polonium	MESH:D011059	Protein	b6c9a192-bc2f-11e5-8abe-001a4ae51246	10.1016/j.febslet.2004.10.070	Occupancy of the PO promoter by HNF4α in intact hepatocytes was studied by using chromatin immunoprecipitation assays performed on DNA from HNF4α FLOX and null adult livers.|||The upstream regulatory region of the PO gene has both HNF4α and HNF1α binding sites and these sites were required for expression of PO induced by HNF4α and HNF1α.|||HNF4α occupies the HNF4α binding sites in the −160 bp upstream fragment of the PO gene in vivo Occupancy of the PO promoter by HNF4α in intact hepatocytes was studied by using chromatin immunoprecipitation assays performed on DNA from HNF4α FLOX and null adult livers.
6		UNIPROT:P05164	activates	Polonium	MESH:D011059	Protein	49308da6-bc31-11e5-9b9d-001a4ae51247	10.1016/j.abb.2004.07.019	Simulations of the model of the PO reaction catalyzed by myeloperoxidase were done using the Berkeley Madonna software (Berkeley, CA).|||The model developed for the PO reaction catalyzed by myeloperoxidase differs from previous models of the reaction catalyzed by horseradish peroxidase[10,18,30,32]in that it has incorporated the binding of chloride to the four enzyme forms iron(III) peroxidase, compound I, compound II, and compound III, where the formation of the compound I–chloride complex leads to release of hypochlorous acid.|||In the latter reaction, iron(II) peroxidase has been observed as an intermediate[17], but up to now there are no observations of this reduced enzyme intermediate in the PO reaction catalyzed by myeloperoxidase.
6		CHEBI:39867	inhibits	Polonium	MESH:D011059	Chemical	5b8ddcae-bbed-11e5-8abe-001a4ae51246	10.1016/j.mcn.2004.12.003	TheKifor direct inhibition of PO by VPA is ∼1.0 mM, which is compatible with the surprisingly high therapeutic blood level of 0.3–0.7 mM that is routinely used to treat bipolar disorder (Taylor et al., 2001).|||The direct inhibition of PO by VPA was at first surprising: because PO inhibitors reversed the action of VPA on growth cones (Williams et al., 2002), we had predicted that if VPA affected PO activity either directly or indirectly, then the effect would be to activate PO rather than inhibit it.|||The unexpected direct inhibition of PO by VPA suggests that, in some circumstances, VPA could increase PIns signaling and, perhaps, inositol availability, the opposite of the effects described previously (Agam et al., 2002; O'Donnell et al., 2000; Williams et al., 2002).
4	Polonium	MESH:D011059	activates		UNIPROT:O00590	Protein	4cfbe064-c46c-11e5-91a7-001a4ae51247	PMC4057972	IP and PO administration of OVA both induced OVA-specific T cells to express α4β7 and CCR9 in PBS-treated mice but not in anti-CD3–treated mice (Figure 2C).
4	Polonium	MESH:D011059	activates		UNIPROT:Q15717	Protein	a62a6f4e-4530-11f0-8cae-0050569a1f61	10.1016/j.jff.2022.105130	Collectively, the above results indicated that CPA effectively mitigated PO-induced HUA and minor kidney injury in mice.
4	Polonium	MESH:D011059	activates		UNIPROT:Q15717	Protein	9a5946b6-1a62-11f0-b759-0050569a791b	10.1016/j.fbio.2024.105256	It has been reported that the HUA mouse model induced by PO may lead to severe renal injury characterized by inflammatory infiltration, dilation of renal tubular lumens, and glomerular atrophy and deformation (Cao et al., 2022; P.Wang et al., 2022).
4	Polonium	MESH:D011059	activates		UNIPROT:Q15717	Protein	05e31018-1b3c-11f0-b759-0050569a791b	10.1016/j.jep.2024.118014	HUA was artificially induced by additional oral administration of PO and adenine 2 weeks prior to the experimental endpoints.
4	Polonium	MESH:D011059	increases		UNIPROT:P53805	Protein	a892e660-bc2f-11e5-8d2d-001a4ae51247	10.1016/j.febslet.2006.09.064	Sanna et al. showed that PO and phenylephrine (PE) plus angiotensin II (AngII) infusion did not detectably increase MCIP1 protein levels in the heart (referred to as EXP 6 later on).
4	Polonium	MESH:D011059	decreases		UNIPROT:P35354	Protein	38f07ece-374f-11e8-8636-001a4a160175	28013186	Furthermore, PO and PT inhibited NF-κB activation, TAK1 phosphorylation, and iNOS and COX-2 expression.
4	Polonium	MESH:D011059	activates		UNIPROT:P04818	Protein	039372b0-bc02-11e5-9b9d-001a4ae51247	10.1016/j.foodchem.2007.08.068	When functioning as a plasticiser, PO globules disrupt the intermolecular hydrogen bonding and hence reduced TM and TS.
4	Polonium	MESH:D011059	activates		UNIPROT:P50336	Protein	a49d5670-341a-11e8-a34b-001a4a160175	17328902	When the molar ratio of EO to PO decreased, indicating the longer PPO block when the polymers have the same molar mass, hydrophobicity of the polymer could be significantly enhanced, making enhanced hydrophobic interaction betweenl-asparaginase and PEO–PPO–PEO polymer and as a result, morel-asparaginase was partitioned into the PEO–PPO–PEO-rich top phase.
4	Polonium	MESH:D011059	activates		UNIPROT:P35916	Protein	e991bb20-04fd-11f0-9c9e-0050569a1f61	10.1016/j.susmat.2024.e01070	In addition, the PO group was detected at 1098 cm−1, further supporting the substitution of PCl with phenolic hydroxyl groups, as described in the above1H NMR analysis.
4	Polonium	MESH:D011059	activates		UNIPROT:P07204	Protein	039372b0-bc02-11e5-9b9d-001a4ae51247	10.1016/j.foodchem.2007.08.068	When functioning as a plasticiser, PO globules disrupt the intermolecular hydrogen bonding and hence reduced TM and TS.
4	Polonium	MESH:D011059	increases		UNIPROT:Q8TCC7	Protein	d4159aa6-3402-11e8-87fd-001a4a160176	26344851	5, compared with Control group mice, PO administration induced a significant up-regulation of the URATl protein expression, as well as a significant down-regulation of the OAT1 and OAT3 protein expressions in mice kidney (p<0.01).
4	Polonium	MESH:D011059	dephosphorylatesProtein		UNIPROT:P35228	Protein	38f07ece-374f-11e8-8636-001a4a160175	28013186	Furthermore, PO and PT inhibited NF-κB activation, TAK1 phosphorylation, and iNOS and COX-2 expression.
4	Polonium	MESH:D011059	decreases		UNIPROT:P35228	Protein	38f07ece-374f-11e8-8636-001a4a160175	28013186	Furthermore, PO and PT inhibited NF-κB activation, TAK1 phosphorylation, and iNOS and COX-2 expression.
4	Polonium	MESH:D011059	activates		UNIPROT:P01584	Protein	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	These data further suggest that PO prevents LPS + PA-induced inflammasome activation and release of mature IL-1β in BMDMs.
4	Polonium	MESH:D011059	decreases		UNIPROT:P01584	Protein	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	PO, LO, KO or FO supplementation notably reduced the elevated serum levels of TNF-α, IL-1βand IL-6 in the HFD-fed mice.
4	Polonium	MESH:D011059	inhibits		UNIPROT:P01584	Protein	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	These data further suggest that PO prevents LPS + PA-induced inflammasome activation and release of mature IL-1β in BMDMs.
4	Polonium	MESH:D011059	activates		UNIPROT:P08254	Protein	b49f8a88-1c26-11f0-b759-0050569a791b	10.1016/j.biopha.2023.116119	In particular, PO-induced increases in tissue inhibitor of matrix metalloproteinase (TIMP1), matrix metalloproteinase 3 (MMP3), periostin (Postn) and scleraxis (Scx) mRNA levels were prevented by ALY688 (Fig. 3F).
4	Polonium	MESH:D011059	activates		UNIPROT:P04040	Protein	c6d5e780-390a-11e8-87fd-001a4a160176	25481373	While PO at doses of 20 and 40mg/kg significantly increased the CAT activity (P<0.05,P<0.05) in parallel to the vehicle group.
4	Polonium	MESH:D011059	inhibits		UNIPROT:P04040	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	Furthermore, dietary PO diet also reduced the activities of SOD and CAT, in comparison with dietary FO diet (P< 0.05,Fig. 6B and C).
4	Polonium	MESH:D011059	activates		UNIPROT:P08235	Protein	839c787c-1ba1-11f0-b759-0050569a791b	10.1016/j.aqrep.2024.102016	These results suggested that FO and PO may promote lipid transport and accumulation in hepatopancreas of mud crab, thereby promoting MR and WG (Fig. 5A).
4	Polonium	MESH:D011059	activates		UNIPROT:P06213	Protein	c0b26d08-2cdf-11f0-b759-0050569a791b	10.1016/S1381-5148(01)00066-9	PO and MPO were synthesized by the reaction of benzyl magnesium chloride with epichlorohydrin and β-methylepichlorohydrin, respectively, followed by treatment with NaOH solution.1H-NMR, IR spectra and epoxy equivalent weight (EEW) of the obtained compounds showed good agreement with those of the desired structures.
4	Polonium	MESH:D011059	activates		UNIPROT:Q04912	Protein	743aba64-eed0-11ee-b346-0050569a791b	10.1016/j.quascirev.2004.09.009	granosumis typical of clayey substrates enriched in organic matter, like the pelitic belt due to the Po contributions in the Adriatic Sea (Jorissen, 1988).
4	Polonium	MESH:D011059	activates		UNIPROT:P0AGB3	Protein	3b045b1a-8646-11f0-8978-0050569a1f61	10.1016/j.geoderma.2020.114919	Although the soil pH values in region #3 were pH 6.03–6.28 at 24 h after biochar addition, similar to the bulk soil pH (6.28 ± 0.21), the PO technique allows continuous monitoring of pHin situand at a fine resolution to identify the development of the charosphere and its distinct characteristics, which is not possible with destructive measurement techniques applied to bulk soil samples.
4	Polonium	MESH:D011059	inhibits		UNIPROT:P08311	Protein	222d225c-f083-11ee-b346-0050569a791b	10.1016/S0015-0282(03)00982-8	In animals with induced disease, glycodelin expression as assessed by RT-PCR was not detectable on day 8 PO and was markedly down-regulated, compared to controls, after CG infusion at days 10 and 14 PO (data not shown).
4	Polonium	MESH:D011059	decreases		UNIPROT:Q9UQ80	Protein	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	Pretreatment/cotreatment of PO decreased the phosphorylated levels of ERK p42 subunit in BMDMs (Fig. 7, lane 5 and 6) compared to LPS or LPS + PA-treated BMDMs.
4	Polonium	MESH:D011059	activates		UNIPROT:P07492	Protein	355e34d0-bc2d-11e5-9b9d-001a4ae51247	10.1016/S0965-1748(03)00029-8	However, when 6HisC-rβGRP was incubated with plasma containing laminarin, PO activity increased approximately 3-fold above that of 6HisC-rβGRP alone.
4	Polonium	MESH:D011059	increases		UNIPROT:P16104	Protein	bc88796c-04b1-11f0-baad-0050569a1f61	10.1016/j.yexcr.2024.114265	Namely, the p21 and γH2AX levels were promoted by PO treatment, reduced by KMT2D silencing, and restored by IDI1 overexpression (Fig. 6B).
4	Polonium	MESH:D011059	activates		UNIPROT:Q03395	Protein	f43f7c92-338b-11e8-9192-001a4a160175	9877431	However, the cytotoxicity was decreased when PO inhibitors (except for Na-benzoate at the lower concentration), serine protease inhibitors, reducing agents, ROM scavengers and quinone scavengers were added to the heterologous BP.
4	Polonium	MESH:D011059	activates		UNIPROT:P00450	Protein	9b009e0e-04e4-11f0-bb39-0050569a791b	10.1016/j.jclepro.2024.143387	PO-1 represents PO produced using HPPO technology, while PO-2 represents PO produced using CP technology.Fig.
4	Polonium	MESH:D011059	activates		UNIPROT:O15519	Protein	d1c9aff6-1b97-11f0-bb75-0050569a1f61	10.1016/j.jenvman.2024.120844	The flame area and red color intensity were further increased by the addition of PO to the biomass pellets.
4	Polonium	MESH:D011059	activates		UNIPROT:P08174	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	The results exhibited that PO diet significantly induced liver TG, TC and LDL-C contents (P< 0.01,Fig. 4A-4C) in croakers, compared with FO diet.
4	Polonium	MESH:D011059	inhibits		UNIPROT:Q38424	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	Moreover, we also found that dietary PO diet with NF addition efficiently inhibited PO diet-induced induction of ALT and AST activities in serum of croaker, indicating that dietary NF may relieve the liver damage induced by PO diet.
4	Polonium	MESH:D011059	inhibits		UNIPROT:Q9NRA2	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	Moreover, we also found that dietary PO diet with NF addition efficiently inhibited PO diet-induced induction of ALT and AST activities in serum of croaker, indicating that dietary NF may relieve the liver damage induced by PO diet.
4	Polonium	MESH:D011059	activates		UNIPROT:Q9V3N1	Protein	dbd1fbaa-3901-11e8-87fd-001a4a160176	26453810	Loss-of-function mutations in Spn27A lead to a high rate of spontaneous melanization and constitutively elevated PO activity in the blood, while overexpression of Spn27A suppresses PO activation following microbial immune challenge[100,138].
4	Polonium	MESH:D011059	activates		UNIPROT:E1V8I0	Protein	4e148fbc-1b4e-11f0-b40b-0050569a1f61	10.1016/j.plaphy.2024.108723	The Po-induced GOGAT activity did not differ significantly from LPi in nodules, but varied markedly in leaf.
4	Polonium	MESH:D011059	activates		UNIPROT:P05231	Protein	bc88796c-04b1-11f0-baad-0050569a1f61	10.1016/j.yexcr.2024.114265	Complementing these findings, ELISA measurements showed that the concentrations of pro-inflammatory CCL2 and IL-6 in the culture supernatant of AML12 cells were increased by PO, decreased by sh-KMT2D, and then restored by oe-IDI1 (Fig. 6F–G).
4	Polonium	MESH:D011059	decreases		UNIPROT:P05231	Protein	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	Pretreatment of PO followed by TNFα exposure significantly decreased the mRNA levels of IL-1β, IL-6, and TNFα (Fig. 1E) Together, these data suggest that supplementation of PO prevents the activation of LPS or TNFα-induced inflammatory responses in BMDMs and PO also prevents LPS/ATP-induced NLRP3 inflammasome activation in both mouse and human macrophages.
4	Polonium	MESH:D011059	decreases		UNIPROT:P05231	Protein	c6d5e780-390a-11e8-87fd-001a4a160176	25481373	However, PO at dose of 20 and 40mg/kg significantly reduced the levels of the pro-inflammatory cytokines TNF-α (P<0.05) and IL-6 (P<0.01).
4	Polonium	MESH:D011059	decreases		UNIPROT:P25445	Protein	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	PO, LO, KO or FO supplementation prominently reduced the increase of ACC, FAS and SCD1 mRNA levels, and inhibited the decrease of CPT-1αand CPT-2 mRNA levels in the eWAT and liver of HFD-fed mice.
4	Polonium	MESH:D011059	inhibits		UNIPROT:Q96HC4	Protein	a882b46a-bc4e-11e5-8abe-001a4ae51246	10.1016/j.conb.2005.06.008	These include the posterior (PO), postero-medial (PM), limitans (LIM) and suprageniculate (SG) nuclei of the thalamus, in addition to the magnocellular (MGm) and anterior dorsal (AD) divisions of the medial geniculate nucleus.
4	Polonium	MESH:D011059	activates		UNIPROT:Q15063	Protein	b49f8a88-1c26-11f0-b759-0050569a791b	10.1016/j.biopha.2023.116119	In particular, PO-induced increases in tissue inhibitor of matrix metalloproteinase (TIMP1), matrix metalloproteinase 3 (MMP3), periostin (Postn) and scleraxis (Scx) mRNA levels were prevented by ALY688 (Fig. 3F).
4	Polonium	MESH:D011059	inhibits		UNIPROT:P01266	Protein	e370baec-3549-11e8-9192-001a4a160175	18165129	Moreover, PO caused additional statistically significant elevation of intracellular TG content, probably by decreasing TG degradation by intracellular lipases.
4	Polonium	MESH:D011059	activates		UNIPROT:P01266	Protein	e370baec-3549-11e8-9192-001a4a160175	18165129	Moreover, PO caused additional statistically significant elevation of intracellular TG content, probably by decreasing TG degradation by intracellular lipases.
4	Polonium	MESH:D011059	inhibits		UNIPROT:Q9S7H8	Protein	e0fe0168-c46a-11e5-8491-001a4ae51247	24874867	The other parameters, qPQ, ϕPo,ϕEo, and ψ0, which were decreased inmpk4-2/ics1, correlate with the reduction of the PQ pool, the maximum quantum yield of primary photochemistry, the quantum yield for electron transport, and the probability that the electron moves further than QA, respectively.
4	Polonium	MESH:D011059	decreases		UNIPROT:P01375	Protein	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	PO, LO, KO or FO supplementation notably reduced the elevated serum levels of TNF-α, IL-1βand IL-6 in the HFD-fed mice.
4	Polonium	MESH:D011059	decreases		UNIPROT:P01375	Protein	c6d5e780-390a-11e8-87fd-001a4a160176	25481373	However, PO at dose of 20 and 40mg/kg significantly reduced the levels of the pro-inflammatory cytokines TNF-α (P<0.05) and IL-6 (P<0.01).
4	Polonium	MESH:D011059	inhibits		UNIPROT:P29083	Protein	5ea8d346-f139-11ee-b346-0050569a791b	10.1016/S1352-2310(03)00147-X	After standard addition of 95±1.3mBqg−1, each sample was completely dissolved with mineral acids and polonium was spontaneously plated onto a silver discs in 0.5N HCl in the presence of ascorbic acid to reduce Fe+3to Fe+2.
4	Polonium	MESH:D011059	activates		UNIPROT:Q96M11	Protein	5e54a8b2-bbf4-11e5-8abe-001a4ae51246	10.1016/j.cbpa.2006.02.042	At concentrations of 0.1 and 0.01 mM, respectively, PO inhibitors DETC, NC and PTU completely suppressed the oxidase activity of the HLS (Table 2).
4	Polonium	MESH:D011059	activates		UNIPROT:P01009	Protein	8aa31644-003f-11f0-a3d5-0050569a1f61	10.1016/j.envres.2024.120599	It can not only mineralise Po by producing phosphatase and increasing the P transport rate but also solubilise Pi by secreting organic acids to increase soil AP (Ikoyi et al., 2018;Bi et al., 2020;Deng et al., 2024).
4	Polonium	MESH:D011059	decreases		UNIPROT:P01588	Protein	4e4a5ffa-1a79-11f0-b759-0050569a791b	10.1016/j.buildenv.2024.112043	This finding suggested that elevated levels of PO correspond to diminished levels of EP, while reduced levels of PO align with heightened levels of EP.
4	Polonium	MESH:D011059	inhibits		UNIPROT:P22466	Protein	c21fc488-ab15-11e6-81c1-001a4ae51246	27794387	It was suggested that CUR improved GalN induced neurotoxicity by decreasing lipid peroxidation, protein oxidation (PO), and cleaved caspase-3 (CASP3) expression, as well as increasing antioxidant content in the neuronal mitochondria[36].
4	Polonium	MESH:D011059	activates		UNIPROT:Q15672	Protein	c068f996-4528-11f0-afc2-0050569a791b	10.1016/j.micres.2022.127017	SCS and ECB elicited the secretion of a similar protein profile by PO and TR.
4	Polonium	MESH:D011059	activates		UNIPROT:P36956	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	Dietary PO diet significantly elevated the mRNA expressions in lipid synthesis-related genes (srebp1,acc1,fas,scd1anddgat1) (P< 0.05,Fig. 5A-5E) in livers of croakers, compared with FO diet.
4	Polonium	MESH:D011059	inhibits		UNIPROT:P02730	Protein	81294c34-8792-11f0-afc2-0050569a791b	10.1016/j.ejsobi.2020.103245	On the harvest day (60 d after transplantation), the highest disease incidence in the control treatment was 58.3%, whereas the FV, LE and PO treatments significantly (p< 0.05) reduced disease incidence by 53.3%, 25.7% and 37.9%, respectively.
4	Polonium	MESH:D011059	decreases		UNIPROT:P05164	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	But, these elevated levels of MPO and MDA were strikingly attenuated by PO.
4	Polonium	MESH:D011059	activates		UNIPROT:P81274	Protein	5b8ddcae-bbed-11e5-8abe-001a4ae51246	10.1016/j.mcn.2004.12.003	By analogy with such a sound compressor, the inhibitory effects of the three mood stabilizers on PIns signaling that we described previously (Williams et al., 2002) may act to limit the highs, while the direct inhibition of PO by VPA may act to limit the lows of PIns signaling, thereby maintaining PIns signaling in mood-related circuits within the range required for mood stability.
4	Polonium	MESH:D011059	decreases		UNIPROT:P04179	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	Furthermore, dietary PO diet significantly decreased the protein expressions of SOD2 (P< 0.05,Figure 8), and the protein expressions of SOD2 significantly elevated with the increasing addition of NF in diets with palm oil (linear and quadratic trend,P< 0.05,Figure 8).
4	Polonium	MESH:D011059	inhibits		UNIPROT:Q99766	Protein	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	Additionally, the ratio ofFirmicutesandBacteroidetes(F/B) was dramatically elevated in the HFD-fed mice, whereas PO or LO supplementation prominently reduced HFD-induced the increase of F/B ratio in the feces of mice (Fig. 6D).
4	Polonium	MESH:D011059	activates		UNIPROT:Q14032	Protein	4710c9c0-341e-11e8-8636-001a4a160175	11189023	An injection of lidocaine into the VMH suppressed the BAT thermogenesis elicited by PO cooling (Imai-Matsumura and Nakayama, 1987).
4	Polonium	MESH:D011059	activates		UNIPROT:P09615	Protein	839c787c-1ba1-11f0-b759-0050569a791b	10.1016/j.aqrep.2024.102016	These results suggested that FO and PO may promote lipid transport and accumulation in hepatopancreas of mud crab, thereby promoting MR and WG (Fig. 5A).
4	Polonium	MESH:D011059	activates		CHEBI:35584	Chemical	adc990c0-04c3-11f0-bd9d-0050569a1f61	10.1016/j.ijbiomac.2024.134782	This suggests that PO and adenine intake promotes purine metabolism and increased UA production in HUA-mice.
4	Polonium	MESH:D011059	inhibits		CHEBI:29805	Chemical	292370e6-bc40-11e5-8abe-001a4ae51246	10.1016/j.freeradbiomed.2007.01.014	Here for both intraperoxisomal oxidases, UOX and GlyOX, detergent-mediated disruption of PO increased oxidase activity due to facilitated influx of urate and glycolate (Fig. 3C, middle and right).
4	Polonium	MESH:D011059	inhibits		CHEBI:73571	Chemical	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	6C, the relative abundance ofBacteroideteswas significantly declined in the HFD-fed mice as compared to the LFD group, which was notably reversed by PO or LO supplementation.
4	Polonium	MESH:D011059	activates		CHEBI:35895	Chemical	870ba83e-04c7-11f0-bd9d-0050569a1f61	10.1016/j.cej.2024.154591	Phosphorus-containing groups could also be decomposed to produce PO·
4	Polonium	MESH:D011059	activates		CHEBI:6364	Chemical	355e34d0-bc2d-11e5-9b9d-001a4ae51247	10.1016/S0965-1748(03)00029-8	However, when 6HisC-rβGRP was incubated with plasma containing laminarin, PO activity increased approximately 3-fold above that of 6HisC-rβGRP alone.
4	Polonium	MESH:D011059	activates		CHEBI:35864	Chemical	b547941a-3954-11e8-87fd-001a4a160176	10422793	When we applied 10 μM gold sodium thiomalate to thecisside of the bilayer in the presence of 0.5–10 μMcisCa2+, the open probability (Po) of the Ca2+-release channel prepared from frog skeletal muscle was increased 2.5-fold, from 0.031 in controls to 0.078, because of a marked increase in number of open events/s (Table 2), althoughPowas not significant due to large variations.
4	Polonium	MESH:D011059	activates		CHEBI:29108	Chemical	8cac4a42-cbf0-11e5-a19a-001a4ae51247	10556582	2the NOC-7-modified calcium release channel (Po=0.67;Fig. 2B) was markedly activated by 100 μM 4-CMPS (Po=0.95;Fig. 2C) and then completely blocked.
4	Polonium	MESH:D011059	inhibits		CHEBI:16398	Chemical	25f5ad60-3779-11e8-8636-001a4a160175	15145690	However, despite a relatively unchanged MLC response, the specific DTH response was markedly suppressed by both the administration of PO and PV alloantigen.
4	Polonium	MESH:D011059	activates		CHEBI:26020	Chemical	00cf3f1c-8639-11f0-8cae-0050569a1f61	10.1016/j.apcatb.2020.119635	eV peak conforms to the PO bond inPO43-. The superficial oxidation of metal phosphide produced signals of phosphate after exposure to air (Fig. 2f).
4	Polonium	MESH:D011059	activates		CHEBI:38472	Chemical	34ccf576-3555-11e8-9fbf-001a4a160176	10720226	There is little difference between the logαPOvalues in 50 and 60% acetonitrile, but the oligomer selectivity for the PO units is much lower in mobile phases with 70 and 80% acetonitrile and reversed elution order is observed for the oligomers with different numbers of PO units in 90% acetonitrile (line 5 inFig.
4	Polonium	MESH:D011059	inhibits		CHEBI:16052	Chemical	27c92dbc-0cae-11f0-aa93-0050569a1f61	10.1016/S0926-3373(00)00118-1	Slow propene oxidation initiation by PO*allows NO to react through surface intermediates (NRO, NO) to nitrogen at 400°C. Propene oxidation proceeds very quickly at 500°C limiting NO reduction to nitrogen.
4	Polonium	MESH:D011059	inhibits		CHEBI:33351	Chemical	a882b46a-bc4e-11e5-8abe-001a4ae51246	10.1016/j.conb.2005.06.008	These include the posterior (PO), postero-medial (PM), limitans (LIM) and suprageniculate (SG) nuclei of the thalamus, in addition to the magnocellular (MGm) and anterior dorsal (AD) divisions of the medial geniculate nucleus.
4	Polonium	MESH:D011059	inhibits		CHEBI:51231	Chemical	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	We also observed that pre/cotreatment of PO diminished the number of DAPI-positive cells compared to LPS + PA-treated BMDMs (Fig. 5A).
4	Polonium	MESH:D011059	increases		CHEBI:27226	Chemical	c98db940-049f-11f0-bb39-0050569a791b	10.1016/j.jep.2024.118492	Compared with the control group, intraperitoneal injection of PO and intragastric HX could significantly increase the serum uric acid levels in mice, suggesting that a mouse model of hyperuricemia have been established successfully (Fig. 2B).
4	Polonium	MESH:D011059	activates		CHEBI:39867	Chemical	463a7512-bc54-11e5-8abe-001a4ae51246	10.1016/j.cca.2006.09.001	The inhibition of PO by valproic acid was surprising, since PO inhibitors reversed the action of valproic acid on growth cones, so valproic acid was expected to activate rather than inhibit PO.
4	Polonium	MESH:D011059	inhibits		CHEBI:29034	Chemical	34cb0cee-352c-11e8-87fd-001a4a160176	27577696	Polonium was spontaneously plated onto silver discs in 0.5 M HCl in the presence of ascorbic acid to reduce Fe3+to Fe2+.
4	Polonium	MESH:D011059	inhibits		CHEBI:17775	Chemical	292370e6-bc40-11e5-8abe-001a4ae51246	10.1016/j.freeradbiomed.2007.01.014	Here for both intraperoxisomal oxidases, UOX and GlyOX, detergent-mediated disruption of PO increased oxidase activity due to facilitated influx of urate and glycolate (Fig. 3C, middle and right).
4	Polonium	MESH:D011059	inhibits		PUBCHEM:8583	Chemical	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	Dietary PO, LO, KO or FO significantly decreased the AUC of both OGTT and ITT in the HFD-fed mice.
4	Polonium	MESH:D011059	activates		MESH:D006984	Phenotype	2b381ef8-1a4c-11f0-b759-0050569a791b	10.1016/j.phrs.2024.107514	Furthermore, berberine could upregulate Fbxo32 to ameliorate PO-induced myocardial hypertrophy in Pak1-deficient mice.
4	Polonium	MESH:D011059	activates		MESH:D006984	Phenotype	b17e45a2-c478-11e5-85e4-001a4ae51246	PMC3257317	We asked (1) whether endogenous MAFbx is upregulated during hypertrophy induced by PO, (2) whether endogenous MAFbx positively or negatively mediates cardiac hypertrophy induced by PO, and (3) which downstream target mediates the effect of MAFbx on pathological hypertrophy.
4	Polonium	MESH:D011059	activates		GO:0006810	Phenotype	8aa31644-003f-11f0-a3d5-0050569a1f61	10.1016/j.envres.2024.120599	It can not only mineralise Po by producing phosphatase and increasing the P transport rate but also solubilise Pi by secreting organic acids to increase soil AP (Ikoyi et al., 2018;Bi et al., 2020;Deng et al., 2024).
4	Polonium	MESH:D011059	activates		GO:0006810	Phenotype	15fe2366-ea09-11ef-999a-0050569a1f61	10.1016/j.ecss.2024.109019	This process combined with the increase in sediment transport by the Po River in 2011 (Ninfo et al., 2018) suggests that the stabilization of the inlets focused the flood in the NW direction causing the sudden increase in sand content only in the central-northern portion of the tidal flat, as shown inFig.
4	Polonium	MESH:D011059	activates		MESH:D008748	Phenotype	f43f7c92-338b-11e8-9192-001a4a160175	9877431	The dark pigmentation observed inside collapsed MC vacuoles may be phaeomelanin forming, according to Nicolaus[17], upon the reaction of the amino acid with quinones deriving from the PO-driven oxidation of MC vacuolar polyphenols by PO.
4	Polonium	MESH:D011059	activates		MESH:D011809	Phenotype	f43f7c92-338b-11e8-9192-001a4a160175	9877431	However, the cytotoxicity was decreased when PO inhibitors (except for Na-benzoate at the lower concentration), serine protease inhibitors, reducing agents, ROM scavengers and quinone scavengers were added to the heterologous BP.
4	Polonium	MESH:D011059	inhibits		GO:0044546	Phenotype	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	These data suggest that PO prevents the molecular events downstream of NLRP3 inflammasome activation.
4	Polonium	MESH:D011059	activates		MESH:D006863	Phenotype	648dba12-009f-11f0-9e78-0050569a1f61	10.1016/j.jclepro.2024.144107	PO was used as a proton scavenger to slowly and evenly increase the pH value of the solution, thus triggering gel.
4	Polonium	MESH:D011059	inhibits		MESH:D000431	Phenotype	c6d5e780-390a-11e8-87fd-001a4a160176	25481373	Herewith, the observation indicated that PO might attenuate the ethanol-induced changes via regulation of oxidant–antioxidant balance.
4	Polonium	MESH:D011059	inhibits		MESH:D000431	Phenotype	38f07ece-374f-11e8-8636-001a4a160175	28013186	Treatment with PO or PT suppressed ethanol-induced activity of myeloperoxidase.
4	Polonium	MESH:D011059	increases		MESH:D011059	Phenotype	529d28c8-3532-11e8-9192-001a4a160175	24945574	RNAi silencing of the prophenoloxidase acting system gene (proPO), the inactive precursor of PO, significantly decreased PO expression and phagocytic activity and increased bacterial growth and the cumulative mortality of crayfish submitted to bacterial infection.
4	Polonium	MESH:D011059	inhibits		MESH:D011059	Phenotype	a367d486-d483-11e5-a1eb-001a4ae51246	PMC4282987	Neurons in the internal medullary laminar (IML) region of PTD-treated rats were more sparse, but not absent, with the exception that in some animals there was a loss of neurons in the paracentral (PC) and posterior (Po) thalamic nuclei.
4	Polonium	MESH:D011059	increases		MESH:D011059	Phenotype	31efd5f0-bbde-11e5-8abe-001a4ae51246	10.1016/S0166-445X(01)00175-8	PO activities in tunicates exposed to TBT increased with dose such that 2 and 5 μg/l TBT elicited PO levels that were significantly greater than those of nonexposed tunicates.
4	Polonium	MESH:D011059	inhibits		GO:0006955	Phenotype	7d1b91ae-00a3-11f0-9c09-0050569a791b	10.1016/j.scitotenv.2024.175467	(Asterales: Asteraceae) extracts led to dose-dependent suppression of cellular immunity, phagocytosis, nodulation and PO activity inE.
4	Polonium	MESH:D011059	activates		GO:0009058	Phenotype	2f495d3a-e9e2-11ef-95dd-0050569a1f61	10.1016/j.cej.2025.160196	Interestingly, peaks of POC and PO were also observed in the FTIR profile of L-Trp@PA/TPEP, supporting the successful synthesis of L-Trp@PA/TPEP.
4	Polonium	MESH:D011059	inhibits		GO:0110148	Phenotype	cf32f820-3c9d-11f0-afc2-0050569a791b	10.1016/j.envadv.2022.100247	We hypothesized that this variability in the ability of NFTs to increase P bioavailability could be due to different Po cycling in soil, because Po sequestration in microbial biomass would prevent Po mineralization by phosphatases and therefore efficient Po recycling.
4	Polonium	MESH:D011059	inhibits		MESH:D006859	Phenotype	039372b0-bc02-11e5-9b9d-001a4ae51247	10.1016/j.foodchem.2007.08.068	When functioning as a plasticiser, PO globules disrupt the intermolecular hydrogen bonding and hence reduced TM and TS.
4	Polonium	MESH:D011059	activates		GO:0042311	Phenotype	4710c9c0-341e-11e8-8636-001a4a160175	11189023	One extends from the caudal edge of the lateral hypothalamus to the reticular formation and the periaqueductal gray: chemical stimulation of this region produced skin vasodilation and a knife cut suppressed the skin vasodilation elicited by the PO warming.
4	Polonium	MESH:D011059	increases		MESH:D008315	Phenotype	e292a6b8-002f-11f0-8027-0050569a1f61	10.1016/j.clnu.2024.12.033	In addition, PMP attenuated PO-induced lipotoxicity by reducing the levels of the lipid peroxidation product malondialdehyde (Fig. 1F).
4	Polonium	MESH:D011059	decreases		MESH:D008315	Phenotype	38f07ece-374f-11e8-8636-001a4a160175	28013186	Finally, we also observed that PT and PO inhibited ethanol-induced malondialdehyde and NO levels (Fig. 6).
4	Polonium	MESH:D011059	activates		MESH:D008315	Phenotype	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	The results exhibited that dietary PO diet significantly increased the contents of MDA in livers of croakers, in comparison with FO diet (P< 0.05,Fig. 6A).
4	Polonium	MESH:D011059	activates		GO:0006869	Phenotype	839c787c-1ba1-11f0-b759-0050569a791b	10.1016/j.aqrep.2024.102016	These results suggested that FO and PO may promote lipid transport and accumulation in hepatopancreas of mud crab, thereby promoting MR and WG (Fig. 5A).
4	Polonium	MESH:D011059	activates		MESH:D020058	Phenotype	fe694392-da10-11ee-b346-0050569a791b	10.1016/S0195-9255(98)00010-9	The PO plant will produce 285,000 tons of PO per year and 685,000 tons of styrene monomer as a co-product.
4	Polonium	MESH:D011059	decreases		MESH:D009569	Phenotype	38f07ece-374f-11e8-8636-001a4a160175	28013186	Finally, we also observed that PT and PO inhibited ethanol-induced malondialdehyde and NO levels (Fig. 6).
4	Polonium	MESH:D011059	inhibits		MESH:D002784	Phenotype	febad0e8-0ca7-11f0-a2ca-0050569a1f61	10.1093/ajcn/71.6.1462	When compared with the control diet, the high-isoflavone diet lowered the ratio of total cholesterol to HDL cholesterol by 10.2% (P< 0.002) and the ratio of LDL cholesterol to HDL cholesterol by 13.8% (P< 0.002) in the PO phase.
4	Polonium	MESH:D011059	inhibits		MESH:D015430	Phenotype	9a5946b6-1a62-11f0-b759-0050569a791b	10.1016/j.fbio.2024.105256	Similar to the findings ofZhao et al. (2022), the administration of the modeling agent, potassium oxonate (PO), variably reduced the rate of weight gain.
4	Polonium	MESH:D011059	activates		MESH:D015431	Phenotype	1281befa-bc0a-11e5-8abe-001a4ae51246	10.1016/j.postharvbio.2006.06.016	This may explain why the use of 38-μm microperforated PO film also reduced weight loss although it did not modify the atmosphere inside the packages to any practical extent.Moura et al. (1997)found that ‘Taubaté’ persimmon fruit in PVC film had little weight loss after 72d storage at 0°C. Fig. 4shows that only the modified atmospheres generated for 58-μm PO and 50-μm LDPE films retarded softening of the fruit during storage.
4	Polonium	MESH:D011059	inhibits		GO:0016032	Phenotype	4e3c6e76-3404-11e8-a34b-001a4a160175	26117730	For bacterial infected group, PO activity reached the maximum at 78 h but decreased gradually to the minimum at 120 h. For viral infection, the maximum was at 12 h, and then decreased rapidly to reach the minimum value at 120 h, and was significantly lower than the PBS group (P < 0.05).
4	Polonium	MESH:D011059	inhibits		MESH:D001564	Phenotype	59a87df2-3910-11e8-8f56-001a4a160175	PMC5705288	The α2-adrenergic receptor agonist clonidine (0.1 mg PO) is effective to reduce nocturnal BP in MSA from residual sympathetic tone; however, it can elicit paradoxical increases in BP in PAF with depressed sympathetic outflow.
4	Polonium	MESH:D011059	activates		GO:0008152	Phenotype	adc990c0-04c3-11f0-bd9d-0050569a1f61	10.1016/j.ijbiomac.2024.134782	This suggests that PO and adenine intake promotes purine metabolism and increased UA production in HUA-mice.
4	Polonium	MESH:D011059	inhibits		MESH:D010590	Phenotype	a3053ffa-aba2-11e6-9ac8-001a4ae51246	PMC4572469	Because PO treatment blocks rhodamine phalloidin labeling, cells were fixed after 1 h after partial PO stabilization.
4	Polonium	MESH:D011059	activates		MESH:D003596	Phenotype	b392afc4-392c-11e8-a51f-001a4a160176	9385398	Recent studies of the mutagenic activity of PO indicated that DNA adducts induced by PO at template cytosine residues are mutagenic inE.
4	Polonium	MESH:D011059	inhibits		MESH:D014456	Phenotype	38f07ece-374f-11e8-8636-001a4a160175	28013186	Pre-treatment with PO or PT significantly lowered the ethanol-induced gross gastric lesion score, ulcer lesion area, and myeloperoxidase activity in the gastric mucosa.
4	Polonium	MESH:D011059	activates		MESH:D033461	Phenotype	007586f4-1adf-11f0-85c3-0050569a1f61	10.1016/j.freeradbiomed.2024.09.023	To further address whether blood bilirubin levels are altered in HUA models, we compared the plasma uric acid, TBil and UCB levels in C57BL/6 mice with PO induced hyperuricemia.
4	Polonium	MESH:D011059	activates		MESH:D014508	Phenotype	6a7d7e44-0cd4-11f0-b759-0050569a791b	10.1016/S0304-4203(99)00103-6	The PO method had the highest overall recovery of the compounds tested (93±13%;Table 4); PO produced nearly quantitative recovery of urea, NH4+and glycine in DW; EDTA and antipyrine were less efficiently oxidized.
4	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	4cfbe064-c46c-11e5-91a7-001a4ae51247	PMC4057972	IP and PO administration of OVA both induced OVA-specific T cells to express α4β7 and CCR9 in PBS-treated mice but not in anti-CD3–treated mice (Figure 2C).
4	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	99e53448-0026-11f0-9c09-0050569a791b	10.1016/j.yjmcc.2024.12.009	PO-induced increases in cardiomyocyte size were attenuated in all Mst-deficient groups, including Mst1cKO;Mst2KO mice (Fig. 1G).
4	Polonium	MESH:D011059	inhibits		GO:0006954	Phenotype	da3bba62-3512-11e8-8f56-001a4a160175	26800098	The results indicate that PO can reduce the degree of pathological inflammation in lung tissues in acute lung injury.
4	Polonium	MESH:D011059	activates		GO:0006954	Phenotype	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	Together, these data suggest a potent anti-inflammatory role of PO against LPS-induced macrophage inflammation.
4	Polonium	MESH:D011059	activates		MESH:D003094	Phenotype	99e53448-0026-11f0-9c09-0050569a791b	10.1016/j.yjmcc.2024.12.009	Histological analysis of myocardium revealed attenuated PO-induced collagen deposition in all 4 Mst deficient groups compared to control mice (Fig. 1D).
4	Polonium	MESH:D011059	inhibits		GO:0007165	Phenotype	da3bba62-3512-11e8-8f56-001a4a160175	26800098	In all, these results showed that PO (20mg/kg) could simultaneously block NF-κB signaling pathway efficiently and activate Nrf2 pathway in a mouse model of ALI.
4	Polonium	MESH:D011059	decreases		MESH:D010712	Phenotype	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	Supplementation of PO significantly decreases the levels of IL-1β release into the culture media in both 200 and 400 μM of PA + LPS-treated BMDMs.
4	Polonium	MESH:D011059	inhibits		MESH:D001835	Phenotype	d13004cc-3388-11e8-87fd-001a4a160176	24976442	The mean PO decrease of relative body weight was significantly higher in group 3 compared with all other groups (P= 0.0004).
4	Polonium	MESH:D011059	inhibits		MESH:D001835	Phenotype	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	PO, LO, KO or FO supplementation significantly reduced the body weight gain, eWAT weights, and liver weights in the HFD-fed mice.
4	Polonium	MESH:D011059	activates		MESH:D006540	Phenotype	74cb1c6c-1b84-11f0-b759-0050569a791b	10.1016/j.envres.2024.118330	The assay was applied to detect the presence of total herbicides in real river samples (Po river, Italy) allowing to detect the total herbicide content in the nM range after sample preparation (concentration and dilution steps).
4	Polonium	MESH:D011059	activates		MESH:D009285	Phenotype	a663e298-3b8e-11f0-86f5-0050569a1f61	10.1016/j.tet.2017.10.037	It also shows that the PO bond ofN4aais much resisted to be reduced than the CO bonds in naphthoquinone framework.
4	Polonium	MESH:D011059	activates		MESH:D005227	Phenotype	2fa6ce9a-1c17-11f0-aa93-0050569a1f61	10.1016/j.molmet.2024.101882	Furthermore, Rgs14, Rgs14(E92A/N93A) and Rgs14(R336L) reduced the mRNA expression of genes involved in fatty acid uptake and synthesis (Figure 4D) and the inflammatory response (Figure 4F), accelerated the mRNA expression of genes involved in fatty acid utilization and oxidation (Figure 4E) in primary mouse hepatocytes induction elicited by PO.
4	Polonium	MESH:D011059	inhibits		MESH:D012330	Phenotype	eb3cef4e-1ad8-11f0-b759-0050569a791b	10.1016/j.fsi.2024.109925	The hemolymph PO activity ofLvPPAEs-silenced shrimp was significantly (P < 0.05) decreased throughout the EHP infection, when compared to the control group injected withGFP dsRNA(Fig. 5B).
4	Polonium	MESH:D011059	activates		MESH:D008543	Phenotype	e1d8f97c-3a82-11e8-87fd-001a4a160176	26748247	During wound healing or parasite encapsulation, crystal cell-derived PO catalyzes melanin deposits at the injury site or around foreign invaders (Crozatier and Meister, 2007; Lebestky et al., 2000).
4	Polonium	MESH:D011059	inhibits		MESH:D002129	Phenotype	df2dc3f0-3ab0-11e8-a34b-001a4a160175	24768833	Mill experience has demonstrated that introducing an acid washing stage in a eucalyptus bleaching sequence (O/OAZD(PO)) could significantly decrease calcium oxalate-related problems (Rodrigues da Silva et al., 2002).
4	Polonium	MESH:D011059	activates		FPLX:Phosphatase	ProteinFamily	8aa31644-003f-11f0-a3d5-0050569a1f61	10.1016/j.envres.2024.120599	It can not only mineralise Po by producing phosphatase and increasing the P transport rate but also solubilise Pi by secreting organic acids to increase soil AP (Ikoyi et al., 2018;Bi et al., 2020;Deng et al., 2024).
4	Polonium	MESH:D011059	decreases		FPLX:ACC	ProteinFamily	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	PO, LO, KO or FO supplementation prominently reduced the increase of ACC, FAS and SCD1 mRNA levels, and inhibited the decrease of CPT-1αand CPT-2 mRNA levels in the eWAT and liver of HFD-fed mice.
4	Polonium	MESH:D011059	activates		FPLX:G:i	ProteinFamily	6332c1f2-374e-11e8-9192-001a4a160175	28774414	300 mg LNF PO BID achieved a 2-log reduction at 4 weeks, but had increased GI side effects.
4	Polonium	MESH:D011059	inhibits		FPLX:HDL	ProteinFamily	febad0e8-0ca7-11f0-a2ca-0050569a1f61	10.1093/ajcn/71.6.1462	When compared with the control diet, the high-isoflavone diet lowered the ratio of total cholesterol to HDL cholesterol by 10.2% (P< 0.002) and the ratio of LDL cholesterol to HDL cholesterol by 13.8% (P< 0.002) in the PO phase.
4	Polonium	MESH:D011059	inhibits		PF:PF09793	ProteinFamily	a882b46a-bc4e-11e5-8abe-001a4ae51246	10.1016/j.conb.2005.06.008	These include the posterior (PO), postero-medial (PM), limitans (LIM) and suprageniculate (SG) nuclei of the thalamus, in addition to the magnocellular (MGm) and anterior dorsal (AD) divisions of the medial geniculate nucleus.
4	Polonium	MESH:D011059	activates		FPLX:Protease	ProteinFamily	d3a8ca7e-ca01-11e5-b88f-001a4ae51247	15857824	Previously it was reported that insect pro-PO system induced the activation of serine protease zymogen to active serine protease during 1,3-β-d-glucan-dependent pro-PO activation (11,21).
4	Polonium	MESH:D011059	increases		FPLX:PPAR	ProteinFamily	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	Dietary PO, LO, KO or FO notably suppressed the elevated protein expression of SREBP-1 and PPARγ, and reversed the decrease of PPARαprotein levels in the eWAT and liver of HFD-fed mice.
4	Polonium	MESH:D011059	inhibits		FPLX:SOD	ProteinFamily	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	Furthermore, dietary PO diet also reduced the activities of SOD and CAT, in comparison with dietary FO diet (P< 0.05,Fig. 6B and C).
4	Polonium	MESH:D011059	decreases		FPLX:ERK	ProteinFamily	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	Pretreatment/cotreatment of PO decreased the phosphorylated levels of ERK p42 subunit in BMDMs (Fig. 7, lane 5 and 6) compared to LPS or LPS + PA-treated BMDMs.
4	Polonium	MESH:D011059	activates		FPLX:Integrins	ProteinFamily	a3053ffa-aba2-11e6-9ac8-001a4ae51246	PMC4572469	Conversely altering the cytoskeleton had much more drastic effects than cross-linking integrins; PO-stabilized actin increased attachment strength drastically more than cross-linking integrins, whereas preventing actin polymerization with cytochalasin D completely abolished attachment strength.
4	Polonium	MESH:D011059	activates		FPLX:RYR	ProteinFamily	ff701c52-bc1e-11e5-9b9d-001a4ae51247	10.1016/j.ceca.2007.04.002	Thus, the question arises as to whether it is the increase in RyR open probability (Po)per seor the combined effects of increasingPoand elevating SR Ca2+content that is responsible for the occurrence of spontaneous Ca2+release under these circumstances of enhanced β-adrenergic drive in heart failure or CPVT.
4	Polonium	MESH:D011059	inhibits		IP:IPR002042	ProteinFamily	8def9494-e9f1-11ef-95dd-0050569a1f61	10.1016/j.bioorg.2024.108108	PO was then given after 0.5 h to inhibit uricase activity.
4	Polonium	MESH:D011059	activates		UNIPROT:Q16236	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Since NF-κB and Nrf2 are critical pathways associated with inflammatory response to LPS-induced ALI in mice, Western blot analysis was made to analyze the possibility that PO suppresses pro-inflammatory NF-κB activity and activates anti-inflammatory Nrf2.|||Effects of PO on NF-κB and Nrf2 signaling pathways in mice with LPS-induced ALI Since NF-κB and Nrf2 are critical pathways associated with inflammatory response to LPS-induced ALI in mice, Western blot analysis was made to analyze the possibility that PO suppresses pro-inflammatory NF-κB activity and activates anti-inflammatory Nrf2.
4	Polonium	MESH:D011059	inhibits		UNIPROT:P50336	Protein	ada1cb40-04d1-11f0-bb39-0050569a791b	10.1016/j.fbio.2024.104746	An important parameter to be considered during the extraction of betalains is the inactivation of polyphenol oxidase (PPO) and peroxidase (PO) enzymes, which are responsible for betalain decomposition (Nirmal et al., 2021;Popa, Moldovan, & David, 2015).|||Betalain An important parameter to be considered during the extraction of betalains is the inactivation of polyphenol oxidase (PPO) and peroxidase (PO) enzymes, which are responsible for betalain decomposition (Nirmal et al., 2021;Popa, Moldovan, & David, 2015).
4	Polonium	MESH:D011059	activates		UNIPROT:P05231	Protein	721c9e74-377e-11e8-9fbf-001a4a160176	10591154	Under the conditions of these assays, neither the Ps nor the Po compounds with single bases induced significant production of either IL-6 or IL-12 (data not shown), pointing to a requirement for an ISS for production of cytokines.|||To determine whether cytokine responses followed the same pattern as proliferation, the ability of the two sets of Po and Ps compounds to induce IL-6 and IL-12 was tested.
4	Polonium	MESH:D011059	inhibits		UNIPROT:Q14032	Protein	82a3e454-bbee-11e5-8abe-001a4ae51246	10.1016/S0006-8993(02)04203-8	Warm-sensitive neurons in the PO are considered to send tonic inhibitory signals for BAT thermogenesis, because stimulation of the PO with an excitatory substance,dl-homocysteic acid, suppressed BAT thermogenesis just as PO warming did, and transection applied caudal to the PO produced a strong BAT thermogenesis[4].|||VMH stimulation elicits BAT thermogenesis and this response is completely suppressed by PO warming[4].
4	Polonium	MESH:D011059	activates		CHEBI:16336	Chemical	8e0ec16e-390b-11e8-8636-001a4a160175	25498544	PO was previously found to stimulate cell proliferation and induce the synthesis of hyaluronic acid in mouse skin fibroblasts and human dermal fibroblasts[18,19].|||Improvements in skin barrier function in the present study may be related to the synthesis of hyaluronic acid by PO and the slightly altered expression of its gene.
4	Polonium	MESH:D011059	activates		CHEBI:39867	Chemical	5b8ddcae-bbed-11e5-8abe-001a4ae51246	10.1016/j.mcn.2004.12.003	The direct inhibition of PO by VPA was at first surprising: because PO inhibitors reversed the action of VPA on growth cones (Williams et al., 2002), we had predicted that if VPA affected PO activity either directly or indirectly, then the effect would be to activate PO rather than inhibit it.|||Direct inhibition of PO by VPA was surprising for three reasons: First, we found previously that both PO inhibitors and inositol reverse the effects of VPA and other mood stabilizers indicating that VPA depletes inositol or inhibits the PIns signaling pathway (Williams et al., 2002).
4	Polonium	MESH:D011059	activates		MESH:D006984	Phenotype	fbfa8fe8-352b-11e8-9192-001a4a160175	27339326	Cardiac-specific overexpression TRAF2 mice show enhanced PO-mediated cardiac hypertrophy and dysfunctionviathe activation of Akt/GSK3β[194].|||TRAF5 inhibits MEK–ERK1/2 signaling to block PO-mediated cardiac hypertrophy[196], but aggravates NF-κB activation and blunts Akt/FOXO1 signaling to enlarge brain ischemic lesions[197].
4	Polonium	MESH:D011059	inhibits		MESH:D059808	Phenotype	ada1cb40-04d1-11f0-bb39-0050569a791b	10.1016/j.fbio.2024.104746	Betalain An important parameter to be considered during the extraction of betalains is the inactivation of polyphenol oxidase (PPO) and peroxidase (PO) enzymes, which are responsible for betalain decomposition (Nirmal et al., 2021;Popa, Moldovan, & David, 2015).|||An important parameter to be considered during the extraction of betalains is the inactivation of polyphenol oxidase (PPO) and peroxidase (PO) enzymes, which are responsible for betalain decomposition (Nirmal et al., 2021;Popa, Moldovan, & David, 2015).
4	Polonium	MESH:D011059	activates		GO:0042438	Phenotype	d3a8ca7e-ca01-11e5-b88f-001a4ae51247	15857824	When melanin synthesis induced by the activated PO has been started, MIP might be dissociated from the 47-kDa protein and then degraded from hemolymph.|||Based on these results, the pro-PO cascade can be divided into three steps: 1) recognition with pattern recognition proteins, 2) activation consisting of pro-PO-activating enzymes and their adaptor proteins, and 3) finally melanin synthesis induced by PO, MEP, MIP, and unidentified regulatory protein(s).
4	Polonium	MESH:D011059	activates		MESH:D033461	Phenotype	91a1f7d4-3527-11e8-a51f-001a4a160176	25614106	PO was applied to induce hyperuricemia in mice.|||Experimental design PO was applied to induce hyperuricemia in mice.
4	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	da3bba62-3512-11e8-8f56-001a4a160175	26800098	In this study, we investigated the effects and the mechanism of PO on LPS-induced ALI in mice.|||Effects of PO on the production of TNF-α, IL-6 and IL-1β in BALF of LPS-induced ALI mice To expose the anti-inflammatory effect of PO on mice with ALI, the levels of inflammatory cytokines TNF-α, IL-1β, and IL-6 were analyzed at 12h after LPS challenge by ELISA.
4	Polonium	MESH:D011059	inhibits		GO:0006954	Phenotype	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	In the present study, PO or LO supplementation significantly attenuated low-grade chronic inflammation in the HFD-fed mice, as evidenced by reducing the serum, eWAT and hepatic levels of TNF‐α, IL-1βand IL-6, as well as inhibiting HFD-induced the infiltration of macrophages into eWAT and liver.|||Dietary PO and FO attenuated low-grade chronic inflammation in the HFD-fed mice As depicted inTable 1, compared to the LFD group, the serum levels of TNF-α, IL-1βand IL-6 were significantly elevated in the HFD-fed mice.
4	Polonium	MESH:D011059	inhibits		PF:PF00141	ProteinFamily	ada1cb40-04d1-11f0-bb39-0050569a791b	10.1016/j.fbio.2024.104746	Betalain An important parameter to be considered during the extraction of betalains is the inactivation of polyphenol oxidase (PPO) and peroxidase (PO) enzymes, which are responsible for betalain decomposition (Nirmal et al., 2021;Popa, Moldovan, & David, 2015).|||An important parameter to be considered during the extraction of betalains is the inactivation of polyphenol oxidase (PPO) and peroxidase (PO) enzymes, which are responsible for betalain decomposition (Nirmal et al., 2021;Popa, Moldovan, & David, 2015).
4		FPLX:Phosphatase	activates	Polonium	MESH:D011059	ProteinFamily	6326b3c4-bc41-11e5-8abe-001a4ae51246	10.1016/S0038-0717(02)00093-7	However, these observations do not provide direct evidence that phosphatase activity produced by agroforestry species enhanced the mineralisation of Po.
4		FPLX:Phosphatase	inhibits	Polonium	MESH:D011059	ProteinFamily	993a5fa4-3757-11e8-b868-001a4a160176	27300290	Soil acidification due to high N fertilizer application might decrease microbial biomass and activity and phosphatase activity (Liu et al., 2011; Weand et al., 2010; Yang et al., 2014), which in turn, might decrease the mineralization of soil Po.
4		UNIPROT:P51811	inhibits	Polonium	MESH:D011059	Protein	67090284-1c1e-11f0-b759-0050569a791b	10.1016/j.cej.2024.148676	However, the excessive Na may introduce more acidic sites and thus decreases PO selectivity.
4		UNIPROT:P06401	decreases	Polonium	MESH:D011059	Protein	47954558-bc46-11e5-8d2d-001a4ae51247	10.1016/S0014-4886(03)00338-8	As shown inTable 1, after normalization with 28s rRNA, the treatment with the antagonist of PR is able to significantly decrease the mRNA levels of Po at 20d; this effect is not evident at 30d or 90d.
4		UNIPROT:Q99558	activates	Polonium	MESH:D011059	Protein	f4f82cdc-bbf2-11e5-9b9d-001a4ae51247	10.1016/S0896-6273(04)00196-5	Given that the complexity of unfamiliar Hangul letters was basically equivalent between the HS and HN conditions(Figure 1B), we also excluded the possibility that the HS-selective activations in the left PITG and the left PO were reflective solely of visual exposure to new and complex letters.
4		CHEBI:26536	activates	Polonium	MESH:D011059	Chemical	2d556980-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2003.12.004	The RA (Relative Average) PO activity showed that chitosan elicited the highest PO activity with RA value of 3.15±0.70unitmg−1protein (Table 1).
4		MESH:D004095	inhibits	Polonium	MESH:D011059	Phenotype	4491a844-3532-11e8-8f56-001a4a160175	24995840	The dihydropyridine derivative nifedipine (10μM) reduced the Po (from 0.357 to 0.171) (Fig. 6A1), whereas Bay K8644 (10μM) increased the Po (from 0.0314 to 1.2082) (Fig. 6B1).
4		PF:PF00089	activates	Polonium	MESH:D011059	ProteinFamily	c697b4fc-bc42-11e5-8d2d-001a4ae51247	10.1016/j.jip.2006.09.004	Trypsin also appeared to increase PO activity but only in wasp venom (Table 1).
4		MESH:D015742	activates	Polonium	MESH:D011059	Phenotype	105262ca-04b1-11f0-bb39-0050569a791b	10.1016/j.jbc.2024.107778	Propofol and o-PD produced strong direct activation (Povalues of 92 ± 17% and 88 ± 4%, respectively), whereas AziPm showed minimal direct activation (Po∼1%) (Table 1).
4		CHEBI:4806	inhibits	Polonium	MESH:D011059	Chemical	70f9d8cc-1b06-11f0-b759-0050569a791b	10.1016/j.jhazmat.2024.134602	Following SMZ exposure, EGCG treatment reduced PO activity compared to the untreated group (P < 0.05).
4		MESH:D009020	inhibits	Polonium	MESH:D011059	Phenotype	c6b47c08-bc4d-11e5-9b9d-001a4ae51247	10.1016/j.neuropharm.2004.11.002	This finding is consistent with earlier studies demonstrating that morphine decreases the responses of nociceptive neurones in the thalamus (Hill et al., 1982), VPL (Martin et al., 1996; Yang et al., 1999), Po (Shigenaga and Inoki, 1976), thalamic nucleus submedius (Fu et al., 2002) and ventromedial thalamus (Monconduit et al., 2002, 2003).
4		CHEBI:17234	activates	Polonium	MESH:D011059	Chemical	0115a016-04b5-11f0-bb39-0050569a791b	10.1016/j.aqrep.2024.102362	vannamei,Lee et al. (2020)reported the abundance of rhamnose, fucose, and glucose in cacao pod husk (CPH) strengthened degranulation of hemocytes through toll-like receptors 1 and 3 and increased THC and PO activity and resistance againstV.
4		CHEBI:17234	activates	Polonium	MESH:D011059	Chemical	0dcb3e88-050f-11f0-bb39-0050569a791b	10.1016/j.apsoil.2024.105495	The addition of glucose provided energy for microbial growth, stimulated microbial metabolism, enhanced the activities of C and N extracellular enzymes (BG, PPO, PO, and LAP), and immediately promoted the ability of microorganisms to co-metabolize SOM (Fig. 5) (Fang et al., 2018).
4		MESH:D006863	activates	Polonium	MESH:D011059	Phenotype	29dd53f6-bc42-11e5-8d2d-001a4ae51247	10.1016/j.mimet.2007.09.020	The pH-activity profiles indicated that acid pH ranging from 2.0 to 3.0 allowed the best PO activity to be obtained.
4		MESH:D006863	activates	Polonium	MESH:D011059	Phenotype	6c594888-351d-11e8-a34b-001a4a160175	28578263	In comparison to the CK, the pH significantly increased by 1.5 unit in the treatments with PF and PO whereas it was slightly decreased in the treatment with OF.
4		MESH:D000431	activates	Polonium	MESH:D011059	Phenotype	ba33ce28-340c-11e8-87fd-001a4a160176	24657220	Ethanol can activate rPPO1(53FS54), but α-chymotrypsin cleaves it into many smaller bands, by which to eliminate any PO activity, even if ethanol is added (Fig. 8D).
4		MESH:D011059	increases	Polonium	MESH:D011059	Phenotype	31efd5f0-bbde-11e5-8abe-001a4ae51246	10.1016/S0166-445X(01)00175-8	PO activities in tunicates exposed to TBT increased with dose such that 2 and 5 μg/l TBT elicited PO levels that were significantly greater than those of nonexposed tunicates.
4		MESH:D011059	increases	Polonium	MESH:D011059	Phenotype	529d28c8-3532-11e8-9192-001a4a160175	24945574	RNAi silencing of the prophenoloxidase acting system gene (proPO), the inactive precursor of PO, significantly decreased PO expression and phagocytic activity and increased bacterial growth and the cumulative mortality of crayfish submitted to bacterial infection.
4		MESH:D011059	inhibits	Polonium	MESH:D011059	Phenotype	a367d486-d483-11e5-a1eb-001a4ae51246	PMC4282987	Neurons in the internal medullary laminar (IML) region of PTD-treated rats were more sparse, but not absent, with the exception that in some animals there was a loss of neurons in the paracentral (PC) and posterior (Po) thalamic nuclei.
4		MESH:D008274	activates	Polonium	MESH:D011059	Phenotype	cc146f32-1a30-11f0-a2ca-0050569a1f61	10.1016/j.scitotenv.2024.177810	However, Mg-doped biochar enhances PO₄3−adsorption by facilitating the replacement of surface -OH groups on MgO with PO₄3−, forming stable Mg-phosphate complexes such as MgHPO₄ (Vamvuka et al., 2024).
4		FPLX:Notch	increases	Polonium	MESH:D011059	ProteinFamily	40e7fa1c-bc45-11e5-ac4e-001a4ae51246	10.1016/j.semcdb.2005.06.009	To test the possibility that Notch signaling directed cells toward a glial fate, Wakamatsu and colleagues assessed whether NICDcaused increased expression of Po, a marker of glial differentiation[54].
4		UNIPROT:P50336	activates	Polonium	MESH:D011059	Protein	40edf4fe-3514-11e8-9192-001a4a160175	26519623	Thus, the double knockdown of PPO genes indeed suppressed the PO enzymatic activity, possibly leading to the weakened defense phenotype againstB.
4		UNIPROT:P20396	inhibits	Polonium	MESH:D011059	Protein	49fc05f4-1c34-11f0-a2ca-0050569a1f61	10.1016/j.chemosphere.2023.140747	It was observed that TRL, TRM and TRH exposure decreased the proportion of cortical alveolus oocyte (CO) and perinucleolar oocyte (PO) in zebrafish ovary, and increased the percentage of early vitellogenic oocyte (EV) and late vitellogenic oocyte (LV) after 21 d exposure (Fig. 1B).
4		UNIPROT:P80888	activates	Polonium	MESH:D011059	Protein	48bd664a-3a8e-11e8-a51f-001a4a160176	28465179	Generally hemocyanin in native form lack or show weak enzymatic activity and activation allows conversion to PO or elicitation of PO activity[35,65,92].
4		UNIPROT:B0YJ81	inhibits	Polonium	MESH:D011059	Protein	16c3e830-ee14-11e5-9b35-001a4ae51246	PMC4336228	CAP responses from TRPV1-expressing CHO cells showed that the addition of Tmem100-3Q lowered its Po as well as NPo (Figures 6B,S6B, and S6D).
4		UNIPROT:Q96TA2	activates	Polonium	MESH:D011059	Protein	48bd664a-3a8e-11e8-a51f-001a4a160176	28465179	Laminarin serving as a PAMP activated PO activity in MrHc2 by 109%, MrHc3 by 32% and in MrHc4 by 36% (p<0.05), whereas MrHc1 showed no response.
4		CHEBI:39381	inhibits	Polonium	MESH:D011059	Chemical	7d1b91ae-00a3-11f0-9c09-0050569a791b	10.1016/j.scitotenv.2024.175467	Among chitin biosynthesis inhibitors, buprofezin decreased nodulation and phenoloxidase (PO) activity ofSpodoptera littoralis(Boisduval) (Lepidoptera: Noctuidae) larvae (Nasr et al., 2010).
4		MESH:D014357	activates	Polonium	MESH:D011059	Phenotype	4fa1681c-bbf6-11e5-9b9d-001a4ae51247	10.1016/S1096-4959(03)00120-9	PO activity was enhanced by trypsin treatment especially in band 2 (mainly enriched in morula cells, 55%) (Fig. 2c).
4		MESH:D014357	activates	Polonium	MESH:D011059	Phenotype	8ae0c36e-1b64-11f0-b759-0050569a791b	10.1016/j.jip.2024.108098	Thus, the optimum concentrations for activating PO activity by trypsin, SDS and laminarin were standardized.
4		UNIPROT:Q02318	inhibits	Polonium	MESH:D011059	Protein	03016a02-1b64-11f0-b40b-0050569a1f61	10.1016/j.aspen.2024.102240	We found that haemocoel injection of CTX inhibited the melanization reaction of haemolymph (Fig. 1B) and decreased the activities of PO (Fig. 1C), total haemocyte counts (Fig. 1D) and granular cell counts (Fig. 1E) in a dose-dependent manner.
4		UNIPROT:O15516	activates	Polonium	MESH:D011059	Protein	8ec41b2e-bc47-11e5-ac4e-001a4ae51246	10.1016/j.aca.2006.09.052	The direct digital conversion is set by the logic multiplication of the (not LB) PO signal by the system clock signal (CLK).
4		UNIPROT:Q66K79	activates	Polonium	MESH:D011059	Protein	2a2a752e-3ab1-11e8-bf76-001a4a160175	24755143	In the inside–out patch configuration, the single channel current traces at different membrane potentials with or without 20μM CPZ showed that CPZ increased the Po of the channel at every corresponding membrane potential (Fig. 1A and B).
4		CHEBI:78505	inhibits	Polonium	MESH:D011059	Chemical	3cba9ccc-c476-11e5-91a7-001a4ae51247	26685058	Injection of 0.75 equivalents venom plus calyx fluid induced even lower PO activity than calyx fluid alone during the sampling periods (inhibition rates reduced from about 95% to 85%) (Fig. 5C).
4		UNIPROT:O42713	activates	Polonium	MESH:D011059	Protein	55255eec-352a-11e8-8f56-001a4a160175	25543001	PPO1ΔandPPO2Δsingle mutants show reduced melanization at the wound site consistent with the notion that both PPO1 and PPO2 contribute to hemolymph PO (Binggeli et al., 2014).
4		FPLX:CLK	activates	Polonium	MESH:D011059	ProteinFamily	8ec41b2e-bc47-11e5-ac4e-001a4ae51246	10.1016/j.aca.2006.09.052	The direct digital conversion is set by the logic multiplication of the (not LB) PO signal by the system clock signal (CLK).
4		UNIPROT:Q9NV29	inhibits	Polonium	MESH:D011059	Protein	16c3e830-ee14-11e5-9b35-001a4ae51246	PMC4336228	Interestingly, coexpression of Tmem100 with TRPA1 in the absence of TRPV1 significantly reduced the TRPA1 Po for both the main conductance and unitary single-channel conductance (Figures 4A, 4E,S4C, and S4E).
4		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	ca0b1cce-3403-11e8-8f56-001a4a160175	26093205	LPS and βG were used in thein vitroPO activity assay to activate the intrinsic serine proteinase cascade that catalyzes proPO into functional PO.
4		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	1e8f8bc2-45a9-11f0-8cae-0050569a1f61	10.1016/j.jinsphys.2022.104395	In the case of PO activity disruption, this might be due to serpins, which have been previously detected in parasitoid venoms and are known to inhibit proteases that activate pro-PO (Ali et al., 2015; Laurino et al., 2016; Scieuzo et al., 2021; Pinto et al., 2021).
4		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	a74b5ed4-3ab0-11e8-8f56-001a4a160175	24878742	ProPO-activating enzymes (PPAEs), serine proteinases (SPs) and serine proteinases homologs (SPHs) that activate the PO system are referred as prophenoloxiase activating factors (PPAFs)[3].
4		FPLX:Protease	inhibits	Polonium	MESH:D011059	ProteinFamily	4b090670-3390-11e8-9fbf-001a4a160176	10658644	In agreement with this interpretation, it has been shown that, during dissection and thawing of nerves(Cammer et al., 1981), the glycoprotein Po is rapidly degraded by endogenous proteases.
4		MESH:D009569	activates	Polonium	MESH:D011059	Phenotype	c44cf4e0-3aa4-11e8-b868-001a4a160176	25934217	The present study showed that NO caused an increase in Po of L-type Ca2+channels.
4		MESH:D009569	activates	Polonium	MESH:D011059	Phenotype	7447a188-bbf4-11e5-8abe-001a4ae51246	10.1016/S1095-6433(02)00324-0	The NO donor SNP (10−5M) caused increases of SV, SW and PO (Fig. 6), which may be consistent with a positive inotropic influence of exogenous NO.
4		FPLX:PKA	activates	Polonium	MESH:D011059	ProteinFamily	dbb884d6-bbd6-11e5-956b-001a4ae51247	10.1016/S0092-8674(03)00434-3	PKA phosphorylation significantly increased the activities (open probability; Po) of the wt-RyR2 and CPVT mutant channels (bottom tracings inFigure 4B).
4		FPLX:PKA	activates	Polonium	MESH:D011059	ProteinFamily	7a9bbf14-bc18-11e5-9b9d-001a4ae51247	10.1016/j.yjmcc.2004.05.026	PKA also accelerated the subsequent decline in Po(attributed to adaptation).
4		FPLX:PKA	inhibits	Polonium	MESH:D011059	ProteinFamily	7a9bbf14-bc18-11e5-9b9d-001a4ae51247	10.1016/j.yjmcc.2004.05.026	Valdivia et al.[62]found that PKA slightly decreased basal Poat 100 nM [Ca], but greatly increased peak Po(to nearly 1.0) during a rapid photolytic increase of [Ca].
4		MESH:D002784	increases	Polonium	MESH:D011059	Phenotype	401b0e0c-47ec-11f0-afc2-0050569a791b	10.1016/j.aaf.2017.02.001	The concentration of cholesterol increased with increasing PO levels with the highest mean recorded in fish fed 8% PO.
4		MESH:D003907	inhibits	Polonium	MESH:D011059	Phenotype	0ed69292-bbdf-11e5-9b9d-001a4ae51247	10.1016/j.jinsphys.2003.11.002	prolixuswith dexamethasone, indomethacin and NDGA decreased the PO activity, and the inoculation of arachidonic acid in insects previously fed on blood containing dexamethasone and challenged withT.
4		MESH:D005473	activates	Polonium	MESH:D011059	Phenotype	463a7512-bc54-11e5-8abe-001a4ae51246	10.1016/j.cca.2006.09.001	Both the antidepressant fluoxetine and the anti-manic drug valproic aid restore PO activity to normal levels.
4		MESH:D017830	inhibits	Polonium	MESH:D011059	Phenotype	292370e6-bc40-11e5-8abe-001a4ae51246	10.1016/j.freeradbiomed.2007.01.014	Moreover, addition of Triton X-100 immediately decreases H2O2steady-state concentrations in suspensions of intact PO that are exposed to urate (Fig. 1B).
4		MESH:D000728	increases	Polonium	MESH:D011059	Phenotype	4b090670-3390-11e8-9fbf-001a4a160176	10658644	It is quite possible that, in these in vivo experiments, the gene expression of Po is stimulated by androgen-dependent mechanisms acting in an indirect fashion on Schwann cells.
4		UNIPROT:P13569	activates	Polonium	MESH:D011059	Protein	3ba139ba-ca00-11e5-9b70-001a4ae51247	15463939	Stimulation of membrane resident CFTR channels with cAMP agonists will increase their open probability (Po) and hence, increase membrane conductance (Gm).
4		MESH:D019163	inhibits	Polonium	MESH:D011059	Phenotype	bc3d90fe-3810-11e6-aaca-001a4ae51246	PMC4409767	Captopril was shown to act as a membrane permeable thiol reducing agent that decreases the open probability (Po) of RyR2[48].
4		MESH:D005643	activates	Polonium	MESH:D011059	Phenotype	0115a016-04b5-11f0-bb39-0050569a791b	10.1016/j.aqrep.2024.102362	vannamei,Lee et al. (2020)reported the abundance of rhamnose, fucose, and glucose in cacao pod husk (CPH) strengthened degranulation of hemocytes through toll-like receptors 1 and 3 and increased THC and PO activity and resistance againstV.
4		MESH:D001599	activates	Polonium	MESH:D011059	Phenotype	2b381ef8-1a4c-11f0-b759-0050569a791b	10.1016/j.phrs.2024.107514	Furthermore, berberine could upregulate Fbxo32 to ameliorate PO-induced myocardial hypertrophy in Pak1-deficient mice.
4		UNIPROT:F4JF21	activates	Polonium	MESH:D011059	Protein	6720c1c6-c46c-11e5-91a7-001a4ae51247	PMC4064829	PAP3, like PAP1 in CH, did cause a drastic increase in PO activity beyond its own ability to activate proPOs via proteolysis.
4		UNIPROT:P52575	activates	Polonium	MESH:D011059	Protein	9c400fe6-87cc-11f0-9ac3-0050569a1f61	10.1016/j.indcrop.2020.112628	The decomposition of the IFR produces PO·
4		MESH:D014700	inhibits	Polonium	MESH:D011059	Phenotype	4491a844-3532-11e8-8f56-001a4a160175	24995840	Verapamil also decreased the Po to 0.354 from 0.858 in these cells (Fig. 5B1).
4		MESH:D012643	inhibits	Polonium	MESH:D011059	Phenotype	b96e5d7e-3c6e-11f0-86f5-0050569a1f61	10.1016/j.aqrep.2022.101215	Also, extra Se supplemented diet (1.17 mg/kg) decreased PO activity in this species suggesting optimum dietary Se required for proper innate immune responses.
4		MESH:D019810	inhibits	Polonium	MESH:D011059	Phenotype	5e54a8b2-bbf4-11e5-8abe-001a4ae51246	10.1016/j.cbpa.2006.02.042	In contrast, even at the highest dose tested in the current study (10 mM) the peroxidase inhibitor, sodium azide suppressed less than 50% of the blue crab PO activity, a finding similar to the reported 23.5% inhibition of brown shrimp PO at 10 mM NaN3(Gollas-Galván et al., 1999).
4		MESH:D003902	inhibits	Polonium	MESH:D011059	Phenotype	292370e6-bc40-11e5-8abe-001a4ae51246	10.1016/j.freeradbiomed.2007.01.014	Here for both intraperoxisomal oxidases, UOX and GlyOX, detergent-mediated disruption of PO increased oxidase activity due to facilitated influx of urate and glycolate (Fig. 3C, middle and right).
4		UNIPROT:P00450	inhibits	Polonium	MESH:D011059	Protein	01933542-bbd8-11e5-956b-001a4ae51247	10.1016/S0168-1656(03)00104-4	The CP can also be lowered by increasing the PO content of the polymer.
4		UNIPROT:P41235	increases	Polonium	MESH:D011059	Protein	b6c9a192-bc2f-11e5-8abe-001a4ae51246	10.1016/j.febslet.2004.10.070	Expression of both PO and PDH was significantly decreased by liver-specific deletion of the HNF4α gene, whereas expression of TO was not downregulated by targeted inactivation of HNF4α in the liver.
4		UNIPROT:Q99707	activates	Polonium	MESH:D011059	Protein	993a5fa4-3757-11e8-b868-001a4a160176	27300290	Compared with that of the C treatment, the MS treatment (i) increased the proportion of labile P (H2O-Pt and NaHCO3-Pi) but decreased that of residual-P in Pt, which was determined by sequential fractionation (Table 6), and (ii) increased the proportion of diesters in Po after correction for diesters degradation in 0–30 cm depth soil determined by31P NMR (Table 7).
4		CHEBI:15903	activates	Polonium	MESH:D011059	Chemical	40edf4fe-3514-11e8-9192-001a4a160175	26519623	In the case of another coleopteran species,Holotrichia diomphalia, the PO activity in hemolymph is reported to be enhanced by curdlan (Lee et al., 1998).
4		MESH:D012210	activates	Polonium	MESH:D011059	Phenotype	0115a016-04b5-11f0-bb39-0050569a791b	10.1016/j.aqrep.2024.102362	vannamei,Lee et al. (2020)reported the abundance of rhamnose, fucose, and glucose in cacao pod husk (CPH) strengthened degranulation of hemocytes through toll-like receptors 1 and 3 and increased THC and PO activity and resistance againstV.
4		CHEBI:74528	inhibits	Polonium	MESH:D011059	Chemical	918fc58e-1a60-11f0-b759-0050569a791b	10.1016/j.scienta.2024.113767	Results indicated that LL stress decreased φo, PI (abs), φRo, φEo, φPo, and Sm/t(Fm), whereas M0, Sm, and δRo increased.
4		UNIPROT:Q9UQ90	activates	Polonium	MESH:D011059	Protein	67986e8c-340a-11e8-a34b-001a4a160175	27387151	Laminarin, Lys-PGN and DAP-PGN activated PO activity at all three doses tested, while 20 ng LTA did not activate PO system at a given time.
4		CHEBI:35895	activates	Polonium	MESH:D011059	Chemical	02033f90-1a4c-11f0-aa93-0050569a1f61	10.1016/j.ijbiomac.2024.137562	The process of phosphorus decomposition will produce PO·
4		UNIPROT:P0A3T1	activates	Polonium	MESH:D011059	Protein	c9cdc1c2-c8de-11e5-9624-001a4ae51246	16421099	6B, both the native Tm-PGRP and r-Tm-PGRP specifically induced PO activity in the presence of soluble Lys-PGN and the pass-through fraction from the T-4P2-coupled column (columns 3and7), suggesting that the native Tm-PGRP and r-Tm-PGRP can recognize soluble Lys-PGN and induce Lys-PGN-dependent PO activity in the presence of the pass-through fraction.
4		UNIPROT:G5DC91	activates	Polonium	MESH:D011059	Protein	8714801a-3749-11e8-8636-001a4a160175	26163046	1B, the application of 1 μM NS11021 increased mean BK channel open probability (Po) from ∼0.21 to 0.38, or 1.81-fold, which was reversed by the BK channel inhibitor paxilline, indicating the effect of NS11021 on BK channel activation.
4		MESH:D000077261	activates	Polonium	MESH:D011059	Phenotype	19309df4-3528-11e8-9fbf-001a4a160176	25257351	Each dog was administered (1) spironolactone (Aldactone, GD Searle) at a dosage of 50 mg orally (PO) twice daily, (2) enalapril (Vasotec, Merck) at a dosage of 10 mg PO twice daily for 1 week and then a maintenance dosage of 20 mg PO twice daily, and (3) carvedilol (Coreg, SmithKline Beecham) at a dosage of 12.5 mg PO twice daily for 1 week and then increased to 25 mg PO twice daily.
4		UNIPROT:Q9V3N1	activates	Polonium	MESH:D011059	Protein	dbd1fbaa-3901-11e8-87fd-001a4a160176	26453810	Loss-of-function mutations in Spn27A lead to a high rate of spontaneous melanization and constitutively elevated PO activity in the blood, while overexpression of Spn27A suppresses PO activation following microbial immune challenge[100,138].
4		UNIPROT:E1V8I0	inhibits	Polonium	MESH:D011059	Protein	149efcc6-001f-11f0-9c09-0050569a791b	10.1016/j.scitotenv.2025.178479	Interestingly, Nir, GS, and GOGAT were down-regulated in diatom groups such asSkeletonema,Pseudo-nitzschia, andThalassiosiraat the PO stage compared with the EB stage, indicating that utilization of N was depressed in these diatoms, while they were enhanced inK.
4		CHEBI:6364	activates	Polonium	MESH:D011059	Chemical	8ae0c36e-1b64-11f0-b759-0050569a791b	10.1016/j.jip.2024.108098	Thus, the optimum concentrations for activating PO activity by trypsin, SDS and laminarin were standardized.
4		CHEBI:6364	activates	Polonium	MESH:D011059	Chemical	67986e8c-340a-11e8-a34b-001a4a160175	27387151	Laminarin, Lys-PGN and DAP-PGN activated PO activity at all three doses tested, while 20 ng LTA did not activate PO system at a given time.
4		CHEBI:86477	inhibits	Polonium	MESH:D011059	Chemical	340f95ac-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2004.06.001	The PO activity was almost entirely inhibited by benzoic acid and sodium sulfite, greatly inhibited by citric acid, 1-phenyl-2-thiourea, thio urea, and cysteine, but inhibition by ascorbic acid was low.
4		CHEBI:86477	inhibits	Polonium	MESH:D011059	Chemical	d4086096-3aa3-11e8-b868-001a4a160176	25700784	Results showed that sodium sulfite and cysteine could strongly inhibit the PO-like activity of skHbI and skHbII and that ascorbic acid and citric acid could strongly inhibit that of skHbII but had only a slight ability to inhibit that of skHbI (Table 1).
4		CHEBI:86477	inhibits	Polonium	MESH:D011059	Chemical	29984cae-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2005.03.012	The PO activity was entirely inhibited by sodium sulfite and 1-phenyl-2-thiourea, greatly inhibited by thiourea and benzoic acid, but inhibition by citric acid, cysteine and ascorbic acid was low.
4		UNIPROT:Q00024	activates	Polonium	MESH:D011059	Protein	55255eec-352a-11e8-8f56-001a4a160175	25543001	PPO1ΔandPPO2Δsingle mutants show reduced melanization at the wound site consistent with the notion that both PPO1 and PPO2 contribute to hemolymph PO (Binggeli et al., 2014).
4		MESH:D000255	inhibits	Polonium	MESH:D011059	Phenotype	6c27243a-cbf1-11e5-83a8-001a4ae51246	10526167	Truncation moderately increases the apparent IC50(ATP)[19,31], but millimolar concentrations of ATP will reduce the Po to nearly undetectable levels.
4		CHEBI:26020	activates	Polonium	MESH:D011059	Chemical	dc5d3bc6-bc39-11e5-ac4e-001a4ae51246	10.1016/j.pedobi.2005.06.007	Ectomycorrhizal fungi produce extracellular acid phosphate enzymes that enhance Po mineralization (Dighton, 1983;Maschner and Dell, 1987).
4		MESH:D010670	activates	Polonium	MESH:D011059	Phenotype	340f95ac-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2004.06.001	The PO activity was almost entirely inhibited by benzoic acid and sodium sulfite, greatly inhibited by citric acid, 1-phenyl-2-thiourea, thio urea, and cysteine, but inhibition by ascorbic acid was low.
4		MESH:D010670	activates	Polonium	MESH:D011059	Phenotype	d8b945b8-374e-11e8-87fd-001a4a160176	28027986	In the assay of proPO activating system or PO activity, 150 μg of shrimp plasma protein was pre-incubated with 0.433 μM final concentration of rLvA2M or phenylthiourea (PTU) as a positive control and 10 μL of 5 mg/ml lipopolysaccharides (LPS).
4		MESH:D010670	inhibits	Polonium	MESH:D011059	Phenotype	29984cae-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2005.03.012	The PO activity was entirely inhibited by sodium sulfite and 1-phenyl-2-thiourea, greatly inhibited by thiourea and benzoic acid, but inhibition by citric acid, cysteine and ascorbic acid was low.
4		MESH:D010670	inhibits	Polonium	MESH:D011059	Phenotype	05bcc49c-3900-11e8-8636-001a4a160175	26279217	The finding that phenylthiourea (PTU) inhibited PO-like activity in a dose-dependent manner supports the specificity of the PO-activity, excluding the possibility of nonspecific substrate degradation.
4		MESH:D010670	inhibits	Polonium	MESH:D011059	Phenotype	4b5bbdb6-352a-11e8-9fbf-001a4a160176	25596090	To ensure that we were not observing Tyr metabolism from another metabolic pathway, we repeated our Tyr measurements in 5th instar D1 plasma samples containing the PO inhibitor phenylthiourea (PTU).
4		MESH:D010670	inhibits	Polonium	MESH:D011059	Phenotype	3155cb8e-351e-11e8-bf76-001a4a160175	28987622	The finding that phenylthiourea inhibited the PO activity in a dose-dependent manner demonstrated the specificity of the PO activity assay, excluding the possibility of nonspecific substrate degradation (data not shown).
4		UNIPROT:O95139	inhibits	Polonium	MESH:D011059	Protein	99e02178-e9de-11ef-999a-0050569a1f61	10.1016/j.jep.2024.118922	To investigate the regulatory effects of TSCS and CI on lipid accumulation in hepatocytes under metabolic stress, we treated AML12 cells with TSCS and CI under 250 μM PO stimulation for 24 h. Oil Red O staining showed that the lowest levels of TSCS and CI notably decreased PO-induced intracellular lipid droplet accumulation, similar to the positive control OCA (Fig. 2D–E).
4		IP:IPR001314	activates	Polonium	MESH:D011059	ProteinFamily	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	Chymotrypsin induced significantly (p<0.05) more PO activity in hemolymph lysates than trypsin, increasing activity by up to three fold relative to controls.
4		UNIPROT:Q16769	activates	Polonium	MESH:D011059	Protein	6b203f80-351d-11e8-8f56-001a4a160175	28576731	From the group point of view, the number of seizure segments emerging cortico–thalamic EC gradually increased from P2 to P1 or PO and then slowly decreased, but that in O2 was still larger than that in interictal periods (Fig. 5).
4		CHEBI:73344	inhibits	Polonium	MESH:D011059	Chemical	a0e4ea22-37f8-11e6-b56c-001a4ae51246	PMC4442876	In the present study, ADs containing BO, EO, or FO for 16 weeks reduced hepatic total neutral lipid content (i.e., TG and CE) relative to PO (Fig. 7A), but FC and PL contents were similar among all diet groups.
4		UNIPROT:Q96P20	activates	Polonium	MESH:D011059	Protein	30258594-e9e7-11ef-999a-0050569a1f61	10.1016/j.foodchem.2024.141082	This suggests that the Mws of Mf increased because of incubation with PO.
4		UNIPROT:P23760	inhibits	Polonium	MESH:D011059	Protein	5b611ba4-ca5e-11e5-9bd2-001a4ae51247	12643284	As shown here, expression of Pax3 in the same F10.9 cells conversely represses the ability of IL6RIL6 to activate the promoters of the myelin Po and MBP genes.
4		CHEBI:27086	increases	Polonium	MESH:D011059	Chemical	31efd5f0-bbde-11e5-8abe-001a4ae51246	10.1016/S0166-445X(01)00175-8	PO activities in tunicates exposed to TBT increased with dose such that 2 and 5 μg/l TBT elicited PO levels that were significantly greater than those of nonexposed tunicates.
4		UNIPROT:O43566	inhibits	Polonium	MESH:D011059	Protein	2fa6ce9a-1c17-11f0-aa93-0050569a1f61	10.1016/j.molmet.2024.101882	To further study the expression alterations of RGS14 in hepatocytes, primary mouse hepatocytes were subjected to PO (0.5 mM palmitic acid (PA) and 1.0 mM oleic acid (OA)) for 0, 6, 12 and 24 h. Consistent with the results obtained from the livers of human and mice subjects, RGS14 expression gradually decreased in a time-dependent manner in primary mouse hepatocytes challenged by PO stimulus (Figure 1E, F).
4		PF:PF13146	inhibits	Polonium	MESH:D011059	ProteinFamily	49fc05f4-1c34-11f0-a2ca-0050569a1f61	10.1016/j.chemosphere.2023.140747	It was observed that TRL, TRM and TRH exposure decreased the proportion of cortical alveolus oocyte (CO) and perinucleolar oocyte (PO) in zebrafish ovary, and increased the percentage of early vitellogenic oocyte (EV) and late vitellogenic oocyte (LV) after 21 d exposure (Fig. 1B).
4		MESH:D014508	activates	Polonium	MESH:D011059	Phenotype	340f95ac-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2004.06.001	The PO activity was almost entirely inhibited by benzoic acid and sodium sulfite, greatly inhibited by citric acid, 1-phenyl-2-thiourea, thio urea, and cysteine, but inhibition by ascorbic acid was low.
4		CHEBI:52392	inhibits	Polonium	MESH:D011059	Chemical	f05ba2d4-ab8a-11e6-9646-001a4ae51246	PMC4772732	Moreover, using PO (1μM) to inhibit all Ces activity, the hydrolysis of exogenous 2-AG in spleen homogenates was completely abolished (Fig. 3B), suggesting that Ces can hydrolyze 2-AG in the spleen.
4		CHEBI:34907	activates	Polonium	MESH:D011059	Chemical	8714801a-3749-11e8-8636-001a4a160175	26163046	1B, the application of 1 μM NS11021 increased mean BK channel open probability (Po) from ∼0.21 to 0.38, or 1.81-fold, which was reversed by the BK channel inhibitor paxilline, indicating the effect of NS11021 on BK channel activation.
4		MESH:D007239	activates	Polonium	MESH:D011059	Phenotype	4e3c6e76-3404-11e8-a34b-001a4a160175	26117730	From the PO activity and variance of PO activity of each treatment group, WSSV infection would cause a greater damage, while a dose of bacterial infection can certainly stimulate or induce the action of PO.
4		MESH:D007239	inhibits	Polonium	MESH:D011059	Phenotype	bd0787e2-3c70-11f0-afc2-0050569a791b	10.1016/j.fsi.2022.06.005	However, PO activity was inhibited by WSSV infection (Fig. 4B).
4		MESH:D051379	activates	Polonium	MESH:D011059	Phenotype	cdc66e62-3904-11e8-8f56-001a4a160175	PMC5845798	Optogenetic stimulation of Po-projecting SpVIr neurons that expressed channelrhodopsin further confirmed that the SpVIr-Po-facial dual projection activates muscle nasolabialis (six mice;Figures 5F and 5G).
4		MESH:D000860	activates	Polonium	MESH:D011059	Phenotype	8a2fe0b0-1ad0-11f0-aa93-0050569a1f61	10.1016/j.fsi.2024.109962	In contrast, the PO activity of the Hc group steadily dropped as the hypoxia time increased, reaching its lowest point at 12 h. Nevertheless, ACP, AKP, and PO activity in the Ni and Hi groups did not significantly differ.
4		CHEBI:61695	activates	Polonium	MESH:D011059	Chemical	c60bc428-3914-11e8-b868-001a4a160176	PMC9301656	Byin vitroreconstituting the proPO activation system, we found that recombinant PGRP-S5 or tested PG from different bacterial strains alone increased PO activity.
4		MESH:D009543	inhibits	Polonium	MESH:D011059	Phenotype	4491a844-3532-11e8-8f56-001a4a160175	24995840	The dihydropyridine derivative nifedipine (10μM) reduced the Po (from 0.357 to 0.171) (Fig. 6A1), whereas Bay K8644 (10μM) increased the Po (from 0.0314 to 1.2082) (Fig. 6B1).
4		UNIPROT:Q9H3Z4	inhibits	Polonium	MESH:D011059	Protein	9b009e0e-04e4-11f0-bb39-0050569a791b	10.1016/j.jclepro.2024.143387	To solve the shortcomings of SP technology, CIAC has developed the CSP technology (Zhou et al., 2023), which greatly reduces the viscosity of the reaction system; improves the heat withdrawal capacity, catalytic efficiency, PO conversion rate, and molecular weight of the product, and reduces the energy consumption of production effectively.
4		UNIPROT:P06619	activates	Polonium	MESH:D011059	Protein	2b7ded16-340d-11e8-9192-001a4a160175	24892755	Therefore, the highest PTZ-induced mortality rate occurred in the MM PO group in comparison with other experimental groups (Fig. 3).
4		CHEBI:27082	inhibits	Polonium	MESH:D011059	Chemical	f03f443e-bc22-11e5-8abe-001a4ae51246	10.1016/j.bbamem.2007.06.016	The fact that the PO stretching was diminished in intensity by effect of trehalose lipid already suggested major changes occurring in this band, and the displacement to lower values indicated a dehydration effect, confirming the results discussed above from the CO stretching.
4		UNIPROT:O15467	activates	Polonium	MESH:D011059	Protein	8aa31644-003f-11f0-a3d5-0050569a1f61	10.1016/j.envres.2024.120599	In addition, only LEC significantly increased the Po fractions, including MLPo, FAPo, and HAPo (Fig. 3d).
4		UNIPROT:Q9Y3T9	inhibits	Polonium	MESH:D011059	Protein	149efcc6-001f-11f0-9c09-0050569a791b	10.1016/j.scitotenv.2025.178479	Interestingly, Nir, GS, and GOGAT were down-regulated in diatom groups such asSkeletonema,Pseudo-nitzschia, andThalassiosiraat the PO stage compared with the EB stage, indicating that utilization of N was depressed in these diatoms, while they were enhanced inK.
4		IP:IPR002905	inhibits	Polonium	MESH:D011059	ProteinFamily	49fc05f4-1c34-11f0-a2ca-0050569a1f61	10.1016/j.chemosphere.2023.140747	It was observed that TRL, TRM and TRH exposure decreased the proportion of cortical alveolus oocyte (CO) and perinucleolar oocyte (PO) in zebrafish ovary, and increased the percentage of early vitellogenic oocyte (EV) and late vitellogenic oocyte (LV) after 21 d exposure (Fig. 1B).
4		UNIPROT:O76090	inhibits	Polonium	MESH:D011059	Protein	3479a0fa-e9f4-11ef-b63f-0050569a1f61	10.1016/j.fbio.2024.105776	These results indicated that MYBCH contributed to the prevention of osteoporosis by increasing cortical bone BMD, BV/TV, Tb.N, and Tb.Th, while decreasing cortical bone Tb.Sp and Po.
4		CHEBI:30746	inhibits	Polonium	MESH:D011059	Chemical	340f95ac-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2004.06.001	The PO activity was almost entirely inhibited by benzoic acid and sodium sulfite, greatly inhibited by citric acid, 1-phenyl-2-thiourea, thio urea, and cysteine, but inhibition by ascorbic acid was low.
4		FPLX:RPA	inhibits	Polonium	MESH:D011059	ProteinFamily	82a3e454-bbee-11e5-8abe-001a4ae51246	10.1016/S0006-8993(02)04203-8	Bicuculline injection into the RPa suppressed the effect of PO warming onTbatrise in response to VMH stimulation.Fig.
4		UNIPROT:P01009	inhibits	Polonium	MESH:D011059	Protein	6587b9b4-454f-11f0-86f5-0050569a1f61	10.1016/j.cub.2022.03.073	Pi-deficient roots increase the mineralization of Po in the soil by secreting various hydrolytic enzymes, including nucleases, phosphodiesterases, phosphatases, and phytases, into the rhizosphere.
4		CHEBI:42191	inhibits	Polonium	MESH:D011059	Chemical	ee4ee6de-3402-11e8-8636-001a4a160175	26314521	In addition, the PO activities of SnPO1, SnPO2 and SnPO3 were all notably inhibited by EDTA and DETC, which were divalent cation chelator and specific copper chelator respectively.
4		UNIPROT:P20132	activates	Polonium	MESH:D011059	Protein	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	Like Triton X-100, SDS significantly induced (p<0.05) the PO activities of hemocyte suspensions when compared to FSW treated samples (Fig. 2B).
4		UNIPROT:P20132	activates	Polonium	MESH:D011059	Protein	8ae0c36e-1b64-11f0-b759-0050569a791b	10.1016/j.jip.2024.108098	Thus, the optimum concentrations for activating PO activity by trypsin, SDS and laminarin were standardized.
4		UNIPROT:P20132	activates	Polonium	MESH:D011059	Protein	97c74c86-374d-11e8-9fbf-001a4a160176	28668255	However, in HLS, sodium dodecyl sulphate (SDS) was found to enhance the PO activity to 0.37±0.027 (469% increase) (p<0.05), compared with the plasma (56% increase) (p<0.05).
4		UNIPROT:P20132	activates	Polonium	MESH:D011059	Protein	c697b4fc-bc42-11e5-8d2d-001a4ae51247	10.1016/j.jip.2006.09.004	When elicitors of PO were tested, SDS was found to elevate PO activity in crude venom and pharate adult plasma as evidenced by large, dark brown spot formation on the nylon membranes.
4		UNIPROT:P20132	inhibits	Polonium	MESH:D011059	Protein	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	However, unlike Triton X-100, SDS inhibited PO activity in hemolymph lysates (Fig. 2C).
4		UNIPROT:P48147	inhibits	Polonium	MESH:D011059	Protein	3580ffa6-1bb4-11f0-aa93-0050569a1f61	10.1016/j.psep.2024.02.007	For example,X. Li et al. (2022); W. Li et al. (2022)concluded that addition of both PE and PVC reduced sediment catalase, polyphenol oxidase (PO), and urease activities, and decreased physicochemical indicators, including total TOC, TN, and pH value.
4		MESH:D001835	inhibits	Polonium	MESH:D011059	Phenotype	d13004cc-3388-11e8-87fd-001a4a160176	24976442	Body weight was reduced PO in all groups.
4		UNIPROT:P04591	activates	Polonium	MESH:D011059	Protein	23886544-37f9-11e6-aaca-001a4ae51246	PMC4404746	Thus, the dissolution of MA was greatly enhanced by increasing the portion of Eudragit®E PO, and up to 25% drug loading.
4		UNIPROT:P04591	activates	Polonium	MESH:D011059	Protein	1281befa-bc0a-11e5-8abe-001a4ae51246	10.1016/j.postharvbio.2006.06.016	This delay of softening probably resulted from the retardation of senescence processes due to inhibition of the respiration rate at low O2and high CO2levels caused by the MA inside the packages of 58-μm PO and 50-μm LDPE films.
4		UNIPROT:P15144	activates	Polonium	MESH:D011059	Protein	6e22477a-049e-11f0-ac21-0050569a1f61	10.1016/j.fochx.2024.101754	The incorporation of MP led to a decrease in the APN and PD, while increasing the PO and APA in the CSB, resulting in a more coarse and sparsely distributed pore structure.
4		UNIPROT:O43593	activates	Polonium	MESH:D011059	Protein	30bc79d4-e9e4-11ef-b356-0050569a1f61	10.1016/j.cej.2024.158931	The previous study has reported that small-sized electron-rich Au can promote PO resolution[38], which aligns with the results of XPS andin situCO-DRIFTS.
4		UNIPROT:P02812	activates	Polonium	MESH:D011059	Protein	03016a02-1b64-11f0-b40b-0050569a1f61	10.1016/j.aspen.2024.102240	PS restored the haemocyte counts and PO activities of the CTX-treated silkworms to even above the normal levels.
4		UNIPROT:Q6UXB2	activates	Polonium	MESH:D011059	Protein	9aa69ac4-488e-11f0-8978-0050569a1f61	10.1016/j.jcou.2016.06.011	The CO2/PO copolymerization by ZnGA/DMC composite catalyst showed high reaction efficiency and fine polymerization products, which revealed that ZnGA/DMC composite catalyst showed a synergistic effect in PO/CO2copolymerization, while the copolymerization of CO2and PO catalyzed by ZnGA/DMC composite catalysts with varying ZnGA/DMC ratios were shown inTable 2.
4		UNIPROT:P14678	activates	Polonium	MESH:D011059	Protein	63080fbe-3363-11e8-bf76-001a4a160175	12812738	The existence of increasing trend of DOM in the Malše River at Pořešı́n during the 1983–2000 period is supported by the increase of COD by 0.72 mg l−1(+14%) determined for the same period in water abstracted from the downstream situated Řı́mov Reservoir with an average hydraulic residence time of 0.3 year (based on unpublished data of WSS-SB).
4		CHEBI:15858	activates	Polonium	MESH:D011059	Chemical	d6b81d2e-ab82-11e6-9ac8-001a4ae51246	26496611	In addition to documented reductions in unitary conductance (Linsdell, 2001), perturbations of the filter by replacement of permeating chloride with nitrate, bromide, or formate all affected gating: nitrate and bromide that bind more tightly in the pore (Linsdell, 2001) increased Po, while formate that binds less tightly (Linsdell, 2001) decreased it (Figures 5A and 5D).
4		CHEBI:25812	inhibits	Polonium	MESH:D011059	Chemical	15b46908-861a-11f0-afc2-0050569a791b	10.1016/j.envres.2021.110868	Ozone exposure decreased the maximum quantum efficiency of PSII (ϕPo; FV/FM), the average performance (PITOT), and the activity of PSII RCs as reported before (Contran et al., 2009;Bussotti et al., 2011;Pellegrini et al., 2011;Salvatori et al., 2013;Zhang et al., 2018b).
4		CHEBI:113455	inhibits	Polonium	MESH:D011059	Chemical	f43f7c92-338b-11e8-9192-001a4a160175	9877431	The following substances were added to BPs to determine their effects on cytotoxicity: PO inhibitors sodium benzoate (Na-benzoate; Sigma; 10 and 20 mM), tropolone (Fluka; 1 and 2 mM) and phenylthiourea (PTU; Sigma; 0.5 and 1 mM), serine protease inhibitors phenylmethylsulfonyl fluoride (PMSF; Sigma) and benzamidine (Sigma), both at 1 and 2 mM concentrations, N-tosyl-l-phenylalanine chloromethyl ketone (TPCK; Sigma) and N-tosyl-l-lysine chloromethyl ketone (TLCK; Fluka), both at 10 and 50μM concentrations, antioxidants,l-cysteine (Sigma) and ascorbic acid (Sigma), both at 1 and 2 mM concentrations, scavenger enzymes superoxide dismutase (SOD; Sigma; 60 and 120 U\ml) and catalase (Sigma; 70 and 140 U\ml) and the quinone scavenger 3-methyl-2-benzothiazolinone hydrazone (MBTH; Fluka; 1 and 2 mM).
4		MESH:D013481	activates	Polonium	MESH:D011059	Phenotype	d63ca03e-1ba1-11f0-b759-0050569a791b	10.1016/j.aqrep.2024.102012	This heightened immune activity can manifest in increased PO activity, enhanced phagocytic activity, and elevated production of superoxide during the respiratory burst.
4		MESH:D001729	activates	Polonium	MESH:D011059	Phenotype	f5b6d7a4-d953-11ee-9133-0050569a1f61	10.1016/j.pnucene.2005.09.006	Bismuth produces Polonium, which is an alpha emitter and a serious contaminant.
4		UNIPROT:P05164	activates	Polonium	MESH:D011059	Protein	52bd8f9a-bc31-11e5-8d2d-001a4ae51247	10.1016/S0003-9861(02)00689-6	We again assume that the PO reaction catalyzed by MPO occurs at pH 5.
4		UNIPROT:P15104	inhibits	Polonium	MESH:D011059	Protein	149efcc6-001f-11f0-9c09-0050569a791b	10.1016/j.scitotenv.2025.178479	Interestingly, Nir, GS, and GOGAT were down-regulated in diatom groups such asSkeletonema,Pseudo-nitzschia, andThalassiosiraat the PO stage compared with the EB stage, indicating that utilization of N was depressed in these diatoms, while they were enhanced inK.
4		UNIPROT:P06850	activates	Polonium	MESH:D011059	Protein	84d87244-bc3e-11e5-9b9d-001a4ae51247	10.1016/S0306-4522(01)00239-1	One hour after the termination of restraint stress, CRH mRNA increased in the Po (Fig. 3).
4		CHEBI:7625	inhibits	Polonium	MESH:D011059	Chemical	0ed69292-bbdf-11e5-9b9d-001a4ae51247	10.1016/j.jinsphys.2003.11.002	prolixuswith dexamethasone, indomethacin and NDGA decreased the PO activity, and the inoculation of arachidonic acid in insects previously fed on blood containing dexamethasone and challenged withT.
4		UNIPROT:P62140	activates	Polonium	MESH:D011059	Protein	6e22477a-049e-11f0-ac21-0050569a1f61	10.1016/j.fochx.2024.101754	The incorporation of MP led to a decrease in the APN and PD, while increasing the PO and APA in the CSB, resulting in a more coarse and sparsely distributed pore structure.
4		UNIPROT:P42768	activates	Polonium	MESH:D011059	Protein	2fab04d8-3c65-11f0-86f5-0050569a1f61	10.1016/j.jinsphys.2022.104425	luteus, which activated PPO into PO, and then wasp saliva and substrate solution were added.
4		MESH:D001424	activates	Polonium	MESH:D011059	Phenotype	4e3c6e76-3404-11e8-a34b-001a4a160175	26117730	From the PO activity and variance of PO activity of each treatment group, WSSV infection would cause a greater damage, while a dose of bacterial infection can certainly stimulate or induce the action of PO.
4		UNIPROT:P22735	inhibits	Polonium	MESH:D011059	Protein	3580ffa6-1bb4-11f0-aa93-0050569a1f61	10.1016/j.psep.2024.02.007	For example,X. Li et al. (2022); W. Li et al. (2022)concluded that addition of both PE and PVC reduced sediment catalase, polyphenol oxidase (PO), and urease activities, and decreased physicochemical indicators, including total TOC, TN, and pH value.
4		UNIPROT:Q9UHK6	activates	Polonium	MESH:D011059	Protein	47cdb9fe-3905-11e8-8f56-001a4a160175	PMC5568115	Changes in PO deaths in combination with other substances by race/ethnicity Increases in overall PO deaths, those in combination with other substances, and patterns of change differed by race/ethnicity.
4		MESH:D003932	activates	Polonium	MESH:D011059	Phenotype	4db88ae4-c46b-11e5-a92e-001a4ae51246	PMC4277710	the mean age at which participants initiated nonmedical PO use and heroin use; the number of participants who reported ever injecting any drug) were quantified in order to more precisely characterize dominant patterns within the sample.
4		UNIPROT:O15534	increases	Polonium	MESH:D011059	Protein	401b0e0c-47ec-11f0-afc2-0050569a791b	10.1016/j.aaf.2017.02.001	The protein efficiency ratio (PER) increased with elevated dietary PO levels up to 6%.
4		MESH:D012967	activates	Polonium	MESH:D011059	Phenotype	97c74c86-374d-11e8-9fbf-001a4a160176	28668255	However, in HLS, sodium dodecyl sulphate (SDS) was found to enhance the PO activity to 0.37±0.027 (469% increase) (p<0.05), compared with the plasma (56% increase) (p<0.05).
4		MESH:D005308	inhibits	Polonium	MESH:D011059	Phenotype	22dd452c-4575-11f0-afc2-0050569a791b	10.1016/j.still.2022.105390	The structural equation model revealed that both straw and P fertilizer application can promote Po turnover through their effects on P-related enzymes and genes, directly or indirectly affect soil P availability (Fig. 6).
4		MESH:D005308	inhibits	Polonium	MESH:D011059	Phenotype	993a5fa4-3757-11e8-b868-001a4a160176	27300290	These results suggest that N fertilizer application decreased mineralization of soil Po or favoured the transformation of Pi to Po in greenhouse soil.Zhang et al. (2014)also found that application of N fertilizer decreased the proportion of orthophosphate and increased that of monoesters in Pt in temperate grassland soil with higher soil available P.
4		MESH:D014334	inhibits	Polonium	MESH:D011059	Phenotype	4fa1681c-bbf6-11e5-9b9d-001a4ae51247	10.1016/S1096-4959(03)00120-9	Preincubation with tropolone and PTU completely inhibited PO activity (Table 2), establishing that copper-dependent PO activity was involved.
4		MESH:D014334	activates	Polonium	MESH:D011059	Phenotype	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	4A reveals that the PO inhibitor, tropolone, caused dose dependent inhibition of PO activity when incubated with hemolymph lysates.
4		MESH:D014334	inhibits	Polonium	MESH:D011059	Phenotype	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	Treatment with tropolone and PTU totally inhibited PO activity on Native-PAGE against all three substrates.Fig.
4		MESH:D014334	inhibits	Polonium	MESH:D011059	Phenotype	48bd664a-3a8e-11e8-a51f-001a4a160176	28465179	Also inhibition of PO by tropolone in plasma and hemocyanin proved PO activity as oxidation of phenyl substrate by oxidase activity and not peroxidase[91].
4		CHEBI:86345	activates	Polonium	MESH:D011059	Chemical	c0b26d08-2cdf-11f0-b759-0050569a791b	10.1016/S1381-5148(01)00066-9	PO and MPO were synthesized by the reaction of benzyl magnesium chloride with epichlorohydrin and β-methylepichlorohydrin, respectively, followed by treatment with NaOH solution.1H-NMR, IR spectra and epoxy equivalent weight (EEW) of the obtained compounds showed good agreement with those of the desired structures.
4		MESH:D010300	activates	Polonium	MESH:D011059	Phenotype	6e22477a-049e-11f0-ac21-0050569a1f61	10.1016/j.fochx.2024.101754	The incorporation of MP led to a decrease in the APN and PD, while increasing the PO and APA in the CSB, resulting in a more coarse and sparsely distributed pore structure.
4		CHEBI:16234	activates	Polonium	MESH:D011059	Chemical	c9241032-04f2-11f0-bb39-0050569a791b	10.1016/j.jwpe.2024.106069	The hydrated form of zirconium produces hydroxide ions and water molecules, which promote the exchange of PO₄3−.
4		CHEBI:16234	activates	Polonium	MESH:D011059	Chemical	8e5249aa-485a-11f0-9ac3-0050569a1f61	10.1016/j.jcou.2016.12.010	Furthermore, Cheng et al.[41]and Wang et al.[42]studied the mechanistic details of cycloaddition of CO2with PO catalyzed by hydroxyl-functionalized ionic liquids through DFT (density functional theory) method.
4		CHEBI:17544	activates	Polonium	MESH:D011059	Chemical	cf32f820-3c9d-11f0-afc2-0050569a791b	10.1016/j.envadv.2022.100247	Alternatively, bicarbonate-extracted Po may also contribute to plant P bioavailability, requiring easily bicarbonate-extractable Po to be available for mineralization by phosphatase enzymes to contribute to plant P nutrition.
4		CHEBI:18139	activates	Polonium	MESH:D011059	Chemical	33479db0-482a-11f0-afc2-0050569a791b	10.1016/j.cogsc.2016.08.003	In the initial stage, TMA initiated PO homo-polymerization to afford oligo-ether triol, then thein situformed oligo-ether triol acted as new CTA to participate in the copolymerization forming the oligo(carbonate-ether) triol[63•].
4		CHEBI:421707	activates	Polonium	MESH:D011059	Chemical	df3c1318-1b92-11f0-aa93-0050569a1f61	10.1016/j.jclepro.2024.141438	Chemical suppression is mainly due to the fact that the decomposition products of ABC dry powder at high temperature can produce a large number of N, P, PO radicals and other free radicals, which can rapidly capture a large number of H and O free radicals (Luo et al., 2014).
4		UNIPROT:O14578	activates	Polonium	MESH:D011059	Protein	112e6cc4-1b14-11f0-b759-0050569a791b	10.1016/j.geoderma.2024.116927	Inversion tillage in C-IT and O-IT increased the pore structure indices SP and PO (Fig. 4), indicating higher pore connectivity or lower tortuosity in the topsoil (0.1 m depth).
4		UNIPROT:Q13936	activates	Polonium	MESH:D011059	Protein	b384098a-340c-11e8-b868-001a4a160176	24681347	It has been suggested that the N terminal inhibitory module (NTI) of Cav1.2 decreases the channel's maximal open probability (PO,max), in a manner that is partially relieved by the β subunit[23].|||2 It has been suggested that the N terminal inhibitory module (NTI) of Cav1.2 decreases the channel's maximal open probability (PO,max), in a manner that is partially relieved by the β subunit[23].
4		PF:PF00141	activates	Polonium	MESH:D011059	ProteinFamily	49308da6-bc31-11e5-9b9d-001a4ae51247	10.1016/j.abb.2004.07.019	As for the PO reaction catalyzed by horseradish peroxidase, the substrates NAD(P)H and O2tend to oscillate if the two substrates are continuously supplied and if a suitable aromatic compound is present in the reaction mixture[13].|||Some of these aromatic compounds are naturally occurring[26], and recently it was found that melatonin, a hormone synthesized by the pineal gland and by neutrophils[27], can induce oscillations in the PO reaction catalyzed by horseradish peroxidase[28].
4		CHEBI:29036	activates	Polonium	MESH:D011059	Chemical	31efd5f0-bbde-11e5-8abe-001a4ae51246	10.1016/S0166-445X(01)00175-8	The ability of TBT or copper exposure in aquaria to enhance PO activity is in direct contrast to data from in vitro experiments in which hemocytes from nonexposed tunicates were incubated with metals in tissue culture.|||Exposure of tunicates to TBT or copper in aquaria increased PO activity relative to nonexposed animals.
4		UNIPROT:Q0V967	activates	Polonium	MESH:D011059	Protein	52bd8f9a-bc31-11e5-8d2d-001a4ae51247	10.1016/S0003-9861(02)00689-6	Numerical simulations of the PO reaction To get a better understanding of the mechanism underlying the changes in oscillation frequency we have developed a model of the PO reaction catalyzed by HRP.|||To get a better understanding of the mechanism underlying the changes in oscillation frequency we have developed a model of the PO reaction catalyzed by HRP.
4		UNIPROT:Q9UHA4	activates	Polonium	MESH:D011059	Protein	3b6d65f2-c8e0-11e5-9cb8-001a4ae51247	16861233	"These results indicate that
                      MP1 and MP2 must be activated by zymogen cleavage to induce melanization and PO activity.|||MP1 or MP2 Activity Is Sufficient to Induce Constitutive Melanization and PO Activity—To check whether MP1 or MP2 activity is sufficient to induce constitutive melanization and PO activity, we generated transgenic
                      flies in which the UAS/Gal4 system could be used to overexpress a preactivated form of MP1 or MP2 consisting of just the catalytic
                      domain after signal sequence cleavage."
4		UNIPROT:P02689	activates	Polonium	MESH:D011059	Protein	3b6d65f2-c8e0-11e5-9cb8-001a4ae51247	16861233	"MP1 or MP2 Activity Is Sufficient to Induce Constitutive Melanization and PO Activity—To check whether MP1 or MP2 activity is sufficient to induce constitutive melanization and PO activity, we generated transgenic
                      flies in which the UAS/Gal4 system could be used to overexpress a preactivated form of MP1 or MP2 consisting of just the catalytic
                      domain after signal sequence cleavage.|||These results indicate that
                      MP1 and MP2 must be activated by zymogen cleavage to induce melanization and PO activity."
4		CHEBI:6364	activates	Polonium	MESH:D011059	Chemical	7b222a14-352d-11e8-a51f-001a4a160176	29028485	When compared to other sugars, laminarin only induce the PO activity after the formation of the β-G-β-GBP complex.|||Laminarin andFiβ-GBP (β-G-β-GBP complex) triggered PO activityin vitrowhereas other sugars failed to activate PO.
4		CHEBI:53311	activates	Polonium	MESH:D011059	Chemical	2928ccda-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2005.10.010	Therefore, LPS, glucan, levamisole, sodium alginate and Lf added to the diet can trigger the PO activity indicating an increase in immune ability.|||Administration of sodium alginate by injection at 50μg g−1body weight or less has been reported to increase the PO activity and enhanced resistance againstV.
4		UNIPROT:P00918	activates	Polonium	MESH:D011059	Protein	a72bc39a-bc17-11e5-8abe-001a4ae51246	PMC1301459	We have previously demonstrated that Ca2+-dependent increases in the Po of sheep cardiac RyRs are associated with a decrease in the mean closed time (Ashley and Williams, 1990; Sitsapesan and Williams, 1994b).|||Analysis of lifetime distributions We have previously demonstrated that Ca2+-dependent increases in the Po of sheep cardiac RyRs are associated with a decrease in the mean closed time (Ashley and Williams, 1990; Sitsapesan and Williams, 1994b).
4		IP:IPR028651	activates	Polonium	MESH:D011059	ProteinFamily	13a698c6-bbdf-11e5-8abe-001a4ae51246	10.1016/j.jinsphys.2006.10.012	Our visual observations of reduced melanization support the idea that indomethacin inhibits PO activation inG.|||Our data indicate that orally administered indomethacin strongly impaired nodulation reaction and PO activation inG.
4		UNIPROT:Q14117	increases	Polonium	MESH:D011059	Protein	7e81055e-bbe0-11e5-9b9d-001a4ae51247	10.1016/S0197-4580(02)00234-8	In particular, P, DHP and THP are able to increase Po expression, while THP seems to be able to specifically stimulate PMP22 expression[30,41].|||Interestingly, data so far obtained have indicated that, similarly to that observed in the sciatic nerves of adult male rats, DHP is also able to significantly increase the expression of the myelin protein Po in the sciatic nerve of aged male rat[30].
4		UNIPROT:Q14117	increases	Polonium	MESH:D011059	Protein	45758b70-392b-11e8-a34b-001a4a160175	9622253	6, progesterone and DHP are able to induce a significant increase of Po gene expression very rapidly (2h), and appear less effective at later intervals (6h).|||On the contrary, DHP was able to strongly increase the levels of the Po messenger.
4		UNIPROT:P20132	activates	Polonium	MESH:D011059	Protein	1f166102-3917-11e8-a51f-001a4a160176	24486681	Studies carried out byBaird et al. (2007)andCong et al. (2009)demonstrated clearly that the micellar form of SDS was required to induce optimal PO activity in chelicerate Hcs.|||High concentrations of SDS lead to the gradual unfolding of Hc and concurrently induce PO activity for a short period of time, before denaturing the protein.
3	Polonium	MESH:D011059	inhibits		UNIPROT:P01266	Protein	791a5c82-75fa-11ee-ae93-0050569a1f61	10.1007/s13346-023-01371-2	In addition, both PO and PO-S-glycerosomes upregulated the glycerolipid triacylglycerol (TG) (18:2e/10:1/10:1), TG (11:0/9:0/18:2), and TG (20:5/20:5/20:5) and downregulated TG (18:2e/8:0/11:0), TG (15:0/16:0/16:1), and TG (16:1e/9:0/9:0) abundance in the SC (Fig.9).
3	Polonium	MESH:D011059	activates		UNIPROT:P01266	Protein	791a5c82-75fa-11ee-ae93-0050569a1f61	10.1007/s13346-023-01371-2	In addition, both PO and PO-S-glycerosomes upregulated the glycerolipid triacylglycerol (TG) (18:2e/10:1/10:1), TG (11:0/9:0/18:2), and TG (20:5/20:5/20:5) and downregulated TG (18:2e/8:0/11:0), TG (15:0/16:0/16:1), and TG (16:1e/9:0/9:0) abundance in the SC (Fig.9).
3	Polonium	MESH:D011059	activates		UNIPROT:A6NDG6	Protein	a6c34c58-ca5d-11e5-9088-001a4ae51247	12538842	"In contrast, the lipophilic copolymers with the long PO block L121 (group III b) or intermediate PO block P85 (group II) decreased
                      the Pgp ATPase activity in Pgp-overexpressing membranes."
3	Polonium	MESH:D011059	activates		GO:0006955	Phenotype	861aadc0-c9cd-11ee-b346-0050569a791b	10.1016/j.fsi.2022.10.054	PO contributes to the activation of hemocytes to enhance the phagocytic capacity and humoral immunity, the activity of PO was considered to be an important indicator to evaluate the immune function of crustaceans [51].
3	Polonium	MESH:D011059	activates		MESH:D002784	Phenotype	19a5ea34-c46c-11e5-8491-001a4ae51247	24717342	"In particular, substitution of PO for stearic acid induced
                      higher concentrations of several biomarkers, both unfavorable (TC, LDL cholesterol, apolipoprotein B, and LDL cholesterol/HDL
                      cholesterol ratio) and favorable (HDL cholesterol and apolipoprotein A-I), whereas substitution for myristic/lauric acid resulted
                      in lower concentrations of almost all the same biomarkers."
3	Polonium	MESH:D011059	activates		MESH:D002784	Phenotype	a948caf0-352e-11e8-87fd-001a4a160176	20363590	In a study with normocholesterolemic and hypercholesterolemic subjects, a PO diet caused a significant reduction in serum total cholesterol, LDL cholesterol, and ratio of total cholesterol to HDL cholesterol[18].
3	Polonium	MESH:D011059	activates		MESH:D004487	Phenotype	d51d6006-6fe8-11e9-b6ad-001a4a160175	PMC6369610	The reference standard group received phenylbutazone (100 mg/kg PO) for carrageenan-induced paw edema and diclofenac sodium (5 mg/kg PO) for formalin-induced paw edema.
3		MESH:D006863	activates	Polonium	MESH:D011059	Phenotype	25579d76-ae96-11ec-840e-0050569a791b	PMCPMC8452985	"Particularly, when considering the specific case of CaCO   conversion into hydroxyapatite (HA), the tuning of pH can modulate the distribution of various phosphate species (i.e., H  PO  , H  PO  
  , HPO  
  , and PO  
  ) characterized by different pH values at the equilibrium point."
3		CHEBI:26078	activates	Polonium	MESH:D011059	Chemical	8b410386-c832-11ee-b346-0050569a791b	10.1016/j.scitotenv.2023.162812	This indicated that ball milling and phosphoric acid modification of C increased the functional groups of PO, PO, POC, PO, SiO on the PBC surface.
3		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	f8b8a818-bc35-11e5-9b9d-001a4ae51247	PMC4372372	It has been shown inM.sextathat after hemolymph proteinase HP21 activates proPAP2 and 3 [49], these active proteinases, along with SPHs, then produce active PO at the site of infection [19].
3		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	84f3d002-c463-11e5-91a7-001a4ae51247	PMC4722754	In arthropods, comparisons of intrinsic PO activity (PO enzymes activated by endogenous proteases) and the total PO activity (intrinsic PO + PO enzymes activated by exogenous proteases) provide an important parameter used to assess immunocompetence and health status in an ecological context [17].
3		MESH:D000077185	activates	Polonium	MESH:D011059	Phenotype	852fce92-bc32-11e5-8abe-001a4ae51246	PMC3839872	Resveratrol increases ASL depth Resveratrol increased ASL depth in MNSE cultures (in μm: 8.08±1.68 vs. 6.11±0.47, DMSO control, *p<0.05, n ≥ 5 per condition) (Figure 6) indicating a robust treatment effect resulting from stimulation of apical Cl-secretion and enhanced CFTR channel Po.
3		UNIPROT:P20061	inhibits	Polonium	MESH:D011059	Protein	32c342c0-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2008.09.014	alginolyticusat 1.8 × 105cfu shrimp−1decreased later at 12 h, whereas HC decreased earlier at 3 h. Furthermore, the PO activity, PO activity per 107GCs, and PO activity per 107THC of shrimpL.
2	Polonium	MESH:D011059	increases		UNIPROT:P48506	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Therefore, we investigated the possibility that PO inhibited the gene expression of TNF-α, IL-1β and IL-6 by interfering with the activation of NF-κB, as examined the potential that PO increased the gene expression of GCLC, NQO1, and HO-1 by activation of Nrf2.
2	Polonium	MESH:D011059	activates		UNIPROT:P08865	Protein	b58ad454-c67b-11ee-b346-0050569a791b	10.1016/j.aquaculture.2023.740147	In our study the up-regulation oftnfaip6andTP53I3(2.53, 2.52, 3.20) induced by PO after SA invasion may suppress the excessive effects of the inflammatory response and promote the phagocytosis and apoptosis of antigens, thus minimizing damage to Tilapia.
2	Polonium	MESH:D011059	increases		UNIPROT:Q16236	Protein	117dbed8-390c-11e8-9fbf-001a4a160176	25172744	The HF, HF+PP and HF+WP diets significantly increased the expression of Nrf2 to levels higher than the control, most likely due to the greater lipid intake that stimulated the oxidative pathways, although further mechanisms may be involved because the HF+PO diet, which had a lipid content similar to all HF diets, did not increase the level of Nrf2 expression.
2	Polonium	MESH:D011059	activates		UNIPROT:Q15717	Protein	e955a97e-c7b3-11ee-b346-0050569a791b	10.1016/j.jep.2023.116530	Our findings demonstrated that serum UA level was increased, while the intervention of SmS prevents this alteration in acute HUA mouse induced by PO and HX (Fig. 1), which is in line with the investigations those in the ICR, KM, and C57BL/6 mouse with HUA induced by PO (Hu et al., 2010;Hua et al., 2012;Shui et al., 2022).
2	Polonium	MESH:D011059	activates		UNIPROT:P05783	Protein	a34a63d4-f587-11eb-8ae1-001a4a160175	30205236	Deitary PO led to increase the transcripts ofatp5b, krt18,andselenbp1which were related to the abundance of their proteins (p 
2	Polonium	MESH:D011059	activates		UNIPROT:P0C0P6	Protein	9fb4f98a-3904-11e8-a34b-001a4a160175	28694160	This is evident, where Eudragit RS PO produced smaller NPs than EC.
2	Polonium	MESH:D011059	increases		UNIPROT:P07477	Protein	a34a63d4-f587-11eb-8ae1-001a4a160175	30205236	Dietary PO led to up-regulated expression of FAH and PRSS1, and dietary LO contributed to the increase in PRSS36.
2	Polonium	MESH:D011059	phosphorylatesProtein		UNIPROT:P35354	Protein	38f07ece-374f-11e8-8636-001a4a160175	28013186	Furthermore, PO and PT inhibited NF-κB activation, TAK1 phosphorylation, and iNOS and COX-2 expression.
2	Polonium	MESH:D011059	decreases		UNIPROT:P29466	Protein	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	In response to both stimuli on the activation of inflammasome, PO dramatically prevented the increased levels of caspase 1 p10 and p20 subunits.
2	Polonium	MESH:D011059	phosphorylatesProtein		UNIPROT:O43318	Protein	38f07ece-374f-11e8-8636-001a4a160175	28013186	Furthermore, PO and PT inhibited NF-κB activation, TAK1 phosphorylation, and iNOS and COX-2 expression.
2	Polonium	MESH:D011059	dephosphorylatesProtein		UNIPROT:O43318	Protein	38f07ece-374f-11e8-8636-001a4a160175	28013186	Furthermore, PO and PT inhibited NF-κB activation, TAK1 phosphorylation, and iNOS and COX-2 expression.
2	Polonium	MESH:D011059	activates		UNIPROT:P25490	Protein	41548cd4-4874-11f0-b8fe-0050569a1f61	10.1016/j.ecss.2016.06.018	Delta subsidence was additionally accelerated by: 1) petroleum mining, with the Po, Mississippi, Yellow and Niger deltas being typical examples (Sestini, 1992; Morton et al., 2005; Olea and Coleman, 2014), and 2) peat oxidation, with the Mississippi, Po, and Rhine deltas being representative (Knights, 1979; Sestini, 1992).
2	Polonium	MESH:D011059	decreases		UNIPROT:P20396	Protein	4ffc2404-29b6-11f0-b759-0050569a791b	10.1016/j.cnr.2004.09.015	Orally administrated PO inhibitors increased substance P, vasopressin and TRH levels in the rat brain[39–42], and increased substance P and α-MSH levels in mice[43].
2	Polonium	MESH:D011059	inhibits		UNIPROT:O60218	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	In this study, we also demonstrated that PO diet with NF addition could effectively decrease HSI of croaker.
2	Polonium	MESH:D011059	activates		UNIPROT:A9YF60	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	Moreover, we also demonstrated that dietary PO diet with 0.05%NF addition increased the FWB and SGR of croaker.
2	Polonium	MESH:D011059	inhibits		UNIPROT:A9YF60	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	Similar to these results, our current study proved dietary PO diet reduced FWB and SGR of croaker without influencing the SR.
2	Polonium	MESH:D011059	activates		UNIPROT:O75575	Protein	058dfe1e-7ab3-11ee-ae93-0050569a1f61	10.1007/s10530-022-02981-6	the Po Valley, and low-elevation areas in the Apennines) will strongly increase their climatic suitability in both RCP 2.6 and RCP 8.5.
2	Polonium	MESH:D011059	increases		UNIPROT:P10145	Protein	38f07ece-374f-11e8-8636-001a4a160175	28013186	Effects of PT and PO on ethanol-induced IL-8 and TNF expression and NF-kB activation in KATO III cells To investigate whether PO or PT could affect ethanol-induced gastritis, we examined their effects on the secretion of IL-8 and TNF-α and the activation of NF-κB in LPS-stimulated KATO III cells (Fig. 2).
2	Polonium	MESH:D011059	activates		UNIPROT:P01189	Protein	0a5a7e4a-bbe4-11e5-8abe-001a4ae51246	10.1016/j.domaniend.2012.03.001	The researchers also reported a stimulatory effect of PO onIL8secretion and on neutrophil survival in sheep, supporting the observed difference between PO + ACTH and ACTH in the “Regulation of cell death” and immune-related genes (IL2,MAPK3, andNFkB1) at T51.
2	Polonium	MESH:D011059	activates		UNIPROT:P09486	Protein	cce3a568-3513-11e8-8636-001a4a160175	26582465	Pressure-overload (PO) hypertrophy induced by transverse aortic constriction (TAC) in mice leads to increased collagen accumulation, increased SPARC, and increased myocardial stiffness.
2	Polonium	MESH:D011059	inhibits		UNIPROT:Q9GZY6	Protein	7a84473e-ea23-11ee-b346-0050569a791b	10.1016/j.lwt.2022.113921	Considering that PO could significantly inhibit the reduction of LAB counts, therefore PO inhibits the activity of LAB to produce lactic acid.
2	Polonium	MESH:D011059	decreases		UNIPROT:Q4U2R8	Protein	d4159aa6-3402-11e8-87fd-001a4a160176	26344851	In this study, PO administration significantly increased URAT1 expression and decreased OAT1 and OAT3 expressions in mice kidney.
2	Polonium	MESH:D011059	increases		UNIPROT:P81172	Protein	b58ad454-c67b-11ee-b346-0050569a791b	10.1016/j.aquaculture.2023.740147	PO significantly promoted the expression of Hepcidin antimicrobial peptide (hamp) after SA challenge.
2	Polonium	MESH:D011059	activates		UNIPROT:Q8IVW6	Protein	44287832-c88f-11ee-b346-0050569a791b	10.1016/j.reactfunctpolym.2023.105549	The FTIR of PAA-2 shows the presence of an absorption vibration peak at 1089 cm−1, which was formed by the single bond PO absorption vibration peak of PO, which caused the BDP in the coating to react with CA to form a PO bond.
2	Polonium	MESH:D011059	decreases		UNIPROT:P35228	Protein	e10ec44e-374f-11e8-8f56-001a4a160175	28122663	On the other hand, administration of PO could reduce the iNOS expression and scavenge the ROS thus mitigate the acid induced histopathological changes.
2	Polonium	MESH:D011059	activates		UNIPROT:P01584	Protein	7e08c97a-cafc-11ee-b346-0050569a791b	10.1016/j.jff.2016.02.029	Comparing to positive control (C+), all concentrations of PO hydrolysates reduced TNF-α (around 31% on average) (P <0.05) (Fig. 4A) and MP hydrolysates decreased IL-1β at 0.1 mg/mL (20.7%, time 0) and at 5 mg/mL (24.8% and 48.2%, time 0 and 6, respectively) (P <0.05) (Fig. 4D).
2	Polonium	MESH:D011059	decreases		UNIPROT:P01584	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	In this study, PO clearly reduced the levels of TNF-α, IL-1β and IL-6 compared to the LPS group.
2	Polonium	MESH:D011059	activates		UNIPROT:P01584	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Administration of PO decreased W/D ratio, reduced the activity of MPO and the proinflammatory cytokines (TNF-α, IL-1β, and IL-6) in BALF, inhibited the MDA production, and improved alleviated the pulmonary inflammation.
2	Polonium	MESH:D011059	activates		UNIPROT:P01308	Protein	a14615ba-c8e8-11e5-9cb8-001a4ae51247	17634263	The PO diet, on the other hand, prevented both sucrose-mediated islet hypertrophy and the linoleate-mediated decrease in insulin-positiveβ-cells, which could suggestβ-cell dysfunction.
2	Polonium	MESH:D011059	activates		UNIPROT:P01308	Protein	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	This suggests that both the PO and DDC pathways contribute to melanization inS.
2	Polonium	MESH:D011059	activates		UNIPROT:P01308	Protein	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	Moreover, PO or LO supplementation also notably enhanced the glucose tolerance and insulin sensitivity, and reduced the elevated serum levels of fasting glucose and insulin, as well as HOMA-IR in the HFD-fed mice.
2	Polonium	MESH:D011059	activates		UNIPROT:P31944	Protein	ca9ad126-5c6c-11e7-9fde-001a4ae51247	PMC4960998	Oral Antibiotics Increase Treg Frequency in Lymphoid Tissue and the Retina in EAU Mice In the inducible EAE model of demyelinating disease, PO broad-spectrum antibiotics caused attenuation of disease while enriching Tregs in the peripheral lymph nodes.6Foxp3 is a transcription factor that characterizes regulatory T cells.
2	Polonium	MESH:D011059	increases		UNIPROT:P09601	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Therefore, we investigated the possibility that PO inhibited the gene expression of TNF-α, IL-1β and IL-6 by interfering with the activation of NF-κB, as examined the potential that PO increased the gene expression of GCLC, NQO1, and HO-1 by activation of Nrf2.
2	Polonium	MESH:D011059	activates		UNIPROT:Q04912	Protein	1a8fc3b8-3759-11e8-a51f-001a4a160176	27448037	The Po River is the main freshwater contributor to the Adriatic Sea, contributing with 86% of the water discharged there (Struglia et al., 2004).
2	Polonium	MESH:D011059	decreases		UNIPROT:Q9NQT5	Protein	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	In response to both stimuli on the activation of inflammasome, PO dramatically prevented the increased levels of caspase 1 p10 and p20 subunits.
2	Polonium	MESH:D011059	activates		UNIPROT:P29508	Protein	5c5d124e-1b56-11f0-b759-0050569a791b	10.1016/j.prevetmed.2024.106208	The increase of PO and DIM increases SCC, whereas the increase in MF and MY reduces it.
2	Polonium	MESH:D011059	activates		UNIPROT:Q940U6	Protein	50f316ba-352b-11e8-9fbf-001a4a160176	25011711	However, it is noteworthy that in cats (despite the low oral F%) a dose of 5 mg/kg PO produced FLU plasma concentrations is higher than the plasma concentrations produced by the PO clinical dose (100 mg/subject) reported in humans (Hlavica and Niebch, 1985).
2	Polonium	MESH:D011059	activates		UNIPROT:Q940U6	Protein	7dd37686-3745-11e8-a34b-001a4a160175	26681139	However, it is noteworthy that in horses (despite the lower oral F% than in humans) a dose of 5 mg/kg PO produced FLU plasma concentrations higher that the plasma concentrations produced by the PO clinical dose (100 mg/subject/day) reported in humans (Hlavica and Niebch, 1985).
2	Polonium	MESH:D011059	phosphorylatesProtein		UNIPROT:O00429	Protein	c210a3e6-5c94-11e7-86a3-001a4ae51246	PMC4811679	Currently, the molecular mechanisms by which PO leads to Ser616 phosphorylation and Ser637 dephosphorylation of Drp1 are unknown.
2	Polonium	MESH:D011059	activates		UNIPROT:Q969P5	Protein	b17e45a2-c478-11e5-85e4-001a4ae51246	PMC3257317	We asked (1) whether endogenous MAFbx is upregulated during hypertrophy induced by PO, (2) whether endogenous MAFbx positively or negatively mediates cardiac hypertrophy induced by PO, and (3) which downstream target mediates the effect of MAFbx on pathological hypertrophy.
2	Polonium	MESH:D011059	activates		UNIPROT:Q9NRA2	Protein	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	Moreover, we also found that dietary PO diet with NF addition efficiently inhibited PO diet-induced induction of ALT and AST activities in serum of croaker, indicating that dietary NF may relieve the liver damage induced by PO diet.
2	Polonium	MESH:D011059	activates		UNIPROT:Q14574	Protein	8d701b04-390b-11e8-9fbf-001a4a160176	25499726	Animal studies showed that PO or DSC could promote bile secretion, accompanied by decrease of cholesterol level and increase of bile acid level by feeding rats with PO or DSC into duodenum.
2	Polonium	MESH:D011059	inhibits		UNIPROT:P09525	Protein	85f9f3e4-3362-11e8-8636-001a4a160175	9474780	Electrophoretic analysis of pro-PO Purified pro-PO was separated on polyacrylamide gels in Laemmli's buffer system without SDS or reducing agent (Laemmli, 1970) at 4°C under constant current (12mA/gel) using the Mini-PROTEIN II system (Bio-Rad).
2	Polonium	MESH:D011059	activates		UNIPROT:Q9UNW1	Protein	4ffc2404-29b6-11f0-b759-0050569a791b	10.1016/j.cnr.2004.09.015	discoideum, PO negatively modulates MIPP activity through an unknown mechanism, causing the increased breakdown of higher order inositol phosphates and increasing basal InsP3levels.
2	Polonium	MESH:D011059	activates		UNIPROT:P62158	Protein	87b414f4-bc17-11e5-8abe-001a4ae51246	PMC1483070	Changes occurring upon in vitro phosphorylation at Ser-2809 are significant, including an increased Po(15,17), the abrogation of the inhibitory effects of calmodulin (CaM)(15)and Mg2+(18), an increased Ca2+sensitivity of Po(19), dissociation of regulatory factors (e.g., FKBP12.6), expression of subconductance states, and the expression of channel activity at diastolic [Ca2+]free(17).
2	Polonium	MESH:D011059	increases		UNIPROT:P62158	Protein	466fbb20-3351-11e8-bf76-001a4a160175	16797888	PO ZYM significantly increased expression of CAM by 3h of incubation.
2	Polonium	MESH:D011059	activates		UNIPROT:P05231	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Administration of PO decreased W/D ratio, reduced the activity of MPO and the proinflammatory cytokines (TNF-α, IL-1β, and IL-6) in BALF, inhibited the MDA production, and improved alleviated the pulmonary inflammation.
2	Polonium	MESH:D011059	decreases		UNIPROT:P05231	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Therefore, we investigated the possibility that PO inhibited the gene expression of TNF-α, IL-1β and IL-6 by interfering with the activation of NF-κB, as examined the potential that PO increased the gene expression of GCLC, NQO1, and HO-1 by activation of Nrf2.
2	Polonium	MESH:D011059	increases		UNIPROT:Q6ZVN8	Protein	1727a2ec-bbdf-11e5-9b9d-001a4ae51247	10.1016/j.jinsphys.2008.04.006	In particular,pro-Po(prophenoloxidase) gene expression increases during the second half of pupal development, coinciding with declining ecdysteroid titers and increasing levels of JH (Rembold, 1987;Lourenço et al., 2005).
2	Polonium	MESH:D011059	activates		UNIPROT:Q8RXA7	Protein	4b09a648-1c0e-11f0-b759-0050569a791b	10.1016/j.bbrc.2024.149493	However, it remains unclear why PO supplement can reverse the inhibitory effect of SCD1 deficiency on BAT thermogenesis and hyperplastic sympathetic network, and further research is still needed.
2	Polonium	MESH:D011059	activates		UNIPROT:Q03403	Protein	01641448-74d6-11eb-8df6-001a4a160175	PMC7894875	In agreement with Siedler (2018), KH  PO   and NaH  PO   caused significantly higher AUC   sP [71].
2	Polonium	MESH:D011059	increases		UNIPROT:Q96S37	Protein	d4159aa6-3402-11e8-87fd-001a4a160176	26344851	In this study, PO administration significantly increased URAT1 expression and decreased OAT1 and OAT3 expressions in mice kidney.
2	Polonium	MESH:D011059	decreases		UNIPROT:P01375	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	In this study, PO clearly reduced the levels of TNF-α, IL-1β and IL-6 compared to the LPS group.
2	Polonium	MESH:D011059	inhibits		UNIPROT:P01375	Protein	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	It is not clear how PO only prevents TNF-α but not the other proinflammatory cytokines in trophoblasts and that requires further investigation.
2	Polonium	MESH:D011059	increases		UNIPROT:P01375	Protein	38f07ece-374f-11e8-8636-001a4a160175	28013186	Effects of PT and PO on ethanol-induced IL-8 and TNF expression and NF-kB activation in KATO III cells To investigate whether PO or PT could affect ethanol-induced gastritis, we examined their effects on the secretion of IL-8 and TNF-α and the activation of NF-κB in LPS-stimulated KATO III cells (Fig. 2).
2	Polonium	MESH:D011059	activates		UNIPROT:P01375	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Administration of PO decreased W/D ratio, reduced the activity of MPO and the proinflammatory cytokines (TNF-α, IL-1β, and IL-6) in BALF, inhibited the MDA production, and improved alleviated the pulmonary inflammation.
2	Polonium	MESH:D011059	inhibits		UNIPROT:P04637	Protein	10841c60-bbf6-11e5-8abe-001a4ae51246	PMC3139501	The extraction of PO suppresses the proliferation of breast and colon cancer cells via p53-dependent and p53-independent pathways [3].
2	Polonium	MESH:D011059	decreases		UNIPROT:P10415	Protein	878b211e-c782-11ee-8b99-0050569a1f61	10.1016/j.jddst.2023.104820	Moreover, PO decreased the antiapoptotic Bcl2-gene expression by 30%, whereas PO/Ns decreased the Bcl-2 expression by 57% (Fig. 9B).
2	Polonium	MESH:D011059	increases		UNIPROT:O15360	Protein	a34a63d4-f587-11eb-8ae1-001a4a160175	30205236	Dietary PO led to up-regulated expression of FAH and PRSS1, and dietary LO contributed to the increase in PRSS36.
2	Polonium	MESH:D011059	decreases		UNIPROTPRO:PRO:0000024970	Protein	4ffc2404-29b6-11f0-b759-0050569a791b	10.1016/j.cnr.2004.09.015	Orally administrated PO inhibitors increased substance P, vasopressin and TRH levels in the rat brain[39–42], and increased substance P and α-MSH levels in mice[43].
2	Polonium	MESH:D011059	activates		UNIPROT:P62304	Protein	ce018f86-c785-11ee-b346-0050569a791b	10.1016/j.jddst.2023.104809	To confirm the drug release profile according to the manufacturing method using the finally selected polymer, the AAP + HPC + IBF + Eudragit E PO were mixed together to produce PM, the SME which was produced through a single HME process of AAP + HPC + IBF + Eudragit E PO, and the SME (AAP)+SME (IBF) which were produced by separately mixing of SME with AAP + HPC, and IBF + Eudragit E PO.
2	Polonium	MESH:D011059	decreases		UNIPROTPRO:PRO:0000033530	Protein	4ffc2404-29b6-11f0-b759-0050569a791b	10.1016/j.cnr.2004.09.015	Orally administrated PO inhibitors increased substance P, vasopressin and TRH levels in the rat brain[39–42], and increased substance P and α-MSH levels in mice[43].
2	Polonium	MESH:D011059	inhibits		UNIPROT:P02730	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Administration of PO decreased W/D ratio, reduced the activity of MPO and the proinflammatory cytokines (TNF-α, IL-1β, and IL-6) in BALF, inhibited the MDA production, and improved alleviated the pulmonary inflammation.
2	Polonium	MESH:D011059	phosphorylatesProtein		UNIPROT:P11137	Protein	69673342-c9fe-11e5-b88f-001a4ae51247	PMC1565147	We first sought to determine whether or not an acute treatment of PO granulosa cells with hCG stimulated MAP2 phosphorylation.
2	Polonium	MESH:D011059	inhibits		UNIPROT:P05164	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	As might be expected, results showed that PO could significantly inhibit the MPO activity in lung tissues after LPS challenge, while the MPO level of model group clearly increased in lung tissues after LPS exposure.
2	Polonium	MESH:D011059	activates		UNIPROT:P02749	Protein	88e462a8-1a8a-11f0-a2ca-0050569a1f61	10.1016/j.still.2024.106241	Microorganisms mineralize organic matter and release Po by increasing BG The ecoenzyme stoichiometry reflects responses to resource stress, where energy (C) or nutrient (N and P) limitations prompt an enhancement in the ecoenzymes to cope with such constraints (Moorhead et al., 2016; Sinsabaugh et al., 2009).
2	Polonium	MESH:D011059	activates		UNIPROT:P22735	Protein	3edd2e56-04aa-11f0-bb39-0050569a791b	10.1016/j.scitotenv.2024.174265	Besides that, the planar optode (PO) technique enables the visualization of O2in the rhizosphere, providing accurate and real-time results (Li et al., 2019;Liu et al., 2022;Lussich et al., 2024).
2	Polonium	MESH:D011059	activates		UNIPROT:Q9Y5K6	Protein	4e88fadc-8705-11f0-afc2-0050569a791b	PMC7718345	Hypertrophy in response to PO causes CMs to disproportionately increase in width relative to length, resulting in a universal thickening of the cardiac wall (termed concentric remodeling) [8,9].
2	Polonium	MESH:D011059	inhibits		UNIPROT:P81274	Protein	5b8ddcae-bbed-11e5-8abe-001a4ae51246	10.1016/j.mcn.2004.12.003	The unexpected direct inhibition of PO by VPA suggests that, in some circumstances, VPA could increase PIns signaling and, perhaps, inositol availability, the opposite of the effects described previously (Agam et al., 2002; O'Donnell et al., 2000; Williams et al., 2002).
2	Polonium	MESH:D011059	activates		UNIPROT:O00592	Protein	eae31270-e9fb-11ef-b449-0050569a791b	10.1016/j.jcou.2024.102999	Hai et al.[52]showed that the CO2and PO cycloaddition reaction catalyzed by tetrabutylammonium iodide (TBAI) and a small amount of wool powder (WP) produced 2.5 times more PC than that produced using TBAI alone.
2	Polonium	MESH:D011059	inhibits		UNIPROT:Q9NRC9	Protein	bfd84284-cc10-11e5-83a8-001a4ae51246	9684865	The FDP-induced increase in Po could be reversed by perfusing away the FDP (results not shown).
2	Polonium	MESH:D011059	inhibits		UNIPROT:P41684	Protein	5d73ed6a-1a39-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.741347	PO induces melanin production and actives secondary metabolites, while inhibits extracellular cell and chitinase activity of pathogens.
2	Polonium	MESH:D011059	inhibits		UNIPROT:P48539	Protein	25bc6b16-bc08-11e5-9b9d-001a4ae51247	10.1016/j.peptides.2005.05.016	Our results demonstrated that PO is able to degrade PEP-19 and neurogranin derived peptides.
2	Polonium	MESH:D011059	inhibits		UNIPROT:P46060	Protein	02b7f948-c480-11e5-85e4-001a4ae51246	20308040	"Regarding only those eleven patients followed up for 24 months, mean serum PO level decreased from 1.91 ± 0.21 at baseline
                         to 1.76 ± 0.21 (SD) mmol/l in Week 3–6 (P= 0.1) and to 1.78 ± 0.36 (SD) mmol/l in Week 19–24 (P= 0.2)."
2	Polonium	MESH:D011059	activates		UNIPROT:P08922	Protein	a50cf35a-3748-11e8-8636-001a4a160175	26004319	Excessive activation of PO activity produces more ROS which is thought to be detrimental to animals[27,28].
2	Polonium	MESH:D011059	increases		UNIPROT:P15559	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Therefore, we investigated the possibility that PO inhibited the gene expression of TNF-α, IL-1β and IL-6 by interfering with the activation of NF-κB, as examined the potential that PO increased the gene expression of GCLC, NQO1, and HO-1 by activation of Nrf2.
2	Polonium	MESH:D011059	inhibits		UNIPROT:Q14032	Protein	4710c9c0-341e-11e8-8636-001a4a160175	11189023	In this study another excitatory amino acid,d,l-homosysteic acid was injected into the PO, which significantly attenuated the BAT thermogenesis.
2	Polonium	MESH:D011059	activates		UNIPROT:Q14032	Protein	82a3e454-bbee-11e5-8abe-001a4ae51246	10.1016/S0006-8993(02)04203-8	Warm-sensitive neurons in the PO are considered to send tonic inhibitory signals for BAT thermogenesis, because stimulation of the PO with an excitatory substance,dl-homocysteic acid, suppressed BAT thermogenesis just as PO warming did, and transection applied caudal to the PO produced a strong BAT thermogenesis[4].
2	Polonium	MESH:D011059	inhibits		UNIPROT:Q92686	Protein	25bc6b16-bc08-11e5-9b9d-001a4ae51247	10.1016/j.peptides.2005.05.016	Our results demonstrated that PO is able to degrade PEP-19 and neurogranin derived peptides.
2	Polonium	MESH:D011059	inhibits		UNIPROT:O60259	Protein	c6d5e780-390a-11e8-87fd-001a4a160176	25481373	Effect of PO on non-protein-sulfhydryl (NP-SH) and prostaglandin E2(PGE2) levels Administration of rats with PO significantly (P<0.05) restored the depletion of NP-SH caused by ethanol pretreatment (Table 3).
2	Polonium	MESH:D011059	increases		UNIPROT:O60259	Protein	c6d5e780-390a-11e8-87fd-001a4a160176	25481373	PO significantly increased basal levels of NP-SH groups, confirming the involvement of these groups in the gastroprotective effect.
2	Polonium	MESH:D011059	activates		CHEBI:49168	Chemical	347013c2-bc2d-11e5-8abe-001a4ae51246	PMC2104791	Most immune-related melanization models begin with the hydroxylation of tyrosine by PO to produce DOPA, then some of the DOPA is thought to be oxidized by PO to generate DOPA quinone, and some is thought to be decarboxylated by dopa decarboxylase (DDC) to produce dopamine, which is then oxidized by PO to dopamine quinone.
2	Polonium	MESH:D011059	activates		CHEBI:25179	Chemical	d3a8ca7e-ca01-11e5-b88f-001a4ae51247	15857824	It is known that melanins induced by arthropod PO are closely linked to protein matrices in the form of melanoproteins (7–9).
2	Polonium	MESH:D011059	activates		CHEBI:28842	Chemical	cc542772-1a48-11f0-b759-0050569a791b	10.1016/j.aninu.2024.04.024	In the present study, the SO diet increased C18:2 and C18:3 PUFA in the breast muscle, while LO, PO diets increased C16:0 and C18:0 and BO diets increased C16:1 and C18:1, indicating that the fatty acid composition of chicken meat reflects dietary fatty acid composition.
2	Polonium	MESH:D011059	activates		CHEBI:48400	Chemical	7b76b9ac-0d8a-11f0-b759-0050569a791b	10.1016/S0965-1748(99)00007-7	During the reactions,o-quinone produced by PO-catalyzed hydrocaffeic acid oxidation reacts with HKN, which leads to the oxidation of HKN and reduction of theo-quinone back to hydrocaffeic acid.
2	Polonium	MESH:D011059	activates		CHEBI:17234	Chemical	c68f16ec-bbe0-11e5-9b9d-001a4ae51247	10.1016/j.metabol.2006.10.021	In addition, we have shown that 1 week of mifepristone treatment (once per day, 100 mg/kg PO) reduces endogenous glucose output and increases glucose disposal in the Zuckerfa/farat[27].
2	Polonium	MESH:D011059	inhibits		CHEBI:17234	Chemical	c68f16ec-bbe0-11e5-9b9d-001a4ae51247	10.1016/j.metabol.2006.10.021	In addition, we have shown that 1 week of mifepristone treatment (once per day, 100 mg/kg PO) reduces endogenous glucose output and increases glucose disposal in the Zuckerfa/farat[27].
2	Polonium	MESH:D011059	activates		CHEBI:17234	Chemical	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	Moreover, PO or LO supplementation also notably enhanced the glucose tolerance and insulin sensitivity, and reduced the elevated serum levels of fasting glucose and insulin, as well as HOMA-IR in the HFD-fed mice.
2	Polonium	MESH:D011059	activates		CHEBI:24996	Chemical	24843cbc-351c-11e8-a51f-001a4a160176	28302463	Thus, the PO was either increased or decreased by 10W until the highest PO eliciting a stable lactate (i.e., MLSS, <1.0mmolL−1increase between the 10th and 30th min) was determined.
2	Polonium	MESH:D011059	activates		CHEBI:16240	Chemical	1f166102-3917-11e8-a51f-001a4a160176	24486681	Komarov et al. (2005)demonstrated clearly that hydrogen peroxide (H2O2) and superoxideO2-radicals are produced in abundance during the oxidation of diphenols by mushroom PO.
2	Polonium	MESH:D011059	activates		CHEBI:16240	Chemical	26ba5d46-3949-11e8-8f56-001a4a160175	17029705	It is generally believed that the function of the PO reaction is to produce hydrogen peroxide used in the synthesis of lignin[56, 57].
2	Polonium	MESH:D011059	activates		CHEBI:49713	Chemical	4ffc2404-29b6-11f0-b759-0050569a791b	10.1016/j.cnr.2004.09.015	The role of PO in modulating InsP3levels has also been demonstrated in studies[8–10]showing that PO inhibition reverses the morphological effects of lithium, valproic acid and carbamazepine.
2	Polonium	MESH:D011059	activates		CHEBI:78505	Chemical	c697b4fc-bc42-11e5-8d2d-001a4ae51247	10.1016/j.jip.2006.09.004	As well, it is entirely plausible that during venom gland/reservoir extraction from adult wasps, endogenous pro-PO activators fully activate the enzyme, giving the false appearance of a constitutively active enzyme in crude venom.
2	Polonium	MESH:D011059	increases		CHEBI:18332	Chemical	994a7792-1b4b-11f0-b759-0050569a791b	10.1016/j.pestbp.2024.105961	The heightened T3 and T4 levels induced by PO may result from increased biosynthesis, with no apparent rise in corresponding metabolism, consistent with the unchanged expression ofdio1.
2	Polonium	MESH:D011059	activates		CHEBI:18332	Chemical	994a7792-1b4b-11f0-b759-0050569a791b	10.1016/j.pestbp.2024.105961	In this study, the expression ofdio2was significantly up-regulated in larvae following exposure to 0.6 mg/L PO, suggesting that PO may promote the conversion of T4 to T3 at 0.6 mg/L, consistent with the decrease in the ratio of T4/T3.
2	Polonium	MESH:D011059	activates		CHEBI:17253	Chemical	7b76b9ac-0d8a-11f0-b759-0050569a791b	10.1016/S0965-1748(99)00007-7	During the reactions,o-quinone produced by PO-catalyzed hydrocaffeic acid oxidation reacts with HKN, which leads to the oxidation of HKN and reduction of theo-quinone back to hydrocaffeic acid.
2	Polonium	MESH:D011059	activates		CHEBI:29108	Chemical	b286ad76-0d26-11f0-b759-0050569a791b	10.1016/S0025-326X(99)00088-0	Much of the variation in calcium concentration is caused by the diluting influence of the Po, mean calcium concentration in the river just before the delta was found to be 1.4 mM (data from ENEL, Milan, Italy).
2	Polonium	MESH:D011059	activates		CHEBI:49108	Chemical	37296c4e-bc2d-11e5-8abe-001a4ae51246	10.1016/j.ibmb.2005.01.014	Although the mammalian enzymes dopachrome tautomerase and DHICA oxidase specifically catalyze the conversion of dopachrome to DHICA melanin, in insects PO and DCE mediate the oxidative decarboxylation of dopachrome to generate DHI (Bai et al., 1996;Fang et al., 2002;Han et al., 2002;Johnson et al., 2001;Li and Nappi, 1991;Li, 1994;Li et al., 1994;Pawelek, 1990;Sugumaran and Semensi, 1991;Zhao et al., 1995).
2	Polonium	MESH:D011059	activates		CHEBI:42191	Chemical	8ae0c36e-1b64-11f0-b759-0050569a791b	10.1016/j.jip.2024.108098	Compared to the control, the serum PO activity significantly decreased with different inhibitors such us sodium azide, Thiourea, EDTA and PTU at 7 mM concentration.
2	Polonium	MESH:D011059	activates		CHEBI:16852	Chemical	33754f4c-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2004.12.001	PO catalyses the oxidation of dopa rapidly to dopaquinone, which in turn polymerises non-enzymatically into insoluble melanin[3].
2	Polonium	MESH:D011059	activates		CHEBI:25812	Chemical	8bf48b38-d94c-11ee-9133-0050569a1f61	10.1016/j.envsoft.2004.11.003	Northern Italy domains The validation exercise has been performed on the Po Valley region (Northern Italy), where the critical anthropogenic emissions, the frequent stagnating meteorological conditions and the Mediterranean solar radiation regularly cause high ozone level episodes, especially during summer months (Silibello et al., 1998; Neftel et al., 2002).
2	Polonium	MESH:D011059	activates		CHEBI:39867	Chemical	4ffc2404-29b6-11f0-b759-0050569a791b	10.1016/j.cnr.2004.09.015	The role of PO in modulating InsP3levels has also been demonstrated in studies[8–10]showing that PO inhibition reverses the morphological effects of lithium, valproic acid and carbamazepine.
2	Polonium	MESH:D011059	inhibits		CHEBI:24848	Chemical	5b8ddcae-bbed-11e5-8abe-001a4ae51246	10.1016/j.mcn.2004.12.003	The unexpected direct inhibition of PO by VPA suggests that, in some circumstances, VPA could increase PIns signaling and, perhaps, inositol availability, the opposite of the effects described previously (Agam et al., 2002; O'Donnell et al., 2000; Williams et al., 2002).
2	Polonium	MESH:D011059	activates		CHEBI:24848	Chemical	4ffc2404-29b6-11f0-b759-0050569a791b	10.1016/j.cnr.2004.09.015	It is unclear how these inositol-depleting drugs reduce PO activity.
2	Polonium	MESH:D011059	activates		CHEBI:17775	Chemical	d4159aa6-3402-11e8-87fd-001a4a160176	26344851	These results suggested that PO might both induce urate reabsorption and reduce urate secretion.
2	Polonium	MESH:D011059	inhibits		CHEBI:422	Chemical	7a84473e-ea23-11ee-b346-0050569a791b	10.1016/j.lwt.2022.113921	Therefore, the most significant effect of PO addition on organic acids is that PO reduced tartaric, citric and malic acids and lactic acid of PBY during storage.
2	Polonium	MESH:D011059	activates		MESH:D006984	Phenotype	b49f8a88-1c26-11f0-b759-0050569a791b	10.1016/j.biopha.2023.116119	PO-induced hypertrophy is exaggerated in adiponectin knockout mice and can be attenuated by adiponectin administration[15,21,41,42].
2	Polonium	MESH:D011059	activates		MESH:D006984	Phenotype	89e50c0a-bc18-11e5-9b9d-001a4ae51247	PMC2902863	RhoA is activated by PO[23]and Gαq-agonists inducing concentric hypertrophy[24], whereas it is inhibited by LIF[22].
2	Polonium	MESH:D011059	activates		MESH:D006333	Phenotype	25b72a15-dc39-11ea-a26b-001a4a160175	PMC6502694	Selective inhibition of GSK-3α using isoform-specific inhibitors could be a viable therapeutic strategy to limit PO-induced heart failure.
2	Polonium	MESH:D011059	activates		MESH:D006333	Phenotype	4561c198-c8e5-11e5-9624-001a4ae51246	17306713	Because late-stage VO- or PO-mediated heart failure (the stage at which we see many patients clinically) seems to have many more similarities in cardiac structure, it seems premature to exclude a role for ACE-I in the clearly dilated, late-stage failing heart (e.g., nonsurgical candidates).
2	Polonium	MESH:D011059	activates		MESH:D004194	Phenotype	4ffc2404-29b6-11f0-b759-0050569a791b	10.1016/j.cnr.2004.09.015	PO activity and mental health Studies of PO activity in psychiatric disorders were originally initiated because altered neuropeptide degradation was theorised to play a role in these diseases[2].
2	Polonium	MESH:D011059	activates		MESH:D002415	Phenotype	9820a27a-3385-11e8-bf76-001a4a160175	26626097	In normotensive healthy cats, PO enalapril leads to a slight but significant decrease in SBP (Uechi et al., 2002).
2	Polonium	MESH:D011059	activates		GO:0006629	Phenotype	23fe470c-1b50-11f0-b759-0050569a791b	10.1016/j.jff.2024.106234	Consistent with these findings, the present results revealed that dietary PO and LO might contribute to maintaining a healthy balance in lipid metabolism in the HFD-fed mice by inhibiting lipid biosynthesis through reducing the expression of SREBP-1 and its targeted genes including ACC, FAS and SCD1, as well as PPARγ, and enhancing lipid degradation via enhancing the expression of PPARαand its targeted genes including CPT-1αand CPT-2.
2	Polonium	MESH:D011059	activates		GO:0044546	Phenotype	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	We next tested the protective role of PO against LPS and ATP-induced NLRP3 inflammasome activation in the BMDMs.
2	Polonium	MESH:D011059	activates		MESH:D011059	Phenotype	4d041ed2-bc2e-11e5-8abe-001a4ae51246	10.1016/j.bmc.2006.12.038	8 An attractive theory states that interaction between PO and ORF378 is mediated by the accommodation of Tyr98in the substrate-binding pocket of PO.
2	Polonium	MESH:D011059	activates		MESH:D010636	Phenotype	21e5d60a-bbd4-11e5-8abe-001a4ae51246	10.1016/j.aquaculture.2007.10.049	The active PO initiates transformation of phenols to melanin, a potent antimicrobial substance that is deposited around encapsulated material or haemocytes nodules.
2	Polonium	MESH:D011059	activates		MESH:D010636	Phenotype	eb3cef4e-1ad8-11f0-b759-0050569a791b	10.1016/j.fsi.2024.109925	Active PO causes the oxidation of phenols into quinones, which can subsequently crosslink nearby molecules in a non-specific manner to form melanin.
2	Polonium	MESH:D011059	activates		GO:0006955	Phenotype	5d0d0bcc-053f-11f0-9c9e-0050569a1f61	10.1016/j.pestbp.2024.106003	For example,immulectin-1regulates PO-mediated immune response against entomogenous fungus inLocusta migratoria.GNBP-2plays an important role in L.migratoriaregulating the PPO (prophenoloxidase) system to resist fungal invasion.
2	Polonium	MESH:D011059	activates		GO:0006955	Phenotype	70cf7840-5cad-11e7-8b40-001a4ae51247	PMC4767563	In addition to PO-mediated humoral immunity in the mosquito hemolymph, a recent study reported an extracellular pattern recognition mechanism mediated by dual complement-like proteins highly expressed in hemocytes that limited flaviviral infection ofA.
2	Polonium	MESH:D011059	activates		GO:0006955	Phenotype	c865c044-1bec-11f0-b759-0050569a791b	10.1016/j.ijbiomac.2024.129747	The explanation may be that althoughMnserpinknockdown increased PO activity, which helps to enhance the immunity ofM.
2	Polonium	MESH:D011059	activates		GO:0006351	Phenotype	33b67efa-c8e7-11e5-9ad8-001a4ae51247	17855335	In summary, pretreating animals with proPO dsRNA resulted in lower proPO transcription, decreased PO activity, significantly faster cumulative mortality, and higher number of bacteria in hemolymph following a challenge withA.
2	Polonium	MESH:D011059	activates		GO:0009058	Phenotype	8e0ec16e-390b-11e8-8636-001a4a160175	25498544	PO was previously found to stimulate cell proliferation and induce the synthesis of hyaluronic acid in mouse skin fibroblasts and human dermal fibroblasts[18,19].
2	Polonium	MESH:D011059	activates		GO:0042060	Phenotype	19a88df6-ca5d-11e5-9088-001a4ae51247	12923175	Several groups have determined the biological functions of proPO-activating factors and proPOs, suggesting that the proPO system is activated by a serine protease cascade and activated PO can synthesize melanin pigments for inhibiting spread of a microbial infection or for wound healing (8,9).
2	Polonium	MESH:D011059	activates		MESH:D003371	Phenotype	14e753c8-3c69-11f0-afc2-0050569a791b	PMC9422192	"</ce:given-name>
                                 <ce:surname>Katz</ce:surname>
                              </sb:author>
                           </sb:authors>
                           <sb:title>
                              <sb:maintitle>Esophageal cyst a cause of chronic cough</sb:maintitle>
                           </sb:title>
                        </sb:contribution>
                        <sb:host>
                           <sb:issue>
                              <sb:series>
                                 <sb:title>
                                    <sb:maintitle>Chest</sb:maintitle>
                                 </sb:title>
                                 <sb:volume-nr>86</sb:volume-nr>
                              </sb:series>
                              <sb:date>1984</sb:date>
                           </sb:issue>
                           <sb:pages>
                              <sb:first-page>150</sb:first-page>
                              <sb:last-page>152</sb:last-page>
                           </sb:pages>
                        </sb:host>
                     </sb:reference>
                     <ce:source-text id=""srct0065"">Bowton DL, Katz PO, Esophageal cyst a cause of chronic cough."
2	Polonium	MESH:D011059	inhibits		GO:0014823	Phenotype	9820a27a-3385-11e8-bf76-001a4a160175	26626097	The main aims of the study were: (1) to elucidate whether pre-exercise PO administration of an ACEI reduces the hypertensive response to exercise, and (2) to assess whether the changes in BP after exercise are associated with inhibition of circulating/serum ACE activity.
2	Polonium	MESH:D011059	inhibits		MESH:D008315	Phenotype	ccb34e2a-1b7c-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.740821	The results showed that dietary PO diet with NF addition efficiently impeded PO diet-induced increase in MDA contents in liver of croakers.
2	Polonium	MESH:D011059	activates		MESH:D008315	Phenotype	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Administration of PO decreased W/D ratio, reduced the activity of MPO and the proinflammatory cytokines (TNF-α, IL-1β, and IL-6) in BALF, inhibited the MDA production, and improved alleviated the pulmonary inflammation.
2	Polonium	MESH:D011059	inhibits		GO:0042438	Phenotype	d3a8ca7e-ca01-11e5-b88f-001a4ae51247	15857824	To date, several melanization-inhibitory molecules have been isolated and characterized from several animals, and these molecules have been shown to be inhibitors of melanin synthesis induced by the activated PO of invertebrates or by the tyrosinase of vertebrates.
2	Polonium	MESH:D011059	inhibits		MESH:D010149	Phenotype	013d4760-04c9-11f0-bb39-0050569a791b	10.1016/j.anl.2024.07.009	As a sedative, it is possible that dexmedetomidine could have caused excessive sleepiness and thus reduced PO, although given that dexmedetomidine has also been shown to decrease postoperative pain and nausea, it could have contributed to increased PO.
2	Polonium	MESH:D011059	activates		MESH:D009293	Phenotype	444d050c-c46b-11e5-9da3-001a4ae51247	PMC4250325	While seemingly innocuous, our results reveal that PO misuse can lead to long-term opioid dependence, as well as transition to heroin use and drug injection.
2	Polonium	MESH:D011059	activates		GO:0008283	Phenotype	8e0ec16e-390b-11e8-8636-001a4a160175	25498544	PO was previously found to stimulate cell proliferation and induce the synthesis of hyaluronic acid in mouse skin fibroblasts and human dermal fibroblasts[18,19].
2	Polonium	MESH:D011059	activates		MESH:D009369	Phenotype	292370e6-bc40-11e5-8abe-001a4ae51246	10.1016/j.freeradbiomed.2007.01.014	Overexpression of UOX in cultured human cells causes malignant transformation[6]and, in rodents, PO proliferation leads to liver tumors[11].
2	Polonium	MESH:D011059	inhibits		MESH:D009369	Phenotype	0e61566c-3a9f-11e8-b868-001a4a160176	23041228	Combined treatment with SGI-1776 (200mg/KG PO) and sunitinib (40mg/KG PO) QDx5 for 3 weeks dramatically reduced the tumor burden in two RCC cell line (768-O and caki-1) xenograft models compared with single-agent therapy and was very well tolerated[126].
2	Polonium	MESH:D011059	inhibits		MESH:D002784	Phenotype	65d2f290-3534-11e8-9fbf-001a4a160176	21718775	The above results ensure that PO seeds decreased bad cholesterol, increased friendly cholesterol and in sum decrease hyperlipidaemia.
2	Polonium	MESH:D011059	decreases		MESH:D002784	Phenotype	a948caf0-352e-11e8-87fd-001a4a160176	20363590	PO reduces the blood levels of total cholesterol, triglycerides, and LDL cholesterol[18], while higher levels of dietarytransfatty acids, mainlytrans-9 and -10 18:1 isomers, raise serum LDL cholesterol and decrease serum HDL cholesterol levels[45].
2	Polonium	MESH:D011059	activates		GO:0007586	Phenotype	721c9e74-377e-11e8-9fbf-001a4a160176	10591154	In culture, Po oligos are subject to nuclease digestion, leading to release of nucleotides that can dilute the thymidine pool.
2	Polonium	MESH:D011059	inhibits		GO:0030431	Phenotype	c687bf16-87ad-11f0-afc2-0050569a791b	PMC7501165	Interestingly, increasing orexin-A peptide into the PO has been shown to increase wakefulness and to suppress both REM and slow-wave sleep (Mavanji et al., 2015;Methippara, Alam, Szymusiak, & McGinty, 2000).
2	Polonium	MESH:D011059	activates		GO:0009877	Phenotype	13166486-bbdf-11e5-8abe-001a4ae51246	10.1016/j.jinsphys.2006.11.003	Another important aspect of immunocompetence is the prophenoloxidase (PO) cascade, that allows for the melanotic encapsulation or nodulation of invading particles (Iwanaga and Lee, 2005).
2	Polonium	MESH:D011059	activates		MESH:D013890	Phenotype	8ae0c36e-1b64-11f0-b759-0050569a791b	10.1016/j.jip.2024.108098	Compared to the control, the serum PO activity significantly decreased with different inhibitors such us sodium azide, Thiourea, EDTA and PTU at 7 mM concentration.
2	Polonium	MESH:D011059	activates		MESH:D017382	Phenotype	2ef618e8-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2006.03.013	In proPO activating system, an inactive form of proPO is synthesized in haemocytes and converted to an active form of phenoloxidase (PO) by a serine proteinase, and PO promotes the melanization and the production of reactive oxygen species for immune defences[5,10].
2	Polonium	MESH:D011059	activates		MESH:D007501	Phenotype	4b840e1e-0e63-11f0-b759-0050569a791b	10.1182/blood.V91.4.1446	In previous studies with this model, we found that the iron excretion induced by PO administration of HBED was only about 10% of that resulting from the SC administration of an equivalent dose of DFO31(Fig4).
2	Polonium	MESH:D011059	decreases		MESH:D007501	Phenotype	8518eecc-3ab4-11e8-bf76-001a4a160175	17566617	For the different matrices, from the HCl 0.3M solutions, the polonium was deposited on a silver disc (diameter 18mm) for 4h at 90°C, after adding 5ml of ascorbic acid 10gL−1and 5ml of hydroxylamine hydrochloride 300gL−1to reduce the amount of iron and manganese (Flynn, 1968; Skarwzec and Bojanowski, 1988).
2	Polonium	MESH:D011059	decreases		MESH:D008345	Phenotype	8518eecc-3ab4-11e8-bf76-001a4a160175	17566617	For the different matrices, from the HCl 0.3M solutions, the polonium was deposited on a silver disc (diameter 18mm) for 4h at 90°C, after adding 5ml of ascorbic acid 10gL−1and 5ml of hydroxylamine hydrochloride 300gL−1to reduce the amount of iron and manganese (Flynn, 1968; Skarwzec and Bojanowski, 1988).
2	Polonium	MESH:D011059	activates		MESH:D019810	Phenotype	8ae0c36e-1b64-11f0-b759-0050569a791b	10.1016/j.jip.2024.108098	Compared to the control, the serum PO activity significantly decreased with different inhibitors such us sodium azide, Thiourea, EDTA and PTU at 7 mM concentration.
2	Polonium	MESH:D011059	inhibits		MESH:D001564	Phenotype	9820a27a-3385-11e8-bf76-001a4a160175	26626097	PO administration of ACEIs in sodium-repleted normotensive human subjects induces a mild decrease in BP.
2	Polonium	MESH:D011059	activates		GO:0006952	Phenotype	1673d932-d725-11ee-b346-0050569a791b	10.4308/hjb.14.3.105	However, the increasing of PO activities did not prevent the TMV accumulation, suggested the PO elicit plant's defense response at the early of infection stage rather than viral suppression.
2	Polonium	MESH:D011059	activates		MESH:D002220	Phenotype	4ffc2404-29b6-11f0-b759-0050569a791b	10.1016/j.cnr.2004.09.015	The role of PO in modulating InsP3levels has also been demonstrated in studies[8–10]showing that PO inhibition reverses the morphological effects of lithium, valproic acid and carbamazepine.
2	Polonium	MESH:D011059	inhibits		GO:0006817	Phenotype	f8e4d316-04e7-11f0-baad-0050569a1f61	10.1016/j.envres.2024.119250	Moreover, MPs contributed to Po mineralization and assimilatory sulfate reduction, despite inhibiting phosphate transport and the SOX system.
2	Polonium	MESH:D011059	inhibits		MESH:D005355	Phenotype	b49f8a88-1c26-11f0-b759-0050569a791b	10.1016/j.biopha.2023.116119	Here, we observed that treatment with ALY688 resulted in a reduction in PO-induced fibrosis.
2	Polonium	MESH:D011059	activates		MESH:D009361	Phenotype	b58ad454-c67b-11ee-b346-0050569a791b	10.1016/j.aquaculture.2023.740147	In our study the up-regulation oftnfaip6andTP53I3(2.53, 2.52, 3.20) induced by PO after SA invasion may suppress the excessive effects of the inflammatory response and promote the phagocytosis and apoptosis of antigens, thus minimizing damage to Tilapia.
2	Polonium	MESH:D011059	activates		MESH:D013438	Phenotype	b412f382-e843-11e5-96c9-001a4ae51247	10.1074/jbc.272.11.7069	At the single-channel level, thiol-reducing agents were also shown to decrease the open channel probability (Po).
2	Polonium	MESH:D011059	activates		GO:0007155	Phenotype	c697b4fc-bc42-11e5-8d2d-001a4ae51247	10.1016/j.jip.2006.09.004	Additional studies are needed to elucidate PO’s involvement in cell death, particularly to determine if adhesion to host hemocytes and then lysis is mediated by venom PO.
2	Polonium	MESH:D011059	activates		GO:0007155	Phenotype	466fbb20-3351-11e8-bf76-001a4a160175	16797888	PO ZYM treatment increased expression of the cell adhesion molecule VCAM in a dose-dependent manner (Fig. 2B).
2	Polonium	MESH:D011059	inhibits		MESH:D000255	Phenotype	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	PO decreases the expression of Pro-IL-1β in trophoblasts HTR-8 cells were treated with LPS 1 μg/ml for 4 h and ATP for 30 min to activate NLRP3 inflammasome.
2	Polonium	MESH:D011059	activates		MESH:D005756	Phenotype	38f07ece-374f-11e8-8636-001a4a160175	28013186	This supports earlier work demonstrating that PO isolated fromPonciri fructusmay protect against HCl/ethanol-induced gastritis in pylorus-ligated rats[11].
2	Polonium	MESH:D011059	hydroxylatesProtein		MESH:D019800	Phenotype	347013c2-bc2d-11e5-8abe-001a4ae51246	PMC2104791	A PO fromPacifastacus leniusculus(crayfish) hydroxylates tyrosine and another monophenol, tyramine (Aspan et al., 1995).
2	Polonium	MESH:D011059	activates		MESH:D033461	Phenotype	788d2cb6-4fb0-11e8-b53e-001a4a160176	PMC5921330	To assess the hypouricemic effect in vivo, we used potassium oxonate (PO)-induced hyperuricemia in a rat model, in which hyperuricemia is induced by oral administration of PO (250 mg/kg,b.w.
2	Polonium	MESH:D011059	activates		MESH:D008070	Phenotype	2fb9ebe2-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2006.06.014	Tropolone, a specific inhibitor of PO and a potential substrate for peroxidase, repressed the spontaneous activity and abolished the stimulating effect of LPS (Table 2).
2	Polonium	MESH:D011059	inhibits		MESH:D008070	Phenotype	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Previously, we reported that intraperitoneal injection of LPS caused obvious liver and lung damage in mice, while intravenous injection of PO could attenuate LPS-elicited liver and lung damage[24].
2	Polonium	MESH:D011059	activates		MESH:D008070	Phenotype	a329c522-3513-11e8-8f56-001a4a160175	26522339	Administering LPS increases PO activity and resistance against virus, and improves the survival of shrimp at postVibrio harveyichallenge (Takahashi et al., 2000; Rungrassamee et al., 2013).
2	Polonium	MESH:D011059	inhibits		MESH:D008070	Phenotype	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	PO decreases the expression of Pro-IL-1β in trophoblasts HTR-8 cells were treated with LPS 1 μg/ml for 4 h and ATP for 30 min to activate NLRP3 inflammasome.
2	Polonium	MESH:D011059	activates		MESH:D008070	Phenotype	30258594-e9e7-11ef-999a-0050569a1f61	10.1016/j.foodchem.2024.141082	PO-glycation also induces LPS-stimulated inflammation by suppressing the gene expression ofcd14, thereby enhancing the suppressive effect of Mf on the TLR4-MyD88-dependent inflammatory signaling pathway.
2	Polonium	MESH:D011059	activates		GO:0071897	Phenotype	4ffc2404-29b6-11f0-b759-0050569a791b	10.1016/j.cnr.2004.09.015	The nuclear fraction is of interest because PO has been shown to play a role in DNA replication—PO inhibitors block DNA synthesis and cell replication in insect cells (Sacraphaga peregrineor flesh fly)[68]and mouse 3T3 cells[23].
2	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	6914a40a-352d-11e8-b868-001a4a160176	29069630	In our study, twelve serum metabolites that were significantly changed, between normal and PO-induced hyperuricemic mice, were identified.
2	Polonium	MESH:D011059	inhibits		MESH:D051379	Phenotype	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	Interestingly, PO prevents the molecular activities downstream of inflammasome activation in mice and human-derived macrophages.
2	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	38f07ece-374f-11e8-8636-001a4a160175	28013186	PO and PT also protected against ethanol-induced gastric damage in mice, as revealed by several different assays.
2	Polonium	MESH:D011059	inhibits		MESH:D051379	Phenotype	e7fb94b8-de09-11e5-be6f-001a4ae51246	26907623	3A, acute administration of NCX1404 at 19, 63, and 190μmol/kg, PO, (7.1, 23.7, and 71 mg/kg) reduced mechanical allodynia in a time- and dose-dependent fashion (PWTNCX1404_60 min= 2.6 ± 0.2 g, 3.9 ± 0.3 g, and 4.6 ± 0.2g for 19, 63, and 190μmol/kg, PO, of NCX1404, respectively) versus vehicle (PWTVehicle_60 min= 1.3 ± 0.2 g) in STZ-induced PDN mice model.
2	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	7c401fcc-ab87-11e6-9236-001a4ae51247	PMC4651813	However, PO-induced impairment of FA utilization was attenuated in PPARα+/−mice (Figure 2A), in which PO-induced downregulation of the imperfect DR1 group of genes was normalized (Figure 1A; Figure IIA in the Data Supplement).
2	Polonium	MESH:D011059	activates		MESH:D051379	Phenotype	6a5b72f6-bc2d-11e5-8d2d-001a4ae51247	PMC4665888	oldhamiileaf extract in PO-induced hyperuricemic mice.
2	Polonium	MESH:D011059	activates		GO:0006915	Phenotype	10841c60-bbf6-11e5-8abe-001a4ae51246	PMC3139501	Evaluation of the Critical Pathway of Apoptosis Induced by PO and VV subsection To evaluate the critical pathway of apoptosis induced by the protein extracts of PO and VV, an extract concentration of 10μg mL−1was used.
2	Polonium	MESH:D011059	activates		GO:0008219	Phenotype	5b29557c-bbfc-11e5-8abe-001a4ae51246	10.1016/j.pep.2012.01.021	Furthermore, human PO expression is upregulated by the tumor suppressor p53 protein, inducing cell death pathways and helping to prevent cancer progression[15].
2	Polonium	MESH:D011059	inhibits		GO:0008219	Phenotype	2530fa56-c480-11e5-a92e-001a4ae51246	PMC2847010	Collectively, our present findings suggest that the lipokine PO attenuates saturated FFA-induced cell death in hepatocytes by inhibiting ER stress-associated dysregulation of pro-apoptotic Bcl-2 proteins.
2	Polonium	MESH:D011059	inhibits		GO:0006954	Phenotype	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	PO inhibits inflammation in trophoblasts Next, we validated the protective role of PO in trophoblasts of placental origin, affected during MO (36).
2	Polonium	MESH:D011059	increases		MESH:D003094	Phenotype	9defda32-3906-11e8-9192-001a4a160175	PMC5909408	CSD Inhibits PO-Induced FibrosisIn Vivo Fibrosis in TAC-induced PO was determined in terms of the levels of collagen and the collagen chaperone HSP47 (which has frequently been used as a surrogate marker for collagen) in the LV by western blotting, by IHC for HSP47, and by Picrosirius Red Staining for collagen (Figure 1).
2	Polonium	MESH:D011059	inhibits		GO:0035148	Phenotype	353aaed4-bc37-11e5-8d2d-001a4ae51247	PMC2925949	In summary, we demonstrated that PO inhibited bFGF-stimulated proliferation, migration, tube formation in human endothelial cells and also disruptedin vivoneovascularization.
2	Polonium	MESH:D011059	activates		GO:1990523	Phenotype	f749957c-5cd5-11e7-bcb7-001a4ae51246	PMC4641003	Thus, a Wnt-based therapy may not directly target the PO, but may indirectly enhance PO-mediated bone regeneration.
2	Polonium	MESH:D011059	activates		GO:0007165	Phenotype	30258594-e9e7-11ef-999a-0050569a1f61	10.1016/j.foodchem.2024.141082	Effect of PO-glycation on LPS-stimulated signaling pathway in macrophages The effects of Mf and Mf-PO on the LPS-stimulated signaling pathway in macrophages were investigated to clarify the molecular mechanism of the enhanced anti-inflammatory effect of Mf by PO-glycation.
2	Polonium	MESH:D011059	inhibits		GO:0045453	Phenotype	14ed1fda-c797-11ee-9aaa-0050569a1f61	10.1016/j.lfs.2023.121611	Thus, we hypothesized that PO may inhibit breast cancer-induced bone resorption by acting on these signaling molecules.
2	Polonium	MESH:D011059	inhibits		MESH:D010146	Phenotype	57cde206-bbf5-11ee-9d3b-0050569a791b	10.1007/s40140-019-00340-1	A subsequent trial in opioid-addicted human patients undergoing minor surgery found that carbamazepine 400 mg PO given 2 h before surgery decreased pain behaviors and VAS pain scores at 12 h postoperatively, and blunted serum IL-6 levels (an inflammatory marker) to levels comparable to the opioid-naïve patients [64].
2	Polonium	MESH:D011059	inhibits		MESH:D008697	Phenotype	70a10938-c99d-11ee-8b99-0050569a1f61	10.1016/j.jenvman.2022.116519	The accumulative methane yield of the CC is more than four time of the yield of the PO + CC, showing that the biotoxicity of the PO reduces the methane yield.
2	Polonium	MESH:D011059	activates		MESH:D013481	Phenotype	cd92c582-bc54-11e5-9b9d-001a4ae51247	10.1016/S1532-0456(02)00123-0	Hydrogen peroxide, in turn, originates from dismutation of the superoxide anions produced in the course of the oxidation ofo-quinones by PO.
2	Polonium	MESH:D011059	inhibits		GO:0016049	Phenotype	6b2eeab8-1a61-11f0-b759-0050569a791b	10.1016/j.sajb.2024.10.017	At a later stage, PO activity decreases, which in turn facilitates cell expansion and growth (Zhang et al., 2017).
2	Polonium	MESH:D011059	activates		MESH:D009202	Phenotype	25b72a15-dc39-11ea-a26b-001a4a160175	PMC6502694	Genetic ablation of cardiomyocyte GSK-3α protects against chronic PO-induced cardiomyopathy and adverse LV remodeling, and preserves contractile function.
2	Polonium	MESH:D011059	activates		MESH:D003932	Phenotype	325e4efa-5c9f-11e7-9fde-001a4ae51247	PMC4767561	Growing evidence also suggests that illicit PO use has expanded pathways to heroin initiation and contributed to the heroin epidemic in the United States.
2	Polonium	MESH:D011059	inhibits		MESH:D003932	Phenotype	7b9d3d14-3904-11e8-87fd-001a4a160176	PMC5722230	The implication of these findings is that the reduction in access or relative desirability of PO for non-medical use has led to an increase in the number of individuals using heroin and thus responsible for the increase in heroin-related harm.
2	Polonium	MESH:D011059	decreases		MESH:D007052	Phenotype	8b9fdb66-5c34-11e7-8c5f-001a4ae51246	PMC5243980	In another study, Abbaspour,et alalso reported that although addition of Eudragit RS PO and/or RL PO reduced the rate of ibuprofen release from pellets, but did not eliminate the need for coating (19).
2	Polonium	MESH:D011059	inhibits		MESH:D009325	Phenotype	013d4760-04c9-11f0-bb39-0050569a791b	10.1016/j.anl.2024.07.009	As a sedative, it is possible that dexmedetomidine could have caused excessive sleepiness and thus reduced PO, although given that dexmedetomidine has also been shown to decrease postoperative pain and nausea, it could have contributed to increased PO.
2	Polonium	MESH:D011059	activates		MESH:D008543	Phenotype	5d73ed6a-1a39-11f0-b759-0050569a791b	10.1016/j.aquaculture.2024.741347	PO induces melanin production and actives secondary metabolites, while inhibits extracellular cell and chitinase activity of pathogens.
2	Polonium	MESH:D011059	activates		MESH:D008543	Phenotype	347299c6-bc2d-11e5-8d2d-001a4ae51247	PMC2077082	sextahemolymph or baculovirus-infected insect cells, we demonstrated how recognition of a pathogen-associated molecular pattern (β-1,3-glucan) leads to a host defense response (melanization): binding of curdlan andβGRP2 triggers the autoactivation of proHP14 (Wang and Jiang, 2006), HP14 processes proHP21, HP21 cleaves proPAP-2, PAP-2 activates proPO in the presence of SPHs (Fig. 7), and PO produces quinones and melanin.
2	Polonium	MESH:D011059	activates		MESH:D008543	Phenotype	842ca890-3402-11e8-b868-001a4a160176	26899630	Activation of the proPO system by pattern-recognition proteins is by the specific recognition of microorganisms (PRPs), triggers a serine proteinase cascade, eventually leading to the cleavage of the inactive proPO to the active PO that functions to produce the melanin and toxic reactive intermediates against invading pathogens.
2	Polonium	MESH:D011059	activates		MESH:D008543	Phenotype	b6b53182-1a83-11f0-a2ca-0050569a1f61	10.1016/j.dci.2024.105251	PO catalyzes melanin production, which plays a crucial role in the bactericidal process (González-Santoyo and Córdoba-Aguilar, 2012).
2	Polonium	MESH:D011059	activates		MESH:D008543	Phenotype	b346e5be-bc13-11e5-8abe-001a4ae51246	10.1016/j.anireprosci.2005.05.034	This leads to an increase in the activity of the pro-PO system, which in turn increases the melanin production.
2	Polonium	MESH:D011059	activates		MESH:D008543	Phenotype	730d6458-e9e7-11ef-b449-0050569a791b	10.1016/j.aquaculture.2024.741414	PO as one of the key enzymes can lead to melanin production, helping the host cell eliminate of pathogens (Chen and Lu, 2018;Ferrandon et al., 2004;Kavanagh and Reeves, 2004).
2	Polonium	MESH:D011059	activates		MESH:D006331	Phenotype	99e53448-0026-11f0-9c09-0050569a791b	10.1016/j.yjmcc.2024.12.009	Pressure overload (PO) stress, which results clinically from aortic valve stenosis or systemic hypertension, is routinely modeled in mice to elicit heart disease.
2	Polonium	MESH:D011059	activates		MESH:D020246	Phenotype	2cfb9a77-7f6f-11ea-8181-001a4a160175	10.1016/b978-1-4557-0892-5.00018-0	• Clopidogrel (Plavix), 4 mg/kg PO q24h on day 1 and 2 mg/kg PO q24h on subsequent treatments may inhibit platelet activation and may decrease the likelihood of laminitis and colon and jugular venous thrombosis; the absorption of the drug in horses with colitis is unknown.
2	Polonium	MESH:D011059	activates		MESH:D019308	Phenotype	cc542772-1a48-11f0-b759-0050569a791b	10.1016/j.aninu.2024.04.024	In the present study, the SO diet increased C18:2 and C18:3 PUFA in the breast muscle, while LO, PO diets increased C16:0 and C18:0 and BO diets increased C16:1 and C18:1, indicating that the fatty acid composition of chicken meat reflects dietary fatty acid composition.
2	Polonium	MESH:D011059	inhibits		GO:0036269	Phenotype	994a7792-1b4b-11f0-b759-0050569a791b	10.1016/j.pestbp.2024.105961	Likewise, our previous studies found that PO exposure induced a series of embryonic deformities (such as yolk sac oedema and pericardial oedema), and inhibition of free swimming behavior in zebrafish larvae (Qian et al., 2019).
2	Polonium	MESH:D011059	activates		FPLX:Phosphatase	ProteinFamily	26377956-001d-11f0-9c09-0050569a791b	10.1016/j.foreco.2024.122434	Studies have confirmed that the presence of high concentrations of available Pi inhibits phosphatase activity, while the presence of the substrate Po induces phosphatase activity (Allison et al., 2010; Nakayama et al., 2021).
2	Polonium	MESH:D011059	activates		PF:PF05384	ProteinFamily	b58ad454-c67b-11ee-b346-0050569a791b	10.1016/j.aquaculture.2023.740147	PO up-regulates DEGs in the cluster 1 dynamically and with balance to exert anti-SA effects.
2	Polonium	MESH:D011059	activates		FPLX:G:i	ProteinFamily	7b1ea3fc-bc27-11e5-8abe-001a4ae51246	10.1016/j.phymed.2004.10.005	PO caused the typical GI effects like heartburn (n=14) and anal/perianal burning or discomfort sensations (n=26), whereas the anticholinergics caused dry mouth (n=21) and blurred vision (n=14).
2	Polonium	MESH:D011059	activates		PF:PF00720	ProteinFamily	c4da2f96-3387-11e8-bf76-001a4a160175	27810207	PO colic can increase SSI through surgical site trauma associated with rolling/recumbency, tension associated with abdominal distension, and prolonged withholding of feed could influence wound healing and immunity.
2	Polonium	MESH:D011059	activates		PF:PF06392	ProteinFamily	8d11ae44-bc3e-11e5-8abe-001a4ae51246	10.1016/S0306-4522(02)00710-8	The behavioral data secured in the startle paradigm clearly reveal that exposure of CD-1 mice to PO enhanced ASR for up to 1 week following odor presentation.
2	Polonium	MESH:D011059	activates		PF:PF00141	ProteinFamily	1ccd52fc-8842-11f0-afc2-0050569a791b	10.1016/j.cpb.2020.100151	Activity of Peroxidase (PO) The data presented inTable 4indicated that application of all the IR chemicals significantly increased the peroxidase activity up to six days of challenge inoculation at different 5, 10, 15- and 20-days interval withUromyces appendiculatusand declined thereafter.
2	Polonium	MESH:D011059	activates		FPLX:OR	ProteinFamily	5c5d124e-1b56-11f0-b759-0050569a791b	10.1016/j.prevetmed.2024.106208	The increase of PO and DIM increases the OR of a cow having SCM, whereas the increase in MF and MY indicates a protective effect on it.
2	Polonium	MESH:D011059	inhibits		FPLX:Protease	ProteinFamily	0cee422a-455c-11f0-86f5-0050569a1f61	10.1016/j.fsi.2022.04.046	After the crab hemocytes serine protease was knockdown by RNA interference, the activity of PO and the survival rate ofE.
2	Polonium	MESH:D011059	activates		FPLX:Protease	ProteinFamily	8fc21802-0cc7-11f0-b40b-0050569a1f61	10.1016/S1095-6433(00)00163-X	Smith and Peddie (1992)have shown that in the solitary tunicateCiona intestinalisthe morula cells are the principal repositories of the phenoloxidase (PO) activating serine protease.
2	Polonium	MESH:D011059	inhibits		FPLX:PKA	ProteinFamily	21dcc9c2-cd1b-11e5-85cd-001a4ae51247	8789956	PKA-Mediated Regulation of NMDA Receptor Po These experiments provide evidence that the amplitude of NMDA receptor–mediated EPSCs in hippocampal neurons is regulated by PKA, since cycling of the test EPSC from high amplitude (T+) to low amplitude (T−) can be blocked by inhibiting PKA with PKI.
2	Polonium	MESH:D011059	inhibits		PF:PF00683	ProteinFamily	4e23648e-bbee-11e5-9b9d-001a4ae51247	10.1016/j.brainres.2004.10.003	Actually, dopamine is one of the most important thermoregulatory neurotransmitters, and it is accepted that increasing PO dopamine concentrations causes reduction of Tb in mammals[13].
2	Polonium	MESH:D011059	activates		PF:PF00683	ProteinFamily	cb3de090-351b-11e8-8f56-001a4a160175	PMC5832504	However, our previous data generated from 2 PO BCG dose escalation trials demonstrated that PO BCG can induce TB-specific sIgA responses.9,17These results indicate that PO BCG can uniquely induce mucosal immune responses relevant for TB immunity.
2	Polonium	MESH:D011059	dephosphorylatesProtein		FPLX:ERK	ProteinFamily	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	In addition, PO also prevented the activation of JNK and ERK phosphorylation with LPS + PA treatment conditions.
2	Polonium	MESH:D011059	dephosphorylatesProtein		FPLX:JNK	ProteinFamily	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	In addition, PO also prevented the activation of JNK and ERK phosphorylation with LPS + PA treatment conditions.
2	Polonium	MESH:D011059	activates		FPLX:GSK3	ProteinFamily	fbfa8fe8-352b-11e8-9192-001a4a160175	27339326	Cardiac-specific overexpression TRAF2 mice show enhanced PO-mediated cardiac hypertrophy and dysfunctionviathe activation of Akt/GSK3β[194].
2	Polonium	MESH:D011059	activates		IP:IPR028651	ProteinFamily	69b36ed8-0040-11f0-9c09-0050569a791b	10.1016/j.envpol.2024.125413	Among the investigated physiological responses, the activities of catalase and PO enzymes increased inG.
2	Polonium	MESH:D011059	inhibits		IP:IPR028651	ProteinFamily	13a698c6-bbdf-11e5-8abe-001a4ae51246	10.1016/j.jinsphys.2006.10.012	Our data indicate that BHSV-1 challenge stimulates PO activation and the activation is attenuated inG.
2	Polonium	MESH:D011059	inhibits		IP:IPR002042	ProteinFamily	d4159aa6-3402-11e8-87fd-001a4a160176	26344851	PO is a widely used reagent to induced HUA in rodents because PO can block uricase that degrades uric acid to allantoin (Wu et al., 2014).
2	Polonium	MESH:D011059	activates		FPLX:IL12	ProteinFamily	721c9e74-377e-11e8-9fbf-001a4a160176	10591154	To determine whether cytokine responses followed the same pattern as proliferation, the ability of the two sets of Po and Ps compounds to induce IL-6 and IL-12 was tested.
2	Polonium	MESH:D011059	activates		IP:IPR001267	ProteinFamily	b392afc4-392c-11e8-a51f-001a4a160176	9385398	Forward mutations induced by PO at the thymidine kinase locus were studied in cultures of L5178Y clone 3.7.2C mouse lymphoma cells in the presence of 5-trifluorothymidine and S9 mix.
2	Polonium	MESH:D011059	inhibits		FPLX:p38	ProteinFamily	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	MAPK p38 is a known regulator of NF-κB and supplementation of PO prevents the activation of p38 (43–46).
2	Polonium	MESH:D011059	inhibits		PF:PF12338	ProteinFamily	7b222a14-352d-11e8-a51f-001a4a160176	29028485	Overall, our result revealed that the PO reaction product highly disrupts the membrane of RBCs.
2	Polonium	MESH:D011059	activates		FPLX:AKT	ProteinFamily	fbfa8fe8-352b-11e8-9192-001a4a160175	27339326	Cardiac-specific overexpression TRAF2 mice show enhanced PO-mediated cardiac hypertrophy and dysfunctionviathe activation of Akt/GSK3β[194].
2		UNIPROT:P10275	activates	Polonium	MESH:D011059	Protein	8b7ce9fc-bc45-11e5-8d2d-001a4ae51247	10.1016/j.molbrainres.2004.03.009	The block of androgen receptor with flutamide inhibits the synthesis of Po, but not that of PMP22 In order to evaluate the possible role of AR on the synthesis of Po and PMP22 we have analyzed, in intact animals, the effect of flutamide, a classical antagonist of this steroid receptor.
2		UNIPROT:P20366	activates	Polonium	MESH:D011059	Protein	a03c3bdc-c6f9-11ee-b346-0050569a791b	10.1016/j.scitotenv.2023.165916	In sweetpotato season soil, compared to the CK treatment, the NPK and NPKM treatments significantly increased the content of labile Po (L-Po), while the NK, NPK, and NPKM treatments had higher moderately labile Po (ML-Po).
2		UNIPROT:P08865	activates	Polonium	MESH:D011059	Protein	ff5a1188-8997-11ee-add2-0050569a791b	10.1007/s40858-022-00500-5	The lethal dose of SA initiated high mitochondrial ROS causing mitochondrial dysfunction and depolarization of membrane potential leading to cell death in plant tissues (Poór143).
2		MESH:D013629	inhibits	Polonium	MESH:D011059	Phenotype	a31f0a80-ca01-11e5-9b70-001a4ae51247	15826942	Tamoxifen diminished the Po maxfrom 0.75 ± 0.06 to 0.24 ± 0.02.
2		FPLX:Sulfonylurea:receptor	activates	Polonium	MESH:D011059	ProteinFamily	3c0c7ca0-c476-11e5-a92e-001a4ae51246	PMC4699857	In addition to conferring sensitivity to Mg-nucleotide activation, SUR enhances the unliganded channel open probability (Po) and increases the affinity for ATP block (5).
2		UNIPROT:Q14654	inhibits	Polonium	MESH:D011059	Protein	9bc2d3fe-bc49-11e5-ac4e-001a4ae51246	PMC2234474	Deletion of the NH2terminus of Kir6.2 has been shown to increase the opening probability (Po) of the heteromeric KATPchannels without affecting the Po of the ΔNKir6.2Δ25 (Koster et al. 1999.J Physiol.515:19–30).
2		PF:PF00089	activates	Polonium	MESH:D011059	ProteinFamily	2fb9ebe2-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2006.06.014	Trypsin enhances PO activity in a more efficient way than LPS or β-glucans (laminarin and zymosan) inC.
2		UNIPROT:P42261	activates	Polonium	MESH:D011059	Protein	98ad1552-bbd7-11e5-8abe-001a4ae51246	10.1016/j.ejcb.2006.01.010	In particular, PKA phosphorylation of Ser845 on the GluR1 subunit increases AMPAR open probability (Po) and helps stabilize AMPARs recruited to synapses during LTP through high Ca2+stimulation of calcium-calmodulin-dependent protein kinase II (CaMKII)-driven exocytosis (Banke et al., 2000;Esteban et al., 2003;Hayashi et al., 2000;Lee et al., 2003).
2		MESH:D007978	activates	Polonium	MESH:D011059	Phenotype	2928ccda-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2005.10.010	Therefore, LPS, glucan, levamisole, sodium alginate and Lf added to the diet can trigger the PO activity indicating an increase in immune ability.
2		MESH:D005442	activates	Polonium	MESH:D011059	Phenotype	0027d360-376a-11e8-b868-001a4a160176	9300626	Flumazenil (6 μmol/kg IP), an antagonist of GABAAreceptors, had no significant effect on cGMP in nonstressed mice, but pretreatment with flumazenil significantly blocked U-101017 (10 μmol/kg PO)-induced reductions in cGMP (Table 3).
2		CHEBI:25016	activates	Polonium	MESH:D011059	Chemical	9e1a6ce2-f588-11eb-941a-001a4a160176	30840922	The observations of the present study indicated that a low concentration of Pb could activate the pro-PO system and promote PO activity, whereas stress induced by long-term exposure to a high concentration of Pb could inhibit the synthesis and release of pro-PO, resulting in a decrease in PO activity after an initial brief increase.
2		UNIPROT:P21817	activates	Polonium	MESH:D011059	Protein	4ef015b8-bc31-11e5-ac4e-001a4ae51246	10.1016/j.abb.2006.03.001	Cytosolic Mg2+may also be involved in the regulation of RyR1 by SR luminal Ca2+: in isolated SR Ca2+channels, increasing [Ca2+] at the luminal face of RyR1 induces an increase in the open probability (Po)[21].
2		UNIPROT:P21817	activates	Polonium	MESH:D011059	Protein	795d0b84-c8df-11e5-9624-001a4ae51246	16737973	Consecutive additions of 4-CmC to the cytoplasmic (cis) face of RyR1 increased the Po from its resting level of 0.073 to 0.341 (25 μm4-CmC) and 0.549 (50 μm4-CmC;Fig. 8A).
2		UNIPROT:Q92736	activates	Polonium	MESH:D011059	Protein	f402c0da-3936-11e8-a34b-001a4a160175	16701909	They found that the CAMKII-dependent RyR2 phosphorylation increases the Po of RyR2 and activates SR-Ca2+-release during diastole and systole.
2		MESH:D063386	inhibits	Polonium	MESH:D011059	Phenotype	d439ad80-c46d-11e5-a92e-001a4ae51246	PMC4448943	We previously reported that signs of cholinergic toxicity in rats following acute PO exposure were reduced by the cannabinoid receptor agonist WIN 55,212-2 (Nallapaneni et al., 2006).
2		MESH:D010664	activates	Polonium	MESH:D011059	Phenotype	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	Phenoloxidase inhibition Both CPIC and PMSF inhibited PO activity significantly (p<0.05) relative to hemocytes prepared in the absence of inhibitors (Fig. 3).
2		MESH:D013395	activates	Polonium	MESH:D011059	Phenotype	bfd84284-cc10-11e5-83a8-001a4ae51246	9684865	Our results demonstrate that sugar phosphates increase the open probability (Po) of the sheep cardiac RyR in the following order of potency: fructose-1,6-diphosphate (FDP)>glucose-1-phosphate (G-1-P)>fructose-6-phosphate (F-6-P)>glucose-6-phosphate (G-6-P)=inorganic phosphate (Pi) and raise the possibility that glycolytic intermediates may play a novel regulatory role in controling SR Ca2+release under physiological and pathophysiological conditions.
2		MESH:D006863	activates	Polonium	MESH:D011059	Phenotype	e2a974aa-c8e5-11e5-9ad8-001a4ae51247	17693413	Somewhat surprisingly, a decrease in pHito 6.2 shifted the common gating curve for the His-847 → Arg mutant to more negative voltages, whereas both low and high pHi(pH 7.9) increased the minimum Po(Fig. 5CandTable 1), reversing the effects of pH changes in wt ClC-1.
2		MESH:D006863	activates	Polonium	MESH:D011059	Phenotype	9bc2d3fe-bc49-11e5-ac4e-001a4ae51246	PMC2234474	Using excised inside-out membrane patches from C127 cells expressing wild-type human CFTR, we found that intracellular pH (pHi) modulates CFTR activity with alkaline pHidecreasing open-probability (Po) and acid pHiincreasing Po.
2		FPLX:TAC	activates	Polonium	MESH:D011059	ProteinFamily	cce3a568-3513-11e8-8636-001a4a160175	26582465	Pressure-overload (PO) hypertrophy induced by transverse aortic constriction (TAC) in mice leads to increased collagen accumulation, increased SPARC, and increased myocardial stiffness.
2		MESH:D000431	inhibits	Polonium	MESH:D011059	Phenotype	2bf6998e-883b-11f0-9ac3-0050569a1f61	10.1016/j.energy.2020.118201	The addition of alcohol fuel prevents the polymerization of PO and has the added benefit of compensating for its inadequate fuel properties, such as acidity, lower energy density, and higher viscosity [17].
2		IP:IPR004993	activates	Polonium	MESH:D011059	ProteinFamily	a135d6ac-c481-11e5-9cc6-001a4ae51246	PMC3383457	Finally, CLR-depletion of GH3 pituitary tumor cell membranes leads to increased BK Po without altering unitary current amplitude (Lin et al., 2006).
2		MESH:D000109	activates	Polonium	MESH:D011059	Phenotype	189f0f2a-bbdf-11e5-9b9d-001a4ae51247	10.1016/j.jinsphys.2008.08.003	Our preliminary observation suggests that application of acetylcholine (Ach) which is thought to convey olfactory information from the antennal lobes to the mushroom body Kenyon cells (Kreissl and Bicker, 1989) increases the Po of Ca2+channels.
2		UNIPROT:P12931	inhibits	Polonium	MESH:D011059	Protein	4f9c0d00-eddc-11e5-872c-001a4ae51246	26275828	Because it has been previously demonstrated that Src reduces the open probability (Po) of Q2–Q3 heteromeric channels in CHO cells (Li et al., 2004), we performed single-channel recordings in oocytes expressing either Q2 (Fig. 2A) or Q3 (Fig. 2B), with or without Src, at a saturating voltage of 0 mV, using the cell-attached configuration of the patch-clamp technique, as previously described (Etzioni et al., 2011).
2		UNIPROT:O43150	activates	Polonium	MESH:D011059	Protein	00a9df76-1b98-11f0-b40b-0050569a1f61	10.1016/j.jia.2023.05.002	As an important APase, PAP can promote the utilization of Po by plants through secretion and activation, which can improve the ability of plants to withstand phosphorus deficiency stress.
2		MESH:D003345	increases	Polonium	MESH:D011059	Phenotype	47954558-bc46-11e5-8d2d-001a4ae51247	10.1016/S0014-4886(03)00338-8	As shown byDèsarnaud et al. (2000), using Schwann cells transiently transfected with a reporter construct in which the luciferase expression is controlled by the promoter region of the Po, dexamethasone and corticosterone are able to stimulate Po expression.
2		MESH:D011059	activates	Polonium	MESH:D011059	Phenotype	4d041ed2-bc2e-11e5-8abe-001a4ae51246	10.1016/j.bmc.2006.12.038	8 An attractive theory states that interaction between PO and ORF378 is mediated by the accommodation of Tyr98in the substrate-binding pocket of PO.
2		MESH:D005936	inhibits	Polonium	MESH:D011059	Phenotype	0b1b7b0c-45a2-11f0-afc2-0050569a791b	10.1016/j.dci.2022.104360	The results reveal that LPS or β-1,3 glucan with FmClipSP effectively induces the proPO system, whereas LTA inhibits PO activity.
2		MESH:D005936	activates	Polonium	MESH:D011059	Phenotype	2928ccda-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2005.10.010	Therefore, LPS, glucan, levamisole, sodium alginate and Lf added to the diet can trigger the PO activity indicating an increase in immune ability.
2		MESH:D006221	activates	Polonium	MESH:D011059	Phenotype	bb8b88b6-bc17-11e5-9b9d-001a4ae51247	PMC1302873	Namely, enflurane and halothane were shown to induce a dehydration of both the PO group and the CO group of the glycerol backbone of DMPC bilayers by breaking the hydrogen bonding (Tsai et al., 1990).
2		UNIPROT:P84077	activates	Polonium	MESH:D011059	Protein	f54452e6-5c29-11e7-b441-001a4ae51247	PMC5427928	Both ARF1 knockdown andasrijnull mutant larvae showed similarly increased PO activity (4 fold above control), which was completely restored by ARF1 overexpression but only partially restored (2 fold above control) upon Asrij over-expression (Figs1Hand2H).
2		UNIPROT:P50336	activates	Polonium	MESH:D011059	Protein	cd8456d2-1bf4-11f0-85c3-0050569a1f61	10.1016/j.aspen.2023.102194	The study demonstrated that AKH Ⅰ has the ability to activate PPO which results in the production of PO in fungal cell walls or spores.
2		UNIPROT:P20396	activates	Polonium	MESH:D011059	Protein	a4e66b0e-bbee-11e5-9b9d-001a4ae51247	10.1016/j.brainres.2005.01.040	In conclusion, TRH-induced non-shivering thermogenesis was probably mediated by TRH-R1 in the DMH, PO, AH and VMH irrelevant of T3.
2		UNIPROT:P80888	activates	Polonium	MESH:D011059	Protein	4ace0fd4-bc50-11e5-8d2d-001a4ae51247	10.1016/j.it.2008.02.009	A physiological role for hemocyanin-produced PO still remains to be firmly established, because, at least in arthropods possessing blood cell–derived PO, hemocyanin catalysed PO activities are exceedingly small in comparison[13].
2		MESH:D010433	activates	Polonium	MESH:D011059	Phenotype	ce6a59a4-bc39-11e5-8abe-001a4ae51246	10.1016/j.eplepsyres.2005.11.001	Pregabalin prevented clonic forelimb seizure activity in mice caused by pentylenetetrazole with an ED50dose of 31mg/kg PO (Table 2).
2		UNIPROT:B0YJ81	activates	Polonium	MESH:D011059	Protein	537fbfbc-0523-11f0-bb39-0050569a791b	10.1016/j.aquaculture.2024.740962	Similar results were observed in the current study, where dietary CAP increased the activities of AKP, AST, ALT, CAT, PO and LYS in the hepatopancreas of L.vannamei, and most of them were significantly different at high stocking densities.
2		CHEBI:29103	activates	Polonium	MESH:D011059	Chemical	a29d5f16-bbed-11e5-9b9d-001a4ae51247	10.1016/j.neuint.2006.12.001	We showed that micromolar Cu2+added to the extracellular side of the high-conductance calcium activated potassium (BKCa) channel induced a time and concentration dependent decrease of its open time probability (Po).
2		MESH:D014357	activates	Polonium	MESH:D011059	Phenotype	4b0a922e-352a-11e8-87fd-001a4a160176	25592878	Firstly, trypsin activates precursor form of PO forming an intermediate form substance, and then it is activated through forming a calcium-activated phenol oxidase tetramer[20].
2		MESH:D014357	activates	Polonium	MESH:D011059	Phenotype	2fb9ebe2-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2006.06.014	For the acellular fraction, the addition of trypsin significantly enhanced the PO-like activity for incubation from 4h to 24h.
2		PF:PF00141	inhibits	Polonium	MESH:D011059	ProteinFamily	359c26e6-3953-11e8-b868-001a4a160176	10556561	Modification of peroxidase Reduction of the PO as prepared by sodium dithionite resulted in elimination of all EPR signals except for the signal from the free radical which, in contrast, increased significantly (data not shown).
2		PF:PF00141	activates	Polonium	MESH:D011059	ProteinFamily	b7a379f2-bc17-11e5-9b9d-001a4ae51247	PMC1302594	Here we first study experimentally the PO reaction catalyzed by horseradish peroxidase enclosed in liposomes while the substrates NADH and O2are continuously supplied to the external medium.
2		MESH:D005665	activates	Polonium	MESH:D011059	Phenotype	ba87e594-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.jvc.2008.09.004	Furosemide dose was increased to 2mg/kg PO in the morning and 1mg/kg PO in the afternoon.
2		UNIPROT:P00738	activates	Polonium	MESH:D011059	Protein	93a092f4-ea04-11ef-999a-0050569a1f61	10.1016/j.fsi.2024.110059	Additionally, supplementation of HP astaxanthin significantly elevated immunoglobulin M levels in Asian seabass (Lates calcarifer) and enhanced THC, PO, and LYZ activity inL.
2		MESH:D002118	activates	Polonium	MESH:D011059	Phenotype	842ca890-3402-11e8-b868-001a4a160176	26899630	Calcium-mediated PO activity enhancement has been reported for a variety of insect species such asBombyx mori[32],Schistocerca gregaria[33],Blaberus craniifer[34],Locusta migratoria[35],Lymantria disparand Galleriamellonella[36].
2		UNIPROT:Q6PJF5	activates	Polonium	MESH:D011059	Protein	3d92a57c-3c7b-11f0-afc2-0050569a791b	10.1016/j.jwpe.2022.102900	Previous studies reported that removal efficiencies of COD[9], total organic carbon (TOC)[10]and NH4+-N[11]were enhanced by using PO aeration in the aerobic process.
2		CHEBI:35223	activates	Polonium	MESH:D011059	Chemical	75da5416-1a4d-11f0-aa93-0050569a1f61	10.1016/j.jece.2024.114793	The catalyst also enhanced TP content in HAK by forming stable compounds like apatite or Ca₃(PO₄)₂, improving the efficacy of slow-release fertilizers.
2		MESH:D003553	activates	Polonium	MESH:D011059	Phenotype	2084a2ac-f579-11eb-8f4e-001a4a160176	32757125	**Indicates ANOVA contrastp-value =p≤ 0.05 Cystine levels are also slightly elevated in PO vs. O samples (p≤ 0.05), and in PO vs. H albeit not significantly (Fig.3a, c) (Table1).
2		UNIPROT:P08246	activates	Polonium	MESH:D011059	Protein	186b2bb2-bc50-11e5-ac4e-001a4ae51246	10.1016/j.jtherbio.2004.12.001	In the PO, NE increased only in the early phase (3H) after the start of cold exposure and then returned to its control level throughout the subsequent cold acclimation period.
2		FPLX:NADPH:oxidase	activates	Polonium	MESH:D011059	ProteinFamily	49308da6-bc31-11e5-9b9d-001a4ae51247	10.1016/j.abb.2004.07.019	The PO reaction will be initiated by NADPH oxidase, which will catalyze the oxidation of NADPH in the cytosol (this NADPH is in turn produced in the hexose monophosphate shunt)[36].
2		UNIPROT:P07911	increases	Polonium	MESH:D011059	Protein	47954558-bc46-11e5-8d2d-001a4ae51247	10.1016/S0014-4886(03)00338-8	In particular, we have demonstrated that in vivo treatment with progesterone (P) or its derivatives, dihydroprogesterone (DHP), which is formed from P by the action of the enzyme 5α-reductase, and tetrahydroprogesterone (THP), which is formed from DHP by the action of the enzyme 3α-hydroxysteroid dehydrogenase(Melcangi et al., 2001), are able to stimulate mRNA and protein levels of Po in the sciatic nerves of male rats(Melcangi et al., 1998a,b, 1999).
2		UNIPROT:P07911	increases	Polonium	MESH:D011059	Protein	7e81055e-bbe0-11e5-9b9d-001a4ae51247	10.1016/S0197-4580(02)00234-8	In particular, P, DHP and THP are able to increase Po expression, while THP seems to be able to specifically stimulate PMP22 expression[30,41].
2		CHEBI:2150	activates	Polonium	MESH:D011059	Chemical	8b7ce9fc-bc45-11e5-8d2d-001a4ae51247	10.1016/j.molbrainres.2004.03.009	The finding that DHT is able to stimulate the synthesis of Po may suggest an involvement of AR.
2		MESH:D005485	activates	Polonium	MESH:D011059	Phenotype	8b7ce9fc-bc45-11e5-8d2d-001a4ae51247	10.1016/j.molbrainres.2004.03.009	The block of androgen receptor with flutamide inhibits the synthesis of Po, but not that of PMP22 In order to evaluate the possible role of AR on the synthesis of Po and PMP22 we have analyzed, in intact animals, the effect of flutamide, a classical antagonist of this steroid receptor.
2		CHEBI:29036	activates	Polonium	MESH:D011059	Chemical	b0eb6b38-3749-11e8-bf76-001a4a160175	26184757	In vivostudies show that only the Cu(II)-H6A/H12A complex, 1hour after injection caused a significant increase in PO enzyme activity, when compared to control beetles.
2		MESH:D010919	activates	Polonium	MESH:D011059	Phenotype	8d316b7c-bc15-11e5-8abe-001a4ae51246	PMC3025927	Analysis of absolute and relative soleus Po demonstrated a significantly greater absolute Po in MI vehicle treated rats compared to sham vehicle treated rats; treatment with PG873637 resulted in a significantly greater absolute and relative sham (19% increase in absolute Po and 14% increase in relative Po) and MI (12% increase in absolute Po and 12% increase in relative Po) soleus muscle Po compared to vehicle treated rats.
2		MESH:D012749	increases	Polonium	MESH:D011059	Phenotype	2ccce8bc-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2004.05.003	The incubation of the humoral fluid with the serine protease inhibitors STI and p-NPGB, prior to reaction with trypsin, consistently reduced the levels of PO activity.
2		UNIPROT:P39664	activates	Polonium	MESH:D011059	Protein	a74b5ed4-3ab0-11e8-8f56-001a4a160175	24878742	ProPO-activating enzymes (PPAEs), serine proteinases (SPs) and serine proteinases homologs (SPHs) that activate the PO system are referred as prophenoloxiase activating factors (PPAFs)[3].
2		UNIPROT:P39664	activates	Polonium	MESH:D011059	Protein	7502a1a6-bbfc-11e5-9b9d-001a4ae51247	10.1016/j.pep.2004.10.011	Different from PO activity produced by PAP-1 and SPHs, PO generated in the fractionated larval hemolymph was stable at room temperature for at least 2h[29].
2		UNIPROT:P97534	activates	Polonium	MESH:D011059	Protein	f402c0da-3936-11e8-a34b-001a4a160175	16701909	The dissociation of calstabin2 from RyR2 increases the Po of RyR2, allowing an increase in SR-Ca2+release and causing an increase in intracytoplasmic Ca2+, thus augmenting cardiac contractility.
2		CHEBI:28794	activates	Polonium	MESH:D011059	Chemical	bd0787e2-3c70-11f0-afc2-0050569a791b	10.1016/j.fsi.2022.06.005	The PO activity of red claw crayfish increased significantly after coumarin treatment, illustrating that coumarin enhances PO activity even after WSSV infection, which is important for antiviral immunity.
2		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	In the current study, the addition of exogenous proteases (chymotrypsin and trypsin) increased PO activity when compared to non-activated samples.
2		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	18389ac6-bc0f-11e5-9b9d-001a4ae51247	10.1016/j.tcb.2005.10.001	On the other hand, SPN27A targets two distinct proteases, Easter in embryos and a PO-activating serine protease in adult flies.
2		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	32ee972e-3360-11e8-b868-001a4a160176	25584519	PO activation involves extracellular proteins such as hemolymph proteinases (HPs), which activate pro-phenoloxidase activating proteinases (PAPs), which then activate pro-PO enzymes in the presence of serine protease homologues (SPHs) (Ragan et al., 2009).
2		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	f43f7c92-338b-11e8-9192-001a4a160175	9877431	In arthropods, PO is present as a proenzyme inside granular cells and is activated by serine proteases which, in turn, are activated by foreign surface carbohydrates[7–9].
2		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	9e2a5292-ca00-11e5-9b70-001a4ae51247	PMC2047598	Thus, HP-14 is apparently a protease that can initiate the pro-PO activation cascade.
2		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	4fa1681c-bbf6-11e5-9b9d-001a4ae51247	10.1016/S1096-4959(03)00120-9	It is significant that the highest level of PO activity from separated granular hemocytes (B3), was reached after incubation with trypsin, suggesting that the pro-PO system is modulated by a serine protease-dependent mechanism as supported by the inhibitory effect of soybean trypsin inhibitor (Arizza et al., 1995; Cammarata et al., 1996, 1999).
2		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	5e54a8b2-bbf4-11e5-8abe-001a4ae51246	10.1016/j.cbpa.2006.02.042	PO is activated in situ by an endogenous serine protease and its activity is controlled by proteinase inhibitors (Cerenius and Söderhäll, 2004).
2		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	ce39d92e-3747-11e8-a51f-001a4a160176	26778205	PO is synthesized from the zymogen proPO after activation by serine proteases, which in turn are regulated by serpins (Leclerc and Reichhart, 2004; Kanost, 1999, Kanost et al., 2004; Bogus et al., 2007).
2		FPLX:Protease	activates	Polonium	MESH:D011059	ProteinFamily	2fb9ebe2-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2006.06.014	The stimulation of PO activity by trypsin, a serine protease, suggests that PO may be present in the acellular fraction of the haemolymph in the form of a pro-enzyme and required a proteolytic cleavage for activation.
2		MESH:D009569	activates	Polonium	MESH:D011059	Phenotype	f402c0da-3936-11e8-a34b-001a4a160175	16701909	NO synthesis by NOS1 increases the Po of the RyR2.
2		UNIPROT:P01584	activates	Polonium	MESH:D011059	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Effects of PO on the production of TNF-α, IL-6 and IL-1β in BALF of LPS-induced ALI mice To expose the anti-inflammatory effect of PO on mice with ALI, the levels of inflammatory cytokines TNF-α, IL-1β, and IL-6 were analyzed at 12h after LPS challenge by ELISA.
2		FPLX:PKA	activates	Polonium	MESH:D011059	ProteinFamily	21dcc9c2-cd1b-11e5-85cd-001a4ae51247	8789956	PKA-Mediated Regulation of NMDA Receptor Po These experiments provide evidence that the amplitude of NMDA receptor–mediated EPSCs in hippocampal neurons is regulated by PKA, since cycling of the test EPSC from high amplitude (T+) to low amplitude (T−) can be blocked by inhibiting PKA with PKI.
2		FPLX:PKA	activates	Polonium	MESH:D011059	ProteinFamily	dbfcf884-c8e5-11e5-9ad8-001a4ae51247	17693412	On average, PKA increases the open probability (Po) of single RyR2 (wt) channels to 16.6 ± 3.7 times (mean ± S.E.,n= 15,p< 0.002) that before PKA treatment (control).
2		UNIPROT:P01308	activates	Polonium	MESH:D011059	Protein	2b198fc2-1c29-11f0-bb75-0050569a1f61	10.1016/j.foodres.2023.113850	In the present study, we observed a lower p-Akt protein content in liver and muscle tissues of the insulin stimulated IPO group, compared with the insulin stimulated PO group.
2		CHEBI:49468	activates	Polonium	MESH:D011059	Chemical	c8153296-3913-11e8-9192-001a4a160175	24246938	In contrast, PO and lysozyme activities were induced only by Ag NP aggregates in clams and worms, respectively.
2		MESH:D003907	increases	Polonium	MESH:D011059	Phenotype	47954558-bc46-11e5-8d2d-001a4ae51247	10.1016/S0014-4886(03)00338-8	As shown byDèsarnaud et al. (2000), using Schwann cells transiently transfected with a reporter construct in which the luciferase expression is controlled by the promoter region of the Po, dexamethasone and corticosterone are able to stimulate Po expression.
2		MESH:D002245	activates	Polonium	MESH:D011059	Phenotype	9b009e0e-04e4-11f0-bb39-0050569a791b	10.1016/j.jclepro.2024.143387	PO produced by CO2-based propylene is technically feasible (Vaquerizo and Kiss, 2023;Zadeh et al., 2023).
2		MESH:D020123	activates	Polonium	MESH:D011059	Phenotype	cde5d6e2-c469-11e5-a92e-001a4ae51246	PMC3945099	A rapamycin-induced increase in cardiac RyR2 Po has also been used to infer that dissociation of FKBP12.6 increases RyR2 Po (11) so we performed similar experiments with RyR2 (seeFig.
2		UNIPROT:Q09428	activates	Polonium	MESH:D011059	Protein	bf37925c-bc17-11e5-8abe-001a4ae51246	PMC1302608	Coexpression of SUR1 with Kir6.2 confers MgADP stimulation as well as sulfonylurea sensitivity and increases channel open probability (Po) (Tucker et al., 1997;John et al., 1998).
2		MESH:D000728	increases	Polonium	MESH:D011059	Phenotype	0d3072ce-0d5f-11f0-b759-0050569a791b	10.1016/S0169-328X(99)00124-2	It is quite possible that, in these `in vivo' experiments, the gene expression of Po is stimulated by androgen-dependent mechanisms acting in an indirect fashion on Schwann cells.
2		UNIPROT:P08118	activates	Polonium	MESH:D011059	Protein	a4268bee-3906-11e8-a34b-001a4a160175	28110033	Likewise, freshwater crayfish lectin induces the PO activity through PRPs such as LGBP like manner which shows that PAMPs found on bacterial and fungal surfaces triggers PO cascade[49].
2		UNIPROT:P23975	activates	Polonium	MESH:D011059	Protein	de30383a-c69f-11ee-b22c-0050569a1f61	10.1016/j.cbpc.2023.109782	The co-exposure of NET and EE2 led to significantly increased number of PO (p ≤ 0.05) as compared to the control group and a non-significant increase in MO as compare to the NET 1000 ng/L group at day 30 (Fig. 3).
2		UNIPROT:Q9P121	activates	Polonium	MESH:D011059	Protein	cf32f820-3c9d-11f0-afc2-0050569a791b	10.1016/j.envadv.2022.100247	To check this hypothesis, we addressed three research questions, namely (i) Is the enhancement of plant growth associated with the increase of enzyme-labile Po by NT?
2		CHEBI:24156	activates	Polonium	MESH:D011059	Chemical	2d556980-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2003.12.004	malcolmsonii, it was observed that chitosan, a polymer ofN-acetyl galactosamine (GalNAc), triggered the PO activity to the highest degree with an average relative value of 3.15±0.70.
2		UNIPROT:F4JF21	activates	Polonium	MESH:D011059	Protein	4e54dfe2-1af7-11f0-bb75-0050569a1f61	10.1016/j.dci.2024.105230	On the premise of the presence of SPH complex, PAP3 activates PPO to form active PO (Wang et al., 2014).
2		MESH:D004737	activates	Polonium	MESH:D011059	Phenotype	bb8b88b6-bc17-11e5-9b9d-001a4ae51247	PMC1302873	Namely, enflurane and halothane were shown to induce a dehydration of both the PO group and the CO group of the glycerol backbone of DMPC bilayers by breaking the hydrogen bonding (Tsai et al., 1990).
2		CHEBI:33314	activates	Polonium	MESH:D011059	Chemical	af6cb628-3980-11ef-9c6b-0050569a1f61	10.1016/j.apgeochem.2019.03.019	The radon in the RAD7 chamber decays, producing detectable alpha emitting progenies, particularly the polonium isotopes (218Po,214Po).
2		CHEBI:17254	activates	Polonium	MESH:D011059	Chemical	d3a8ca7e-ca01-11e5-b88f-001a4ae51247	15857824	Under the same conditions, when we checked the effects of PO activity by addition of recombinant 43-kDa protein to the hemolymph solution, PO activity induced by synthetic substrates 4-methylcatechol and 4-hydroxyproline ethylester as PO substrates was not affected (Fig. 5B).
2		MESH:D003902	activates	Polonium	MESH:D011059	Phenotype	1f166102-3917-11e8-a51f-001a4a160176	24486681	The anionic detergent, SDS, induces PO activity in most Hcs (Decker et al., 2001; Baird et al., 2007;Table 1).
2		CHEBI:35701	activates	Polonium	MESH:D011059	Chemical	d32a6250-3779-11e8-bf76-001a4a160175	17257788	Since the skin shows a high enzymatic activity, mainly due to esterase activity (Pannatier et al., 1978; Bickers and Kappas, 1980), many ester prodrugs have been designed and thoroughly investigated to increase drug topical delivery (Chan and Li Wan Po, 1989; Sloan, 1989).
2		UNIPROT:Q16352	activates	Polonium	MESH:D011059	Protein	70cf7840-5cad-11e7-8b40-001a4ae51247	PMC4767563	A functional PO cascade can be activated by SFV infection inA.
2		MESH:D009538	activates	Polonium	MESH:D011059	Phenotype	45ea1ab0-45e6-11f0-afc2-0050569a791b	10.1016/j.cois.2021.12.002	Nicotine, in contrast, has been shown to enhance PO activity and encapsulation inM.
2		UNIPROT:Q14643	activates	Polonium	MESH:D011059	Protein	4a8a0a82-5c4a-11e7-86a3-001a4ae51246	27840173	These results demonstrated that dietary ACV®and PA administration could enhance PO activity resulting from advancement the gene transcription and translation of proPOs inL.
2		CHEBI:15903	activates	Polonium	MESH:D011059	Chemical	347299c6-bc2d-11e5-8d2d-001a4ae51247	PMC2077082	sextahemolymph or baculovirus-infected insect cells, we demonstrated how recognition of a pathogen-associated molecular pattern (β-1,3-glucan) leads to a host defense response (melanization): binding of curdlan andβGRP2 triggers the autoactivation of proHP14 (Wang and Jiang, 2006), HP14 processes proHP21, HP21 cleaves proPAP-2, PAP-2 activates proPO in the presence of SPHs (Fig. 7), and PO produces quinones and melanin.
2		CHEBI:15903	activates	Polonium	MESH:D011059	Chemical	2ea052a0-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2007.07.004	In crayfish, Zymosan can activate the prophenoloxidase (pro PO) system, which is considered to be an important component in the innate defence of arthropods[52].
2		UNIPROT:Q0V967	activates	Polonium	MESH:D011059	Protein	e4573d16-bbd2-11e5-956b-001a4ae51247	10.1016/S0301-4622(02)00226-0	The first models omitted per2+, as ferrous peroxidase is present only in small amounts in the PO reaction catalyzed by HRP.
2		CHEBI:40356	activates	Polonium	MESH:D011059	Chemical	2d556980-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2003.12.004	malcolmsonii, it was observed that chitosan, a polymer ofN-acetyl galactosamine (GalNAc), triggered the PO activity to the highest degree with an average relative value of 3.15±0.70.
2		UNIPROT:Q14574	activates	Polonium	MESH:D011059	Protein	8d701b04-390b-11e8-9fbf-001a4a160176	25499726	Animal studies showed that PO or DSC could promote bile secretion, accompanied by decrease of cholesterol level and increase of bile acid level by feeding rats with PO or DSC into duodenum.
2		UNIPROT:Q14574	activates	Polonium	MESH:D011059	Protein	f5515c66-bc48-11e5-9b9d-001a4ae51247	10.1016/j.poly.2011.05.022	The1H NMR spectra,13C NMR spectra, and DSC curves supported formation of genuine poly(propylene carbonate-co-propylene oxide)s, neither a mixture of PPC and poly(PO), nor poly(propylene carbonate-co-propylene oxide) mixed with PPC or poly(PO).
2		UNIPROT:Q9V3N1	inhibits	Polonium	MESH:D011059	Protein	3a0363c0-bc00-11e5-9b9d-001a4ae51247	10.1016/j.bbrc.2005.10.042	The function of Spn27A is to inhibit the activation of the PO probably by blocking pro-POAE.
2		CHEBI:23019	activates	Polonium	MESH:D011059	Chemical	8bd86994-001f-11f0-9c09-0050569a791b	10.1016/j.jep.2024.119094	Moreover, the presence of C2=C3 double bonds, a carbonyl group at C4, and flavonoid substitutions at the 3'- and/or 4'- positions enhance anti-proliferative effects, indicating strong antitumor properties (Poór et al., 2016).
2		MESH:D006886	activates	Polonium	MESH:D011059	Phenotype	0eabb190-04b3-11f0-ac21-0050569a1f61	10.1016/j.jbc.2024.107733	Our single-channel recordings demonstrated that HCQ inhibited TRPV3 by reducing channel Po and decreasing single-channel conductance.
2		CHEBI:6364	activates	Polonium	MESH:D011059	Chemical	d3b6bca2-3385-11e8-b868-001a4a160176	26611720	PO enhancement of β-GBP by laminarin was previously described inB.
2		CHEBI:6364	activates	Polonium	MESH:D011059	Chemical	2fb9ebe2-bc2c-11e5-8abe-001a4ae51246	10.1016/j.fsi.2006.06.014	At 0.5 and 0.6gL−1, laminarin induced the highest PO-like activity (Fig. 4).
2		CHEBI:45825	activates	Polonium	MESH:D011059	Chemical	eae31270-e9fb-11ef-b449-0050569a791b	10.1016/j.jcou.2024.102999	Hai et al.[52]showed that the CO2and PO cycloaddition reaction catalyzed by tetrabutylammonium iodide (TBAI) and a small amount of wool powder (WP) produced 2.5 times more PC than that produced using TBAI alone.
2		UNIPROT:Q8I6K1	activates	Polonium	MESH:D011059	Protein	37e25c9a-1a7e-11f0-b759-0050569a791b	10.1016/j.dci.2024.105260	These facts suggest that PO activity in the later stages post-injection is primarily driven by proPO-I.
2		UNIPROT:P05231	activates	Polonium	MESH:D011059	Protein	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Effects of PO on the production of TNF-α, IL-6 and IL-1β in BALF of LPS-induced ALI mice To expose the anti-inflammatory effect of PO on mice with ALI, the levels of inflammatory cytokines TNF-α, IL-1β, and IL-6 were analyzed at 12h after LPS challenge by ELISA.
2		CHEBI:29108	activates	Polonium	MESH:D011059	Chemical	17639682-f579-11eb-8554-001a4a160175	32750381	We found that the calcium signal of Po neurons was increased during the histaminergic itch-induced scratching behavior in the cheek model, and pharmacogenetic suppression of Po neurons reduced the scratching behaviors.
2		MESH:D009361	activates	Polonium	MESH:D011059	Phenotype	b4df46b8-d9cf-11ee-ae05-0050569a1f61	10.1016/S0965-1748(97)00081-7	The invasion of microorganisms or inter-haemocoelic injection of small amounts of microbial cell wall components (β-1,3-glucans, peptidoglycans or lipopolysaccharides) can activate ProPO to PO by a ProPO activating cascade (Soderhall et al. 1986a, b;Sugumaran et al., 1993;Ashida and Brey, 1997).
2		PF:PF02893	activates	Polonium	MESH:D011059	ProteinFamily	1b85c0cc-bbd4-11e5-9b9d-001a4ae51247	10.1016/j.aquaculture.2007.07.002	The PO elicited by gram-negative bacterial cells was determined earlier inM.
2		UNIPROT:P00918	activates	Polonium	MESH:D011059	Protein	0442313e-cd40-11e5-aade-001a4ae51247	7554124	Open lifetime durations appear to be an order of magnitude longer in canine cardiac channels when activated by Ca2+.171819Cytosolic Ca2+increases Po not just by increasing the frequency of channel opening but also by causing large increases in the duration of the open lifetimes.1819Therefore, with sheep channels, cytosolic Ca2+increases Po by binding to the closed channel state(s), whereas with canine channels, a Ca2+-induced increase in Po results from Ca2+binding to both open and closed channel states.
2		MESH:D012433	activates	Polonium	MESH:D011059	Phenotype	91a24aee-ca5e-11e5-9bd2-001a4ae51247	14557272	We have shown previously that the interaction of ryanodine with single wt RyR2 channels induces a dramatic increase in open probability (Po) and a reduction in unitary conductance (36).
2		IP:IPR000215	inhibits	Polonium	MESH:D011059	ProteinFamily	d134629c-3513-11e8-8f56-001a4a160175	26589634	M.sextaserpin-1J is another serpin that blocks pro-PO activation and forms complexes with PAP-1, -2, and -3.
2		UNIPROT:P15924	inhibits	Polonium	MESH:D011059	Protein	93f80f74-c68e-11ee-b346-0050569a791b	10.1016/j.cej.2023.147786	According to the above discussion, the flame-retarding mechanism of DP to the VERDP10materials can be concluded as the follows: The phosphate-containing structure in DP degraded to produce PO·
2		MESH:D000432	activates	Polonium	MESH:D011059	Phenotype	57560630-bc0a-11e5-9b9d-001a4ae51247	10.1016/j.bej.2011.03.013	The presence of MA minimized the methanol deactivation of lipase, and the combined effect of methanol and MA leads to enhance transesterification of PO to BD as methanol is more active than MA[10].
2		MESH:D002351	activates	Polonium	MESH:D011059	Phenotype	dfce30ec-bbf0-11e5-9b9d-001a4ae51247	10.1016/j.bmcl.2004.11.051	When dosed PO in 1% methocel, the EP2agonist9inhibited carrageenan-induced rat paw edema18in a dose-dependent manner with an ED50of 3.3mg/kg PO.
2		MESH:D000641	activates	Polonium	MESH:D011059	Phenotype	f1d27796-0c93-11f0-b759-0050569a791b	10.1016/S0925-5214(00)00094-6	Chen et al. (1989)attributed discoloration of bamboo shoots in their experiments to enzymatic browning caused by phenylalanine ammonia–lyase (PAL) and peroxidase (PO), activated by tissue injury at harvest.
2		UNIPROT:P04278	inhibits	Polonium	MESH:D011059	Protein	9820a27a-3385-11e8-bf76-001a4a160175	26626097	The exercise-induced rise in SBP was reduced when ACEIs were administered PO, and the maximal reduction was achieved in the benazepril trial.
2		UNIPROT:P20823	increases	Polonium	MESH:D011059	Protein	b6c9a192-bc2f-11e5-8abe-001a4ae51246	10.1016/j.febslet.2004.10.070	In addition, deletion of the HNF1α gene suppressed expression of PO but not PDH, suggesting that both factors were involved in the control of this gene.
2		MESH:D008982	activates	Polonium	MESH:D011059	Phenotype	2eb6bb82-bbee-11e5-9b9d-001a4ae51247	10.1016/j.brainres.2006.06.115	We have also recently documented that MO application to the pulp induces central sensitization in VPM and PO nociceptive neurons (Zhang et al., in press), but since the relative importance of Vc and Vo in the central expression and modulation of orofacial nociceptive phenomena is still unclear, determining the contribution of Vc and Vo to the pulp-induced thalamic central sensitization would provide new insights into orofacial pain mechanisms and in particular to those related to toothache.
2		CHEBI:27086	activates	Polonium	MESH:D011059	Chemical	31efd5f0-bbde-11e5-8abe-001a4ae51246	10.1016/S0166-445X(01)00175-8	The ability of TBT or copper exposure in aquaria to enhance PO activity is in direct contrast to data from in vitro experiments in which hemocytes from nonexposed tunicates were incubated with metals in tissue culture.
2		UNIPROT:O95164	activates	Polonium	MESH:D011059	Protein	29dd53f6-bc42-11e5-8d2d-001a4ae51247	10.1016/j.mimet.2007.09.020	Results confirmed that the use of MUB at pH 2 is efficient to allow the detection of PO activity in soils.
2		CHEBI:5181	activates	Polonium	MESH:D011059	Chemical	09b9a708-3532-11e8-bf76-001a4a160175	24925762	In the present study, the fucoidan could activate proPO-activating system and increases the PO activity as well as RB activity, which indicated that fucoidan could trigger innate immunity of shrimp.
2		CHEBI:16052	activates	Polonium	MESH:D011059	Chemical	a601ff18-1b1f-11f0-b759-0050569a791b	10.1016/j.cej.2024.151732	The direct epoxidation of propylene with H2and O2to produce PO, abbreviated as HOPO, is viewed as a dream reaction and has garnered significant interest due to its environmentally-friendly and cost-effective advantages compared to conventional chlorohydrin and peroxidation processes[1,2].
2		CHEBI:87192	activates	Polonium	MESH:D011059	Chemical	8bcf485e-ca01-11e5-9b70-001a4ae51247	16311240	Instead, phloxine B (1–5 μm) potentiated G551D-CFTR by enhancing dramatically channel gating, and thus,Po(Fig. 2,AandD,p< 0.01).
2		MESH:D008070	activates	Polonium	MESH:D011059	Phenotype	493f3448-00a9-11f0-9f70-0050569a1f61	10.1016/j.jlr.2024.100672	PO protects against LPS-induced macrophage inflammation To determine the protective role of PO against inflammation, we used mouse BMDMs and stimulated them with LPS (10 ng/ml) for 3 h to induce inflammation.
2		MESH:D008070	activates	Polonium	MESH:D011059	Phenotype	30258594-e9e7-11ef-999a-0050569a1f61	10.1016/j.foodchem.2024.141082	Effect of PO-glycation on the expressions of genes associated with proinflammatory cytokines in LPS-stimulated macrophages The effect of PO-glycation on the expressions of genes associated with proinflammatory cytokines in LPS-stimulated macrophages was examined using Mf and Mf-PO (glycated for 4 h).
2		MESH:D008070	activates	Polonium	MESH:D011059	Phenotype	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	Activation with LPS and zymosan Both LPS and zymosan significantly (p<0.05) increased PO activity relative to negative controls prepared without these PAMPs (Fig. 1).
2		MESH:D008070	activates	Polonium	MESH:D011059	Phenotype	2928ccda-bc2c-11e5-9b9d-001a4ae51247	10.1016/j.fsi.2005.10.010	Therefore, LPS, glucan, levamisole, sodium alginate and Lf added to the diet can trigger the PO activity indicating an increase in immune ability.
2		MESH:D008070	activates	Polonium	MESH:D011059	Phenotype	5f9bf990-390c-11e8-b868-001a4a160176	25107695	β-glucan and LPS activate PO activity in shrimp hemocytes Immunostimulants such as β-glucan or LPS have been widely promoted in shrimp aquaculture to purportedly improve shrimp health based on the fact that they are potent activators of the shrimp proPO systemin vitro[11].
2		MESH:D008070	activates	Polonium	MESH:D011059	Phenotype	30b5e942-bc2c-11e5-9b9d-001a4ae51247	10.1016/S1050-4648(02)00165-1	In this mussel, PO activity was induced by trypsin as well as LPS and β-1, 3-glucans.
2		MESH:D008070	activates	Polonium	MESH:D011059	Phenotype	da3bba62-3512-11e8-8f56-001a4a160175	26800098	Therefore, we used a mouse model of ALI induced by intratracheal administration of LPS to investigate the effect of PO on ALI.
2		MESH:D010455	activates	Polonium	MESH:D011059	Phenotype	48bd664a-3a8e-11e8-a51f-001a4a160176	28465179	Clotting factors and antimicrobial peptide of the defensive system also activate PO activity as reported in hemocyanin of the horseshoe crab,Tachypleus tridentatus[34,35].
2		MESH:D007239	activates	Polonium	MESH:D011059	Phenotype	70cf7840-5cad-11e7-8b40-001a4ae51247	PMC4767563	A functional PO cascade can be activated by SFV infection inA.
2		MESH:D007239	activates	Polonium	MESH:D011059	Phenotype	77241eb2-3385-11e8-a51f-001a4a160176	26621385	Consequently, infections initiate two cross-linking activities, namely transglutaminases and PO, and both activities are involved in covalent clot-stabilization[3].
2		MESH:D051379	activates	Polonium	MESH:D011059	Phenotype	38f07ece-374f-11e8-8636-001a4a160175	28013186	Effects of PT and PO on ethanol-induced gastritis in mice To evaluate the anti-gastritis effect of PO and PT, mice were intra-gastrically injected with absolute ethanol (4mL/kg body weight, 1h exposure) in the absence or presence of PO or PT.
2		MESH:D051379	activates	Polonium	MESH:D011059	Phenotype	cce3a568-3513-11e8-8636-001a4a160175	26582465	Pressure-overload (PO) hypertrophy induced by transverse aortic constriction (TAC) in mice leads to increased collagen accumulation, increased SPARC, and increased myocardial stiffness.
2		UNIPROT:P04637	activates	Polonium	MESH:D011059	Protein	4c87f6ee-bc2a-11e5-9b9d-001a4ae51247	10.1016/j.bbagen.2004.08.008	It has been reported that p53 can induce PO in several tumors[33].
2		MESH:D006973	activates	Polonium	MESH:D011059	Phenotype	4e88fadc-8705-11f0-afc2-0050569a791b	PMC7718345	PO is often initiated by chronic hypertension, in which increased systemic blood pressure generates a greater resistance to the flow of blood from the heart.
2		CHEBI:49470	activates	Polonium	MESH:D011059	Chemical	e4a89118-bc48-11e5-9b9d-001a4ae51247	10.1016/S0277-5387(02)01414-6	Furthermore, based on the work of Inoue, it is known that (porphyrin)Al(OR) compounds initiate the living polymerization of PO by a bimolecular mechanism in [Al][5].
2		CHEBI:49470	inhibits	Polonium	MESH:D011059	Chemical	92269cfc-34f7-11e9-8aa6-001a4a160176	PMC6271318	The magnesium (Mg+2) and aluminum (Al+3) components, like any tri‐ or di‐valent cation can chelate fluoroquinolones or tetracyclines and inhibit PO absorption.
2		UNIPROT:P00846	activates	Polonium	MESH:D011059	Protein	7ca2a256-3415-11e8-bf76-001a4a160175	16130704	Gradient RP separation in the first dimension (90min at 0.2ml/min) and isocratic (micro-column) NP separation in the second dimension (5min at 0.5ml/min) enabled adequate 2D separation of EO–PO (co)oligomer samples.
2		PF:PF12689	activates	Polonium	MESH:D011059	ProteinFamily	cc81b29a-35b2-11e9-913f-001a4a160175	PMC6362968	TRACP-5b, tartrate-resistant acid phosphatase 5b; BAP, bone alkaline phosphatase; AI group, therapy of aromatase inhibitor-induced osteoporosis; PO group, patients of primary postmenopausal osteoporosis.Fig.
2		UNIPROT:Q06141	activates	Polonium	MESH:D011059	Protein	7502a1a6-bbfc-11e5-9b9d-001a4ae51247	10.1016/j.pep.2004.10.011	Different from PO activity produced by PAP-1 and SPHs, PO generated in the fractionated larval hemolymph was stable at room temperature for at least 2h[29].
2		UNIPROT:O75925	activates	Polonium	MESH:D011059	Protein	a329c522-3513-11e8-8f56-001a4a160175	26522339	The complex of βGBP and βG increases the activities of proPO activating enzyme (ppAE) and PO in crayfishP.
2		UNIPROT:Q96M11	activates	Polonium	MESH:D011059	Protein	97c74c86-374d-11e8-9fbf-001a4a160176	28668255	Denaturation induced by SDS enhanced the PO activity in HLS, whereas the recognition of non-self molecule laminarin and tryptic cleavage enhanced the PO activity to a maximum in the serum and plasma.
2		CHEBI:58339	activates	Polonium	MESH:D011059	Chemical	32ee972e-3360-11e8-b868-001a4a160176	25584519	PO activation involves extracellular proteins such as hemolymph proteinases (HPs), which activate pro-phenoloxidase activating proteinases (PAPs), which then activate pro-PO enzymes in the presence of serine protease homologues (SPHs) (Ragan et al., 2009).
2		UNIPROT:Q6PGQ7	activates	Polonium	MESH:D011059	Protein	2fce873c-bc31-11e5-9b9d-001a4ae51247	10.1016/j.csr.2005.03.007	Bora winds cause a cyclonic gyre in the northern Adriatic and a small anti-cyclonic gyre south of the Po region (Paklar et al., 2001).
2		CHEBI:58961	increases	Polonium	MESH:D011059	Chemical	7d26aeb5-dcb2-11ea-8e5b-001a4a160176	PMC6481560	In two patches containing one active channel with very high basal Po levels 0.86 and 0.76, NAGly failed to considerably increase the Po levels (3μM NAGly: Po=0.90 and 0.81, respectively).
2		CHEBI:82587	inhibits	Polonium	MESH:D011059	Chemical	5e54a8b2-bbf4-11e5-8abe-001a4ae51246	10.1016/j.cbpa.2006.02.042	The sensitivities of the reaction to PO inhibitors sodium diethyldithiocarbamate (DETC),N-nitrocatechol (NC),N-phenylthiourea (PTU) and to a peroxidase inhibitor, sodium azide (NaN3), were measured to assure that the observed oxidation ofl-DOPA was due to the activity of PO.
2		UNIPROT:Q5R1U3	inhibits	Polonium	MESH:D011059	Protein	4ca199f2-bbf6-11e5-8abe-001a4ae51246	10.1016/j.cbpb.2007.07.089	Both CPIC and PMSF inhibited PO activity significantly (p<0.05) relative to hemocytes prepared in the absence of inhibitors (Fig. 3).
2		UNIPROT:P01009	activates	Polonium	MESH:D011059	Protein	bfd84284-cc10-11e5-83a8-001a4ae51246	9684865	We have previously demonstrated that Pi can increase the Po of cardiac RyR incorporated into bilayers[10].
2		CHEBI:42191	activates	Polonium	MESH:D011059	Chemical	d4086096-3aa3-11e8-b868-001a4a160176	25700784	It is noteworthy that Fe2+could greatly enhance the PO-like activity of skHbs, and 20 mM Fe2+were found to restore the PO-like activity after pre-inhibition by EDTA.
2		CHEBI:42191	inhibits	Polonium	MESH:D011059	Chemical	4123fd86-ea18-11ef-b449-0050569a791b	10.1016/j.cbpc.2024.110044	EDTA is a divalent cation chelating agent and by some types of disorganization in the structural formation of PO can decrease the PO activity (Feng et al., 2008;Zibaee et al., 2011).
2		MESH:D011374	increases	Polonium	MESH:D011059	Phenotype	45758b70-392b-11e8-a34b-001a4a160175	9622253	It is possible to observe that progesterone induced in the sciatic nerve of aged rats a slight increase of Po gene expression.
2		MESH:D000077185	activates	Polonium	MESH:D011059	Phenotype	e0d60a66-ab8f-11e6-90f5-001a4ae51247	PMC4587346	Indeed, resveratrol has been shown to increase the open probability (Po) of murine CFTR[12], and it is likely that some potentiator component exists in our observations; however it is unlikely that this is the sole mechanism of action as potentiators do not, ab initio, cause CFTR activity, but rather enhance activated CFTR activity.
2		CHEBI:49807	inhibits	Polonium	MESH:D011059	Chemical	ee4ee6de-3402-11e8-8636-001a4a160175	26314521	The effects of divalent mental ions and inhibitors on PO activities Usingl-DOPA as substrate, Cu2+, Mn2+and Fe2+greatly enhanced, and EDTA, DETC, sodium sulfite and ascorbic acid notably inhibited the PO activities of SnPO1, SnPO2 and SnPO3; Pb2+and Cd2+strongly inhibited the PO activity of SnPO1, but had no obvious effects on those of SnPO2 and SnPO3; Ca2+, Mg2+, Zn2+and citric acid showed no obvious effects on the PO activities of SnPO1, SnPO2 and SnPO3 (Fig. 3).
2		UNIPROT:Q765P3	activates	Polonium	MESH:D011059	Protein	9956cdd2-ca5e-11e5-8050-001a4ae51246	14583608	But, addition of Hd-PGRP-2 did not result in an increase in PO activity under the same conditions (column 9), whereas a mixture of Hd-PGRP-1 and Hd-PGRP-2 increased the PO activity ∼2.0-fold (column 11).
2		UNIPROT:Q765P4	activates	Polonium	MESH:D011059	Protein	9956cdd2-ca5e-11e5-8050-001a4ae51246	14583608	By performingin vitroreconstitution experiments, it was found that Hd-PGRP-1 could induce 1,3-β-d-glucan-dependent PO activity.
2		CHEBI:25812	activates	Polonium	MESH:D011059	Chemical	c87e8a0c-2916-11f0-a2ca-0050569a1f61	10.1016/j.atmosenv.2005.01.037	The difference of 10–20ppb was attributed to ozone production in the Po basin and in the southern Alpine foothills.
2		CHEBI:40968	activates	Polonium	MESH:D011059	Chemical	93a092f4-ea04-11ef-999a-0050569a1f61	10.1016/j.fsi.2024.110059	Additionally, supplementation of HP astaxanthin significantly elevated immunoglobulin M levels in Asian seabass (Lates calcarifer) and enhanced THC, PO, and LYZ activity inL.
2		MESH:D011802	inhibits	Polonium	MESH:D011059	Phenotype	7d0b2c26-bc4a-11e5-8d2d-001a4ae51247	10.1016/j.ejphar.2004.05.048	Quinidine blocks the K+currents includingIKrand the Na+current in cardiac cells(Po et al., 1999).
2		MESH:D000584	activates	Polonium	MESH:D011059	Phenotype	4b7bb0b0-3513-11e8-bf76-001a4a160175	26303089	They induce an increase in amiloride-sensitive sodium current and generally impact ENaC function by increasing both the number of ENaC at the cell surface and the open probability (PO) of the channel[90].
2		CHEBI:39867	inhibits	Polonium	MESH:D011059	Chemical	4eab6592-bbed-11e5-9b9d-001a4ae51247	10.1016/j.mcn.2006.01.015	We recently showed that VPA directly inhibits the enzyme prolyl oligopeptidase (PO) (Cheng et al., 2005), which is also implicated in regulation of PIns metabolism, and we proposed that VPA inhibition of PO may partly explain the dual action of the drug in limiting mood swings to both mania and depression (Cheng et al., 2005).
2		UNIPROT:P20061	inhibits	Polonium	MESH:D011059	Protein	1f166102-3917-11e8-a51f-001a4a160176	24486681	The interaction between Hc and tachyplesin most likely involves the hydrophobic side of the AMP, as site directed mutagenesis of tryptophan and tyrosine residues led to a severe reduction in tachyplesin affinity for Hc (and loss of PO activity;Nagai et al., 2001).
2		MESH:D007052	inhibits	Polonium	MESH:D011059	Phenotype	3cacc668-bc3f-11e5-8d2d-001a4ae51247	10.1016/j.ejpb.2007.01.018	Kidokoro et al.[16]also demonstrated that ibuprofen was an effective plasticizer for Eudragit RS PO in the thermal processes and lowered the glass transition temperature of Eudragit RS PO in matrix tablets.
2		UNIPROT:P49903	activates	Polonium	MESH:D011059	Protein	a74b5ed4-3ab0-11e8-8f56-001a4a160175	24878742	ProPO-activating enzymes (PPAEs), serine proteinases (SPs) and serine proteinases homologs (SPHs) that activate the PO system are referred as prophenoloxiase activating factors (PPAFs)[3].
2		MESH:D012330	activates	Polonium	MESH:D011059	Phenotype	33b67efa-c8e7-11e5-9ad8-001a4ae51247	17855335	We also tried to elucidate the correlation between PO activity and phagocytosis by monitoring the change of the phagocytic rate if the PO activity were decreased or increased by dsRNA silencing.
2		UNIPROT:P61626	increases	Polonium	MESH:D011059	Protein	198e2d9e-4968-11e8-8ba2-001a4a160175	PMC5919051	Serum total protein (TP), plasma lysozyme (LYZ) and respiratory burst (RB) activity The results for non-specific immune response such as serum lysozyme (LYZ), total protein and respiratory burst (RB) are shown inTable 8. TP and RB increased significantly (p<0.05) with increasing PO levels.
2		CHEBI:47916	activates	Polonium	MESH:D011059	Chemical	8bd86994-001f-11f0-9c09-0050569a791b	10.1016/j.jep.2024.119094	Moreover, the presence of C2=C3 double bonds, a carbonyl group at C4, and flavonoid substitutions at the 3'- and/or 4'- positions enhance anti-proliferative effects, indicating strong antitumor properties (Poór et al., 2016).
2		UNIPROT:O60259	activates	Polonium	MESH:D011059	Protein	7ca2a256-3415-11e8-bf76-001a4a160175	16130704	Gradient RP separation in the first dimension (90min at 0.2ml/min) and isocratic (micro-column) NP separation in the second dimension (5min at 0.5ml/min) enabled adequate 2D separation of EO–PO (co)oligomer samples.
2		UNIPROT:O43895	activates	Polonium	MESH:D011059	Protein	46239ea8-3a7b-11e8-9192-001a4a160175	26699661	If MAMP recognition were to trigger PO activation in aphids, then the constant presence of secondary symbionts in the haemocoel could have significant autotoxic consequences for the host, with active PO being sustained in the absence of pathogens, potentially also damaging the primary symbiont population.