count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
8	Intussusception	MESH:D007443	activates		MESH:D010195	Phenotype	63c1b836-352c-11e8-9192-001a4a160175	27989360	The first was a retrograde jejunoduodenal intussusception causing acute pancreatitis in a 33-year-old patient who underwent duodenojejunostomy in infancy for DA.168The second was a retrograde jejunojejunal intussusception just distal to the anastomosis in a 9-month old.169Late-onset duodenal dilation (megaduodenum) is a condition that may result in a functional bowel obstruction despite early successful feeding.
8		MESH:D002276	activates	Intussusception	MESH:D007443	Phenotype	27061956-ee24-11e5-872c-001a4ae51246	25482665	As they enlarge, carcinoid tumors may cause intussusception or obstruction.
8		FPLX:GJ	inhibits	Intussusception	MESH:D007443	ProteinFamily	5293d6f4-f022-11ee-b346-0050569a791b	10.1053/j.tvir.2003.10.001	Replacement of the GJ tube over a wire, with a shortened GJ tube without a distal pigtail, usually suffices to reduce the intussusception.
8		MESH:D009362	activates	Intussusception	MESH:D007443	Phenotype	27061956-ee24-11e5-872c-001a4ae51246	25482665	Metastases typically appear as mural nodules and may cause transient intussusception.
8		MESH:D009362	activates	Intussusception	MESH:D007443	Phenotype	a2ab1d8a-377a-11e8-87fd-001a4a160176	17556028	Melanoma produces smooth, rounded metastases that may cause transient intussusceptions.
8		MESH:D014657	activates	Intussusception	MESH:D007443	Phenotype	02d8fba0-3938-11e8-9192-001a4a160175	16150401	Intestinal vasculitis in SLE can also cause mucosal ulceration with bleeding, bowel edema with paralytic ileus, hemorrhagic ileitis, intussusception, and even bowel gangrene and perforation.
5		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	0c17acf2-bc3f-11e5-8abe-001a4ae51246	PMC3053503	According to several reports, adult colonic intussusception is caused by malignant tumors in 64% to 87% of patients and by benign tumors in 29% to 33% of patients [5,6,9,10].|||Recently, with the improvement of laparoscopic surgery, cases in which a laparoscopic anterior resection was performed after the reduction of the sigmoidorectal intussusception through the anus have been reported; nonetheless, successful laparoscopic treatments of intussusceptions caused by malignant tumors have been rarely reported, and studies on the treatment outcomes of laparotomic surgery for intussusceptions and its prognosis have not been reported [11].|||Based on the advantages of laparoscopic surgery, its cosmetic aspect, shortening of the hospitalization period, and early return to normal life, surgery on the lower rectal area could be avoided injury to the autonomic nervous system Therefore case for sigmoidorectal intussusception caused by tumors, the procedure of reduction first, followed by laparoscopic surgery may be considered.|||Furthermore, different from pediatric cases showing very specific symptoms or syndrome, the diagnosis of an adult sigmoidorectal intussusception caused by malignant tumors may be difficult, and on the digital rectal examination, it may be misdiagnosed as lower rectal cancer.
5		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	647f1b74-c947-11e8-ac16-001a4a160176	PMC6181545	[6]Less than 80 cases of adult colonic intussusception induced by a lipoma have been reported, and rectal intussusception has rarely been reported in the English-language literature.|||[7]We first report a case of upper rectal intussusception caused by a giant rectal lipoma, while only 3 giant rectal lipoma cases have been reported.|||Conclusion Laparoscopic segmental resection of the rectum with preservation of the LCA is a safe and feasible technique for the treatment of upper rectal intussusception caused by a giant rectal lipoma.|||A diagnosis of upper rectal intussusception caused by a giant rectal lipoma was established based on these characteristic imaging findings.|||[3]In this case report, we describe a giant rectal lipoma that caused upper rectal intussusception, and we discuss our management and the outcome.
4	Intussusception	MESH:D007443	activates		UNIPROT:P62158	Protein	f4e1609a-3776-11e8-87fd-001a4a160176	15780907	Additional factors, such as erythropoietin are able to induce proliferation and migration of endothelial cells and in vivo angiogenesis in the CAM mainly by intussusception[40].
4	Intussusception	MESH:D007443	activates		GO:0001525	Phenotype	f4e1609a-3776-11e8-87fd-001a4a160176	15780907	Additional factors, such as erythropoietin are able to induce proliferation and migration of endothelial cells and in vivo angiogenesis in the CAM mainly by intussusception[40].
4	Intussusception	MESH:D007443	inhibits		GO:0001525	Phenotype	f4e1609a-3776-11e8-87fd-001a4a160176	15780907	A better understanding of the molecular mechanism of intussusception may help to inhibit tumor angiogenesis.
4	Intussusception	MESH:D007443	activates		GO:0008283	Phenotype	f4e1609a-3776-11e8-87fd-001a4a160176	15780907	Additional factors, such as erythropoietin are able to induce proliferation and migration of endothelial cells and in vivo angiogenesis in the CAM mainly by intussusception[40].
4	Intussusception	MESH:D007443	inhibits		MESH:D009369	Phenotype	f4e1609a-3776-11e8-87fd-001a4a160176	15780907	A better understanding of the molecular mechanism of intussusception may help to inhibit tumor angiogenesis.
4	Intussusception	MESH:D007443	activates		MESH:D003967	Phenotype	2a66f6e8-efc3-11ee-b22c-0050569a1f61	10.1016/S1542-3565(04)00003-5	Rectal examination is mandatory to assess the mucosa, wall defects (e.g., rectocele), or occult intussusception that might cause overflow diarrhea and to assess the anal continence mechanism.
4	Intussusception	MESH:D007443	activates		UNIPROT:P16410	Protein	dce64b6c-3547-11e8-9fbf-001a4a160176	18237865	Strictures can be treated with medical therapy (including cessation of NSAIDs and pharmaceutical treatment for CD), as well as endoscopic37or bougie dilations,26surgical stricturoplasty, or pouch diversion or excision.26,38 In addition to adhesions, NSAID-induced strictures, and fibrostenotic CD, distal small-bowel obstruction also can be caused by an acute angulation, prolapse, or intussusceptions of the afferent limb at the junction to the pouch—this is calledafferent limb syndrome.|||Strictures can be treated with medical therapy (including cessation of NSAIDs and pharmaceutical treatment for CD), as well as endoscopic37or bougie dilations,26surgical stricturoplasty, or pouch diversion or excision.26,38 Afferent Limb Syndrome In addition to adhesions, NSAID-induced strictures, and fibrostenotic CD, distal small-bowel obstruction also can be caused by an acute angulation, prolapse, or intussusceptions of the afferent limb at the junction to the pouch—this is calledafferent limb syndrome.
4	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	63aaf2d8-45b7-11f0-b8fe-0050569a1f61	PMC9046794	The clinical and radiological findings in the patient established that this was a case of colocolic intussusception causing closed-loop intestinal obstruction due to a competent ileocecal valve.|||Discussion Intussusception is an uncommon cause of intestinal obstruction in adults representing 1% of bowel obstructions and 0.003% to 0.02% of all hospital admissions[8].|||Intussusception is an uncommon cause of intestinal obstruction in adults representing 1% of bowel obstructions and 0.003% to 0.02% of all hospital admissions[8].
4	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	da98c466-3362-11e8-9fbf-001a4a160176	16626900	Necrotising enterocolitis, meckel's diverticulum, intussusception and inguinal hernia's can cause intestinal obstruction in the newborn.|||Others Necrotising enterocolitis, meckel's diverticulum, intussusception and inguinal hernia's can cause intestinal obstruction in the newborn.
4	Intussusception	MESH:D007443	activates		MESH:D004760	Phenotype	da98c466-3362-11e8-9fbf-001a4a160176	16626900	Necrotising enterocolitis, meckel's diverticulum, intussusception and inguinal hernia's can cause intestinal obstruction in the newborn.|||Others Necrotising enterocolitis, meckel's diverticulum, intussusception and inguinal hernia's can cause intestinal obstruction in the newborn.
4	Intussusception	MESH:D007443	activates		MESH:D008467	Phenotype	da98c466-3362-11e8-9fbf-001a4a160176	16626900	Necrotising enterocolitis, meckel's diverticulum, intussusception and inguinal hernia's can cause intestinal obstruction in the newborn.|||Others Necrotising enterocolitis, meckel's diverticulum, intussusception and inguinal hernia's can cause intestinal obstruction in the newborn.
4		MESH:D006547	activates	Intussusception	MESH:D007443	Phenotype	e7d39236-5d12-11e7-bcb7-001a4ae51246	25475874	Patients were also excluded if obstruction was caused by inflammatory bowel disease, abdominal cancer or peritoneal carcinomatosis, abdominopelvic irradiation, or intussusception caused by a hernia, or were under 16 years of age.
4		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	ad3bc846-351b-11e8-9192-001a4a160175	28865529	It is also the most common cause of LBO and is the most common malignant neoplasm causing colonic intussusception.
4		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	2eb30b3e-341b-11e8-8f56-001a4a160175	17412545	Intussusceptions in patients with AIDS are generally ileal-based and may be caused by lymphoma, atypical mycobacterial infection, or another unusual inflammatory process[30–32].
4		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	c43c93a6-458d-11f0-b8fe-0050569a1f61	10.1016/j.bpg.2022.101789	Intussusceptions were caused by polyps with a median size of 35 mm (range 15–60 mm).
4		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	56072948-354e-11e8-87fd-001a4a160176	15900295	These polyps can lead to intussusception or anemia and develop into cancers.
4		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	cc02ac22-3953-11e8-87fd-001a4a160176	10770377	For controls, the intestinal specimens were obtained from 4 age-matched patients undergoing intestinal resection for intestinal stricture (n = 1), intussusception caused by polyps (n = 1), and autopsy with no evidence of GI disease (n = 2).
4		MESH:D007239	activates	Intussusception	MESH:D007443	Phenotype	2eb30b3e-341b-11e8-8f56-001a4a160175	17412545	Intussusceptions in patients with AIDS are generally ileal-based and may be caused by lymphoma, atypical mycobacterial infection, or another unusual inflammatory process[30–32].
4		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	4aa8ce58-376f-11e8-87fd-001a4a160176	16179166	Lipomas usually cause obstruction secondary to an associated intussusception rather than luminal compromise as they are pliable in consistency.4Only very large tumours or a sarcomatous change in the lipoma results in obstructive features.
4		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	1e44bfde-334b-11e8-9fbf-001a4a160176	18434264	Until our technique has been confirmed, we cannot overemphasize its applications to lipomas that cause bleeding, intermittent intussusceptions or obstructions and perhaps those that are suspected to cause non-specific symptoms.
4		CHEBI:37136	inhibits	Intussusception	MESH:D007443	Chemical	9490d2e4-2be7-11f0-b40b-0050569a1f61	10.1016/S0736-4679(02)00726-6	Sonographic findings, such as thickness of the hypoechoic “doughnut,” color flow doppler, or the presence or absence of free peritoneal fluid, have been shown to be unreliable indicators of the likelihood of successful barium enema reduction of a pediatric intussusception(7,20,21).
4		MESH:D003560	activates	Intussusception	MESH:D007443	Phenotype	56962576-3544-11e8-87fd-001a4a160176	16997526	Distal ileal cysts may cause intussusception.
4		MESH:D012400	activates	Intussusception	MESH:D007443	Phenotype	2b0bd57c-3404-11e8-bf76-001a4a160175	26122581	Thus, one might hypothesize that wild-type rotavirus infection could be a cause of intussusception.|||If this is the case, rotavirus vaccination may prevent cases of intussusception caused by wild-type rotavirus infection later in infancy, as was suggested by preliminary data from the clinical trial of RV1 conducted in Latin America[58].
4		MESH:D012400	activates	Intussusception	MESH:D007443	Phenotype	4ece0422-376e-11e8-b868-001a4a160176	16314179	If intussusception was caused by, or was associated with, rotavirus infection, one would expect it to have the same seasonal pattern of occurrence as rotavirus.|||It remains unclear whether natural rotavirus infections cause intussusception.
4		MESH:D006406	activates	Intussusception	MESH:D007443	Phenotype	43a609f8-3351-11e8-bf76-001a4a160175	16797906	Intestinal distension by fluid without evidence of an effective site of obstruction may be observed in patients with blunt abdominal trauma, although it can be related to intramural hematoma that in rare cases may cause an intussusception of the intestine[14], often as a non-occlusive and transient event (Figs.|||Functional disorders Intestinal distension by fluid without evidence of an effective site of obstruction may be observed in patients with blunt abdominal trauma, although it can be related to intramural hematoma that in rare cases may cause an intussusception of the intestine[14], often as a non-occlusive and transient event (Figs.
4		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	4f600ec6-0552-11f0-bb39-0050569a791b	10.1016/j.radcr.2024.04.021	Conclusion A small bowel intussusception in adults is rare but is mostly caused by a tumor or neoplasm.|||A small bowel intussusception in adults is rare but is mostly caused by a tumor or neoplasm.
4		MESH:D000650	activates	Intussusception	MESH:D007443	Phenotype	9ded3a4c-3ca1-11f0-afc2-0050569a791b	PMC9240364	Right colectomy is needed for ileocolic intussusceptions caused by AM.|||As reduction to allow limited resection is not recommended for intussusceptions caused by AM to prevent rupture, right colectomy is the treatment[13].
4		MESH:D008070	activates	Intussusception	MESH:D007443	Phenotype	f0fda844-3947-11e8-a51f-001a4a160176	17848241	However, in the LPS-induced animal model of intussusception, none of the animals showed prominent mucosal lymphoid follicles, hypertrophied Peyer patches, or other pathologic process at the apex of the intussusception[6].|||Intraperitoneal injection of bacterial lipopolysaccharides (LPS) has shown to induce intussusception in mice[6].|||In an LPS-induced experimental model of intussusception, altered intestinal motility is shown to be the result of increased release of nitric oxide (NO), which in turn leads to increased incidence of intussusception[7].
4		MESH:D006391	activates	Intussusception	MESH:D007443	Phenotype	19ac3ede-04fe-11f0-8fe6-0050569a1f61	10.1016/j.ijscr.2024.110108	Intussusception caused by a small bowel hemangioma is extremely rare.|||The final diagnosis was a mixed hemangioma causing intussusception of the jejunum.
4		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	5c483a04-0544-11f0-8fe6-0050569a1f61	10.1016/j.ijscr.2024.109920	In a recent review, Tasselli et al. reported that colonic lipomas causing colo-colic intussusception were most frequently found in the transverse colon (28 %), followed by the sigmoid colon (20 %), the cecum (19 %), the ascending colon (15 %), the descending colon (14 %), and the rectum (4 %) [3].|||Conclusion Our study demonstrates the possibility of colo-colic intussusception being caused by a giant colonic lipoma, a rare benign adipose tumor.|||Our study demonstrates the possibility of colo-colic intussusception being caused by a giant colonic lipoma, a rare benign adipose tumor.
4		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	4885532e-ae96-11ec-840e-0050569a791b	PMCPMC8864818	In this study, we described a rare case with intussusception caused by either intestinal hemangiomas or appendiceal mucinous neoplasms.|||Occasionally, these tumors may cause intestinal obstructions, intussusception, intramural hematoma, perforation, and platelet sequestration.|||Besides, cases with intussusception caused by either intestinal hemangiomas or appendiceal mucinous neoplasms are extremely rare.|||Cases with intussusception caused by either intestinal hemangiomas or appendiceal mucinous neoplasms are extremely rare.
4		MESH:D006391	activates	Intussusception	MESH:D007443	Phenotype	4885532e-ae96-11ec-840e-0050569a791b	PMCPMC8864818	Indeed, rare adult cases showed intussusception caused by multiple hemangiomas.|||However, intussusception caused by hemangioma is a very rare entity.|||One case was diagnosed with PHACES syndrome, a newly defined rare congenital disease of hemangioma combined with other organ deformity, which was associated with intestinal hemangioma causing recurrent intussusceptions [6].|||Besides, cases with intussusception caused by either intestinal hemangiomas or appendiceal mucinous neoplasms are extremely rare.
3	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	e02aa247-f588-11eb-942d-001a4a160176	30389283	"</ce:simple-para>
               </ce:abstract-sec></ce:abstract>
            <ce:keywords xml:lang=""en"" id=""kwrds0010"" view=""all"" class=""keyword"">
               <ce:section-title id=""sectitle0040"">Keywords</ce:section-title>
               <ce:keyword id=""kwrd0010"">
                  <ce:text>intussusception</ce:text>
               </ce:keyword>
               <ce:keyword id=""kwrd0015"">
                  <ce:text>sedation</ce:text>
               </ce:keyword>
               <ce:keyword id=""kwrd0020"">
                  <ce:text>children</ce:text>
               </ce:keyword>
               <ce:keyword id=""kwrd0025"">
                  <ce:text>emergency</ce:text>
               </ce:keyword>
            </ce:keywords>
         </head>
         <body view=""all"">
            <ce:sections>
               <ce:section id=""sec1"" role=""introduction"" view=""all"">
                  <ce:section-title id=""sectitle0045"">Introduction</ce:section-title>
                  <ce:para id=""p0010"" view=""all"">Ileocolic intussusception is a major cause for intestinal obstruction in early childhood.|||Box 274</sa:address-line>
                     <sa:city>Kibutz Maayan Tzvi</sa:city>
                     <sa:postal-code>3080500</sa:postal-code>
                     <sa:country>Israel</sa:country>
                  </sa:affiliation>
               </ce:correspondence>
            </ce:author-group>
            <ce:date-received day=""12"" month=""6"" year=""2018""/>
            <ce:date-revised day=""4"" month=""8"" year=""2018""/>
            <ce:date-accepted day=""20"" month=""9"" year=""2018""/>
            <ce:abstract xml:lang=""en"" id=""abs0010"" view=""all"" class=""author""><ce:abstract-sec role=""background"" id=""abssec0010"" view=""all"">
                  <ce:section-title id=""sectitle0015"">Background</ce:section-title>
                  <ce:simple-para id=""abspara0010"" view=""all"">Ileocolic intussusception is a major cause for intestinal obstruction in early childhood.|||</prism:copyright><prism:publisher>Elsevier Inc.</prism:publisher><dc:creator>Shavit, Itai</dc:creator><dc:creator>Shavit, Danielle</dc:creator><dc:creator>Feldman, Oren</dc:creator><dc:creator>Samuel, Nir</dc:creator><dc:creator>Ilivitzki, Anat</dc:creator><dc:creator>Cohen, Daniel M.</dc:creator><dc:description>
                  Background
                  Ileocolic intussusception is a major cause for intestinal obstruction in early childhood."
3		MESH:D008573	inhibits	Intussusception	MESH:D007443	Phenotype	013f4208-f588-11eb-8af9-001a4a160175	30820659	V294 Laparoscopic reduction of jejunojejunostomy intussusception after Roux-en-Y gastric bypass Rana M Higgins, MD, Jon C Gould, MD, Tammy L Kindel, MD, PhD; Medical College of Wisconsin A 36 year-old morbidly obese female underwent a laparoscopic Roux-en-Y gastric bypass.
3		MESH:D012400	activates	Intussusception	MESH:D007443	Phenotype	0f8251c6-3514-11e8-b868-001a4a160176	26590437	Thus, one might hypothesize that wild-type rotavirus infection could be a cause of intussusception.|||If this is the case, rotavirus vaccination may prevent cases of intussusception caused by wild-type rotavirus infection later in infancy, as was suggested by preliminary data from the clinical trial of RV1 conducted in Latin America.58However, a recent analyses exploring this hypothesis in a large database of insured U.S. children indicates that the risk of naturally occurring intussusception was not modified by rotavirus vaccination during the period of one month to one year following vaccination.
3		MESH:D005990	activates	Intussusception	MESH:D007443	Phenotype	5717d930-bc3e-11e5-8abe-001a4ae51246	PMC4496452	The pathogenesis of IFPs is unclear, and the most effective treatment for intussusception caused by an IFP is an exploratory laparotomy.|||Intussusception caused by an IFP is best treated with an exploratory laparotomy, because IFPs do not recur after surgical resection.|||In conclusion, we have described a rare case of intussusception caused by IFP, where surgical resection was necessary to alleviate the patient's symptoms.
3		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	e27e79c6-aaa1-11e8-bde0-001a4a160175	PMC6112951	Additionally, whether laparoscopic surgery for intussusception caused by malignant tumors is appropriate is uncertain.|||[8,27]Lipomas can occur in any part of the gastrointestinal tract, of which the colon is the most common site, and are common benign tumors that lead to intussusception.|||Adenocarcinoma accounts for approximately 30% of small intestinal intussusceptions, whereas colonic intussusceptions are mainly caused by malignant tumors.
3		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	dee35a62-3ee1-11e6-88fc-001a4ae51247	PMC4898003	Hamartomatous polyps in the GI tract are a frequent cause of intussusception and often occur in the setting of Peutz-Jeghers Syndrome.|||Introduction We present a case of non-Peutz Jegher hamartomatous polyps causing jejuno-jejunal intussusception and small bowel obstruction in a pediatric patient.|||Polyps causing small bowel intussusception are uncommon but not rare.
3		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	02d1ea0e-bc3a-11e5-ac4e-001a4ae51246	PMC4457091	SILS can be a suitable choice for the treatment of intestinal intussusception induced by a solitary hamartomatous polyp and offers the opportunity to retain the whole length of the bowel as well as the benefits of its minimally invasive nature.|||Discussion discussion Small bowel intussusceptions induced by polyps can be managed successfully with minimally invasive surgical approaches.|||In this report, we present a case of acute small bowel intussusception that was caused by a 3cm solitary polyp, which was managed by performing single-incision laparoscopic surgery (SILS), and we describe the post-operative pathological characteristics of Peutz-Jeghers polyp (PJP).
3		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	a5941f88-ae95-11ec-b4ed-0050569a1f61	PMCPMC8483869	The clinical presentation of our patient with polyp-induced intussusception confirmed this observation.The causal relationship between PJS and appendiceal carcinoid remains unclear.|||Intussusception caused by intraluminal polyps in PJS is a rare cause of intestinal obstruction.|||Intussusception was caused by jejunal hamartomatous polyps, which were parts of the PJS spectrum.
3		MESH:D002051	activates	Intussusception	MESH:D007443	Phenotype	0817ec90-3f30-11e8-ab82-001a4a160175	PMC5895833	We report a case of multiple jejunal intussusception caused by Burkitt lymphoma in an AIDS patient.|||In comparison, the sporadic form tends to present in the lymphoid tissues of the gut, often presenting as masses in the Waldeyer ring or the terminal ileum, or even with involvement of abdominal organs with the most involvement of the distal ileum, cecum or mesentery [34] Cases of intestinal intussusception caused by Burkitt lymphoma are rarely reported [5].|||Intussusception was thought to be caused by Burkitt lymphoma.
3		MESH:D008467	activates	Intussusception	MESH:D007443	Phenotype	b7003de8-bc06-11e5-8abe-001a4ae51246	PMC3290887	Conclusion Adult intussusception caused by inverted Meckel's diverticulum may be observed in any age.|||Occasionally, inversion of Meckel's diverticulum into the lumen of the bowel can cause intussusception, ischemia and infarction.|||It occurs when the Meckel's diverticulum sags into the bowel lumen and then serves as a lead point to allow telescoping of the small intestine, first into the distal ileum and then in to the large intestine, causing ileo-ileal and ileocolic type of intussusceptions.
2	Intussusception	MESH:D007443	activates		UNIPROT:P49585	Protein	74e8fc0c-45c1-11f0-afc2-0050569a791b	10.1016/j.epsc.2022.102248	Enhanced abdominal CT revealed a small bowel intussusception (Fig. 1b), so emergency open surgical laparotomy was performed.
2	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	2bb2076a-352d-11e8-b868-001a4a160176	27015929	If left untreated, intussusception can lead to bowel obstruction, bowel necrosis, perforation, or infection.
2	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	601b6c24-ec08-11ee-b346-0050569a791b	10.1016/j.mpsur.2013.01.001	Intussusception leads to bowel obstruction and if untreated necrosis of the incarcerated bowel.
2	Intussusception	MESH:D007443	activates		MESH:D012400	Phenotype	53d1ff9a-354e-11e8-9fbf-001a4a160176	15904824	Furthermore, should natural rotavirus infection cause intussusception, their vaccine given at an early age might actually protect against intussusception.
2	Intussusception	MESH:D007443	inhibits		MESH:D012400	Phenotype	d24567d0-c46d-11e5-9cc6-001a4ae51246	PMC4596394	Rotashield and intussusception The first vaccine designed to prevent rotavirus infection (Rotashield®–Wyeth Lederle Vaccines, Philadelphia, PA) was voluntarily withdrawn from the US market by the manufacturer in 1999 due to an increased risk of intussusception among infants receiving the vaccine[77].
2	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	2cfb9a77-7f6f-11ea-8181-001a4a160175	10.1016/b978-1-4557-0892-5.00018-0	• Most commonly, intussusception leads to complete intestinal obstruction and strangulation of the intussusceptum, causing an acute onset of unrelenting abdominal pain, although it may rarely be a cause of a more chronic colic.
2	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	0853db68-04bf-11f0-bb39-0050569a791b	10.1016/j.ijscr.2024.110164	Detecting intussusception based on clinical presentation is challenging and necessitates high clinical suspicion [3], as it presents with vague abdominal symptoms: abdominal pain, nausea, vomiting, weight loss, constipation or diarrhea, hematochezia, and less commonly an abdominal mass [2–4].
2	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	c0bacac4-3779-11e8-8636-001a4a160175	17236852	Acute abdominal pain and vomiting and obstipation from intestinal obstruction in pregnancy can be caused by adhesions, volvulus, intussusception, hernias, or neoplasm.
2	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	6b77226a-c476-11e5-91a7-001a4ae51247	PMC4661476	The characteristic CT imaging features of intussusception allow for rapid diagnosis in an often, challenging clinical picture of nonspecific abdominal pain.
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	25e5ec86-3945-11e8-a51f-001a4a160176	15975542	The clinical presentation of patients with duplications include: (1) intestinal obstruction, caused by intussusception or compression of the adjacent bowel; (2) pain from over distention of the duplication or from an inflammatory reaction of the surrounding viscera; (3) gastrointestinal haemorrhage from ulceration, due to ectopic gastric mucosa or interference with the vascular supply; (4) respiratory distress, if the duplication lies intra-thoracically; or (5) completely asymptomatic, being discovered incidentally on physical or X-ray examination[3,4].
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	48ffc06e-bc2b-11e5-8abe-001a4ae51246	PMC3506898	Introduction Intestinal invagination or intussusception is the leading cause of intestinal obstruction in children, but it is an uncommon process in adults, accounting for only 5% of all intussusceptions and 1% of all intestinal obstruction.
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	717e4c51-7f6f-11ea-bf12-001a4a160176	PMC7271342	SMALL INTESTINAL OBSTRUCTION Small intestinal obstruction can be caused by foreign bodies, tumors, intussusception, volvulus, or strangulation within hernias.
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	79dd748b-7f6f-11ea-8185-001a4a160175	PMC7186847	smAll inTesTinAl oBsTruCTion Small intestinal obstruction can be caused by foreign bodies, tumors, intussusception, volvulus, or strangulation within hernias.
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	9aa858ca-4724-11f0-afc2-0050569a791b	10.1016/j.epsc.2017.05.016	Additionally, intestinal obstruction, the second most common presentation of Meckel's diverticulum, may be caused by a mechanism of intussusception (the diverticulum acts as a leading point, causing ileocolic intussusception) or volvulus, but also as an internal hernia or as an incarcerated inguinal hernia (Littré).
2	Intussusception	MESH:D007443	inhibits		MESH:D012005	Phenotype	6f67216c-338d-11e8-8f56-001a4a160175	12501052	The pelvic floor surgeon should understand that operation for intussusception to prevent overt rectal prolapse is not indicated because the incidence of progression is only 2% to 3%.25 Several studies have demonstrated the usefulness of imaging the pelvic floor, with findings that altered surgical treatment in as much as 41% of the cases.8This study also changed surgical treatment recommendations in 33% of patients with clinical rectocele and defecatory dysfunction.
2	Intussusception	MESH:D007443	activates		MESH:D014839	Phenotype	c0bacac4-3779-11e8-8636-001a4a160175	17236852	Acute abdominal pain and vomiting and obstipation from intestinal obstruction in pregnancy can be caused by adhesions, volvulus, intussusception, hernias, or neoplasm.
2	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	9fb1cd26-3780-11e8-8636-001a4a160175	14620718	Small bowel ischemia secondary to intestinal obstruction is usually caused by bands and adhesions, hernia, or intussusception (with adhesions accounting for up to 70% of small bowel obstruction), and develops when circulation to the obstructed segment is impaired.22,23It is characterized by three coexisting phenomena: mechanical obstruction of an involved bowel segment, closed loop obstruction of the involved segment, and venous congestion of the involved loop.24The bowel segment proximal to an obstruction becomes ischemic because of severe bowel distension.
2	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	a0c78326-1a4b-11f0-a2ca-0050569a1f61	10.1016/j.ijscr.2024.110578	Intestinal intussusception can lead to ischemia, intestinal perforation, and septicemia [15].
2	Intussusception	MESH:D007443	inhibits		MESH:D015431	Phenotype	0853db68-04bf-11f0-bb39-0050569a791b	10.1016/j.ijscr.2024.110164	Detecting intussusception based on clinical presentation is challenging and necessitates high clinical suspicion [3], as it presents with vague abdominal symptoms: abdominal pain, nausea, vomiting, weight loss, constipation or diarrhea, hematochezia, and less commonly an abdominal mass [2–4].
2	Intussusception	MESH:D007443	activates		MESH:D001064	Phenotype	0b7b6f3c-d508-11ee-ae05-0050569a1f61	10.1007/s00247-018-4166-0	The large size of the lesion makes it challenging to identify its origin on MRI Tumors/tumor-like conditions Intussusception Intussusception is the second most common cause of acute abdomen in the pediatric population, following appendicitis.
2	Intussusception	MESH:D007443	activates		MESH:D045823	Phenotype	5e5cc118-3547-11e8-bf76-001a4a160175	12407553	Computed tomography of the abdomen showed a sign of multiple layers, which was interpreted as an intussusception causing strangulated ileus.
2	Intussusception	MESH:D007443	activates		MESH:D010195	Phenotype	52cafa72-3551-11e8-bf76-001a4a160175	17145271	The DJ intussusception presumably caused the acute pancreatitis as follows: initially, the DJ intussusception caused the common channel to be pulled toward the left side, thereby stretching the common channel.
2	Intussusception	MESH:D007443	activates		MESH:D002637	Phenotype	cd66fb36-b213-11e6-a655-001a4ae51247	12091837	Intussusception might be asymptomatic but can cause dysphagia, bleeding, anemia, and chest pain in certain patients.2Radiologically, it might simulate a tumor.2It is usually a transient phenomenon, resolving spontaneously.
2	Intussusception	MESH:D007443	activates		MESH:D007416	Phenotype	a0c78326-1a4b-11f0-a2ca-0050569a1f61	10.1016/j.ijscr.2024.110578	Intestinal intussusception can lead to ischemia, intestinal perforation, and septicemia [15].
2	Intussusception	MESH:D007443	activates		MESH:D007239	Phenotype	2bb2076a-352d-11e8-b868-001a4a160176	27015929	If left untreated, intussusception can lead to bowel obstruction, bowel necrosis, perforation, or infection.
2	Intussusception	MESH:D007443	activates		MESH:D003680	Phenotype	cd66fb36-b213-11e6-a655-001a4ae51247	12091837	Intussusception might be asymptomatic but can cause dysphagia, bleeding, anemia, and chest pain in certain patients.2Radiologically, it might simulate a tumor.2It is usually a transient phenomenon, resolving spontaneously.
2	Intussusception	MESH:D007443	activates		MESH:D010146	Phenotype	45207f3e-3955-11e8-a34b-001a4a160175	14666474	Complications may be caused by mechanical factors; for example, intussusception, or the accumulation of secretions, which can cause pain or obstruct the lumen of the adjacent bowel.2The presence of heterotopic gastric mucosa can cause bleeding or perforation.
2	Intussusception	MESH:D007443	activates		MESH:D010146	Phenotype	6a3fefde-3545-11e8-9fbf-001a4a160176	16111974	Other reported symptoms include intermittent colicky pain caused by intussusception of the mucocele into the cecum,27GI bleeding, or a palpable mass.
2	Intussusception	MESH:D007443	activates		MESH:D010538	Phenotype	25bfbb30-0533-11f0-8fe6-0050569a1f61	10.1016/j.jflm.2024.102727	Disseminated CMV infection, as well as systemic infection by viral and bacterial agents in combination, were also found to be relevant causes of SNCD in younger populations.32,33 SD due to neurological infection was identified in only three autopsy series, with two studies conducted in presumed SIDS patients mentioning only a single case each (meningitis by coxsackie B and echovirus).35,36Enterovirus was the agent responsible for all 3 cases of SD due to meningitis in the study by Tuchtan et al.,28which is consistent with current epidemiological data, as the most common organism involved in viral meningitis.40 Gastrointestinal viral infection was found as a cause of SD in two studies, 5 cases of SD due to intussusception causing peritonitis were associated with rhinoviruses and HHV-6 in the study by Tuchtan et al.,28while 5 cases of SD due to viral gastroenteritis without isolation of any organism were reported in the study by Weber et al.31While gastrointestinal causes seem to represent a relevant proportion of all viral SNCD cases in both studies, the differing etiologies for SD reported by each study may cast doubt on the overall relevance of these findings.
2	Intussusception	MESH:D007443	activates		GO:0030432	Phenotype	1fccc7a8-04b7-11f0-8fe6-0050569a1f61	10.1016/j.ijscr.2024.110242	This is due to chronic pressure and violent peristalsis effects caused by intussusception.
2	Intussusception	MESH:D007443	activates		MESH:D003967	Phenotype	0853db68-04bf-11f0-bb39-0050569a791b	10.1016/j.ijscr.2024.110164	Detecting intussusception based on clinical presentation is challenging and necessitates high clinical suspicion [3], as it presents with vague abdominal symptoms: abdominal pain, nausea, vomiting, weight loss, constipation or diarrhea, hematochezia, and less commonly an abdominal mass [2–4].
2	Intussusception	MESH:D007443	activates		MESH:D000740	Phenotype	cd66fb36-b213-11e6-a655-001a4ae51247	12091837	Intussusception might be asymptomatic but can cause dysphagia, bleeding, anemia, and chest pain in certain patients.2Radiologically, it might simulate a tumor.2It is usually a transient phenomenon, resolving spontaneously.
2	Intussusception	MESH:D007443	activates		MESH:D012421	Phenotype	9ded3a4c-3ca1-11f0-afc2-0050569a791b	PMC9240364	As reduction to allow limited resection is not recommended for intussusceptions caused by AM to prevent rupture, right colectomy is the treatment[13].
2	Intussusception	MESH:D007443	inhibits		MESH:D012421	Phenotype	9ded3a4c-3ca1-11f0-afc2-0050569a791b	PMC9240364	As reduction to allow limited resection is not recommended for intussusceptions caused by AM to prevent rupture, right colectomy is the treatment[13].
2	Intussusception	MESH:D007443	activates		MESH:D006470	Phenotype	cd66fb36-b213-11e6-a655-001a4ae51247	12091837	Intussusception might be asymptomatic but can cause dysphagia, bleeding, anemia, and chest pain in certain patients.2Radiologically, it might simulate a tumor.2It is usually a transient phenomenon, resolving spontaneously.
2	Intussusception	MESH:D007443	activates		MESH:D006470	Phenotype	6a3fefde-3545-11e8-9fbf-001a4a160176	16111974	Other reported symptoms include intermittent colicky pain caused by intussusception of the mucocele into the cecum,27GI bleeding, or a palpable mass.
2	Intussusception	MESH:D007443	activates		MESH:D006470	Phenotype	ebe3145a-393a-11e8-87fd-001a4a160176	12024158	In most cases, the lipoma exceeded 2 cm in diameter with symptoms being caused by intussusception, obstruction, or bleeding.
2	Intussusception	MESH:D007443	activates		MESH:D006470	Phenotype	45207f3e-3955-11e8-a34b-001a4a160175	14666474	Complications may be caused by mechanical factors; for example, intussusception, or the accumulation of secretions, which can cause pain or obstruct the lumen of the adjacent bowel.2The presence of heterotopic gastric mucosa can cause bleeding or perforation.
2	Intussusception	MESH:D007443	activates		MESH:D009325	Phenotype	0853db68-04bf-11f0-bb39-0050569a791b	10.1016/j.ijscr.2024.110164	Detecting intussusception based on clinical presentation is challenging and necessitates high clinical suspicion [3], as it presents with vague abdominal symptoms: abdominal pain, nausea, vomiting, weight loss, constipation or diarrhea, hematochezia, and less commonly an abdominal mass [2–4].
2	Intussusception	MESH:D007443	activates		MESH:D003248	Phenotype	0853db68-04bf-11f0-bb39-0050569a791b	10.1016/j.ijscr.2024.110164	Detecting intussusception based on clinical presentation is challenging and necessitates high clinical suspicion [3], as it presents with vague abdominal symptoms: abdominal pain, nausea, vomiting, weight loss, constipation or diarrhea, hematochezia, and less commonly an abdominal mass [2–4].
2	Intussusception	MESH:D007443	activates		FPLX:G:i	ProteinFamily	6a3fefde-3545-11e8-9fbf-001a4a160176	16111974	Other reported symptoms include intermittent colicky pain caused by intussusception of the mucocele into the cecum,27GI bleeding, or a palpable mass.
2	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	0759984c-8d8a-11e7-82ff-001a4ae51246	PMC5480074	Ileocolic intussusception is a rare cause of abdominal pain in adults that can often be elusive due to the frequent lack of peritoneal irritation signs and specific symptoms.|||Intussusception is a rare cause of abdominal pain in the adult population, accounting for only 1%-5% of all cases of intestinal obstructions and 5% of all cases of intussusception[2-4].
2	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	b37077ee-c948-11ee-b22c-0050569a1f61	PMC9691416	Introduction Intussusception is a rare cause of abdominal pain or melena in adult population[1].|||Discussion Intussusception as rare cause of intestinal obstruction in older adult population Intussusception in the adult population is extremely rare cause of abdominal pain and melena[1].
2	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	e91b046e-1b58-11f0-a2ca-0050569a1f61	10.1016/j.ijscr.2024.109689	Our report highlights that although rare, the abdominal pain caused by intestinal intussusception induced by ectopic pancreas in patients should not be ignored.|||Conclusion Our report highlights that although rare, the abdominal pain caused by intestinal intussusception induced by ectopic pancreas in patients should not be ignored.
2	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	0d1ca66c-3419-11e8-a51f-001a4a160176	15276346	Intussusception is an unusual cause of abdominal pain in the adult.1Most cases occur secondary to a pathologic lead point.|||Introduction Intussusception is an unusual cause of abdominal pain in the adult.1Most cases occur secondary to a pathologic lead point.
2	Intussusception	MESH:D007443	activates		GO:0001525	Phenotype	4d8cec14-bc0e-11e5-9b9d-001a4ae51247	PMC3854347	The P1.HTR cell line is able to induce a rapid hyperpermeability of the chick embryo chorioallantoic membrane vasculature and later angiogenesis, most probably by an intussusception mechanism.|||Twenty-four hours after inoculation, the presence of a large number of split small blood vessels in treated specimens compared to control in our study supports the hypothesis that mast cells could induce angiogenesis by activation of an intussusception angiogenic mechanism, most probably due to an interaction between surrounding stroma and mast cells.
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	7b342df4-ab22-11e6-8237-001a4ae51246	PMC4995810	"Intussusception is a rare cause of intestinal obstruction in adults associated with a high morbidity and mortality from peritonitis following delayed diagnosis and treatment.|||Background:.

Intussusception is a rare cause of intestinal obstruction in adults."
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	8c2fbdce-390d-11e8-a34b-001a4a160175	27211600	Discussion discussion Intussusception is the common cause of intestinal obstruction in young children worldwide and is associated with high morbidity and mortality.|||Introduction introduction Intussusception is the commonest cause of acute intestinal obstruction in infancy and early childhood [1].
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	48b55bee-8838-11f0-8cae-0050569a1f61	10.1016/j.epsc.2020.101550	Intussusception is a major cause of acute intestinal obstruction in children [1].|||Introduction Intussusception is a major cause of acute intestinal obstruction in children [1].
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	66dfec82-b646-11e7-8d2b-001a4a160176	PMC5633663	A necropsy was performed and confirmed a jejuno-jejunal intussusception causing mechanical intestinal obstruction, and gastric dilatation without volvulus.|||Recognition of gastric dilatation with volvulus or gastric dilatation secondary to a small intestinal obstruction caused by an intussusception or other etiology, is critical.
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	80f5fcda-f53f-11eb-ae08-001a4a160175	31364039	Introduction Intussusception is a rare cause of intestinal obstruction in the adult accounting for only 1% of all obstruction cases.|||Intussusception is the leading cause of intestinal obstruction among children, but is highly uncommon among adults, accounting for less than 1% of all small bowel obstruction [5,6].
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	47e57f08-bc43-11e5-8d2d-001a4ae51247	PMC3852475	This is mainly because intussusception causes acute intestinal obstruction whose sequelae may be life threatening, especially gut strangulation with gangrene.|||Discussion discussion We have highlighted that adult intussusception causing intestinal obstruction and occurring simultaneously with complete rectal prolapse is uncommon.
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	09fa53b4-3778-11e8-87fd-001a4a160176	15051258	(Dr. W. B. Perry) Intussusception, although relatively common in children, is a rare cause of intestinal obstruction in adults.|||Literature update with commentary (Dr. W. B. Perry) Intussusception, although relatively common in children, is a rare cause of intestinal obstruction in adults.
2	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	1da791a2-37a1-11e6-aaca-001a4ae51246	PMC4747958	Discussion Intussusception is a rare cause of postoperative intestinal obstruction in adults.|||Conclusions In summary, we experienced two cases of intussusception causing a postoperative intestinal obstruction following FJT.
2	Intussusception	MESH:D007443	activates		MESH:D003085	Phenotype	409a191d-7f6f-11ea-bf10-001a4a160176	PMC7167529	Intussusception of the large colon causes infarction and severe colic.|||Cecocolic intussusception causes acute severe colic and cecocecal intussusception causes mild, intermittent colic.
2	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	87b1927a-3545-11e8-b868-001a4a160176	12698176	To the Editor: I read with interest the case of a patient with acute leukemia and segmental esophageal necrosis reported by Salo and associates.1The authors imply that intussusception led to ischemia, and circumferential full-thickness loss of the esophagus was repaired “without interruption.|||I read with interest the case of a patient with acute leukemia and segmental esophageal necrosis reported by Salo and associates.1The authors imply that intussusception led to ischemia, and circumferential full-thickness loss of the esophagus was repaired “without interruption.
2	Intussusception	MESH:D007443	activates		MESH:D000163	Phenotype	0817ec90-3f30-11e8-ab82-001a4a160175	PMC5895833	In conclusion, physicians should consider the possibility of intussusception caused by non- Hodgkin lymphoma when examining AIDS patients with acute abdominal pain.|||However, intussusception caused by GI tract non-Hodgkin lymphoma in an AIDS patient has rarely been reported [141516].
2	Intussusception	MESH:D007443	activates		MESH:D007418	Phenotype	a9e57240-c9d6-11ee-9aaa-0050569a1f61	10.1016/j.epsc.2022.102482	Background Intussusception may induce intestinal pseudo-obstruction that was characterized by dilatation of the bowel in the absence of anatomical obstruction.|||Intussusception can induce Intestinal pseudo-obstruction or total obstruction.
2	Intussusception	MESH:D007443	activates		MESH:D008551	Phenotype	b37077ee-c948-11ee-b22c-0050569a1f61	PMC9691416	Discussion Intussusception as rare cause of intestinal obstruction in older adult population Intussusception in the adult population is extremely rare cause of abdominal pain and melena[1].|||Introduction Intussusception is a rare cause of abdominal pain or melena in adult population[1].
2	Intussusception	MESH:D007443	activates		MESH:D013577	Phenotype	5b51dbb6-3902-11e8-9192-001a4a160175	26190659	This case report brings the added insight that the very rare complication of intimo-intimal intussusception in type B aortic dissection may cause visceral malperfusion syndrome.|||Antegrade intussusceptions can partially or completely occlude the ostia of the branches of the distal or proximal aorta, and might cause dynamic obstruction malperfusion syndrome, such as coronary insufficiency, stroke, transient ischemic attack, paraplegia, or visceral or limb ischemia.
2	Intussusception	MESH:D007443	activates		MESH:D005242	Phenotype	382487d0-a6a2-11ec-a19c-0050569a1f61	31471696	There is new evidence that rectal intussusception may be an important cause of fecal incontinence [3,4–5].|||However, rectal intussusception may cause passive fecal incontinence more commonly by the inappropriate activation of the rectoanal inhibitory reflex (RAIR) [15].
2	Intussusception	MESH:D007443	activates		MESH:D020047	Phenotype	1336e9ce-ab1f-11e6-ab72-001a4ae51246	PMC5028812	Thus, the internal Delorme’s procedure should be considered an alternative for patients with ODS induced by intra-rectal intussusception or internal rectal prolapse with relatively minor rectocele, and with supposed postoperative risk of fecal incontinence due to sphincter weakness.|||These two techniques are also suitable for treatment of ODS induced by internal rectal intussusception (less than 5.0 cm) and/or rectocele.
2		MESH:D012400	activates	Intussusception	MESH:D007443	Phenotype	095f24a2-3958-11e8-8f56-001a4a160175	11675060	Another possibility is that young Rotashield-vaccinated infants might subsequently be at lower risk of intussusception caused by natural rotavirus infection later in infancy.
2		MESH:D008573	activates	Intussusception	MESH:D007443	Phenotype	eb4f40ea-c46b-11e5-8491-001a4ae51247	24685339	In secondary intussusception, MD is the most common lead point.17Idiopathic intussusception typically occurs between the ages of 3 months and 3 years.
2		MESH:D008573	activates	Intussusception	MESH:D007443	Phenotype	ea14b9b2-45b7-11f0-afc2-0050569a791b	PMC8924532	Intussusception caused by MD is uncommon and has been estimated to occur in 4% of all cases of intestinal obstruction attributed to intussusception[12].
2		MESH:D007889	activates	Intussusception	MESH:D007443	Phenotype	7a4448d2-4585-11f0-86f5-0050569a1f61	10.1016/j.epsc.2022.102262	To our knowledge, this is the first reported case of benign leiomyoma causing a small bowl intussusception and subsequent bowel necrosis in a pediatric patient.
2		MESH:D004240	activates	Intussusception	MESH:D007443	Phenotype	9aa858ca-4724-11f0-afc2-0050569a791b	10.1016/j.epsc.2017.05.016	Additionally, intestinal obstruction, the second most common presentation of Meckel's diverticulum, may be caused by a mechanism of intussusception (the diverticulum acts as a leading point, causing ileocolic intussusception) or volvulus, but also as an internal hernia or as an incarcerated inguinal hernia (Littré).
2		MESH:D053706	activates	Intussusception	MESH:D007443	Phenotype	b386a626-f570-11eb-8c8e-001a4a160176	31512021	This first report of ileocolic intussusception caused by typhlitis in an adult patient with acute lymphoblastic leukemia illustrates that, albeit rare in adults, the differential diagnosis of abdominal pain in patients with leukemia should include typhlitis-induced intussusception and that CT is a successful diagnostic tool.
2		MESH:D008545	activates	Intussusception	MESH:D007443	Phenotype	6b77226a-c476-11e5-91a7-001a4ae51247	PMC4661476	Although the most common metastases to the small bowel are melanoma metastases, intussusception caused by metastatic melanoma is very rare.
2		MESH:D010335	activates	Intussusception	MESH:D007443	Phenotype	6180e224-d565-11ee-ae05-0050569a1f61	10.1053/j.sult.2008.06.007	Pathologic processes underlie small bowel intussusceptions in a minority of cases in older children and adults, eg, due to small bowel metastases such as from melanoma, from benign lesions such as a polyp or Meckel's diverticulum, or in transient intussusception such as may be seen in celiac disease or Crohn's disease.
2		MESH:D007417	activates	Intussusception	MESH:D007443	Phenotype	d903d738-002b-11f0-9c09-0050569a791b	10.1016/j.gore.2024.101673	Later that year, she underwent surgery for intussusception caused by small intestinal polyps, which involved resection of the gastric and jejunal polyps.
2		UNIPROT:P51812	activates	Intussusception	MESH:D007443	Protein	1fccc7a8-04b7-11f0-8fe6-0050569a1f61	10.1016/j.ijscr.2024.110242	In this context, it is uncertain whether the proximity of multiple CLs increases the risk of intussusception through mechanical mechanisms.
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	6d117430-377a-11e8-8636-001a4a160175	17560209	Intestinal obstruction may result from either direct compression of the lumen by an expanding mass or by an intussusception triggered by the intraluminal projection of a small tumor mass[6].
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	9588fe58-3403-11e8-a51f-001a4a160176	26068097	In conclusion, ureteral intussusception caused by a tumor shows specific radiological findings on CT, including multiplanar reconstruction images; therefore, its diagnosis is possible.
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	0a8c4c64-8776-11f0-86f5-0050569a1f61	PMC7722476	The mass effect of the tumor can cause obstruction, intussusception, or mesenteric ischemia.
2		MESH:D004487	activates	Intussusception	MESH:D007443	Phenotype	3e1cd188-3419-11e8-87fd-001a4a160176	15213920	Intraoperatively, the leading edge of the intussusception showed “conspicuous,” “local,” “mucosal edema at the leading edge of the intussusception.
2		MESH:D000072281	activates	Intussusception	MESH:D007443	Phenotype	09fa53b4-3778-11e8-87fd-001a4a160176	15051258	Computed tomography and upper gastrointestinal series showed multiple intermittent intussusceptions caused by small bowel polyps and significant retroperitoneal adenopathy.
2		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	0d1ca66c-3419-11e8-a51f-001a4a160176	15276346	The occurrence of intussusception in HIV+ patients is often related to pathologic entities unique to this patient population.2-10We present a case of an HIV + patient who presented with an intussusception caused by an enteric lymphoma, which was previously undiagnosed.
2		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	6d117430-377a-11e8-8636-001a4a160175	17560209	However, it is generally believed that intussusception caused by lymphomas is unlikely to be completely reduced by an air-contrast or barium enema.
2		MESH:D014657	activates	Intussusception	MESH:D007443	Phenotype	fa81e710-f0ff-11ee-9aaa-0050569a1f61	10.1016/S0016-5085(03)00327-5	Necrotizing angiitis of the small blood vessels (hypersensitivity angiitis, leukocytoclastic vasculitis) involves the gastrointestinal tract and produces melena, diarrhea, cramps, and intussusception.
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	9d2ea7a6-377e-11e8-9192-001a4a160175	10726706	The patient underwent an uncomplicated total proctocolectomy and end ileostomy in an attempt to cure her cancer, prevent the future development of cancer, and also to palliate symptoms that were suggestive of episodic intussusception caused by her multiple, large, pedunculated polyps.
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	e01fa7d8-3385-11e8-9192-001a4a160175	26826408	These hamartomatous polyps can cause abdominal pain and intussusception, sometimes leading to bowel obstruction and severe GI bleeding[10].
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	9588fe58-3403-11e8-a51f-001a4a160176	26068097	A fibroepithelial polyp led to intussusception in this case.
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	09fa53b4-3778-11e8-87fd-001a4a160176	15051258	Computed tomography and upper gastrointestinal series showed multiple intermittent intussusceptions caused by small bowel polyps and significant retroperitoneal adenopathy.
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	52cafa72-3551-11e8-bf76-001a4a160175	17145271	However, the present patient had no obstructive ampullary neoplasm and DJ intussusception was induced by the duodenal PJS polyp.
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	d4c66bfa-d86c-11ee-b346-0050569a791b	10.1016/j.ejrex.2006.09.008	While paediatric intussusception is usually idiopathic, adults with intussusception are much more likely to have a pathological ‘lead point’ such as a polyp or tumour causing the intussusception, although estimates of the prevalence of such lead points in adult intussusception vary[4,5].
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	b70271e2-bc49-11e5-ac4e-001a4ae51246	10.1016/j.bbcan.2006.08.003	Characteristically, symptoms emerge during the second and third decade of life as the growing polyps cause occlusions, intussusceptions, abdominal pain, and bleeding.
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	d2c2d16e-453e-11f0-afc2-0050569a791b	10.1016/j.epsc.2022.102306	A rare case has been reported of pyloroduodenal intussusception caused by juvenile polyps [10].
2		MESH:D013577	activates	Intussusception	MESH:D007443	Phenotype	6ad9c3bc-cb25-11ee-b346-0050569a791b	10.1016/j.fjs.2015.10.002	Few cases of Rapunzel syndrome in patients presenting with intussusceptions have been reported.3We report a case of a 5-year-old girl with Rapunzel syndrome causing intussusceptions and bowel obstruction.
2		MESH:D013577	activates	Intussusception	MESH:D007443	Phenotype	d2c2d16e-453e-11f0-afc2-0050569a791b	10.1016/j.epsc.2022.102306	This report high-lights a rare case of juvenile polyposis syndrome causing jejunal-jejunal intussusception requiring a partial small bowel resection of the affected segment.
2		UNIPROT:Q15831	activates	Intussusception	MESH:D007443	Protein	52cafa72-3551-11e8-bf76-001a4a160175	17145271	However, the present patient had no obstructive ampullary neoplasm and DJ intussusception was induced by the duodenal PJS polyp.
2		UNIPROT:P02730	activates	Intussusception	MESH:D007443	Protein	5147c2ac-3547-11e8-b868-001a4a160176	12407559	In the current case, DI caused standard intussusception symptoms and was indistinguishable from classical intussusception preoperatively.
2		UNIPROT:P12272	activates	Intussusception	MESH:D007443	Protein	74e8fc0c-45c1-11f0-afc2-0050569a791b	10.1016/j.epsc.2022.102248	Blakelock et al. reported that the proportion of episodes of intussusception induced by a PLP increases with age and that 60% of intussusceptions in patients aged five to 14 years had a PLP, whereas fewer than 10% of those in infants aged zero to 11 months did [9].
2		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	5630d15c-bc3e-11e5-ac4e-001a4ae51246	PMC4079814	In this case report, we present one case of a giant transverse colonic lipoma causing a transverse colo-colonic intussusception and one case of a cecal lipoma causing an ileo-colic intussusception.
2		MESH:D018366	activates	Intussusception	MESH:D007443	Phenotype	fa81e710-f0ff-11ee-9aaa-0050569a1f61	10.1016/S0016-5085(03)00327-5	Necrotizing angiitis of the small blood vessels (hypersensitivity angiitis, leukocytoclastic vasculitis) involves the gastrointestinal tract and produces melena, diarrhea, cramps, and intussusception.
2		CHEBI:37136	inhibits	Intussusception	MESH:D007443	Chemical	6d117430-377a-11e8-8636-001a4a160175	17560209	However, it is generally believed that intussusception caused by lymphomas is unlikely to be completely reduced by an air-contrast or barium enema.
2		MESH:D003560	activates	Intussusception	MESH:D007443	Phenotype	3dee597a-3c64-11ef-b466-0050569a791b	10.1016/S0720-048X(97)00061-2	Ultrasonographic diagnosis of intussusception led by an enterogenous cyst has only been reported once in the literature in a 17 month old boy[19].
2		MESH:D004715	activates	Intussusception	MESH:D007443	Phenotype	c7a0d8cc-04ba-11f0-bd9d-0050569a1f61	10.1016/j.epsc.2024.102859	Appendiceal mucoceles and appendiceal endometriosis are rare causes of secondary ileocecal intussusception, as are appendiceal polyps [5].
2		MESH:D020047	activates	Intussusception	MESH:D007443	Phenotype	1336e9ce-ab1f-11e6-ab72-001a4ae51246	PMC5028812	When treating patients with ODS induced by rectocele and rectocele with relatively minor rectal intussusception (depth of rectocele more than 4.5 cm), the Bresler procedure or improved linear stapling procedure combined with a Bioabsorbable Seamguard (BSG) should be a smart choice[9,45].
2		MESH:D009078	activates	Intussusception	MESH:D007443	Phenotype	9ded3a4c-3ca1-11f0-afc2-0050569a791b	PMC9240364	Here, a rare case of ileocolic intussusceptions caused by appendiceal mucocele is presented.
2		MESH:D009078	activates	Intussusception	MESH:D007443	Phenotype	c7a0d8cc-04ba-11f0-bd9d-0050569a1f61	10.1016/j.epsc.2024.102859	Appendiceal mucoceles and appendiceal endometriosis are rare causes of secondary ileocecal intussusception, as are appendiceal polyps [5].
2		MESH:D008467	activates	Intussusception	MESH:D007443	Phenotype	c06c1772-45bc-11f0-afc2-0050569a791b	10.1016/j.epsc.2022.102236	There is a wide range of complications caused by Meckel's diverticulum including: hemorrhage, ulceration, diverticulitis, perforation, umbilical fistula, intussusceptions, Littre's herniation and neoplasm [2–4].
2		MESH:D004240	activates	Intussusception	MESH:D007443	Phenotype	86a2ca74-ca10-11e8-89c7-001a4a160175	PMC6162243	Upon sectioning of the finger projection, the cut surface showed serosa infolding with mesenteric tissue, consistent with an inverted diverticulum causing intussusception without heterotopic tissue (Figure2E).|||Inverted Meckel’s diverticulum can cause two clinical manifestations: GI bleeding and intussusception, as in our two cases.
2		FPLX:G:i	activates	Intussusception	MESH:D007443	ProteinFamily	0817ec90-3f30-11e8-ab82-001a4a160175	PMC5895833	DISCUSSION discussion Intussusceptions caused by gastrointestinal (GI) tract non-Hodgkin lymphoma are occasionally reported [59].|||However, intussusception caused by GI tract non-Hodgkin lymphoma in an AIDS patient has rarely been reported [141516].
2		MESH:D005990	activates	Intussusception	MESH:D007443	Phenotype	3b466f5c-bc0f-11e5-9b9d-001a4ae51247	PMC3078240	Exploratory laparotomy is frequently recommended as the best treatment for intussusceptions caused by IFP.|||We report an unusual case of intestinal obstruction complicated by necrosis and perforation due to ileo-ileal intussusception caused by an IFP, whose diagnosis was confirmed by immunohistochemistry.
2		MESH:D005990	activates	Intussusception	MESH:D007443	Phenotype	1ab5aeba-bc23-11e5-9b9d-001a4ae51247	PMC2769462	Here, we report an unusual case of ileo-ileal intussusception caused by an IFP.|||Inflammatory fibroid polyps (IFP) rarely cause ileal intussusception.
2		MESH:D007417	activates	Intussusception	MESH:D007443	Phenotype	aed98176-ea27-11ee-b346-0050569a791b	10.1016/j.asjsur.2022.03.133	2 In this case, intestinal intussusception was caused by intestinal polyp as the pathological lead point.|||Secondary intussusception is mostly due to organic lesions in the intestinal wall or lumen, such as intestinal polyps, tumors, meckel's diverticulum, etc., as the pathological lead point of intussusception.1This paper describes a case of multilayer intussusception caused by small intestinal polyp.
2		MESH:D007890	activates	Intussusception	MESH:D007443	Phenotype	22f60b30-bc4e-11e5-8abe-001a4ae51246	PMC546237	However, in this patient intraluminal component of dumb bell jejunal leiomyosarcoma was causing intussusception.|||Review of English literature revealed only one case of jejunal intussusception caused by leiomyosarcoma [9].
2		MESH:D002288	activates	Intussusception	MESH:D007443	Phenotype	0c17acf2-bc3f-11e5-8abe-001a4ae51246	PMC3053503	Adult intussusception caused by a malignant mucinous adenocarcinoma is a very rare disease.|||First, we reduced the sigmoidorectal intussusception which was caused by a mucinous adenocarcinoma that had developed in the sigmoid colon.
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	7e3081f8-ae94-11ec-8b2e-0050569a1f61	PMCPMC8080982	"During laparotomy a large mass of 20×20 cm was identified in mid jejunum and a leading tumor had caused intussusception and coiling of the small intestine (
Figure 1 and
Figure 2).|||This leading tumor caused intussusception and coiling of the small intestine."
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	145421a6-bbff-11e5-9b9d-001a4ae51247	PMC4024935	However, since small-intestinal intussusception is mostly benign in cause, manual reduction could be considered, but large intestinal intussusception is mostly caused by malignant neoplasms so bowel resection without manual reduction should be a prior option [3,5,6,7,8,10,11,12,13,14,15,16,19].|||Neoplasm is a major cause of intussusception with other factors such as inflammatory bowel disease, postoperative adhesion, and Mekel's diverticulum.
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	25277c22-bc4e-11e5-8abe-001a4ae51246	PMC4340886	First, MRI showed a hyper-intense tumor in the T2-weighted image, and second, lipoma is the most common benign tumor that causes adult intussusception confined to the small intestine [9].|||Background introduction Adult intussusceptions constitute approximately 5% to 10% of all intussusceptions and are usually caused by a tumor that acts as the lead point [1,2].
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	d709ed1e-bc1a-11e5-9b9d-001a4ae51247	PMC4017524	Jejunal intussusception caused by a huge Vanek's tumor: a case report.|||Surgical consult was requested and the patient was planned for urgent laparotomy with a diagnosis of small bowel obstruction.At the surgery a jejunal tumor causing jejuno-jejunal intussusceptions was found (Figure 3).
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	be648770-ae93-11ec-a61d-0050569a1f61	PMCPMC8164803	Malignant tumors are the most common cause of intussusception caused by tumors (50–73 %) [5].|||The tumor is the main cause of intussusception in adults, accounting for 63–77 % of the total cases.
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	637ec020-375d-11e8-b868-001a4a160176	24355127	Because intussusception is caused by tumor in 63% of cases in adult patients, emergency surgery is required in most cases.|||In the review by Felix et al, intussusception caused by tumor was observed in 63% of cases in adults[3].
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	fcd6815a-bc48-11e5-8abe-001a4ae51246	PMC2650702	Colonic intussusception is most commonly caused by a primary carcinoma and benign tumors, including submucosal masses and accounts for the majority of cases of intestinal intussusception [3].|||An intraluminal tumor, submucosal edema or any process that causes dysrhythmic contractions may initiate intussusception.
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	5c483a04-0544-11f0-8fe6-0050569a1f61	10.1016/j.ijscr.2024.109920	Our study demonstrates the possibility of colo-colic intussusception being caused by a giant colonic lipoma, a rare benign adipose tumor.|||Conclusion Our study demonstrates the possibility of colo-colic intussusception being caused by a giant colonic lipoma, a rare benign adipose tumor.
2		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	3237a020-bc0f-11e5-9b9d-001a4ae51247	PMC3670636	The intussusception was found to be caused by an ileal tumor located 70 cm from Bauhin's valve.|||Based on these findings, we diagnosed the patient with intussusception caused by an intestinal tumor.
2		UNIPROT:Q9Y4P9	activates	Intussusception	MESH:D007443	Protein	4aca9e28-ae96-11ec-b4ed-0050569a1f61	PMC8497451	Via a longitudinal pouchotomy, the transposed small intestinal segment is grasped with a suitable (e.g., Babcock) clamp to initiate intussusception.cAfter intussusception is completed, the nipple valve is formed and stabilized paramesenterically on both sides by staple applications with a bladeless linear cutter (= internal valve stabilization).|||Approximately 15 cm orally of the pouch, the afferent loop is divided between B and C. Via a longitudinal pouchotomy (alternatively via the former pouch outlet), the surgeon grasps the former afferent loop with a suitable (e.g., Babcock) clamp to initiate intussusception.bAfter complete intussusception, the nipple valve is formed and stabilized paramesenterically on both sides with two applications of a bladeless linear cutter (= internal valve stabilization).
2		MESH:D001064	activates	Intussusception	MESH:D007443	Phenotype	40b81af0-ae96-11ec-8b2e-0050569a1f61	PMC8607209	We reported a case of appendiceal intussusception caused by chronic appendicitis.|||The appendiceal intussusception was caused by chronic appendicitis.
2		MESH:D018194	activates	Intussusception	MESH:D007443	Phenotype	a883d54c-bbd7-11e5-9b9d-001a4ae51247	PMC4527800	Clinically, our case presented with intussusceptions caused by adenomyomas of the ileum.|||To our knowledge, our case is the first report of two synchronous adenomyomas of small intestine, and the third report of adenomyomas causing intestinal intussusceptions in an adult6,7.
2		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	22c02cd2-3950-11e8-a34b-001a4a160175	19917477	Malignant lymphoma is an uncommon cause of intussusception.|||The most common lymphoma causing intussusception is diffuse large B-cell lymphoma.
2		MESH:D009362	activates	Intussusception	MESH:D007443	Phenotype	5bc31ace-3b5f-11e8-bf76-001a4a160175	PMC5726180	Ileoileal intussusception caused by the metastasis of cutaneous malignant melanoma to the small bowel 6 years after its excision presenting with small bowel obstruction.|||One of the metastases had an inverted shape (70 cm proximal to ileo-cecal junction) and led to isoperistaltic ileoileal intussusception [Figure 1].
2		MESH:D009362	activates	Intussusception	MESH:D007443	Phenotype	117df142-c46e-11e5-85e4-001a4ae51246	24924845	Because intestinal intussusception caused by secondary metastasis may cause bowel obstruction, intestinal necrosis, and bleeding, surgical intervention is necessary in almost every case[2].|||Herein, we report a case of recurrent intussusception caused by multiple metastases of pulmonary pleomorphic carcinoma, with the hope that our experience will aid readers in clinical decision-making.
2		MESH:D000163	activates	Intussusception	MESH:D007443	Phenotype	0817ec90-3f30-11e8-ab82-001a4a160175	PMC5895833	In Korea, intussusception caused by Burkitt lymphoma in AIDS patients has not yet been reported.|||We report a case of multiple jejunal intussusception caused by Burkitt lymphoma in an AIDS patient.
2		MESH:D006965	activates	Intussusception	MESH:D007443	Phenotype	cfc46d9e-3905-11e8-9fbf-001a4a160176	28065716	It is postulated that focal lymphoid hyperplasia of the Payer paches in the terminal ileum may serve as a leading point for intestinal peristalsis, causing most intussusceptions, and that viral agents associated with enteric infection may be the etiology of mesenteric lymphadenopathy in intussusceptions[10,11].|||Discussion Focal lymphoid hyperplasia in the terminal ileum may serve as a leading point for the intestinal peristalsis, causing most intussusceptions.
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	c8b1997a-ecda-11ee-b22c-0050569a1f61	10.1016/j.epsc.2013.07.010	Experts suggest that the mean age for Peutz–Jeghers polyps causing intussusception is 9 years old[2].|||Here, we discuss a rarely encountered case of a solitary Peutz–Jeghers type polyp causing duodeno-jejunal intussusception in a girl without other signs of PJS, such as characteristic mucocutaneous pigmentation, a strong family history or existing polyposis.
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	3d6d5da4-351a-11e9-87c2-001a4a160175	PMC6020095	(B) Left decubitus.Fig 3 Given his history of Peutz-Jeghers polyps causing intussusception requiring operative intervention, the patient was urgently taken to the operating room for a diagnostic laparoscopy, reduction of the presumed intussusception, and possible further bowel resection.|||This case report describes a 2-year-old boy known to have PJS who previously developed a small bowel intussusception caused by a polyp requiring a very short segmental small bowel resection[5].
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	c7a0d8cc-04ba-11f0-bd9d-0050569a1f61	10.1016/j.epsc.2024.102859	Conclusion Appendiceal polyps are an infrequent cause of secondary ileocolic and/or appendiceal intussusception, but should be included in the differential diagnosis of patients with recurrent intussusception.|||Appendiceal polyps are an infrequent cause of secondary ileocolic and/or appendiceal intussusception, but should be included in the differential diagnosis of patients with recurrent intussusception.
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	3377eb16-bc0f-11e5-9b9d-001a4ae51247	PMC4322696	We herein report a case of a large, nondysplastic, hyperplastic gastric polyp causing gastroduodenal intussusception, biliary obstruction and biochemical pancreatitis, treated solely with endoscopic management.|||Currently, there are no formal guidelines in the literature for the management of gastroduodenal intussusception caused by nondysplastic hyperplastic polyps [8].
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	41b66052-ae95-11ec-ae7b-0050569a1f61	PMCPMC8363990	In young patients with small bowel intussusception caused by lead-point polyps, PJS should be considered.|||The small bowel loops that were about 50-cm long carrying these three polyps with their mesentery were resected, and end-to-end enteric anastomosis was performed.Macroscopically, the two sessile polyps causing intussusception were located next to each other with sizes of 3.0 cm and 3.5 cm; the surface showed cerebriform convolutions (Figure 4).
2		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	562d0532-3516-11e9-913f-001a4a160175	PMC6039895	We report a case of an ileo-ileal intussusception in a 60 years old gentleman who presented with symptoms of subacute intestinal obstruction and anorexia due to an ileo-ileal intussusception caused by inflammatory fibroid polyp.|||Ileal intussusception is rarely caused by inflammatory fibroid polyp [8].
2		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	abe3c4bc-c7b9-11ee-b346-0050569a791b	PMC10425391	Despite all these recent diagnostic innovations, it has been reported that the overall preoperative diagnostic accuracy is only about 62 %, and >70 % of patients require at least two instrumental investigations before receiving a diagnosis of intestinal intussusception caused by a lipoma.|||Lipomas that cause intussusception typically range in size from 4 to 16 cm, with an average size of 7 cm.
2		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	9cffba76-bc4d-11e5-ac4e-001a4ae51246	PMC3715331	More than fifty cases of adult intussusceptions induced by a lipoma, including our present case, have been reported in the English literature during the past decade [3].|||Submucosal lipomas are usually asymptomatic but may cause bleeding, obstruction, intussusception, or abdominal pain.
2		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	d7f09fb2-bc50-11e5-9b9d-001a4ae51247	PMC3391846	In fact, Buetow et al. reported that only 1 in 10 colonic intussusceptions caused by lipoma showed fat-attenuation, whereas the remaining cases had densities varying from half-fat to pure soft-tissue densities.|||Colonic lipoma, though is a benign condition in itself, can lead to intussusception.
2		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	2fae565c-79ec-11ee-add2-0050569a791b	10.1007/s10620-023-08087-w	Endoscopic resection of giant lipomas (≥ 2 cm of diameter) causing intussusception, defined as the telescoping of a proximal segment of the gastrointestinal tract within the lumen of the adjacent segment, is controversial.|||Yet, endoscopic removal (Fig.1d) is associated with a greater risk of perforation, especially when the giant lipomas cause intussusception, influenced by a less efficient electro-surgical conduction through the adipose tissue, prolonging the cutting time [15,19].
2		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	c80d6502-bc1a-11e5-8abe-001a4ae51246	PMC2702939	Jejunal lipoma is a rare cause of adult intussusception, is usually diagnosed during surgery with the presence of mechanical obstructive syndrome.|||Jejunojejunal intussusception caused by lipoma is a rare disease.
2		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	914612cc-89a7-11ee-add2-0050569a791b	PMC9199482	Upper GI—gastroduodenal diseases P252—A rare case of adult jejunal intussusception caused by subserosal lipoma Vlad-Costin Ilie,C.E.|||The laparoscopic approach was chosen, revealing the jejuno-jejunal intussusception caused by a 2/2 cm subserosal lipoma, which was successfully managed with segmental intestinal resection, the patient being discharged 3 days after the intervention.
2		CHEBI:37136	inhibits	Intussusception	MESH:D007443	Chemical	ac3ae6d0-5c8a-11e7-bcb7-001a4ae51246	27033875	He successfully underwent an urgent barium enema reduction of the intussusception.|||The use of a barium enema to reduce intussusceptions has been rarely reported in the setting of acute inflammatory bowel disease, and this case illustrates that it can be a safe and effective intervention even in patients with acute CD flares.
2		MESH:D003560	activates	Intussusception	MESH:D007443	Phenotype	0a8f0126-bbfb-11e5-9b9d-001a4ae51247	PMC4367038	[45] We report a case of an enterogenous cyst causing intussusception and iron deficiency anemia (IDA) in an adult treated by surgical excision and resection of the small bowel.|||[6] Zamir et al. in their study have reported a case of an enterolith filled duodenal duplication cyst causing intussusception and hyperbilirubinemia in a 17-year-old boy.
1	Intussusception	MESH:D007443	activates		UNIPROT:W8JIS5	Protein	8861059c-80de-11e6-81bd-001a4ae51246	PMC5012794	Intussusception was the leading cause of IO in children aged ≤ 1 year, and the second most common cause of IO in children between the ages of 1 and 5 years (Table 4).
1	Intussusception	MESH:D007443	activates		UNIPROT:P49585	Protein	b3ae67d6-0027-11f0-a3d5-0050569a1f61	10.1016/j.asjsur.2024.09.015	Enhanced CT of the abdomen showed ileo-ileal type intussusception with limited thickening of the wall of the intestinal tube proximal to the intussusception and proximal intestinal obstruction.Fig.
1	Intussusception	MESH:D007443	activates		UNIPROT:P49585	Protein	075a2614-7ab8-11ee-ae93-0050569a1f61	PMC10247274	Fig. 1Coronal CT abdomen and pelvis with abscess Fig. 2Axial CT abdomen and pelvis with abscess P091 Acute intussusception cause by suspected secukinumab-induced inflammatory bowel disease Keaton L Altom, MD; Daniel G Chen, MD; Gerald E Bieniek, MD; Tripler Army Medical Center Introduction:Secukinumab (Cosentyx) is a monoclonal antibody that functions by inhibiting the proinflammatory cytokine IL-17.
1	Intussusception	MESH:D007443	activates		UNIPROT:P52895	Protein	85a4a3cc-3906-11e8-9192-001a4a160175	28116695	MR or video defecography may be useful to identify a rectocele or rectal intussusception or anatomical etiologies causing DD (e.g., descending perineum syndrome or a large rectocele).
1	Intussusception	MESH:D007443	inhibits		UNIPROT:P14410	Protein	0acd3b94-ae93-11ec-b4ed-0050569a1f61	PMCPMC8304424	Khalphallah et al. [5] mentioned that buffaloes with intussusception had slightly reduced peristaltic SI movement with non-visualization of the right kidney and LI.Interestingly, ultrasonography could diagnose different complicated intestinal disorders in the examined cattle, such as IO of jejunum or ileum (distal and complete) with liver cirrhosis or IO of the duodenum (proximal and complete) with peritonitis.
1	Intussusception	MESH:D007443	activates		UNIPROT:P60484	Protein	e0b8a17a-c8e5-11e5-a1fd-001a4ae51246	17693663	"An interesting finding from the present study is a high incidence of intestinal intussusception, which often led to the death
                      ofAPCmin/+PTEN+/−mice by 5 months."
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	117df142-c46e-11e5-85e4-001a4ae51246	24924845	Because intestinal intussusception caused by secondary metastasis may cause bowel obstruction, intestinal necrosis, and bleeding, surgical intervention is necessary in almost every case[2].
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	a6faf39a-c858-11ee-9133-0050569a1f61	10.1016/j.ajem.2023.02.027	It is generally believed that children with a history of intussusception within 48 h are suitable for non-surgical treatment [4,6], while a history of intussusception over 48 h will likely increase the risk of ischemic necrosis of the bowel, greatly increasing the risk of non-surgical treatment, and may lead to intestinal perforation, requiring emergency surgical treatment [2,3].
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	e02aa247-f588-11eb-942d-001a4a160176	30389283	"Timely, effective reduction of intussusception is critical to prevent bowel necrosis, perforation, peritonitis, shock, and even death <ce:cross-ref refid=""bib1"" id=""crosref0045"">(1)</ce:cross-ref>."
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	94a8e8a8-1b65-11e6-a85d-001a4ae51246	PMC4854265	Volvulus, intussusception, or increasing pressure to the intestinal wall will inevitably cause intestinal necrosis.
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	806aff60-c9c3-11ee-b346-0050569a791b	10.1016/j.sempedsurg.2022.151234	As discussed in the previous section, this theory has been challenged because, although a vascular accident can explain CA following intrauterine bowel necrosis caused by volvulus or intussusception, there are cases of CA with no evidence of such prenatal events.
1	Intussusception	MESH:D007443	inhibits		GO:0070265	Phenotype	033c66d6-bc49-11e5-ac4e-001a4ae51246	PMC3155120	Early diagnosis of intussusception may prevent the necrosis of the bowel and, in some cases, even save the patient's life [11].
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	795b4e5e-c780-11ee-9133-0050569a1f61	PMC10470304	The affected bowel then becomes oedematous as the intussusception increases, and can lead to ischaemia and necrosis if it is left untreated due to compromised blood flow [2].
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	ce72eb5e-374e-11e8-bf76-001a4a160175	28916856	There were some patients who were not available for intraoperative frozen examination because of intestinal necrosis caused by intestinal obstruction or intussusception, and we directly resected the MD and the corresponding intestine.
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	e27e79c6-aaa1-11e8-bde0-001a4a160175	PMC6112951	Intussusception may lead to intestinal ischemia, intestinal necrosis, or intestinal perforation if not treated in time.
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	2c43aeec-375b-11e8-a51f-001a4a160176	20231020	The risk of the procedure should be considered, however, because intussusception can cause ischemia or even necrosis of the intestine.
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	25cfd15a-eb1c-11ee-8b99-0050569a1f61	10.1016/j.epsc.2014.04.002	Antenatal intussusception leads to a parietal intestinal necrosis and intestinal atresia in the concerned digestive segment.
1	Intussusception	MESH:D007443	inhibits		GO:0070265	Phenotype	12f7d914-d277-11ee-b22c-0050569a1f61	10.1016/j.mpsur.2010.04.001	The colon distal to the intussusception also needs to be inspected for areas of pressure necrosis caused by a partially reduced intussusception.
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	2271a528-bc23-11e5-8abe-001a4ae51246	PMC2740073	Volvulus, intussusception or increasing pressure to the intestinal wall causes necrosis [12].
1	Intussusception	MESH:D007443	activates		GO:0070265	Phenotype	5db3b632-374e-11e8-bf76-001a4a160175	28779197	If untreated, intussusception results in ischemia, eventually leading to bowel necrosis, perforation and peritonitis.
1	Intussusception	MESH:D007443	activates		MESH:D053609	Phenotype	24a0c3c8-bc4c-11e5-9b9d-001a4ae51247	PMC3731624	Here, we describe a 10-month-old boy presenting with lethargy and severe arterial hypertension caused by ileocecal intussusception.
1	Intussusception	MESH:D007443	activates		MESH:D004630	Phenotype	dee35a62-3ee1-11e6-88fc-001a4ae51247	PMC4898003	Discussion Intussusception is a common cause of abdominal emergency and intestinal obstruction in childhood [1].
1	Intussusception	MESH:D007443	activates		MESH:D004630	Phenotype	ac589d9a-bc3d-11e5-8abe-001a4ae51246	PMC3237187	Clinically, the patients presented with varied symptoms ranging from abdominal mass to acute abdominal emergency caused by intussusception.
1	Intussusception	MESH:D007443	activates		MESH:D004630	Phenotype	76901d58-3406-11e8-87fd-001a4a160176	28840373	Introduction Intussusception is a common cause of acute abdominal emergency in pediatrics, but there remains considerable variability regarding both its diagnosis and treatment; non-operative treatment includes reduction with barium, air, or saline enema, under fluoroscopic or ultrasound (US) guidance [1,2–3].
1	Intussusception	MESH:D007443	activates		MESH:D004630	Phenotype	470937d6-cd84-11ee-b346-0050569a791b	10.1016/j.epsc.2014.11.020	Uncommon presentations include intussusception and intestinal perforation which necessitate emergency surgery[1,7–9].
1	Intussusception	MESH:D007443	activates		MESH:D004630	Phenotype	075a2614-7ab8-11ee-ae93-0050569a1f61	PMC10247274	P070 Jejunojejunal intussusception: an idiopathic and offbeat happening in a middle-aged, healthy, female patient ten days after laparoscopic cholecystectomy Miguel Fernando Juárez Moyrón, MD; Luis Andrés Saenz Romero, MD; Nicolás Méndez Martínez, MD; Alfredo Barrera Zavala, MD; Francisco Javier Carballo Cruz, MD; Mariana González Valiente, MD; Secretary of Health of Mexico City Introduction:Intussusception is an exceptional cause of abdominal emergency among adults.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	a2971780-bc1c-11e5-9b9d-001a4ae51247	PMC3212701	Intussusceptions can occur within the ileocolic junction and the small intestines in patients with NS, causing acute abdominal pain.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	d95c3454-bbd5-11e5-9b9d-001a4ae51247	PMC3797946	They can cause abdominal pain, anemia and gastrointestinal bleeding by intussusception or obstruction.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	0703b32b-f510-11eb-9b2e-001a4a160175	32006065	Introduction Ileocolic intussusception is a common cause of abdominal pain in young children and typically occurs between 6 months and 3 years of age [1].
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	25a3effe-cc3b-11ee-9133-0050569a1f61	10.1016/j.epsc.2015.07.006	Discussion Intussusception causes abdominal pain and obstruction most commonly in young children between six months and three years of age[19–21].
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	fc162444-3385-11e8-9192-001a4a160175	26850131	The polyps can grow to very large size and are frequent cause of recurrent intussusception, which can lead to bleeding and abdominal pain.
1	Intussusception	MESH:D007443	inhibits		MESH:D015746	Phenotype	e8df6798-bc39-11e5-8d2d-001a4ae51247	PMC2687895	In these cases, early exploration and reduction of the intussusception (thus avoiding intestinal necrosis) may prevent the onset of short bowel syndrome in the future.We recommend urgent CT-scan in patients with a known history of Crohn’s disease and a sudden onset of abdominal pain to rule out intussusception and its potential complications.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	cd6e8214-3919-11e8-bf76-001a4a160175	21216329	As both intussusception and DIOS can cause acute abdominal pain with obstructive symptoms, accurate diagnosis is important as the former may require operative intervention; whilst DIOS is often managed non-surgically with laxatives, hydration, and hypertonic oral solutions.13,14 The dynamic nature of ultrasound makes it a useful imaging technique in the diagnosis of DIOS.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	3fe35ea0-bc2b-11e5-8abe-001a4ae51246	PMC3655497	Although intussusception is primarily seen in children, adult intussusception is a rare cause of abdominal pain and forms 5% of all intussusceptions [3].
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	933a5c18-3918-11e8-8636-001a4a160175	21262558	Discussion Intussusception is an uncommon cause of abdominal pain in the adult population, and it requires a high level of suspicion to differentiate it from other more frequent conditions.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	623b3f40-c478-11e5-9cc6-001a4ae51246	PMC3123682	Intussusception Intussusception is a rare cause of abdominal pain after gastric bypass, occurring with an incidence of approximately .1%.68Intussusception may occur months or years after gastric bypass and is associated with nausea, vomiting, abdominal pain, and bowel obstruction.86Similar to internal hernia, intussusception may be transient and chronic.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	09ef5c5c-bc14-11e5-9b9d-001a4ae51247	PMC2908657	Intussusception is a rare cause of abdominal pain in the adult population, accounting for five percent of intussusception cases in all ages and 1–5% of intestinal obstruction.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	3b0ae386-3905-11e8-9fbf-001a4a160176	28711692	Intussusception is a rare cause of intermittent abdominal pain in adults.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	597d2aa6-f849-11e7-8bec-001a4a160175	PMC5755640	Introduction Intussusception is a rare cause of abdominal pain in adults, and accounts for 1-5% of mechanical bowel obstructions [1].
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	0817ec90-3f30-11e8-ab82-001a4a160175	PMC5895833	As in this case, intussusception caused by non-Hodgkin lymphoma can cause abdominal pain in an AIDS patient.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	07191bbe-bc44-11e5-ac4e-001a4ae51246	PMC4563835	We postulate that the intussusception was the cause of the intermittent abdominal pain in our patient and that it was likely due to metastasis, however, functional intussusception cannot be excluded as a mass was not visualized.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	7fda57ee-352c-11e8-a51f-001a4a160176	27999885	17Jejunojejunal intussusception caused by a small focal angiodysplasia as a lead point in a 69-year-old male with abdominal pain.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	2683f7da-bc4e-11e5-8abe-001a4ae51246	PMC4545985	Background introduction Intussusception in adults is a rare cause of abdominal pain.
1	Intussusception	MESH:D007443	activates		MESH:D015746	Phenotype	f5a5ad8e-c46d-11e5-9cc6-001a4ae51246	24935997	Intussusception is a common cause of abdominal pain and intestinal obstruction in the pediatric population.
1	Intussusception	MESH:D007443	inhibits		MESH:D015746	Phenotype	232e2e70-bc4e-11e5-ac4e-001a4ae51246	PMC1182398	Other manifestations include asymptomatic patients, intussusception, a palpable mass, gastrointestinal bleeding, increasing abdominal girth, chronic intermittent lower abdominal pain, and secondary genitourinary complications [6,45].
1	Intussusception	MESH:D007443	activates		GO:0001525	Phenotype	aee9b460-ab32-11e6-ab72-001a4ae51246	PMC4954942	Neovascularization in solid tumors is induced by several mechanisms, such as sprouting, intussusceptions, and/or co-option of local vasculature, and incorporation of BM-derived cells, such as EPCs[1,8].
1	Intussusception	MESH:D007443	activates		GO:0001525	Phenotype	b7b5eeba-d7c0-11e5-b317-001a4ae51247	PMC4753668	Angiogenesis, vasculogenesis, and intussusception contribute to tumor neovascularization and tumor growth.
1	Intussusception	MESH:D007443	activates		GO:0001525	Phenotype	d6f5f94c-6fec-11e9-9e35-001a4a160176	PMC6444499	To support cellular function, tumor cells release VEGF that stimulates angiogenesis through vascular sprouting, intussusception and incorporation of bone marrow-derived endothelial precursors (27).
1	Intussusception	MESH:D007443	inhibits		MESH:D005990	Phenotype	3cb9d3fe-5c1a-11e7-8c5f-001a4ae51246	PMC5400470	We describe a patient in whom successful pre-operative colonoscopic reduction for intussusception-induced IFP was very effective in the diagnosis and treatment.
1	Intussusception	MESH:D007443	activates		MESH:D005990	Phenotype	c7597880-bc10-11e5-9b9d-001a4ae51247	PMC3724174	Intratumoral pressure Rapid tumor cell proliferation and weakly developed lymphatics cause high IFP (67,68) and blood vessel remodeling by intussusception (69) or compression (70).
1	Intussusception	MESH:D007443	activates		MESH:D007238	Phenotype	409a191d-7f6f-11ea-bf10-001a4a160176	PMC7167529	Intussusception of the large colon causes infarction and severe colic.
1	Intussusception	MESH:D007443	activates		MESH:D005547	Phenotype	bceaa826-b346-11e8-ac16-001a4a160176	PMC6121166	The main causes of GIP in pediatric patients include meconium ileus, atresia, volvulus, Meckel diverticulum, necrotizing enterocolitis, appendicitis, intussusception, inflammatory bowel disease, peptic ulcer, other gastrointestinal diseases causing obstruction, foreign body ingestion, iatrogenic injury and trauma [1234].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	18b0ea5a-7f6f-11ea-817e-001a4a160175	10.1016/b978-0-323-35775-3.00007-2	Before attributing death to intestinal obstruction caused by intussusception, there is a need to determine if the intussusception took place before or after death.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	53b09f43-7f6f-11ea-bf11-001a4a160176	PMC7151987	Intestinal neoplasia, foreign body, and intussusception are common causes of intestinal obstruction in cats.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	914612cc-89a7-11ee-add2-0050569a791b	PMC9199482	Colorectal—benign P046—Adult colo-colic intussusception due to submucus lipoma: a case report and literature review Hussein Elbernawi1, Albirnawi2, Kadhem3 1University of Benghazi, General surgery, Libya.2Gateshead foundation trust, general surgery, United Kingdom.3Royal Bahrain hospital, general surgery, Bahrain Intussusception is a rare cause of intestinal obstruction in adults and most cases have a pathological lead point.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	99302ab8-374b-11e8-b868-001a4a160176	22595575	Intussusception is a common cause of intestinal obstruction in children.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	3faf7360-bc2b-11e5-8abe-001a4ae51246	PMC3877598	Bashir and Lynch [12] reported a case of double jejunojejunal intussusception causing intestinal obstruction after blunt abdominal trauma.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	87013a3e-ea24-11ee-b346-0050569a791b	PMC9568733	Laparoscopic procedure can be performed in case of symptomatic intestinal obstruction caused by intussusception.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	62f3b75e-34f6-11e9-87c2-001a4a160175	PMC6216089	Small bowel intussusception is a rare cause of intestinal obstruction in adult population, and is caused by neoplasia in 65% of cases [12].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	d9cbdf9a-bc3c-11e5-9b9d-001a4ae51247	PMC3813728	Adult intussusceptions represent only 5% of all intussusceptions [2,4], causing 1% of intestinal obstructions, 0.003–0.02% of all hospital admissions [4] and 1/1300 of all abdominal operations [5].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	56538ccf-f53c-11eb-baae-001a4a160176	29208308	Idiopathic intussusception is the commonest cause of intestinal obstruction in childhood[1].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	a5941f88-ae95-11ec-b4ed-0050569a1f61	PMCPMC8483869	Intussusception caused by intraluminal polyps in PJS is a rare cause of intestinal obstruction.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	3ef557b2-bc0f-11e5-8abe-001a4ae51246	PMC3290021	Discussion Intussusception is a rare cause of mechanical intestinal obstruction in adults, and diagnosis of intussusception in an adult patient strongly suggests the presence of a malignant pathology [4].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	3c98c8de-5c4d-11e7-8b40-001a4ae51247	PMC5095090	These findings led to the diagnosis of intestinal obstruction caused by jejunal intussusception.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	bf1fdc88-3514-11e9-8325-001a4a160175	PMC6046368	Discussion Intussusception is a major cause of intestinal obstruction in young children between the ages of 3 months and 3 years; generally with up to 75% of cases being idiopathic in etiology[1].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	3735fcb2-ab19-11e6-b3b6-001a4ae51247	PMC5051623	INTRODUCTION intro Intussusception is a common cause of intestinal obstruction in children between the ages of 6 and 36 months.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	52a6d16c-6ff4-11e9-b964-001a4a160175	PMC6298289	INTRODUCTION intro Intussusception is a rare cause of intestinal obstruction in adults.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	7832a257-f595-11eb-9786-001a4a160176	31792905	Discussion discussion Intussusception is a rare cause of intestinal obstruction (< 1% cases) in adults.1It occurs due to a benign or malignant tumor acting as a lead point in up to 70% cases.2In a systematic review of 1299 cases, CT had the highest pooled accuracy of 77.8% for diagnosing intussusception.2However, CT has a limited role in determining whether the lead point is benign or malignant.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	bbc678b6-f57a-11eb-85fb-001a4a160175	32020266	Afferent limb syndrome (ALS) was defined as distal intestinal obstruction caused by an acute angulation, prolapse, or intussusception of the afferent limb at the junction to the pouch (Fig.2b), in the absence of intraluminal mucosa associated strictures [5].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	117df142-c46e-11e5-85e4-001a4ae51246	24924845	Because intestinal intussusception caused by secondary metastasis may cause bowel obstruction, intestinal necrosis, and bleeding, surgical intervention is necessary in almost every case[2].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	5420e8de-ca03-11e5-be63-001a4ae51246	PMC2811411	"Because of the intussusception, which caused intestinal obstruction,
                      the survival time of the mice dramatically decreased; for example, 50% of theApc+/−,p27−/−mice fed the western-style diet died at an age of 16 weeks, and none of these mice survived to 30 weeks of age (Fig. 4;P< 0.001)."
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	68df9526-bc3a-11e5-8d2d-001a4ae51247	PMC2828460	Discussion Intussusception is the commonest cause of intestinal obstruction in infants, and occurs with an incidence of approximately 66/100,000 in the UK [1].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	3b466f5c-bc0f-11e5-9b9d-001a4ae51247	PMC3078240	This case is one of the few reported in the literature where intestinal obstruction was caused by ileo-ileal IFP intussusceptions with necrosis and perforation [1,2].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	ad372628-bc42-11e5-9b9d-001a4ae51247	PMC2529271	Discussion Intussusception is an uncommon cause of intestinal obstruction and more than 95% of cases occur in the paediatric age group [1].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	2cfb9a77-7f6f-11ea-8181-001a4a160175	10.1016/b978-1-4557-0892-5.00018-0	• Most commonly, intussusception leads to complete intestinal obstruction and strangulation of the intussusceptum, causing an acute onset of unrelenting abdominal pain, although it may rarely be a cause of a more chronic colic.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	d7edf564-bc3c-11e5-ac4e-001a4ae51246	PMC3789642	We present the case of a 41-year-old female presenting with sub-acute symptoms preceding an intestinal obstruction caused by an ileocolic intussusception with an inflammatory fibroid polyp acting as the lead point.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	2bd35f84-5c32-11e7-9fde-001a4ae51247	PMC5242454	During the course of preoperative chemotherapy, there was only one emergency operation, which was acute intestinal obstruction caused by intussusception.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	89ac1adc-cd65-11ee-b22c-0050569a1f61	10.1016/j.epsc.2014.12.008	Double intussusception may lead to intestinal obstruction, strangulation and gangrene of the prolapsed intestinal loop[1].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	1b42d05c-bbd7-11e5-9b9d-001a4ae51247	PMC3087463	Among the various causes of mechanical ileus, intussusception is an uncommon cause of intestinal obstruction in adult cattle [2].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	8ddb73a4-3b4a-11e8-a34b-001a4a160175	PMC5825960	Furthermore, intussusception is a known cause of intestinal obstruction.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	f52f9220-d3fe-11e5-90d3-001a4ae51247	PMC4729516	INTRODUCTION intro Intussusception is a common cause of acute intestinal obstruction in young children, and it is rarely associated with pathological lesions.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	562d0532-3516-11e9-913f-001a4a160175	PMC6039895	Conclusion Inflammatory fibroid polyp is rare in adults and can present in the emergency as an intussusception causing intestinal obstruction.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	6dc5b5c0-3406-11e8-bf76-001a4a160175	28899672	Small intestinal obstruction in patients with Meckel’s diverticulum may be caused by enteroliths, phytobezoar impaction, anisakiasis, diverticulitis, intussusception, congenital vitelline bands, perforation with abscess formation, or associated tumors.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	7a58b39e-ea0f-11ee-ae05-0050569a1f61	PMC9678981	Intussusception is a rare cause of intestinal obstruction in the postoperative setting.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	d9c336f4-bbd5-11e5-956b-001a4ae51247	PMC3746151	This ileal lipoma was thought to have been responsible for her abdominal pain and weight loss on account of repeated ileocolic intussusceptions causing intermittent intestinal obstructions.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	3c5b15d2-bc0f-11e5-8abe-001a4ae51246	PMC2974997	Discussion discussion Intussusception is a major cause of intestinal obstruction in children, but it is relatively unusual in adults.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	e1de0b04-c994-11ee-b22c-0050569a1f61	10.1016/j.epsc.2022.102529	Discussion Intussusception is a rare cause of intestinal obstruction in the neonatal period.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	1834d9da-f591-11eb-8e4f-001a4a160175	31617099	Of the cases with benign causes (n= 2, 8.7%), one was caused by adenoma, and one was secondary to infection/inflammation.Table 4Pathological characteristicsTypes of intussusception and etiologyN(%)Open (N= 17)Laparoscopic (N= 20)Enteric14 (37.8)Benign10 (71.4)Polyp11Lipoma01Leiomyoma10Lymphoid hyperplasia12Infection/inflammation20Idiopathic10Malignant4 (28.6)Lymphoma21Neuroendocrine tumor01Colonic23 (62.2)Benign2 (8.7)Adenoma01Infective/inflammatory01Malignant21 (91.3)Adenocarcinoma711Lymphoma21 Discussion discussion Intussusception is a rare cause of intestinal obstruction among adults.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	699d99fe-bc44-11e5-9b9d-001a4ae51247	PMC3915189	Introduction Intussusception is a rare cause of postoperative intestinal obstruction in adults.1Various kinds of symptoms have been expressed such as epigastric pain, nausea/vomiting, and hematemesis.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	2a16180e-bc23-11e5-9b9d-001a4ae51247	PMC2783114	Symptoms are produced when compression, intussusception or volvulus of the attached bowel causes intestinal obstruction [1].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	e27e79c6-aaa1-11e8-bde0-001a4a160175	PMC6112951	Introduction Intussusception refers to the telescoping of a part of the intestine and its mesentery into the adjacent intestine, causing symptoms of acute intestinal obstruction in the clinic.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	5ad3d374-bbd7-11e5-8abe-001a4ae51246	PMC4016697	In contrast, childhood intussusception is a leading cause of intestinal obstruction.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	401ae4ea-bc0f-11e5-9b9d-001a4ae51247	PMC3531940	Discussion discussion Intussusception is a rare cause of intestinal obstruction in adults.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	07885772-bc3a-11e5-9b9d-001a4ae51247	PMC3512482	In contrast, childhood intussusception is a leading cause of intestinal obstruction.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	ea47de6e-3773-11e8-87fd-001a4a160176	18022448	At laparotomy, the child was found to have a high jejunojejunal intussusception secondary to a neoplastic lead point and secondary lymphadenopathy posterior to the third part of the duodenum causing intestinal obstruction at this level.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	2aa1b6fa-c472-11e5-a92e-001a4ae51246	19549670	Introduction Intussusception is a common cause of intestinal obstruction in children.1The majority of cases occur in previously healthy infants, with peak incidences at 4–9 months of age.2The cause of intussusception in infants is not well understood.1,3A predominant hypothesis is that gastrointestinal infections, primarily viral infections (e.g.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	5fca6ab6-bbd5-11e5-9b9d-001a4ae51247	PMC3268144	Intussusception is a rare cause of intestinal obstruction in adults compare to the pediatric population.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	41e0fd1a-bbf6-11ee-b7fc-0050569a1f61	10.1007/s12098-019-02878-8	The lesion was resected and proven to be adenocarcinoma of descending colon Miscellaneous Conditions Intussusception Intussusception is a common cause of intestinal obstruction in children.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	41ba448c-bc2b-11e5-8abe-001a4ae51246	PMC3971845	Discussion Intussusception is a major cause of intestinal obstruction in children.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	0b2dfe36-bc49-11e5-8abe-001a4ae51246	PMC2939554	Introduction Intussusception is an uncommon cause of intestinal obstruction in adults [1].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	e8df6798-bc39-11e5-8d2d-001a4ae51247	PMC2687895	Intussusception is an uncommon cause of intestinal obstruction in adults.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	da773bdc-ae94-11ec-8b2e-0050569a1f61	PMCPMC8437426	Intussusception (IS), the invagination of a proximal part of the intestine into the distal portion, is the leading cause of intestinal obstruction in young children [1].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	fcd6815a-bc48-11e5-8abe-001a4ae51246	PMC2650702	Though intussusception is a common cause of intestinal obstruction in the pediatric population, it is quite uncommon in adults living in temperate regions, representing fewer than 10% of total causes [1].
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	730abad4-5c26-11e7-9fde-001a4ae51247	PMC5358816	Conclusion Intussusception is an uncommon cause of intestinal obstruction in adult.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	1e1df940-bc41-11e5-ac4e-001a4ae51246	PMC4493247	Intussusception is a major cause of intestinal obstruction in children.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	d4951e08-ca5f-11ee-ae05-0050569a1f61	10.1016/j.ejrnm.2016.04.002	The majority of cases in children are idiopathic, and childhood intussusception is a leading cause of intestinal obstruction.
1	Intussusception	MESH:D007443	activates		MESH:D007415	Phenotype	5f79ef4c-c70b-11ee-9aaa-0050569a1f61	10.1016/j.ijscr.2023.108935	The manifestation of a duplicative cyst in the cecum in the form of an intussusception that prolapses through the anus and causes a state of intestinal obstruction is very rare, and according to our review of the medical literature, this case is the second case in the medical literature that manifests in this form.
1	Intussusception	MESH:D007443	activates		MESH:D005734	Phenotype	89ac1adc-cd65-11ee-b22c-0050569a1f61	10.1016/j.epsc.2014.12.008	Double intussusception may lead to intestinal obstruction, strangulation and gangrene of the prolapsed intestinal loop[1].
1	Intussusception	MESH:D007443	activates		MESH:D007890	Phenotype	d15c44a6-eda3-11e5-9b35-001a4ae51246	PMC4765121	We present a very rare case of a patient with severe abdominal pain in the right lower quadrant caused by intussusception of the small bowel with a leiomyosarcoma in the caecum with ileocaecal subocclusion.
1	Intussusception	MESH:D007443	inhibits		MESH:D011391	Phenotype	1336e9ce-ab1f-11e6-ab72-001a4ae51246	PMC5028812	For patients with ODS induced by symptomatic very high take-off internal rectal intussusception which is limited to reach the apex of the prolapse by above procedures, a transanal procedure called the TransAnal Endoscopic (internal) Rectal Prolapse” (TERP) may be advised[46].
1	Intussusception	MESH:D007443	activates		MESH:D011391	Phenotype	0e6341f8-3553-11e8-8636-001a4a160175	19577675	Etiology In 1831, Salmon, in his treatise on RP, proposed that prolapse can be caused by intussusception.
1	Intussusception	MESH:D007443	activates		MESH:D012005	Phenotype	0c143536-bc3f-11e5-ac4e-001a4ae51246	PMC3053504	In 1968, Broden and Snallmann [3] demonstrated that rectal intussusception is the cause of rectal prolapse by the use of cinedefecography.
1	Intussusception	MESH:D007443	activates		MESH:D014947	Phenotype	7c37bb54-5c4c-11e7-8b40-001a4ae51247	PMC5097056	Furthermore, the recurrent intussusception may cause trauma, inflammation, mucosal erosion, and bleeding [1].
1	Intussusception	MESH:D007443	activates		MESH:D014947	Phenotype	989498d6-5079-11e8-8d4f-001a4a160176	PMC6392642	[8,11](4)Rectal prolapse and intussusception: Rectal intussusception can lead to localized vascular trauma and consequently the onset of solitary local ulceration.
1	Intussusception	MESH:D007443	activates		MESH:D014947	Phenotype	bceaa826-b346-11e8-ac16-001a4a160176	PMC6121166	The main causes of GIP in pediatric patients include meconium ileus, atresia, volvulus, Meckel diverticulum, necrotizing enterocolitis, appendicitis, intussusception, inflammatory bowel disease, peptic ulcer, other gastrointestinal diseases causing obstruction, foreign body ingestion, iatrogenic injury and trauma [1234].
1	Intussusception	MESH:D007443	activates		MESH:D003681	Phenotype	2ec520c0-7f6f-11ea-8181-001a4a160175	PMC7125662	Proximal jejunal intussusception causes rapid and severe dehydration, electrolyte sequestration, and metabolic alkalosis.
1	Intussusception	MESH:D007443	activates		GO:0008283	Phenotype	e48dab26-bbe6-11e5-8abe-001a4ae51246	PMC4440941	In summary, it is considered that CMV-induced mucosal inflammation acted as a lead point of intussusception, and persistent prolonged intussusception caused nodular florid vascular proliferation of deeper layers, in this case with unique microscopic and gross findings.
1	Intussusception	MESH:D007443	activates		MESH:D009369	Phenotype	8c7845da-375a-11e8-8f56-001a4a160175	29119526	Other conditions can occur, such as benign tumor (lipoma, myxoma of the appendix).2According to the literature, intestinal intussusception with underlying malignant lymphoma is a very rare condition, with only few cases described.3 Given the high rate of underlying organic lesions, including malignant tumor, all intestinal intussusception in the adults must lead to intestinal resection associated with anastomosis; simple reduction should not ever be performed.
1	Intussusception	MESH:D007443	activates		MESH:D009369	Phenotype	b7b5eeba-d7c0-11e5-b317-001a4ae51247	PMC4753668	For example, vessel co-option, vascular mimicry, intussusception, and vasculogenesis support tumor growth and potentially inhibit anti-angiogenic treatment [10,37,52–54].
1	Intussusception	MESH:D007443	activates		MESH:D009369	Phenotype	5420e8de-ca03-11e5-be63-001a4ae51246	PMC2811411	"Not only are the frequency and size of the tumors
                      substantially increased in theApc,p27compound model by feeding of a western-style, high-risk diet but also the incidence of intussusception, leading to a severe
                      shortening of life span."
1	Intussusception	MESH:D007443	activates		MESH:D004487	Phenotype	6baa3c31-6ff4-11e9-9f47-001a4a160176	PMC6416386	Considering that intussusception can cause edema and inflammation due to stasis in the mesenteric blood flow, we evaluated 4 blood serum markers: WBC count, ESR, CRP levels, and albumin.
1	Intussusception	MESH:D007443	activates		MESH:D004487	Phenotype	e1de0b04-c994-11ee-b22c-0050569a1f61	10.1016/j.epsc.2022.102529	The intussusception was incarcerated causing progressive edema, swelling and eventual progression to near total obstruction.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	2d8bc1e9-7f6f-11ea-8181-001a4a160175	PMC7158322	Acute vasculitis and intussusception have been reported to cause segmental bowel ischemia.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	e27e79c6-aaa1-11e8-bde0-001a4a160175	PMC6112951	Intussusception may lead to intestinal ischemia, intestinal necrosis, or intestinal perforation if not treated in time.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	f7ac156e-3522-11e8-9fbf-001a4a160176	23896371	Endoscopic views of colonic HAE (FigureC), which showed mucosa edema and submucosal hemorrhage from intussusception induced ischemia, have not been previously described.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	0f50a932-352d-11e8-bf76-001a4a160175	27048536	In addition, there were seven cases without obvious blood flow in the polyps due to the ischemia caused by the co-existing intussusception, while the blood flow signals in the polyps would be easily detected in the repeated ultrasound examinations after hydrostatic enema.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	1e879776-3910-11e8-a51f-001a4a160176	29150367	Intussusception causes secondary ischemia and intestinal occlusion that account for morbidity and mortality.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	5b51dbb6-3902-11e8-9192-001a4a160175	26190659	We experienced the case of a 63-year-old man with acute type A aortic dissection with intimo-intimal intussusception, which caused severe aortic valve regurgitation and coronary ischemia.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	6f8be552-351c-11e8-b868-001a4a160176	28314199	Intraoperatively, the patient was noted to have a nonreducible jejuno-jejunal intussusception causing obstruction and bowel ischemia (Fig. 4A), with approximately 40cm of devitalized bowel.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	9ababb44-f587-11eb-93d2-001a4a160176	30201347	Long-standing intussusception can sometimes lead to fatal complications, including bowel ischemia or perforation that require immediate surgical intervention.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	a4f5334e-bc4a-11e5-8abe-001a4ae51246	10.1016/j.ejphar.2010.06.044	Discussion The ischemia and reperfusion syndrome plays a fundamental role in the pathophysiology of several clinical-surgical conditions and may be caused by intestinal intussusception, acute mesenteric arterial occlusion and hemodynamic shock (Stefanutti et al., 2004).
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	5c6a39a6-b0ea-11ee-a9a2-0050569a1f61	10.1007/s12262-019-01981-6	Inversion is triggered by abnormal peristaltic movement due to ulceration or ectopic tissue at the base of the diverticulum; intussusceptions can lead to ischemia and perforation as the MD gets its blood supply from the remnant of the primitive Vitelline artery, an end branch of the superior mesenteric artery [2,3].
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	2c43aeec-375b-11e8-a51f-001a4a160176	20231020	The risk of the procedure should be considered, however, because intussusception can cause ischemia or even necrosis of the intestine.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	409a191d-7f6f-11ea-bf10-001a4a160176	PMC7167529	Acute Disease: Infarctive Lesions In acute, complete obstructions of the small intestine, with intestinal ischemia caused by volvulus, intussusception, or strangulation, there is usually an almost immediate onset of severe abdominal pain.
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	a7d5ea00-ae96-11ec-89b1-0050569a791b	PMC8668994	Adult intussusception is rarely observed compared with that in children, accounting for 5% of intussusception and ∼0.003% to 0.02% of all hospital admissions, less than 10% of these cases affect the gastro-duodenal region.Patients with this condition often have nonspecific symptoms, typically characterized by epigastric pain and vomiting.If untreated, intussusception can cause ischemia of the invaginated bowel wall and consequent perforation with peritonitis [7], [8].
1	Intussusception	MESH:D007443	activates		MESH:D007511	Phenotype	65f1bd48-5c5d-11e7-8b40-001a4ae51247	PMC5116046	The tissue trauma is most likely caused by shearing forces and ischemia caused by the intussusception.
1	Intussusception	MESH:D007443	activates		MESH:D045822	Phenotype	7b955b26-eac4-11ee-8b99-0050569a1f61	10.1053/j.scrs.2014.04.007	Other less common causes of acute colonic obstruction include volvulus (Fig. 5), stricture, intussusception, fecal impaction, foreign body, and compression from extrinsic tumors.34Diverticulitis can also lead to obstruction through stricture, inflammation, or extrinsic compression from a large abscess.
1	Intussusception	MESH:D007443	activates		MESH:D001064	Phenotype	b2107336-cd85-11ee-b346-0050569a791b	10.1016/j.epsc.2014.11.004	Appendix was in the ileocecal valve level and we thought that intussusception caused appendiceal luminal obstruction and then appendicitis.
1	Intussusception	MESH:D007443	activates		MESH:D002446	Phenotype	ec63af6e-bc4d-11e5-8abe-001a4ae51246	PMC3852808	Conclusion TUS as, usually, the first diagnostic procedure in abdominal complaints reveals the most of Crohn's SB inflammations, ileus, and intussusceptions enable to express suspicion of celiac disease, significant stenosis, or SMA occlusion.
1	Intussusception	MESH:D007443	inhibits		MESH:D003251	Phenotype	39d964e9-f578-11eb-8f1c-001a4a160176	32572600	The following patients were excluded: (i) history of abdominal surgery, imperforate anus, cloacal and genitourinary abnormalities, known malrotation, and heterotaxy syndrome; (ii) CE for intussusception reduction and evaluation of necrotizing enterocolitis strictures; (iii) incomplete charts or unavailable imaging.
1	Intussusception	MESH:D007443	activates		MESH:D003251	Phenotype	ec63af6e-bc4d-11e5-8abe-001a4ae51246	PMC3852808	Conclusion TUS as, usually, the first diagnostic procedure in abdominal complaints reveals the most of Crohn's SB inflammations, ileus, and intussusceptions enable to express suspicion of celiac disease, significant stenosis, or SMA occlusion.
1	Intussusception	MESH:D007443	activates		MESH:D003251	Phenotype	d8b8768e-bc11-11e5-9b9d-001a4ae51247	PMC3401564	Although Tayeb et al. [6] and Balducci et al. [2] reported jejunal diverticulosis as the setting for obstruction, the latter author attributed the obstruction to inflammatory stenosis caused by repeated episodes of diverticulitis, volvulus or intussusception, and voluminous jejuna stones.
1	Intussusception	MESH:D007443	activates		MESH:D018784	Phenotype	1d859fa6-bc41-11e5-8abe-001a4ae51246	PMC4291447	"Group I, ""catastrophic surgical abdomen,"" includes panperitonitis or abdominal abscesses caused by perforated appendicitis, splenic infarction, bowel perforation due to multiple magnet ingestion with adhesion, and intussusceptions with failure on non-surgical reduction."
1	Intussusception	MESH:D007443	activates		MESH:D007409	Phenotype	c9c9fe7e-ecda-11ee-b346-0050569a791b	10.1016/j.epsc.2013.07.005	Similarly to previous case reports of intussusception induced intestinal atresia, meconium was passed shortly after birth in our patient.
1	Intussusception	MESH:D007443	activates		MESH:D007409	Phenotype	25cfd15a-eb1c-11ee-8b99-0050569a1f61	10.1016/j.epsc.2014.04.002	Antenatal intussusception leads to a parietal intestinal necrosis and intestinal atresia in the concerned digestive segment.
1	Intussusception	MESH:D007443	activates		MESH:D007409	Phenotype	ae6c3c40-394f-11e8-a51f-001a4a160176	19944235	The relation to concurrent intussusception may represent either a cause or a result, as a weakened segment of intestine may predispose to intussusception; however, intrauterine intussusception is a known cause of intestinal atresia and may also be attributed to degeneration of muscle layers[19].
1	Intussusception	MESH:D007443	activates		GO:0007155	Phenotype	f270caea-bc4d-11e5-ac4e-001a4ae51246	PMC4380088	Our method of intussusception without putting two layers of sutures allows a good, unforced, and tension-free adhesion of the intestine wall to the pancreas.
1	Intussusception	MESH:D007443	activates		MESH:D044342	Phenotype	0c1f84d0-9ae0-11ee-ae1b-0050569a1f61	10.1007/s12262-020-02547-7	We have not found any case report with mixed presentation of gastric perforation associated with multiple small bowel intussusceptions causing severe malnutrition.
1	Intussusception	MESH:D007443	activates		MESH:D000471	Phenotype	2ec520c0-7f6f-11ea-8181-001a4a160175	PMC7125662	Proximal jejunal intussusception causes rapid and severe dehydration, electrolyte sequestration, and metabolic alkalosis.
1	Intussusception	MESH:D007443	activates		MESH:D045823	Phenotype	02d1ea0e-bc3a-11e5-ac4e-001a4ae51246	PMC4457091	Gastrointestinal obstruction, rectal bleeding (14%) and perforation are some possible surgical complications, and especially obstructive ileus, that can be caused either directly by a sizable polyp or indirectly by intussusception (45%) [4,7].
1	Intussusception	MESH:D007443	activates		MESH:D011127	Phenotype	d7edf564-bc3c-11e5-ac4e-001a4ae51246	PMC3789642	We present the case of a 41-year-old female presenting with sub-acute symptoms preceding an intestinal obstruction caused by an ileocolic intussusception with an inflammatory fibroid polyp acting as the lead point.
1	Intussusception	MESH:D007443	inhibits		MESH:D011127	Phenotype	135ac018-ae95-11ec-ae7b-0050569a1f61	PMCPMC8862355	Another patient underwent intussusception reduction and resection of multiple polyps in the large and small intestines.
1	Intussusception	MESH:D007443	activates		MESH:D008228	Phenotype	0817ec90-3f30-11e8-ab82-001a4a160175	PMC5895833	However, intussusception caused by GI tract non-Hodgkin lymphoma in an AIDS patient has rarely been reported [141516].
1	Intussusception	MESH:D007443	activates		MESH:D010195	Phenotype	4a67ca8a-3773-11e8-8f56-001a4a160175	18926201	In this article, we describe the previously unreported complication of retrograde jejunoduodenal intussusception causing pancreatitis in an adult patient who underwent loop duodenojejunostomy as an infant.
1	Intussusception	MESH:D007443	activates		MESH:D010195	Phenotype	cd5f94a0-0b23-11e6-918a-001a4ae51246	PMC4834622	In conclusion, we report the unique case of acute pancreatitis induced by gastroduodenal intussusception in a patient with a previously known gastric GIST arising from the corpus and causing duodenal obstruction.
1	Intussusception	MESH:D007443	activates		MESH:D010195	Phenotype	3eb6f59e-bc0f-11e5-9b9d-001a4ae51247	PMC3364087	The duodenoduodenal intussusception presumably caused the acute pancreatitis as follows.
1	Intussusception	MESH:D007443	activates		MESH:D007416	Phenotype	15545c6c-394b-11e8-b868-001a4a160176	17448765	On the other hand, meconium peritonitis usually results from an intestinal perforation caused by intestinal atresia, fetal intussusception, or meconium ileus, and it tends to demonstrate severe peritoneal adhesion, meconium cysts or calcification[4].
1	Intussusception	MESH:D007443	activates		MESH:D007416	Phenotype	e27e79c6-aaa1-11e8-bde0-001a4a160175	PMC6112951	Intussusception may lead to intestinal ischemia, intestinal necrosis, or intestinal perforation if not treated in time.
1	Intussusception	MESH:D007443	activates		GO:0030154	Phenotype	3237a020-bc0f-11e5-9b9d-001a4ae51247	PMC3670636	Diagnosis of intussusceptions by CT enables the differentiation between non-pathologic and pathologic intussusceptions.
1	Intussusception	MESH:D007443	activates		MESH:D007239	Phenotype	ba6364b0-cbf2-11ee-8b99-0050569a1f61	10.1016/j.pepo.2015.08.004	While the potential link between infection caused by rotavirus and intussusception is the subject of numerous considerations, further study is needed to assess the risk of these complications in the course of infection caused by other common factors (e.g.adenovirus) in this age group (Fig. 1).
1	Intussusception	MESH:D007443	activates		MESH:D051379	Phenotype	e0b8a17a-c8e5-11e5-a1fd-001a4ae51246	17693663	"An interesting finding from the present study is a high incidence of intestinal intussusception, which often led to the death
                      ofAPCmin/+PTEN+/−mice by 5 months."
1	Intussusception	MESH:D007443	activates		MESH:D003643	Phenotype	c901c988-351e-11e8-a34b-001a4a160175	28162764	Other complications Among the 49 datasets, we noted the following rare complications: intussusception causing death (n=1)[19]or requiring laparotomy (n=2)[20,21], jejunitis causing death (n=1)[22], buried bumper syndrome (n=1)[23], gastric outlet obstruction (n=3)[24,25], asymptomatic pneumoperitoneum (n=2)[5], abdominal wall infection requiring surgical removal of a congenital diaphragmatic hernia polytetrafluoroethylene patch (n=1)[26], and postoperative stridor and pneumothorax in a laparoscopic GJT placement (n=1)[27].
1	Intussusception	MESH:D007443	activates		MESH:D003643	Phenotype	93be68ef-f53c-11eb-acfe-001a4a160175	29866482	Left untreated, intussusception could lead to the death of the child.
1	Intussusception	MESH:D007443	activates		MESH:D003643	Phenotype	f7ec4a0a-340d-11e8-9fbf-001a4a160176	21683206	During the simulation, there were 4 possible heath states that the patient could exist in: intussusception, well, radiation-induced cancer, or death (Fig. 2).
1	Intussusception	MESH:D007443	activates		MESH:D003643	Phenotype	e8d22f82-6ff8-11e9-bb96-001a4a160175	PMC6406054	A problem related to immunization against RV is an increased risk of intussusception, which can lead to death.
1	Intussusception	MESH:D007443	activates		MESH:D003643	Phenotype	263949f1-f58e-11eb-8d18-001a4a160175	PMC10983083	Intussusception can result in vascular compromise and necrosis of the intestine if not reduced by enema or surgery; when left untreated, intussusception may lead to death, although some cases resolve spontaneously[2,3].
1	Intussusception	MESH:D007443	activates		MESH:D003643	Phenotype	e02aa247-f588-11eb-942d-001a4a160176	30389283	"Timely, effective reduction of intussusception is critical to prevent bowel necrosis, perforation, peritonitis, shock, and even death <ce:cross-ref refid=""bib1"" id=""crosref0045"">(1)</ce:cross-ref>."
1	Intussusception	MESH:D007443	activates		GO:0006954	Phenotype	bf1fdc88-3514-11e9-8325-001a4a160175	PMC6046368	When these entities present concurrently, as in our case, it brings up a “chicken or the egg” type question of whether the inflamed appendix was the lead point of the intussusception or whether the intussusception caused strangulation and inflammation of the appendix.
1	Intussusception	MESH:D007443	activates		GO:0006954	Phenotype	4a48dbb8-6afc-11e8-99e1-001a4a160175	PMC5991763	Severe symptoms of RV infection include malabsorption of nutrients, prolonged dehydration, and intussusception (IS), whereby one segment of the intestine becomes invaginated, causing inflammation, loss of blood flow, and significant pain [7].
1	Intussusception	MESH:D007443	activates		GO:0006954	Phenotype	7c37bb54-5c4c-11e7-8b40-001a4ae51247	PMC5097056	Furthermore, the recurrent intussusception may cause trauma, inflammation, mucosal erosion, and bleeding [1].
1	Intussusception	MESH:D007443	activates		GO:0006954	Phenotype	6baa3c31-6ff4-11e9-9f47-001a4a160176	PMC6416386	Considering that intussusception can cause edema and inflammation due to stasis in the mesenteric blood flow, we evaluated 4 blood serum markers: WBC count, ESR, CRP levels, and albumin.
1	Intussusception	MESH:D007443	activates		MESH:D013577	Phenotype	0647c10e-bc49-11e5-8abe-001a4ae51246	PMC3178522	The advantages of intraoperative reduction of the intussusception prior to resection, especially when the small bowel is affected, are that it may preserve a considerable length of bowel and thereby prevent development of short-bowel syndrome.
1	Intussusception	MESH:D007443	activates		MESH:D013577	Phenotype	a4f5334e-bc4a-11e5-8abe-001a4ae51246	10.1016/j.ejphar.2010.06.044	Discussion The ischemia and reperfusion syndrome plays a fundamental role in the pathophysiology of several clinical-surgical conditions and may be caused by intestinal intussusception, acute mesenteric arterial occlusion and hemodynamic shock (Stefanutti et al., 2004).
1	Intussusception	MESH:D007443	activates		MESH:D013577	Phenotype	af2adba0-bc42-11e5-9b9d-001a4ae51247	PMC3502287	The advantages of intraoperative reduction of the intussusceptions prior to resection, especially when the small bowel is affected, are that it may preserve a considerable length of bowel and thereby prevent development of short-bowel syndrome.
1	Intussusception	MESH:D007443	activates		MESH:D013577	Phenotype	587ec565-7f6f-11ea-bf11-001a4a160176	PMC7155600	In addition, an intussusception may occur in a recently born puppy or kitten and contribute to the fading puppy or kitten syndrome.
1	Intussusception	MESH:D007443	activates		MESH:D006973	Phenotype	24a0c3c8-bc4c-11e5-9b9d-001a4ae51247	PMC3731624	Here, we describe a 10-month-old boy presenting with lethargy and severe arterial hypertension caused by ileocecal intussusception.
1	Intussusception	MESH:D007443	activates		MESH:D012769	Phenotype	e02aa247-f588-11eb-942d-001a4a160176	30389283	"Timely, effective reduction of intussusception is critical to prevent bowel necrosis, perforation, peritonitis, shock, and even death <ce:cross-ref refid=""bib1"" id=""crosref0045"">(1)</ce:cross-ref>."
1	Intussusception	MESH:D007443	activates		MESH:D012769	Phenotype	95807d5e-bc4c-11e5-8d2d-001a4ae51247	PMC3460207	Surgery was required in just over half the cases, and one case was fatal, a five-month girl whose death was attributed to hypovolemic shock caused by intussusception and resulting bowel necrosis (Zanardi et al. 2001).
1	Intussusception	MESH:D007443	inhibits		MESH:D011051	Phenotype	3fa30910-bc51-11e5-8d2d-001a4ae51247	10.1016/j.virusres.2012.04.001	Our findings of interference, increased interferon response, and repressed rotavirus replication in Caco-2 cells with mixed rotavirus and other virus infections may help explain the presence of a small increased risk of intussusception among Mexican infants who received first dose of Rotarix and also parenteral inactivated polio vaccine and the lack of intussusception among Brazilian infants who received first dose of Rotarix and oral polio vaccine (Patel et al., 2011).
1	Intussusception	MESH:D007443	activates		MESH:D010538	Phenotype	e02aa247-f588-11eb-942d-001a4a160176	30389283	"Timely, effective reduction of intussusception is critical to prevent bowel necrosis, perforation, peritonitis, shock, and even death <ce:cross-ref refid=""bib1"" id=""crosref0045"">(1)</ce:cross-ref>."
1	Intussusception	MESH:D007443	activates		MESH:D010538	Phenotype	5db3b632-374e-11e8-bf76-001a4a160175	28779197	If untreated, intussusception results in ischemia, eventually leading to bowel necrosis, perforation and peritonitis.
1	Intussusception	MESH:D007443	inhibits		MESH:D018450	Phenotype	1eb76962-3535-11e8-a34b-001a4a160175	21447436	The early diagnosis and treatment of intussusception are critical to prevent morbidity and mortality related to disease progression[2-4].
1	Intussusception	MESH:D007443	inhibits		MESH:D020345	Phenotype	39d964e9-f578-11eb-8f1c-001a4a160176	32572600	The following patients were excluded: (i) history of abdominal surgery, imperforate anus, cloacal and genitourinary abnormalities, known malrotation, and heterotaxy syndrome; (ii) CE for intussusception reduction and evaluation of necrotizing enterocolitis strictures; (iii) incomplete charts or unavailable imaging.
1	Intussusception	MESH:D007443	activates		GO:0030432	Phenotype	f5c690ce-377c-11e8-87fd-001a4a160176	19715788	The mural and extraluminal lead point cause intussusception by producing focal abnormal peristalsis at that portion, resulting in rotation or kinking of the adjacent bowel segment and subsequent intussusception.36While presenting, lead points of colonic intussusception are more frequently neoplastic compared with that of enteric intussusception.
1	Intussusception	MESH:D007443	inhibits		GO:0030432	Phenotype	ed813643-f598-11eb-90da-001a4a160175	31101196	Decreasing peristalsis can result in intestinal edema and inflammation and can be caused by intussusception, which can develop into malnutrition, necrosis, and perforation of the intestine.
1	Intussusception	MESH:D007443	activates		MESH:D003967	Phenotype	78725a02-8d88-11e7-97d2-001a4ae51247	PMC5508351	Colonic intussusception led to chronic bloody diarrhea in a young German Shepherd dog, and systemic vasculitis was diagnosed in one German Shepherd dog.
1	Intussusception	MESH:D007443	activates		MESH:D000740	Phenotype	d95c3454-bbd5-11e5-9b9d-001a4ae51247	PMC3797946	They can cause abdominal pain, anemia and gastrointestinal bleeding by intussusception or obstruction.
1	Intussusception	MESH:D007443	inhibits		GO:0002432	Phenotype	3810a2ce-bc43-11e5-9b9d-001a4ae51247	PMC3161229	93 These findings were confirmed by Schiff et al., who reported patency and pregnancy rates of approximately 82% and 45%, respectively, using simplified intussusception techniques.32 Interestingly, these studies have also suggested that anastomoses are more water-tight after the use of intussusception techniques, which decreases granuloma formation.
1	Intussusception	MESH:D007443	activates		MESH:D017202	Phenotype	2fca878c-c46e-11e5-9da3-001a4ae51247	PMC4121763	Moreover, if the artery courses within the aortic wall or between the aorta and pulmonary artery, intussusception of the ectopic proximal vessel may occur and can cause myocardial ischemia.
1	Intussusception	MESH:D007443	activates		MESH:D000006	Phenotype	ad372628-bc42-11e5-9b9d-001a4ae51247	PMC2529271	Conclusion Intussusception is a rare cause of acute abdomen in adults.
1	Intussusception	MESH:D007443	activates		MESH:D000006	Phenotype	4e24c04e-351e-11e8-8636-001a4a160175	PMC5613261	"CONCLUSION:.

Intestinal invagination is a rare cause of acute abdomen in adults that may have a variety of etiologies and therefore may present with different clinical pictures."
1	Intussusception	MESH:D007443	activates		MESH:D000006	Phenotype	8044d658-bc2c-11e5-8abe-001a4ae51246	PMC2950270	Introduction Intussusception is an important cause of acute abdomen in infancy and childhood.
1	Intussusception	MESH:D007443	activates		MESH:D000006	Phenotype	806768e4-bc2c-11e5-8abe-001a4ae51246	PMC3092938	Intussusception is a significant cause of acute abdomen in young children, with between 0.5 and 2.3 cases per 1,000 live births.
1	Intussusception	MESH:D007443	activates		MESH:D000006	Phenotype	a5156f84-ae96-11ec-89b1-0050569a791b	PMCPMC8263847	Intussusception is an important cause of acute abdomen in children, where no lead point can usually be identified.In adults, however, a specific lead point is identified in more than 90% of cases, and a neoplasm is the culprit in 65%.
1	Intussusception	MESH:D007443	activates		MESH:D000006	Phenotype	1133de06-375b-11e8-87fd-001a4a160176	20223306	Intussusception is a typical cause of pediatric acute abdomen and is frequently encountered in clinical practice.
1	Intussusception	MESH:D007443	activates		MESH:D006470	Phenotype	875856fe-3551-11e8-8636-001a4a160175	19632648	Misra SP, Dwivedi M. Jejunogastric intussusception—a rare cause of recurrent upper gastrointestinal bleeding: case report and review of literature.
1	Intussusception	MESH:D007443	activates		MESH:D006470	Phenotype	de910b70-bbd5-11e5-8abe-001a4ae51246	PMC3521947	In addition, duodenal bleeding caused by ulceration, peritonitis, pancreatitis, jaundice, intussusception, and infection has been reported.10-12Diseases that should be differentiated from duodenal duplication cysts are all diseases that may appear as duodenal ulcer on the upper gastrointestinal series, such as lipoma, tumors in the ampulla of Vater, carcinoids, pancreatic pseudocysts, and choledochal cysts.6 Duodenal duplication cysts are occasionally detected with recurrent pancreatitis or idiopathic gastrointestinal hemorrhage.
1	Intussusception	MESH:D007443	activates		MESH:D006470	Phenotype	2297bd8c-bc4e-11e5-ac4e-001a4ae51246	PMC2615009	Intussusception may cause gastrointestinal bleeding because of ischemia and necrosis of the tumor; however, in this case the anemia had macrocytic indices and was due to cobalamin deficiency, secondary to the previous gastrectomy.
1	Intussusception	MESH:D007443	activates		MESH:D006470	Phenotype	117df142-c46e-11e5-85e4-001a4ae51246	24924845	Because intestinal intussusception caused by secondary metastasis may cause bowel obstruction, intestinal necrosis, and bleeding, surgical intervention is necessary in almost every case[2].
1	Intussusception	MESH:D007443	activates		MESH:D006470	Phenotype	870b31be-bbfd-11e5-9b9d-001a4ae51247	PMC2980919	Lower gastrointestinal (GI) bleeding in children is most often caused by Meckel’s diverticulum, intussusception, or necrotizing enterocolitis.
1	Intussusception	MESH:D007443	activates		MESH:D006470	Phenotype	d95c3454-bbd5-11e5-9b9d-001a4ae51247	PMC3797946	They can cause abdominal pain, anemia and gastrointestinal bleeding by intussusception or obstruction.
1	Intussusception	MESH:D007443	activates		GO:0030421	Phenotype	1295ff94-bc16-11e5-8abe-001a4ae51246	PMC2778725	This procedure consists of a double transanal rectal resection and is aimed at correcting the anatomical disorder of the rectum in patients with rectocele and rectal intussusception causing obstructed defecation [11,12].
1	Intussusception	MESH:D007443	activates		GO:0030421	Phenotype	600b1e15-f592-11eb-8ea4-001a4a160175	31834458	Intussusception is an important cause of obstructed defecation, but mild intussusception is also seen in asymptomatic patients [13].
1	Intussusception	MESH:D007443	activates		GO:0030421	Phenotype	f658a542-cf9a-11ee-b346-0050569a791b	10.1007/s13304-017-0508-y	STARR Stapled transanal rectal resection is usually performed for obstructed defecation supported by rectocele and/or rectoanal intussusception.
1	Intussusception	MESH:D007443	activates		GO:0030421	Phenotype	88239fd2-bc2f-11e5-8abe-001a4ae51246	PMC4329684	Intussusceptions are an important cause of outlet obstruction and incomplete defecation.
1	Intussusception	MESH:D007443	activates		GO:0030421	Phenotype	89a3078e-d51d-11ee-b346-0050569a791b	10.1053/j.optechgensurg.2008.09.008	This procedure can be considered for the surgical management of obstructed defecation caused by rectoceles and rectal intussusception in patients who can have the circular staplers inserted transanally without injury to the anal sphincters and those patients without an associated enterocele that is present at rest on defecography.
1	Intussusception	MESH:D007443	activates		GO:0030421	Phenotype	382487d0-a6a2-11ec-a19c-0050569a1f61	31471696	Rectal intussusception may cause symptoms of obstructed defecation [1,2] and can be classified into rectorectal and rectoanal intussusception.
1	Intussusception	MESH:D007443	activates		GO:0001974	Phenotype	c7597880-bc10-11e5-9b9d-001a4ae51247	PMC3724174	Intratumoral pressure Rapid tumor cell proliferation and weakly developed lymphatics cause high IFP (67,68) and blood vessel remodeling by intussusception (69) or compression (70).
1	Intussusception	MESH:D007443	activates		MESH:D003248	Phenotype	33ba1912-bc48-11e5-8abe-001a4ae51246	PMC3440488	Causes in women are known to be associated with the number of vaginal deliveries, cases of obstructed labor, and anorectal surgery [8,9] while rectoceles and intussusceptions are also known to induce excessive straining, causing constipation and resulting in a descent of the perineum.
1	Intussusception	MESH:D007443	activates		FPLX:G:i	ProteinFamily	870b31be-bbfd-11e5-9b9d-001a4ae51247	PMC2980919	Lower gastrointestinal (GI) bleeding in children is most often caused by Meckel’s diverticulum, intussusception, or necrotizing enterocolitis.
1	Intussusception	MESH:D007443	activates		IP:IPR003406	ProteinFamily	9fb80edf-dcae-11ea-a5b3-001a4a160175	PMC5878725	Intussusception can initiate a new vascular branch and is considered a normal intermediate in glomerular development [36].
1	Intussusception	MESH:D007443	activates		PF:PF00803	ProteinFamily	25cfd15a-eb1c-11ee-8b99-0050569a1f61	10.1016/j.epsc.2014.04.002	We present a rare case of ileoileal Type 3A atresia caused by neonatal intussusception.
1	Intussusception	MESH:D007443	activates		PF:PF00531	ProteinFamily	3a91952c-bbd9-11e5-9b9d-001a4ae51247	10.1016/j.vaccine.2009.03.016	Death caused by intussusception is uncommon in industrialized countries, occurring in <1% of the cases.
1	Intussusception	MESH:D007443	activates		PF:PF00531	ProteinFamily	740e7d28-bc2f-11e5-8abe-001a4ae51246	PMC3479108	Death caused by intussusception is uncommon in industrialized countries, occurring in <1% of the cases[52].
1		MESH:D006984	activates	Intussusception	MESH:D007443	Phenotype	12f7d914-d277-11ee-b22c-0050569a1f61	10.1016/j.mpsur.2010.04.001	The mechanism may be that the viral illness promotes hypertrophy of the Peyer's patches which leads to intussusception.
1		MESH:D006984	activates	Intussusception	MESH:D007443	Phenotype	43019e4e-c98d-11ee-b346-0050569a791b	10.1016/j.epsc.2022.102492	The majority of cases in infants and toddlers are “idiopathic”, meaning that the hypertrophy of regional lymph nodes in the terminal ileum produces ileocolic intussusception [2].
1		MESH:D004194	activates	Intussusception	MESH:D007443	Phenotype	0c17acf2-bc3f-11e5-8abe-001a4ae51246	PMC3053503	Adult intussusception is generally caused by underlying diseases; on the other hand, in children, it develops without cause in most cases [5].
1		MESH:D004194	activates	Intussusception	MESH:D007443	Phenotype	a0b19286-7c41-11ee-ae93-0050569a1f61	PMC9106268	Intussusception may be caused by anatomical causes, associated diseases and viral infections.
1		MESH:D013274	activates	Intussusception	MESH:D007443	Phenotype	c984cd82-c6a5-11ee-b346-0050569a791b	10.1016/j.vgie.2023.09.003	Second, in the case of large gastric neoplasms causing intussusception, rarely the neoplasm may extend down into the duodenum and obstruct the ampulla of Vater causing acute pancreatitis.2Furthermore, pyloric gland adenomas are rare gastric neoplasms that tend to be polypoid in morphology and are associated with autoimmune gastritis, predominantly occurring in female patients, as in this case.3Lastly, the traditional management for lesions causing gastroduodenal intussusception is surgical because of the risk of malignancy.
1		MESH:D004751	activates	Intussusception	MESH:D007443	Phenotype	cea2ce20-3756-11e8-87fd-001a4a160176	25148744	Eosinophilic enteritis may present as gastric antrum or intestinal disease with chronic gastrointestinal complaints, anemia, or polypoid lesions causing obstruction, intussusception, or gastrointestinal hemorrhage[33].
1		MESH:D004751	activates	Intussusception	MESH:D007443	Phenotype	c6decec8-3530-11e8-bf76-001a4a160175	20138300	"Results
                   Bacterial enteritis significantly increased the relative risk of intussusception."
1		MESH:D012400	activates	Intussusception	MESH:D007443	Phenotype	b97188de-394f-11e8-a34b-001a4a160175	19944222	Moreover, Warfield et al[46]showed in a mouse model that rotavirus infection combined with lipopolysaccharide treatment increased the rates of intussusception compared to lipopolysaccharide treatment alone.
1		MESH:D012400	activates	Intussusception	MESH:D007443	Phenotype	85ed3742-bbd9-11e5-956b-001a4ae51247	10.1016/j.vaccine.2011.08.110	To specifically address the question of whether natural rotavirus infection can cause intussusception, patients that present with intussusception can be examined for rotavirus to determine the biological plausibility of this hypothesis.
1		MESH:D008573	activates	Intussusception	MESH:D007443	Phenotype	5bc407d6-bc04-11e5-8abe-001a4ae51246	PMC4640028	[1] Although Meckel's diverticulum (MD) may cause intussusception and small bowel obstruction, it is usually asymptomatic and found incidentally during surgery.
1		MESH:D008573	activates	Intussusception	MESH:D007443	Phenotype	918e472a-67e0-11e8-8ba0-001a4a160175	PMC5944541	Sometimes, irreducible pediatric intussusception is caused by MD acting as leading point of intussusception.
1		MESH:D004630	activates	Intussusception	MESH:D007443	Phenotype	7edad254-99fc-11e7-9a4f-001a4a160175	PMC5585911	Emergency surgery is necessary in the cases of intestinal obstruction and intussusceptions secondary to multiple and/or large polyps.
1		MESH:D004630	inhibits	Intussusception	MESH:D007443	Phenotype	87f23858-c07d-11e7-b059-001a4a160175	PMC5643278	An emergency colonoscopy was performed to reduce the intussusception, in which the cecum had advanced into the ascending colon.
1		MESH:D004630	inhibits	Intussusception	MESH:D007443	Phenotype	9f2d2288-b7d8-11e7-b059-001a4a160175	PMC5719913	In a case with recurrent ileal intussusception, an emergency surgery was performed to relieve the intussusception and resect the ileum, including the HGM, after two open reductions [1].
1		MESH:D007889	activates	Intussusception	MESH:D007443	Phenotype	0142c834-c875-11ee-b22c-0050569a1f61	PMC10173153	We present herein the case of a man who presented with an acute bowel occlusion related with an intussusception caused by an inflammatory fibroid tumor.
1		MESH:D007889	activates	Intussusception	MESH:D007443	Phenotype	35520588-3530-11e8-a51f-001a4a160176	20006230	Adult jejunojejunal intussusceptions are extremely rare and usually caused by benign leading points: lipomas, leiomyomas, inflammatory polyps, and Meckel diverticulum.
1		MESH:D005767	activates	Intussusception	MESH:D007443	Phenotype	7f333460-5c19-11e7-8b40-001a4ae51247	PMC5417419	This might be attributed to a more severe course of gastrointestinal disease, causing volvulus, intestinal atresia, intussusception, MI, and DIOS in these patients.
1		MESH:D004240	activates	Intussusception	MESH:D007443	Phenotype	3aa5a573-7f6f-11ea-8181-001a4a160175	10.1016/b978-0-7020-5318-4.00007-3	Diverticula can cause impaction, obstruction, intussusception or fistula, and potentially diverticulitis, rupture, and peritonitis.
1		MESH:D004240	activates	Intussusception	MESH:D007443	Phenotype	26398654-3519-11e9-8aa6-001a4a160176	PMC6134666	To the best of our knowledge, this is the first case of double simultaneous intussusception caused by Meckel’s diverticulum and intestinal duplication in a child.
1		MESH:D004240	activates	Intussusception	MESH:D007443	Phenotype	944294c8-ae93-11ec-8b2e-0050569a1f61	PMCPMC8774205	Exploratory laparotomy showed ileoileal intussusception induced by an inverted Meckel’s diverticulum with ulceration.
1		MESH:D004240	activates	Intussusception	MESH:D007443	Phenotype	a6c5d69f-c5ae-11ea-91f3-001a4a160176	10.1016/B978-0-7020-5318-4.00007-3	Diverticula can cause impaction, obstruction, intussusception or fistula, and potentially diverticulitis, rupture, and peritonitis.
1		MESH:D004240	activates	Intussusception	MESH:D007443	Phenotype	bb9436a6-d17a-11ee-9133-0050569a1f61	10.1016/j.ijge.2011.01.001	However, an inverted Meckel’s diverticulum causing intussusception was also reported by Amin et al82after performing an ES.
1		MESH:D053706	activates	Intussusception	MESH:D007443	Phenotype	84beb30c-5c17-11e7-9fde-001a4ae51247	PMC5423586	Plain radiographs are unlikely to be diagnostic; however, double-contrast barium enema, ultrasound, CT scan, endoscopy or exploratory laparotomy are potential diagnostic methods.1,3–9 In common with other reported cases in cats and dogs, it is unclear if the typhlitis was a cause or effect of the caecocolic intussusception.
1		PF:PF07484	activates	Intussusception	MESH:D007443	ProteinFamily	26a559b0-c9c5-11ee-b346-0050569a791b	10.1016/j.ejrad.2022.110611	Typical CT imaging reveals a mass comprising a central area of fat attenuation, surrounded by a thick collar of soft-tissue attenuation within the intussusception, intestinal dilation, and fluid retention in the intussusception mass (Fig. 5B, 5C).
1		MESH:D015746	activates	Intussusception	MESH:D007443	Phenotype	83939b1e-c47e-11e5-9da3-001a4ae51247	PMC3134527	The common channel is most often affected, but it can also occur in the Roux-en-Y and biliopancreatic limbs,251and at the gastrojejunal anastomosis.252The presentation of both retrograde and antegrade intussusception is similar to a bowel obstruction, with abdominal pain, nausea and vomiting.253The exact cause of intussusception remains unknown.
1		MESH:D006406	activates	Intussusception	MESH:D007443	Phenotype	6ad9c3bc-cb25-11ee-b346-0050569a791b	10.1016/j.fjs.2015.10.002	Introduction A small bowel intussusception is rare and can be caused by infection, polyp, lymphoma, vasculitis, Meckel's diverticulum, intestinal duplication, cystic fibrosis, and intramural hematoma.
1		MESH:D006406	activates	Intussusception	MESH:D007443	Phenotype	8d0efbb8-bc2f-11e5-8d2d-001a4ae51247	PMC4094970	Meckel's diverticulum, intestinal polyps, enteric duplication cysts, intramural hematoma, and lymphoma may also cause intussusception.
1		UNIPROT:P09038	activates	Intussusception	MESH:D007443	Protein	b53ebf6a-c8e6-11e5-9cb8-001a4ae51247	17244646	Further vascular growth and remodeling occurs by intussusception, probably supported by bFGF.
1		MESH:D008545	activates	Intussusception	MESH:D007443	Phenotype	3a953f12-8d81-11e7-a20e-001a4ae51247	PMC5565039	Rarely, intestinal melanoma presenting as single or multiple polypoid lesions can cause intestinal intussusception, as in the present case [16].
1		MESH:D008545	activates	Intussusception	MESH:D007443	Phenotype	8808cdae-3416-11e8-a34b-001a4a160175	18513686	An impression of metastatic melanomas of the small bowel, which were causing intussusceptions, was noted.
1		FPLX:G:i	activates	Intussusception	MESH:D007443	ProteinFamily	18c2561c-8100-11ee-add2-0050569a791b	10.1007/s10620-022-07477-w	The predominant clinical features in PJS are bleeding, anemia, and intussusception caused by GI polyposis; the lesions are most frequently located in the SB (60–90%) [8,9].
1		MESH:D005990	activates	Intussusception	MESH:D007443	Phenotype	c085c4b0-ae93-11ec-8f68-0050569a1f61	PMCPMC8874661	However, this is the first special case report concerning combined ileoileal and ileocolic intussusception caused by IFP, which is initially diagnosed as two target structures found by abdominal CT.
1		MESH:D007417	activates	Intussusception	MESH:D007443	Phenotype	4ec4e78a-4ee7-11e8-93a4-001a4a160175	PMC5916640	As discussed, one is to identify sizeable intestinal polyps that could lead to intussusception and obstruction or bleeding and anemia.
1		MESH:D007417	activates	Intussusception	MESH:D007443	Phenotype	8d0efbb8-bc2f-11e5-8d2d-001a4ae51247	PMC4094970	Meckel's diverticulum, intestinal polyps, enteric duplication cysts, intramural hematoma, and lymphoma may also cause intussusception.
1		MESH:D007890	activates	Intussusception	MESH:D007443	Phenotype	d15c44a6-eda3-11e5-9b35-001a4ae51246	PMC4765121	To our best knowledge, there is only one published case of leiomyosarcoma treated by laparoscopic resection, but we have not found any papers concerning chronic recurrent intussusception caused by leiomyosarcoma.
1		MESH:D007890	activates	Intussusception	MESH:D007443	Phenotype	e0e3dd00-3b32-11e9-8aa6-001a4a160176	PMC6380073	We present a case of small bowel obstruction due to intussusception caused by an ileal leiomyosarcoma.
1		MESH:D007890	activates	Intussusception	MESH:D007443	Phenotype	adb1f724-3c65-11f0-afc2-0050569a791b	PMC9403291	Ileo-ileal intussusception caused by small bowel leiomyosarcoma: A rare case report.
1		CHEBI:50430	activates	Intussusception	MESH:D007443	Chemical	56a2b0d6-cd3a-11ee-b346-0050569a791b	10.1007/s00296-018-4129-7	HSP, as a self-limiting disease occasionally lead to severe gastrointestinal involvement, especially intussusception and nephritis/renal impairment [2,6].
1		MESH:D018227	activates	Intussusception	MESH:D007443	Phenotype	35cad8c4-bc0f-11e5-8abe-001a4ae51246	PMC3073789	We found no earlier report of a clear cell sarcoma causing intussusception.
1		UNIPROT:P00738	activates	Intussusception	MESH:D007443	Protein	a686fa78-c463-11e5-9cbe-001a4ae51247	PMC4712542	Occasionally, HP causes gastric outlet obstruction or intussusception of the small bowel [39].
1		MESH:D008297	activates	Intussusception	MESH:D007443	Phenotype	b7ddecf0-bc11-11e5-9b9d-001a4ae51247	PMC3741913	In our case, a 53-year-old male with diffuse large B-cell lymphoma involving the terminal ileum and had caused an ileocolic intussusception.
1		MESH:D014947	activates	Intussusception	MESH:D007443	Phenotype	3735fcb2-ab19-11e6-b3b6-001a4ae51247	PMC5051623	A recent review of the English literature revealed 23 cases of intussusception caused by abdominal trauma, with only 8 cases in preadolescents [2,3].
1		MESH:D014947	activates	Intussusception	MESH:D007443	Phenotype	b05a26f4-374a-11e8-87fd-001a4a160176	22607929	In the pediatric population, intussusception is one of the most common abdominal emergencies and is usually not associated with a pathologic lead point in children less than 5 years of age.1In adults, however, intussusception is rare, accounting for approximately 1% of adult patients with bowel obstruction.2In 58 adult cases of intussusception found during a 30-year review, 93% were associated with an organic lesion.2Three of the 58 cases reported contained a Meckel's diverticulum.2 Intussusception caused by abdominal trauma is exceedingly uncommon.
1		MESH:D000230	activates	Intussusception	MESH:D007443	Phenotype	b62915cc-8cd0-11ee-add2-0050569a791b	PMC9017428	In this report we describe a case of sigmoid intussusception caused by adenocarcinoma and its management.
1		MESH:D000230	activates	Intussusception	MESH:D007443	Phenotype	033c66d6-bc49-11e5-ac4e-001a4ae51246	PMC3155120	In our patient the colocolic intussusception was caused by an adenocarcinoma of the ascending colon.
1		MESH:D000230	activates	Intussusception	MESH:D007443	Phenotype	401ae4ea-bc0f-11e5-9b9d-001a4ae51247	PMC3531940	Gastrointestinal stromal tumors and adenocarcinoma rarely cause ileal intussusceptions [16].
1		MESH:D014839	activates	Intussusception	MESH:D007443	Phenotype	43019e4e-c98d-11ee-b346-0050569a791b	10.1016/j.epsc.2022.102492	In less than 24 months, who present with acute abdominal, bilious vomiting and bloody diarrhea should raise suspicion for intussusception.
1		MESH:D001167	activates	Intussusception	MESH:D007443	Phenotype	18b0ea5a-7f6f-11ea-817e-001a4a160175	10.1016/b978-0-323-35775-3.00007-2	In horses, verminous arteritis may uniquely cause intussusceptions.
1		UNIPROT:Q96PD4	inhibits	Intussusception	MESH:D007443	Protein	485175ca-bbe2-11e5-9b9d-001a4ae51247	PMC3286385	Retroperitoneal injection of 5 ml 1% procaine solution is given to prevent intussusception of the gut.
1		MESH:D016888	activates	Intussusception	MESH:D007443	Phenotype	7fda57ee-352c-11e8-a51f-001a4a160176	27999885	17Jejunojejunal intussusception caused by a small focal angiodysplasia as a lead point in a 69-year-old male with abdominal pain.
1		UNIPROT:Q5D862	activates	Intussusception	MESH:D007443	Protein	5aa7c522-f588-11eb-8b14-001a4a160175	30877330	The intestinal IFPs cause intussusceptions and obstructions more frequently than the gastric IFPs do (Fig.4) [11].
1		UNIPROT:Q5D862	activates	Intussusception	MESH:D007443	Protein	0b2dfe36-bc49-11e5-8abe-001a4ae51246	PMC2939554	About 70% to 90% of intussusception cases are due to benign or malignant neoplasms as a lead point and IFPs, lipomas and adenomas are the benign causes of intussusception [7].
1		UNIPROT:Q5D862	activates	Intussusception	MESH:D007443	Protein	562d0532-3516-11e9-913f-001a4a160175	PMC6039895	But in literature, IFPs causing intussusception has often been described as an emergency with intestinal obstruction [20,[24],[25],[26],[27],[28],[29],[30],[31]].
1		UNIPROT:Q5D862	activates	Intussusception	MESH:D007443	Protein	5640347c-1e01-11e8-a844-001a4a160176	PMC5823309	Although no distinctive radiologic features are reported, radiologists must keep in mind IFPs in the differential diagnosis of large, single, mural, or intramural lesions causing intussusception of the small bowel.
1		CHEBI:138560	inhibits	Intussusception	MESH:D007443	Chemical	edef6122-2db0-11eb-a790-001a4a160175	PMC7103111	Poster #: EDU-025 A Practice Model for the Air Reduction of Intussusception Peter Assaad, MD MPH, Children's Hospital Los Angeles, Los Angeles, CA, peter.s.assaad@gmail.com; Paul Iskander, MD Purpose or Case Report: Intussusception reduction is a procedure that, while familiar to the pediatric radiologist, remains a cause for consternation for the average radiology resident.
1		CHEBI:138560	inhibits	Intussusception	MESH:D007443	Chemical	0a8f0126-bbfb-11e5-9b9d-001a4ae51247	PMC4367038	[4] Air or barium enema has been utilized to reduce intussusception in children without cystic lead points.
1		MESH:D008068	activates	Intussusception	MESH:D007443	Phenotype	52e5e682-3350-11e8-87fd-001a4a160176	20171631	Here, we report a case of jejunal lipomatosis causing small-bowel intussusception that was diagnosed and reduced by double-balloon endoscopy (DBE) before a laparoscopic small-bowel resection.
1		MESH:D008068	activates	Intussusception	MESH:D007443	Phenotype	7ff5cc0c-99fc-11e7-8112-001a4a160175	PMC5597814	Discussion This is an unusual case of ileocolic intussusception caused by diffuse intramural intestinal lipomatosis in an adult.
1		MESH:D010532	activates	Intussusception	MESH:D007443	Phenotype	46d14174-a77d-11e8-9b5b-001a4a160175	PMC6098238	Her history of marked peritoneal disease/carcinomatosis was suspicious as a potential lead point for invagination via bowel to peritoneal tethering, allowing normal peristaltic activity to result in intussusception.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	2b759efe-bbd3-11e5-9b9d-001a4ae51247	PMC4532053	The clinical impression was intussusception caused by small bowel tumor.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	af2adba0-bc42-11e5-9b9d-001a4ae51247	PMC3502287	These findings led to a diagnosis of intussusceptions induced by a tumor most likely begin.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	24d55532-c799-11ee-b346-0050569a791b	10.1016/j.epsc.2023.102680	In addition, these tumors can sometimes lead to intussusception, intestinal obstruction, intramural hematoma, or perforation.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	3eca3f00-bc0f-11e5-9b9d-001a4ae51247	PMC3506066	If the tumor has caused intussusception and the attempt at reduction with local excision fails, segmental resection and primary reanastomosis is the procedure of choice.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	3cd45d14-3405-11e8-bf76-001a4a160175	22107716	The first is a mesenteric lesion with jejunojejunal intussusception.1The second is an ileal lesion with ileocolic intussusception.2Our patient was the third case related to jejunal CFT, a rare benign neoplasm inducing intussusception.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	d8574712-ea64-11ee-b22c-0050569a1f61	10.1016/j.cgh.2022.04.016	The patient underwent laparoscopic surgery, which showed ileoileal intussusception (FigureC) caused by the ileal tumor.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	5a51918e-bc54-11e5-ac4e-001a4ae51246	PMC2478653	There was no evidence of any neoplasm or diverticulum that could have caused the intussusception.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	8e837d6a-bc03-11e5-8abe-001a4ae51246	PMC3083063	Intermittent cramping pain and guaiac-positive stools can be related to intussusception caused by small bowel tumors.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	f3fe88b6-ea39-11ee-b346-0050569a791b	10.1016/j.visj.2022.101461	CT is the most accurate diagnostic modality.1Small bowel neoplasms causing intussusception are commonly benign and due to a lipoma or hamartomatous polyp.2Melanoma with metastatic lesions in the small bowel can also serve as a lead point for intussusception.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	4c085650-f53e-11eb-ada9-001a4a160175	30374750	Colon intussusceptions caused by a low-grade appendiceal mucinous neoplasm.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	b0fca5fc-d41b-11e6-9a62-001a4ae51246	PMC5164886	Colonic lipoma is the most common benign tumor which causes colonic intussusception in adults, but very rarely [5].
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	3eacff58-bc0f-11e5-9b9d-001a4ae51247	PMC3304074	Discussion Most colon intussusceptions in adults are caused by malignant tumors, although other causes and idiopathic forms of intussusception have been reported [1,2,3].
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	fe59e108-3549-11e8-b868-001a4a160176	18187069	Malignant neoplasms cause most adult intussusceptions; surgery is widely advocated as the intervention of choice.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	28046132-f579-11eb-8560-001a4a160175	32779147	Based on these findings, we highly suspected that the jejunal tumor induced mild intussusception of the jejunum.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	de1e82e6-bc3c-11e5-8d2d-001a4ae51247	PMC3649253	INTRODUCTION Adult intussusception (AI) in the Western countries is usually caused by tumors and requires resection.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	afbd03e2-bbe1-11e5-8abe-001a4ae51246	PMC3624648	The rapidity of volumetric doubling of this neoplasm frequently leads to an acute abdomen presentation that may mimic other diseases (bowel obstruction secondary to ileocecal intussusception caused by tumor growth, obstruction or bleeding; some presentations may mimic acute appendicitis) [3,12].
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	3527fe42-bbd3-11e5-9b9d-001a4ae51247	PMC2687598	These tumors may cause obstruction, volvulus, intussusception, ulcertation, bleeding or perforation.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	30c85e32-bc0f-11e5-9b9d-001a4ae51247	PMC3806710	Thus, the diagnosis and therapeutic planning of intestinal tumors causing intussusception in adults has recently been made more feasible with the advent and accessibility of the imaging modality of multislice computed tomography (CT).
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	999b0e2e-bbeb-11e5-9b9d-001a4ae51247	PMC4331823	In addition to foreign bodies, primary neoplasias of the small intestine and colon and metastatic lesions (e.g., melanoma) can cause intussusception.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	62f3b75e-34f6-11e9-87c2-001a4a160175	PMC6216089	Small bowel intussusception is a rare cause of intestinal obstruction in adult population, and is caused by neoplasia in 65% of cases [12].
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	5420e8de-ca03-11e5-be63-001a4ae51246	PMC2811411	Intussusception is usually caused in humans by the presence of an intestinal tumor (25).
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	48d9f0c8-bc2b-11e5-8abe-001a4ae51246	PMC3533629	Adult intussusception is usually caused by a tumor acting as the apex of the intussusception.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	c5b9805a-f9db-11e7-82da-001a4a160175	PMC5766744	Multiple small polypoid tumors in the jejunum were the cause of the intussusception and 25 
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	a4feea7e-cd76-11ee-b346-0050569a791b	10.1016/j.tgie.2015.02.002	Ulceration of the mucosa may cause bleeding, and occasionally, polyps or tumors can lead to intussusception[6].
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	d10f5c2c-cd29-11ee-b346-0050569a791b	10.1016/j.ijge.2014.06.004	The purpose of this study was to retrospectively evaluate the preoperative diagnoses and surgical treatment of elderly patients with intussusception caused by colonic tumors in our hospital.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	4333b8d6-08e8-11e9-9b5e-001a4a160176	PMC6319823	In addition, the metastatic tumor caused intussusception, which is another rare clinical observation in adults.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	351e2b9c-bc0f-11e5-8abe-001a4ae51246	PMC2988933	Although more technically difficult than laparotomy, with an increased risk of perforation and dissemination and metastasis in cases of malignancies or with intestinal dilatation, laparoscopic surgery seems to become a procedure of choice for intussusception caused by benign intestinal tumors in the future.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	3a5a6f6a-73b5-11ee-add2-0050569a791b	10.1007/s12262-023-03879-w	Recently, with remarkable advances in laparoscopic surgery, patients with intussusceptions caused by malignant tumors are also treated laparoscopically [1].
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	49726542-bc2b-11e5-9b9d-001a4ae51247	PMC3443991	Adult intussusception is usually caused by a tumor acting as the apex of the intussusception.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	22f60b30-bc4e-11e5-8abe-001a4ae51246	PMC546237	In adult patients, small bowel intussusception is caused mostly by small benign intraluminal ileal tumors like lipoma and leiomyoma [6,8].
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	87f23858-c07d-11e7-b059-001a4a160175	PMC5643278	Approximately one-third of the intussusceptions of the intestinal tract occur as a result of surgery-induced changes, such as adhesion, submucosal edema, and intestinal motility disorders; colonic intussusceptions in adults are usually caused by malignant or benign tumors[3].
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	d6210b4c-340b-11e8-b868-001a4a160176	20546731	If large, this tumor can cause intussusception and bowel obstruction.
1		MESH:D009369	inhibits	Intussusception	MESH:D007443	Phenotype	24287fd4-67e5-11e8-8ba0-001a4a160175	PMC5887521	In this case, concern for possible neoplasm and inability to reduce the appendiceal intussusception, rather than ulcerative colitis, led to a larger resection.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	7c47bf4e-3910-11e8-9192-001a4a160175	29110230	The histolopathological dilemma is further increased where a secondary lead point is not identified, raising the possibility of a neoplasm which triggered the intussusception.
1		MESH:D009369	activates	Intussusception	MESH:D007443	Phenotype	3eb6f59e-bc0f-11e5-9b9d-001a4ae51247	PMC3364087	We diagnosed duodenoduodenal intussusception caused by this tumor acting as the lead point.
1		MESH:D009569	activates	Intussusception	MESH:D007443	Phenotype	025cdb80-bbcf-11e5-a9ef-001a4ae51247	10.1016/j.autneu.2007.06.213	Wang P, Liu B, Ou H, Tong L, Yang J, Tang C. (1999) Nitric oxide synthase/nitric oxide pathway mediates intussusception pathogenesis in rats.
1		FPLX:VEGF	activates	Intussusception	MESH:D007443	ProteinFamily	8da78928-bbd5-11e5-956b-001a4ae51247	10.1016/j.prp.2013.08.005	Baum et al.[30]suggest that vascular endothelial growth factor promotes intussusception.
1		MESH:D004487	activates	Intussusception	MESH:D007443	Phenotype	1da791a2-37a1-11e6-aaca-001a4ae51246	PMC4747958	The differences in clinical features may suggest the difference in mechanism of occurrence between both situations, and transient edema at the anastomotic site may be a main cause of intussusception after FJT.
1		MESH:D004487	activates	Intussusception	MESH:D007443	Phenotype	83b64bc4-bc03-11e5-9b9d-001a4ae51247	PMC3083058	In this case, we speculate that the intussusception was induced by postpolypectomy mucosal edema acting as a lead point.
1		MESH:D004487	activates	Intussusception	MESH:D007443	Phenotype	fcd6815a-bc48-11e5-8abe-001a4ae51246	PMC2650702	An intraluminal tumor, submucosal edema or any process that causes dysrhythmic contractions may initiate intussusception.
1		MESH:D004487	activates	Intussusception	MESH:D007443	Phenotype	5f314360-bc23-11e5-9b9d-001a4ae51247	PMC4538593	Her allergist recommended beginning treatment with three 1,000-unit doses of IV Cinryze delivered every 2 hours in an attempt to subside the edema causing the intussusception.
1		FPLX:GJ	activates	Intussusception	MESH:D007443	ProteinFamily	4a0b6bfe-d6ab-11ee-8b99-0050569a1f61	10.1007/s40746-018-0126-z	Rarely, GJ tubes may perforate the intestine or cause intussusception [49].
1		FPLX:GJ	inhibits	Intussusception	MESH:D007443	ProteinFamily	524af4d2-34db-11e9-9cf0-001a4a160175	PMC6365386	The tip of the GJ tube was placed at the level of ligament of Treitz to prevent jejuno-jejunal intussusception.
1		UNIPROT:P49585	activates	Intussusception	MESH:D007443	Protein	79a71394-f588-11eb-8b1d-001a4a160175	30809694	Fused axial18F-FDG PET-CT image in the pelvis (c) depicts a second hypermetabolic mass (thin arrow) that the corresponding axial diagnostic CT image (d) shows is causing an intussusception (thick arrows).
1		UNIPROT:P49585	activates	Intussusception	MESH:D007443	Protein	38a12ddc-bc0f-11e5-8abe-001a4ae51246	PMC4520193	Active CD exhibits a malabsorption pattern on CT causing the small bowel to appear dilated, fluid-filled and flaccid, causing telescoping and possible intussusception with large flatus-filled colon from excess gas production with fluid pluming in the right colon and encrusting of the right colonic wall [13].
1		UNIPROT:P49585	activates	Intussusception	MESH:D007443	Protein	11f42922-340e-11e8-87fd-001a4a160176	21704621	Contrast-enhanced CT of the pelvis revealed a well-circumscribed, strongly enhancing mass (FigureD,arrow)—a “lead mass” at the jejunum—causing intussusception.
1		UNIPROT:P49585	activates	Intussusception	MESH:D007443	Protein	1e663004-bc4e-11e5-ac4e-001a4ae51246	PMC4038827	Ultrasonographic and whole-abdomen CT examination showed that the lipoma had caused an ileocolic intussusception and incomplete intestinal obstruction.
1		UNIPROT:P49585	activates	Intussusception	MESH:D007443	Protein	7d2f70b2-ccc8-11ee-8b99-0050569a1f61	10.1016/j.epsc.2015.03.003	The CT scan performed at admission led us to suspect diverticulitis or intussusception of an MD (Fig. 1).
1		UNIPROT:P49585	inhibits	Intussusception	MESH:D007443	Protein	483f4848-3550-11e8-a51f-001a4a160176	17996609	CT permits also to eliminate a rare, but classic, etiology of intussusception, a lipoma[7].
1		UNIPROT:P49585	activates	Intussusception	MESH:D007443	Protein	08f09eda-bc49-11e5-9b9d-001a4ae51247	PMC2830979	In this case, the suspicion of PJS led to active investigation by a CT scan, thereby revealing the intussusceptions.
1		UNIPROT:P49585	activates	Intussusception	MESH:D007443	Protein	b2b79382-ab14-11e6-81c1-001a4ae51246	PMC5062658	The colonicsegment proximal to the mass could not be visualized on colonoscopy, but abdominal computed tomography (CT) showed a 5 x 3 x 4-cm fat density mass at the hepatic flexure causing colocolic intussusception of the ascending colon into the proximal transverse colon.
1		MESH:D007511	activates	Intussusception	MESH:D007443	Phenotype	11613eb2-ea30-11ee-9aaa-0050569a1f61	10.1016/j.epsc.2022.102414	The necrosis of the intestinal mucosa may be the reason for aggravating the reverse movement of the intestinal tube to form intussusceptions, suggests that mesenteric and enteric vascular ischemia could be one trigger of intussusceptions in premature neonates.
1		UNIPROT:P01350	inhibits	Intussusception	MESH:D007443	Protein	9eb81052-3405-11e8-a51f-001a4a160176	28268146	Gas is associated with lower risk of peritoneal contamination compared to liquid enemas in the event of perforation(19–21), and tears in the bowel because of gas enema tend to be smaller than those seen with liquid enema.Figure 4a–cshows the finding of a perforation during a fluoroscopically guided pneumatic reduction of an intussusception.
1		MESH:D008787	activates	Intussusception	MESH:D007443	Phenotype	fa4f34c3-7f6e-11ea-817e-001a4a160175	PMC7158189	"The effects of oxytocin are very short lived; so, the drug must be given frequently (0.5 to 1.0 U/cat, SC, every 30 minutes).117 Metoclopramide (0.1 to 0.2 mg/kg, SC or IM) stimulates prolactin secretion from the anterior pituitary and will cause milk letdown within 15 minutes.117
  Postpartum Intussusception ::: Postpartum Problems Intussusception is reported occasionally in young cats, and often occurs in association with gastroenteritis."
1		UNIPROT:Q9BXC9	activates	Intussusception	MESH:D007443	Protein	ed559330-334a-11e8-87fd-001a4a160176	22041136	Collagenous sprue is a rare condition mainly seen in patients with CD, particularly if refractory; small bowel ulceration and perforation are recognized complications.1 BBS may also cause both intussusception and volvulus.
1		MESH:D045822	activates	Intussusception	MESH:D007443	Phenotype	dda8c0ba-bc3c-11e5-8d2d-001a4ae51247	PMC3649195	Small bowel obstruction is a slightly rarer complication, most frequently caused by volvulus around an associated fibrous or omphalomesenteric band, intussusception, adhesions or incarceration within a hernial sac (2).
1		MESH:D003141	activates	Intussusception	MESH:D007443	Phenotype	bfaa19e2-ae93-11ec-89b1-0050569a791b	PMCPMC8719910	Intussusception can occur in adults throughout the gastrointestinal tract and is often caused by tumors, adhesions, or other noninfectious or infectious disease states and the impact they have on bowel activity.
1		MESH:D014435	activates	Intussusception	MESH:D007443	Phenotype	12045726-ca01-11e5-be63-001a4ae51246	PMC1181841	"Still, enlargement of
                      Peyer's patches is commonly blamed for idiopathic intussusception in
                      infants,5we
                      hypothesize that such a mechanism is responsible for typhoid-induced
                      intussusception."
1		UNIPROT:P07237	activates	Intussusception	MESH:D007443	Protein	88c01672-c8c5-11ee-b346-0050569a791b	10.1016/j.jpedsurg.2022.12.025	Three children were hospitalized due to complications caused by GIT duplications: intestinal obstruction, intussusception and volvulus of the small intestine.
1		UNIPROT:Q8WXI8	activates	Intussusception	MESH:D007443	Protein	22c02cd2-3950-11e8-a34b-001a4a160175	19917477	Although the gastrointestinal tract appears to be involved in a high proportion of patients with MCL, only 2 previous cases of MCL causing intussusception have been reported[2,3].
1		UNIPROT:P98153	activates	Intussusception	MESH:D007443	Protein	3fc8f8f8-cda2-11ee-9133-0050569a1f61	10.1016/j.fjs.2014.08.004	It usually occurs secondary to a neoplasm that acts as a lead point.3Griffin et al2described an IDD that had migrated beyond the ligament of Treitz causing intussusceptions at the distal portion of the duodenum.
1		MESH:D001064	activates	Intussusception	MESH:D007443	Phenotype	41ba448c-bc2b-11e5-8abe-001a4ae51246	PMC3971845	We report a case of cecocolic intussusception caused by an acute appendicitis treated by laparoscopic right hemicolectomy.
1		MESH:D001630	activates	Intussusception	MESH:D007443	Phenotype	0c1f84d0-9ae0-11ee-ae1b-0050569a1f61	10.1007/s12262-020-02547-7	The bezoars may cause hematemesis, gastric outlet obstruction, gastric ulceration and perforation, multiple jejunojejunal intussusceptions, acute pancreatitis, and even cholestatic jaundice.
1		MESH:D010580	activates	Intussusception	MESH:D007443	Phenotype	06e2b3aa-3507-11e9-8325-001a4a160175	PMC6125262	His past history involved a high anterior resection of the rectum in our hospital due to intussusception caused by Peutz-Jeghers polyposis (Fig.1).
1		MESH:D018194	activates	Intussusception	MESH:D007443	Phenotype	3a90b2ac-bc0f-11e5-9b9d-001a4ae51247	PMC3219485	Adenomyoma of the ileum causes intussusceptions in children more often than in adults.
1		MESH:D018194	activates	Intussusception	MESH:D007443	Phenotype	8a0ea2f6-bc07-11e5-8abe-001a4ae51246	PMC4210458	Herein, we report and discuss the case of an infant in the typically affected age group with an ileocolic intussusception triggered by an adenomyoma of the distal ileum wall, a rare benign intramural intestinal tumor, acting as pathological lead point.
1		MESH:D008202	activates	Intussusception	MESH:D007443	Phenotype	dc750be8-bbd5-11e5-9b9d-001a4ae51247	PMC4323441	Large lymphangiomas may produce bowel obstruction, intussusception, bleeding, anemia, and protein-losing enteropathy, in addition to symptoms such as abdominal pain, vomiting, and diarrhea.6Complete surgical excision is considered the treatment of choice for these large, symptomatic lymphangiomas.1,6For pedunculated tumors <2 cm, recent reports indicate a trend towards the use of endoscopic polypectomy.11In the present case, no treatment other than several incisions and excisional biopsies was attempted because the observed tumors were all small, sessile, and did not exhibit symptoms or cause complications.
1		MESH:D008202	activates	Intussusception	MESH:D007443	Phenotype	1e67f280-3505-11e9-8741-001a4a160176	PMC6132174	Lymphangioma is a rare cause of intussusception, and even less common in adults.
1		MESH:D008202	activates	Intussusception	MESH:D007443	Phenotype	0c17acf2-bc3f-11e5-8abe-001a4ae51246	PMC3053503	In addition, although rare, intussusception caused by a lymphangioma in the abdominal cavity has been reported [4].
1		MESH:D008202	activates	Intussusception	MESH:D007443	Phenotype	15dbbefe-bc30-11e5-ac4e-001a4ae51246	PMC2893317	Occasionally, lymphangiomas are large enough to cause obstructive symptoms or intussusception (11,14).
1		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	3c5b15d2-bc0f-11e5-8abe-001a4ae51246	PMC2974997	Chiu et al. described the successful laparoscopic resection of ileocolic intussusception caused by primary ileal lymphoma [6].
1		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	400b4eba-bc2b-11e5-8abe-001a4ae51246	PMC3703414	These two cases demonstrate that lymphoma polyps in any part of the small bowel can cause intussusception.
1		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	2ce780f8-ae94-11ec-b4ed-0050569a1f61	PMCPMC8357410	These lymphomas are extremely aggressive and can sometimes even lead to intussusception [2].
1		MESH:D008223	inhibits	Intussusception	MESH:D007443	Phenotype	0de32e08-bc30-11e5-9b9d-001a4ae51247	PMC2698160	The clinically important medical histories included recent ileocolic intussusception that was reduced by either air enema (n = 2) or surgical manipulation (n = 1), Henoch-Schonlein purpura (HSP, n = 2), nephrotic syndrome (n = 2), and post-chemotherapy state of lymphoma (n = 1).
1		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	6436bf80-bc4a-11e5-ac4e-001a4ae51246	PMC4579673	In our patients, lymphoma caused ileocecal intussusception in 3 cases.
1		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	6ad9c3bc-cb25-11ee-b346-0050569a791b	10.1016/j.fjs.2015.10.002	Introduction A small bowel intussusception is rare and can be caused by infection, polyp, lymphoma, vasculitis, Meckel's diverticulum, intestinal duplication, cystic fibrosis, and intramural hematoma.
1		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	8d0efbb8-bc2f-11e5-8d2d-001a4ae51247	PMC4094970	Meckel's diverticulum, intestinal polyps, enteric duplication cysts, intramural hematoma, and lymphoma may also cause intussusception.
1		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	c506917c-bc41-11e5-8abe-001a4ae51246	PMC3289029	Polypoid growing lymphoma may act as a lead point and cause intussusception.
1		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	35cad8c4-bc0f-11e5-8abe-001a4ae51246	PMC3073789	Non-Hodgkin lymphoma was the lead-point in case A. Lymphomas form approximately 25% of primary small bowel malignancies [7] and have been reported to cause intussusception by several authors, as have lipoma and adenocarcima [1,2,3,4,5,6].
1		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	c63098d6-bc41-11e5-8d2d-001a4ae51247	PMC3259399	In these cases, CT scan examination shows an abnormal multi-layered, targetlike image, with a diameter larger than the normal bowel, consistent with the intussusception (Fig.10); however, as previously reported [2], the direct visualization of the Meckel’s diverticulum as the lead point is often difficult to assess, and the differential diagnosis includes intussusception produced by benign (lipoma) or malignant (metastasis, lymphoma) tumors [28].
1		MESH:D008223	activates	Intussusception	MESH:D007443	Phenotype	ef521b10-1237-11e8-bdf1-001a4a160175	PMC6047971	Malignant lymphoma is an uncommon cause of intussusception, causing less than 1% of all cases of intussusception (5).
1		MESH:D012509	activates	Intussusception	MESH:D007443	Phenotype	95d64d78-bc39-11e5-8abe-001a4ae51246	10.1016/j.jcpa.2010.12.007	In addition to jejunal granuloma (Ogawaet al., 2009), intussusceptions in adult cattle are caused by duodenal sarcoma (Payton, 1954), jejunal adenocarcinoma (Archeret al., 1988) and colonic fibroserous granulation (Okamotoet al., 2007).
1		MESH:D009362	activates	Intussusception	MESH:D007443	Phenotype	c63098d6-bc41-11e5-8d2d-001a4ae51247	PMC3259399	In these cases, CT scan examination shows an abnormal multi-layered, targetlike image, with a diameter larger than the normal bowel, consistent with the intussusception (Fig.10); however, as previously reported [2], the direct visualization of the Meckel’s diverticulum as the lead point is often difficult to assess, and the differential diagnosis includes intussusception produced by benign (lipoma) or malignant (metastasis, lymphoma) tumors [28].
1		MESH:D009362	activates	Intussusception	MESH:D007443	Phenotype	25d51056-3548-11e8-b868-001a4a160176	18853838	Nodular metastases, especially those from melanoma, may produce SBO secondary to intussusception (Fig. 10).
1		MESH:D009362	activates	Intussusception	MESH:D007443	Phenotype	a992d69a-bbfa-11e5-9b9d-001a4ae51247	PMC3168384	Rarely reported, bowel metastasis may lead to intestinal intussusception, which requires prompt surgical intervention.
1		MESH:D009362	activates	Intussusception	MESH:D007443	Phenotype	7c5ed44c-5c19-11e7-bcb7-001a4ae51246	PMC5419932	Chandramohan et al[15]reported that they could not conservatively cure their patient of intussusception caused by osteosarcoma metastasis to the jejunum, so they concluded that surgical management should be considered because of the risk of gangrene and perforation.
1		MESH:D009362	activates	Intussusception	MESH:D007443	Phenotype	1b0ea652-bc4e-11e5-8d2d-001a4ae51247	PMC3751907	Conclusion conclusions Osteosarcoma metastasis causing intussusception is a very rare entity, with a pejorative prognosis.
1		MESH:D009362	activates	Intussusception	MESH:D007443	Phenotype	1a0a44a3-f58b-11eb-8c07-001a4a160175	30777150	One other case relating to isolated bladder cancer metastasis causing intussusception within the transverse colon with subsequent LBO is recorded.258Following colonic resection and primary anastomosis in this case, histology highlighted a pedunculated sarcomatoid bladder carcinoma originating from the colonic mucosa.
1		MESH:D003251	activates	Intussusception	MESH:D007443	Phenotype	d7bf64fe-3b5d-11e8-a34b-001a4a160175	PMC5740779	Small bowel obstruction (SBO) after LRYGB occurs in 1.5–5% of patients nationwide and can be caused by jejunojejunostomy stenosis, adhesions, incarcerated ventral hernia, IH, bezoar, or intussusception.
1		MESH:D000163	activates	Intussusception	MESH:D007443	Phenotype	fcd6815a-bc48-11e5-8abe-001a4ae51246	PMC2650702	It has long been known that various AIDS-related conditions of the bowel can lead to intussusception [10,11].
1		UNIPROT:P05154	activates	Intussusception	MESH:D007443	Protein	a5af9a30-eda1-11e5-9b35-001a4ae51246	PMC4747943	PCI can lead to complications like small or large bowel obstruction, volvulus, intussusception, and intra-abdominal haemorrhage.
1		MESH:D006222	activates	Intussusception	MESH:D007443	Phenotype	2f541de8-340d-11e8-8636-001a4a160175	24368074	As with other adenomas in the GI tract, Brunner's gland adenomas and/or hamartomas may cause obstruction, bleeding, and intussusception, with presentations of abdominal pain, nausea, vomiting, and anemia; less frequently they may present with obstructive jaundice or recurrent pancreatitis.
1		MESH:D006222	activates	Intussusception	MESH:D007443	Phenotype	08f09eda-bc49-11e5-9b9d-001a4ae51247	PMC2830979	In the study conducted by Chiang and Lin, nearly 18% of incidences of hamartomas caused enteric intussusception.
1		MESH:D006222	activates	Intussusception	MESH:D007443	Phenotype	5dfa5656-2144-11e9-bb97-001a4a160175	PMC6327855	According to our knowledge, there are only few cases in the literature of duodenojejunostomy for retrograde intussusception caused by a giant Brunner's gland hamartoma.
1		MESH:D006222	activates	Intussusception	MESH:D007443	Phenotype	f9c42c9a-cd76-11ee-9aaa-0050569a1f61	10.1016/j.tgie.2015.01.002	The hamartomas often cause anemia, intussusceptions, and intestinal obstruction, prompting repeated enteroscopies and laparotomies, with the first events often beginning as early as 4.5 years of age[42].
1		UNIPROT:P09067	activates	Intussusception	MESH:D007443	Protein	c065f5ce-bc3a-11e5-ac4e-001a4ae51246	10.1016/j.mam.2011.04.001	More recently, another study has found that the transcription factor HoxB5 promotes intussusception in an Ang2 dependent manner (Winnik et al., 2009).
1		MESH:D006965	inhibits	Intussusception	MESH:D007443	Phenotype	cfc46d9e-3905-11e8-9fbf-001a4a160176	28065716	Therefore, dexamethasone treatment for the intestinal lymphoid hyperplasia has been advised as a treatment for idiopathic intussusception in children in order to decrease the rate of recurrent intussusceptions.
1		MESH:D006965	activates	Intussusception	MESH:D007443	Phenotype	5605c536-bc2d-11e5-8abe-001a4ae51246	PMC3920992	INTRODUCTION Intussusception in a child during the first year of life is sometimes caused by ileal hyperplasia.
1		MESH:D006965	activates	Intussusception	MESH:D007443	Phenotype	a686fa78-c463-11e5-9cbe-001a4ae51247	PMC4712542	Brunner's gland hyperplasia or duodenal tumor such as lipoma and polyp are reportedly possible causes of intussusception [67].
1		MESH:D006965	activates	Intussusception	MESH:D007443	Phenotype	f4b33cf0-f53b-11eb-ba85-001a4a160176	29232618	We observed two cases of lymphoid hyperplasia of the ileal wall, probably associated with a recent episode of gastroenteritis, causing acute intestinal intussusception.
1		MESH:D006965	activates	Intussusception	MESH:D007443	Phenotype	93be68ef-f53c-11eb-acfe-001a4a160175	29866482	The word idiopathic has also been used in literature to describe intussusceptions caused by enlarged lymph nodes, lymphoid hyperplasia or Peyer's patches because these are variations in normal anatomy as a reaction on an inflammatory process.
1		MESH:D014657	activates	Intussusception	MESH:D007443	Phenotype	c3349792-352d-11e8-8f56-001a4a160175	29079890	The mechanism of mesenteric vasculitis causing intussusception was unclear until now.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	6ad9c3bc-cb25-11ee-b346-0050569a791b	10.1016/j.fjs.2015.10.002	Introduction A small bowel intussusception is rare and can be caused by infection, polyp, lymphoma, vasculitis, Meckel's diverticulum, intestinal duplication, cystic fibrosis, and intramural hematoma.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	d5b2cdc8-bc1a-11e5-9b9d-001a4ae51247	PMC4017480	The polyps can cause anemia and intestinal obstruction and intussusceptions (1).
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	17f858b6-8809-11ee-add2-0050569a791b	10.1007/s12029-021-00647-5	Solitary Peutz-Jeghers polyp can cause intussusception in both adult and pediatric age groups  [27].
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	10765404-9bb3-11ee-a19b-0050569a791b	10.1007/s00431-021-04017-y	In one patient, a large pedunculated polyp led to a colo-colonic intussusception, a very rare complication, maybe because it was pushed distally by peristalsis.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	0142c834-c875-11ee-b22c-0050569a1f61	PMC10173153	Intraoperatively, we found an ileo-ileal intussusception caused by a 4 cm stenotic polyp-like tumor (Fig. 2).
1		MESH:D011127	inhibits	Intussusception	MESH:D007443	Phenotype	e47eb7ad-f53d-11eb-ad8a-001a4a160175	29320750	It is also crucial to timely diagnose an asymptomatic enlarged polyp to prevent the complications of obstruction, intussusception and perforation.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	61c5c39a-bbd7-11e5-8abe-001a4ae51246	PMC4659168	Because children have smaller lumen sizes than adults, smaller polyps may potentially cause an obstruction or an intussusception.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	fc328122-5d6e-11e7-af4d-001a4ae51247	PMC5137662	This showed a small bowel intussusception (target lesion) as seen inFigure 1.Figure 1Axial computed tomography of the abdomen with contrast showing small bowel intussusception with ‘target’ lesion (arrow) The patient subsequently went to theatre for a laparotomy, where a 6cm segment of non-gangrenous intussuscepted distal small bowel was found (ie enteroenteric intussusception), with a palpable polyp causing the lead point of the intussusception (Fig 2).
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	3059c698-bc23-11e5-8abe-001a4ae51246	PMC2596112	Although cases of adult intussusception caused by benign processes are rare, there are reports of inflammatory fibroid polyps causing adult intussusception in the terminal ileum published in the literature.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	3b466f5c-bc0f-11e5-9b9d-001a4ae51247	PMC3078240	The ileum segment is the most common site where these polyps cause intussusception.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	1ab5aeba-bc23-11e5-9b9d-001a4ae51247	PMC2769462	In the small intestine, the ileum is the most common site where these polyps cause intussusception.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	9bafdb4c-c842-11ee-ae05-0050569a1f61	10.1016/j.asjsur.2022.12.108	FAP patients often have no intestinal polyps in childhood and develop intestinal polyps during adolescence, and these polyps can easily lead to intestinal bleeding, obstruction and intussusception as well as inevitably develop into cancers before 40 years old.2So early diagnosis and complete resection of the large intestine are important and valuable.
1		MESH:D011127	inhibits	Intussusception	MESH:D007443	Phenotype	07c5989e-c79e-11ee-ae05-0050569a1f61	10.1016/j.gie.2023.01.056	For example, endoscopic management of small-intestinal polyps is feasible and effective for patients with Peutz-Jeghers syndrome to prevent small-intestinal intussusception and multiple laparotomies.1Balloon dilation in the small intestine for strictures in patients with Crohn’s disease can prevent multiple intestinal resections and short-bowel syndrome.2,3These patients are often referred to surgeons and pediatricians.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	57a45862-bcab-11ee-a53a-0050569a1f61	10.1007/s12328-023-01915-6	In this paper, we report a surgical case of adult intussusception caused by hemorrhagic polyps in a patient with amyloidosis and excessive anticoagulation with warfarin.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	6f8be552-351c-11e8-b868-001a4a160176	28314199	We present a case of massive jejuno-jejunal intussusception caused by a large infarcted Peutz-Jeghers polyp, with atypical clinical presentation and ultrasound (US) features.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	87013a3e-ea24-11ee-b346-0050569a791b	PMC9568733	Her Magnetic Resonance Enterography (MRE) demonstrated tubular lipomatous polyp causing intussusception.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	66c57a4e-5c11-11e7-9fde-001a4ae51247	PMC5437388	Patients with Peutz-Jeghers syndrome are predisposed to multiple small bowel polyps which may frequently cause intussusception.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	22189140-bc23-11e5-9b9d-001a4ae51247	PMC2769477	This was secondary to a large hamartomatous jejunal polyp causing intussusception.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	b0b58838-c8dd-11e5-9624-001a4ae51246	PMC2564523	"PJS patients often present in their first decade of life with intussusception, obstruction,
                                  or volvulus caused by small bowel polyps."
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	37b1a8ba-351c-11e8-bf76-001a4a160175	28303455	These hamartomatous polyps, which are mostly located in the small bowel (60–90%) and colon (50–64%), have been reported to cause gastrointestinal bleeding, abdominal pain, small bowel obstruction, and intussusception as clinical symptoms [2].
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	19d94bd8-cd03-11ee-b22c-0050569a1f61	10.1016/j.mpdhp.2015.04.006	Most of these diseases can be detected in childhood, either owing to a known family history, classical phenotype (for example, FAP), or sometimes owing to unusual presentations (such as intussusception or volvulus caused by polyps in PJS).
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	29c61566-bc41-11e5-ac4e-001a4ae51246	PMC3258555	Large polyps can cause intestinal bleeding, intussusception, or intestinal blockage.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	27a797c2-fc37-11e7-bac8-001a4a160176	PMC5759610	Large PJS polyps can also act as a lead point and lead to an intussusception as an acute presentation [24].
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	ddcf154e-c484-11e5-9da3-001a4ae51247	PMC3372303	We present the case of a 35-year-old woman with CF who presented with a sigmoid intussusception caused by 2 malignant polyps.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	816f5e24-340a-11e8-a51f-001a4a160176	27352980	Her abdominal contrasted computed tomography showed small intestine-to-small intestine intussusception leaded by a large polyp (Fig. 1A, arrow).
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	07fac3c1-2db3-11eb-a7c4-001a4a160175	PMC7149153	Two polyps caused intussusception.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	400b4eba-bc2b-11e5-8abe-001a4ae51246	PMC3703414	These two cases demonstrate that lymphoma polyps in any part of the small bowel can cause intussusception.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	a65b0a66-5c11-11e7-9fde-001a4ae51247	PMC5424870	Patients with PJS have small-bowel polyps that can cause intussusception and bleeding.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	97d51656-bc2d-11e5-9b9d-001a4ae51247	PMC4314827	Polyps may cause gastrointestinal bleeding, intussusception, obstruction, or infarction [1],[4].
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	0cf8e688-340e-11e8-a51f-001a4a160176	21704992	"Background
                   The major problem in the management of Peutz–Jeghers syndrome (PJS) is small-bowel polyps, which can cause intussusception and bleeding."
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	6b8999d4-bc44-11e5-ac4e-001a4ae51246	PMC3473228	We presented the unique case and images of gastroduodenal intussusception caused by a large hyperplastic polyp.
1		MESH:D011127	inhibits	Intussusception	MESH:D007443	Phenotype	8aa3737e-bb2f-11ee-9d3b-0050569a791b	10.1007/s12328-019-00964-0	In children with suspected PJS based on mucocutaneous pigmentation or a family history who exhibit symptoms related to GI polyps, clinicians should consider total GI tract screening and polyp resection to prevent intussusception and possible surgical emergency.
1		MESH:D011127	inhibits	Intussusception	MESH:D007443	Phenotype	2fcdd566-c836-11ee-b346-0050569a791b	10.1016/j.bpg.2023.101852	Large pedunculated polyps with thick stalks should be pulled back or pushed back to the oral side to reduce intussusception before cutting.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	d4b053ea-374d-11e8-8636-001a4a160175	28674119	Polyps can cause bleeding, anemia, abdominal pain, intussusception, obstruction, or infarction.
1		MESH:D011127	activates	Intussusception	MESH:D007443	Phenotype	07885772-bc3a-11e5-9b9d-001a4ae51247	PMC3512482	Our patient’s case described here manifested with relatively typical symptoms of an intraluminal, lipomatous polyp causing intussusception.
1		MESH:D008228	activates	Intussusception	MESH:D007443	Phenotype	0817ec90-3f30-11e8-ab82-001a4a160175	PMC5895833	As in this case, intussusception caused by non-Hodgkin lymphoma can cause abdominal pain in an AIDS patient.
1		MESH:D002051	activates	Intussusception	MESH:D007443	Phenotype	2900f8c6-bc23-11e5-8abe-001a4ae51246	PMC2803985	Our case presentation is the first case of Burkitt's lymphoma with abdominal involvement, causing ileo-ileal intussusception, diagnosed and treated with extensive surgical resection here in Kosova.
1		MESH:D002051	activates	Intussusception	MESH:D007443	Phenotype	afbd03e2-bbe1-11e5-8abe-001a4ae51246	PMC3624648	Intussusception caused by Burkitt lymphoma as a cause of acute abdomen is rare, with often misleading symptoms that make the diagnosis more difficult [3].
1		MESH:D006689	activates	Intussusception	MESH:D007443	Phenotype	0817ec90-3f30-11e8-ab82-001a4a160175	PMC5895833	In conclusion, physicians should consider the possibility of intussusception caused by non- Hodgkin lymphoma when examining AIDS patients with acute abdominal pain.
1		MESH:D046152	activates	Intussusception	MESH:D007443	Phenotype	9797f0be-374b-11e8-b868-001a4a160176	22595603	Gastrointestinal stromal tumors are common in adults and may lead to intussusception[12,13].
1		MESH:D046152	activates	Intussusception	MESH:D007443	Phenotype	401ae4ea-bc0f-11e5-9b9d-001a4ae51247	PMC3531940	Gastrointestinal stromal tumors and adenocarcinoma rarely cause ileal intussusceptions [16].
1		MESH:D008070	activates	Intussusception	MESH:D007443	Phenotype	ee875282-720d-11e8-8ba0-001a4a160175	PMC6023844	[3]Indeed, some reports indicated that metastases of LPS-induced intussusception.
1		MESH:D008070	activates	Intussusception	MESH:D007443	Phenotype	ce16aa12-3404-11e8-8f56-001a4a160175	22503531	Administration of lipopolysaccharide induces multiple intussusceptions in the mouse model, in correlation with a serum increase of tumor necrosis factor-α, nitric oxide, and interleukin-6.
1		MESH:D008070	activates	Intussusception	MESH:D007443	Phenotype	6baa3c31-6ff4-11e9-9f47-001a4a160176	PMC6416386	Recently, some investigations into the pathophysiology of intussusceptions provided experimental evidence that lipopolysaccharide-induced intussusception was mediated by innate immunity, such as by toll-like receptor 4 and phagocytes, and by intestinal hypomotility [2829].
1		MESH:D007239	activates	Intussusception	MESH:D007443	Phenotype	92e6ae40-7f6f-11ea-bf13-001a4a160176	10.1016/b978-0-7234-3832-8.00014-6	Heavy infections may cause intestine occlusion, intussusception, or perforation ( Fig. 14-175 ).
1		MESH:D007239	activates	Intussusception	MESH:D007443	Phenotype	6ad9c3bc-cb25-11ee-b346-0050569a791b	10.1016/j.fjs.2015.10.002	Introduction A small bowel intussusception is rare and can be caused by infection, polyp, lymphoma, vasculitis, Meckel's diverticulum, intestinal duplication, cystic fibrosis, and intramural hematoma.
1		MESH:D007239	activates	Intussusception	MESH:D007443	Phenotype	b97188de-394f-11e8-a34b-001a4a160175	19944222	Nevertheless, in 1998, a comprehensive review of published data by Rennels et al[30]concluded that these 3 small case series lacked control subjects and constituted insufficient evidence to conclude that the infection caused intussusception.
1		MESH:D007239	activates	Intussusception	MESH:D007443	Phenotype	d416ddf2-bc41-11e5-ac4e-001a4ae51246	PMC3034165	Heavy infection can cause serious complications, the most common of which is small bowel obstruction by a bolus of worms, leading to gastrointestinal discomfort, vomiting, and occasionally intussusception and death (de Silva et al., 1997a).
1		MESH:D006099	activates	Intussusception	MESH:D007443	Phenotype	18b0ea5a-7f6f-11ea-817e-001a4a160175	10.1016/b978-0-323-35775-3.00007-2	In cattle and horses, tumors, abscesses, and granulomas may be causes of intussusceptions.
1		MESH:D013577	activates	Intussusception	MESH:D007443	Phenotype	0cf8e688-340e-11e8-a51f-001a4a160176	21704992	"Background
                   The major problem in the management of Peutz–Jeghers syndrome (PJS) is small-bowel polyps, which can cause intussusception and bleeding."
1		CHEBI:61695	activates	Intussusception	MESH:D007443	Chemical	905e3a50-ae94-11ec-b4ed-0050569a1f61	PMCPMC8026799	We herein describe a patient with intestinal intussusception and progressive anemia caused by PG in the ileum.
1		CHEBI:6888	inhibits	Intussusception	MESH:D007443	Chemical	c3349792-352d-11e8-8f56-001a4a160175	29079890	In our patient, mesenteric vasculitis may be the pathogenesis of intussusception, and despite surgical intervention, timely medical therapy of “immunoglobulin” and pulse “methylprednisolone” perhaps may relieve intussusception in SLE.
1		MESH:D012516	activates	Intussusception	MESH:D007443	Phenotype	7c5ed44c-5c19-11e7-bcb7-001a4ae51246	PMC5419932	Chandramohan et al[15]reported that they could not conservatively cure their patient of intussusception caused by osteosarcoma metastasis to the jejunum, so they concluded that surgical management should be considered because of the risk of gangrene and perforation.
1		MESH:D012514	activates	Intussusception	MESH:D007443	Phenotype	51960240-ae93-11ec-a61d-0050569a1f61	PMCPMC8352154	Moreover, Kaposi sarcoma (KS) or intestinal lymphoma may lead to intussusception, abdominal obstruction, and acute abdomen.
1		MESH:D012514	activates	Intussusception	MESH:D007443	Phenotype	c376fde8-3551-11e8-bf76-001a4a160175	19231537	Kaposi sarcoma in the gastrointestinal tract usually presents with gastrointestinal bleeding but may also, rarely, cause intussusception and obstruction.
1		UNIPROT:Q15831	activates	Intussusception	MESH:D007443	Protein	19d94bd8-cd03-11ee-b22c-0050569a1f61	10.1016/j.mpdhp.2015.04.006	Most of these diseases can be detected in childhood, either owing to a known family history, classical phenotype (for example, FAP), or sometimes owing to unusual presentations (such as intussusception or volvulus caused by polyps in PJS).
1		UNIPROT:Q15831	inhibits	Intussusception	MESH:D007443	Protein	d90c88ca-c6f1-11ee-b346-0050569a791b	10.1016/j.dld.2023.05.034	Patients with PJS regularly undergo SBCE to identify larger polyps as to guide polypectomy during enteroscopy and thus prevent intussusception[21–23].
1		UNIPROT:Q15831	activates	Intussusception	MESH:D007443	Protein	a5941f88-ae95-11ec-b4ed-0050569a1f61	PMCPMC8483869	Intussusception caused by intraluminal polyps in PJS is a rare cause of intestinal obstruction.
1		UNIPROT:Q15831	activates	Intussusception	MESH:D007443	Protein	0cf8e688-340e-11e8-a51f-001a4a160176	21704992	"Background
                   The major problem in the management of Peutz–Jeghers syndrome (PJS) is small-bowel polyps, which can cause intussusception and bleeding."
1		UNIPROT:Q2YVZ4	inhibits	Intussusception	MESH:D007443	Protein	322279b2-ea27-11ee-b346-0050569a791b	10.1016/j.asjsur.2022.04.119	Intussusception is a common surgical emergency in children, but small bowel intussusception (SBI) is not common, accounting for 0.4–17% of all intussusception in children, unlike ileocolic intussusception, 57%–100% of SBI can be reduced spontaneously.1We report a case of manual reduction of intussusception under the guidance of ultrasound in a primary hospital.
1		UNIPROT:P01588	activates	Intussusception	MESH:D007443	Protein	5209a7c4-3406-11e8-8f56-001a4a160175	PMC6106155	Symptoms are mostly related to larger EP causing GI luminal obstruction, intussusception, or mucosal ulceration and hemorrhage.
1		MESH:D000038	activates	Intussusception	MESH:D007443	Phenotype	78491ee8-c96e-11ee-b346-0050569a791b	PMC11307608	Chronic anisakiasis of the colon can lead to development of abscesses and granulomas, which may cause intussusception or be misdiagnosed as cancer.
1		MESH:D008697	activates	Intussusception	MESH:D007443	Phenotype	816f5e24-340a-11e8-a51f-001a4a160176	27352980	Her abdominal contrasted computed tomography showed small intestine-to-small intestine intussusception leaded by a large polyp (Fig. 1A, arrow).
1		MESH:D002277	activates	Intussusception	MESH:D007443	Phenotype	c9277d0c-bc0f-11e5-9b9d-001a4ae51247	PMC3818566	Adult colonic intussusception is caused by a primary carcinoma in 65–70% of all cases.
1		MESH:D002277	activates	Intussusception	MESH:D007443	Phenotype	2683f7da-bc4e-11e5-8abe-001a4ae51246	PMC4545985	We herein describe a laparoscopic treatment for adult colonic intussusception caused by cecum carcinoma.
1		MESH:D002277	activates	Intussusception	MESH:D007443	Phenotype	31cad058-5c18-11e7-9833-001a4ae51246	PMC5404618	[22] In contrast to ileo-ileal intussusception, adult colocolic intussusception is caused by a primary carcinoma in majority of cases.
1		MESH:D002277	activates	Intussusception	MESH:D007443	Phenotype	cafb4868-bc08-11e5-8abe-001a4ae51246	PMC4315006	Elective surgery with a median laparotomy was performed, which confirmed the diagnosis of intestinal intussusception caused by a left colon carcinoma.
1		MESH:D002277	activates	Intussusception	MESH:D007443	Phenotype	117df142-c46e-11e5-85e4-001a4ae51246	24924845	Herein, we report a case of recurrent intussusception caused by multiple metastases of pulmonary pleomorphic carcinoma, with the hope that our experience will aid readers in clinical decision-making.
1		MESH:D002277	activates	Intussusception	MESH:D007443	Phenotype	fcd6815a-bc48-11e5-8abe-001a4ae51246	PMC2650702	Colonic intussusception is most commonly caused by a primary carcinoma and benign tumors, including submucosal masses and accounts for the majority of cases of intestinal intussusception [3].
1		UNIPROT:P39060	activates	Intussusception	MESH:D007443	Protein	51960240-ae93-11ec-a61d-0050569a1f61	PMCPMC8352154	Moreover, Kaposi sarcoma (KS) or intestinal lymphoma may lead to intussusception, abdominal obstruction, and acute abdomen.
1		MESH:D000236	activates	Intussusception	MESH:D007443	Phenotype	41ba448c-bc2b-11e5-8abe-001a4ae51246	PMC3971845	Although appendiceal adenocarcinoma, adenoma, or mucocele could cause cecocolic intussusception, acute appendicitis was rarely reported as a leading cause of cecocolic intussusception.
1		MESH:D000236	activates	Intussusception	MESH:D007443	Phenotype	e9bd74ba-5c43-11e7-af4d-001a4ae51247	PMC5121554	A literature search revealed 13 cases of duodenal/ampullary adenomas causing duodeno-duodenal intussusception, and to the best of our knowledge, no case of an ampullary adenoma causing symptomatic intussusception with recurrent chest infections was previously reported.
1		MESH:D000236	activates	Intussusception	MESH:D007443	Phenotype	1e011f06-c465-11e5-85e4-001a4ae51246	23906606	"The authors previously identified a somatic and a germline mutation in a jejunal adenoma that caused intussusception
                      in a male FAP patient (21)."
1		MESH:D000236	activates	Intussusception	MESH:D007443	Phenotype	2f541de8-340d-11e8-8636-001a4a160175	24368074	As with other adenomas in the GI tract, Brunner's gland adenomas and/or hamartomas may cause obstruction, bleeding, and intussusception, with presentations of abdominal pain, nausea, vomiting, and anemia; less frequently they may present with obstructive jaundice or recurrent pancreatitis.
1		MESH:D003967	activates	Intussusception	MESH:D007443	Phenotype	43019e4e-c98d-11ee-b346-0050569a791b	10.1016/j.epsc.2022.102492	In less than 24 months, who present with acute abdominal, bilious vomiting and bloody diarrhea should raise suspicion for intussusception.
1		MESH:D014376	activates	Intussusception	MESH:D007443	Phenotype	5a51918e-bc54-11e5-ac4e-001a4ae51246	PMC2478653	Conclusion Intussusception is rare in the adult population, and, to the best of our knowledge, intussusception caused by intestinal tuberculosis is very rare.
1		MESH:D015738	inhibits	Intussusception	MESH:D007443	Phenotype	b62915cc-8cd0-11ee-add2-0050569a791b	PMC9017428	Mesentery is closed with interrupted sutures with the inclusion of the “Brolin stitch” to prevent intussusception.
1		MESH:D006391	activates	Intussusception	MESH:D007443	Phenotype	f0297368-c468-11e5-85e4-001a4ae51246	24099114	However, intussusception caused by hemangioma is extremely rare.
1		MESH:D009455	activates	Intussusception	MESH:D007443	Phenotype	0b7b6f3c-d508-11ee-ae05-0050569a1f61	10.1007/s00247-018-4166-0	Children can present with abdominal pain, vomiting, abdominal distention or potentially obstruction from a neurofibroma causing an intussusception.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	c63098d6-bc41-11e5-8d2d-001a4ae51247	PMC3259399	In these cases, CT scan examination shows an abnormal multi-layered, targetlike image, with a diameter larger than the normal bowel, consistent with the intussusception (Fig.10); however, as previously reported [2], the direct visualization of the Meckel’s diverticulum as the lead point is often difficult to assess, and the differential diagnosis includes intussusception produced by benign (lipoma) or malignant (metastasis, lymphoma) tumors [28].
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	e27e79c6-aaa1-11e8-bde0-001a4a160175	PMC6112951	Taraneh Azar study of 58 cases of adult intussusception found 3 cases of intestinal intussusception and 3 cases of colonic intussusception caused by lipomas.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	55dfc690-bc3e-11e5-8d2d-001a4ae51247	PMC3659248	Here, we present the case of a 52-year-old woman with an ascending colonic intussusception caused by a lipoma, and we describe the laparoscopic procedure used.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	351e2b9c-bc0f-11e5-8abe-001a4ae51246	PMC2988933	We herein report a preoperatively diagnosed case of adult intussusception caused by a small bowel lipoma.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	78c3ba02-394d-11e8-9fbf-001a4a160176	19766435	In addition, there are also numerous case reports of intraluminal lipomas causing colo-colonic intussusception (3–7).
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	ad372628-bc42-11e5-9b9d-001a4ae51247	PMC2529271	CT scan of the abdomen showed significantly thickened bowel loops with fat density within a proximal segment and a target lesion, consistent with a neoplasm or a lipoma causing Intussusception (Figure2).
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	a3a0534e-ccc1-11ee-ae05-0050569a1f61	10.1053/j.scrs.2015.01.011	This will ensure proper collection of lymph nodes for appropriate staging of presumed colonic carcinoma.23In the case of suspicious pedunculated colonic lipoma causing ileocolic and colocolic intussusception, the procedure of choice should be primary segmental resection without reduction due to the high risk of underlying malignancy.5,24 Colonic liposarcoma Introduction Liposarcoma is one of the most common types of soft tissue malignancies in adults.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	f206025a-8cc9-11ee-add2-0050569a791b	10.1007/s00261-022-03489-2	Lipomas have been reported to cause spontaneous expulsion, GI bleeding from surface ulceration, intussusception (Fig.1), and rarely bowel obstruction [12,13,16,20,22,23,24,25,26–27].
1		MESH:D008067	inhibits	Intussusception	MESH:D007443	Phenotype	18453662-be3d-11ee-a53a-0050569a1f61	10.1007/s12328-019-00943-5	In conclusion, to the best of our knowledge, this is the first report of successful reduction of an intussusception caused by a giant colonic lipoma and curative treatment with a detachable snare after endoscopic reduction with a wedged balloon of the colonoscope tip.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	0759984c-8d8a-11e7-82ff-001a4ae51246	PMC5480074	We present a case of a 29-year-old Asian woman with ileocolic intussusception caused by a lipoma and resected by laparoscopy-assisted surgery.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	3afbe630-bc0f-11e5-9b9d-001a4ae51247	PMC3124324	Moreover, it demonstrated that the lead point was an intraluminal fatty mass measuring 2 cm, suggestive of intussusception caused by lipoma (fig.1).
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	b0fca5fc-d41b-11e6-9a62-001a4ae51246	PMC5164886	The final result was polypoid colonic lipoma causing intussusception and moderate ischemic damage with reactive lymphadenitis.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	b3ae67d6-0027-11f0-a3d5-0050569a1f61	10.1016/j.asjsur.2024.09.015	We now report a case of pathologically confirmed ileocolic lipoma causing intussusception in an adult, aiming to improve clinical and imaging physicians' understanding of this disease.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	af2adba0-bc42-11e5-9b9d-001a4ae51247	PMC3502287	"Fifty-one cases of adult intussusceptions induced by a lipoma, including our present case, have been reported in the English literature during the past decade (Table1)
 [9]."
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	48d9f0c8-bc2b-11e5-8abe-001a4ae51246	PMC3533629	Furthermore, some lipomas by forming a lead point may cause intussusception, as well [10,16].
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	7cfd6eca-bc03-11e5-9b9d-001a4ae51247	PMC3016800	Therefore, mucinous cystadenoma and lipoma causing intussusception are good indications for laparoscopic colectomy.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	0967247e-bc49-11e5-8abe-001a4ae51246	PMC2830981	We report a case of terminal ileal lipoma causing intermittent intussusception in a 52-year-old woman.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	407f75d8-bc2b-11e5-9b9d-001a4ae51247	PMC3676979	Gastrointestinal lipomas greater than 20 mm may produce abdominal pain, intussusception, altered bowel habit, or gastrointestinal blood loss [10].
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	77571818-76a7-11e6-81bd-001a4ae51246	PMC4996905	However, this is possibly the first case reporting a giant ileocolic intussusception produced by 2 neighboring ileal lipomas, in combination with the histopathologic findings of the resected specimen.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	600df484-bc02-11e5-9b9d-001a4ae51247	PMC3713307	CASE REPORT A 44-year-old woman (height, 162 cm; weight, 51 kg) was admitted to the Department of Surgery at this hospital for an extended right hemicolectomy due to colonic intussusceptions caused by cecal lipoma.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	daca058e-ad9a-11e6-a16f-001a4ae51246	PMC5091224	Introduction intro Colonic lipomas are benign mesenchymal tumors that might not require treatment if asymptomatic, whereas large colonic lipomas that cause abdominal pain, hemorrhage, constipation and intussusception require surgical resection.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	3eca3f00-bc0f-11e5-9b9d-001a4ae51247	PMC3506066	The present report describes an unusual case of adult intussusception caused by lipoma of the jejunum with nonspecific abdominal symptoms and reviews some aspects of diagnosis and treatment of intestinal intussusception.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	de614ae8-bbd5-11e5-8abe-001a4ae51246	PMC3401622	Although the colonoscopic findings were not typical for lipoma, she was diagnosed with ascending-transverse colonic intussusception caused by unusual giant lipoma originated at the proximal ascending colon.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	6ca85a94-bc03-11e5-9b9d-001a4ae51247	PMC3016128	Benign lesions, including lipomas that cause intussusception were predominantly found in the cecum and terminal ileum.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	3a49cae8-c752-11ee-b346-0050569a791b	10.1016/j.epsc.2023.102712	In this case, ileal submucosal lipoma led to ileocolic intussusception.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	c11fbc78-bc3c-11e5-8d2d-001a4ae51247	PMC4242997	Adult Ileo-Ileal Intussusception Caused by Intestinal Lipoma.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	b4d15ad0-76bf-11ee-9572-0050569a1f61	10.1007/s00261-023-03909-x	Seldomly, lipomas may cause gastrointestinal bleeding and obstruction, abdominal pain, and intussusception when the diameter is greater than 2 cm [70].
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	35cad8c4-bc0f-11e5-8abe-001a4ae51246	PMC3073789	Pathologic evaluation showed that a polypoid lipoma of 3 cm in diameter was the lead-point for intussusception.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	35520588-3530-11e8-a51f-001a4a160176	20006230	Adult jejunojejunal intussusceptions are extremely rare and usually caused by benign leading points: lipomas, leiomyomas, inflammatory polyps, and Meckel diverticulum.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	c9277d0c-bc0f-11e5-9b9d-001a4ae51247	PMC3818566	These findings led to a diagnosis of intussusceptions induced by a lipoma.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	b00b012f-f53f-11eb-bba6-001a4a160176	29508141	We present a case of intussusception caused by colonic lipoma treated with laparoscopic hemicolectomy.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	afae22ee-bc01-11e5-8abe-001a4ae51246	PMC3166682	Most colonic lipomas are asymptomatic but may cause abdominal pain, bowel habit changes, gastrointestinal bleeding, perforation, intussusception or bowel obstruction according to size and location.1-3Autoamputation of colonic lipoma is indeed rare clinical presentation.4-10 The underlying mechanisms of this presentation are still poorly understood.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	204ab4ac-ad35-11e6-a286-001a4ae51247	PMC4920661	Intra-operatively a large lipoma from the descending colon had caused the colo-colic intussusception (Figure 3).
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	434dd5ac-c478-11e5-a92e-001a4ae51246	21278063	Intussusception caused by ileal lipoma was diagnosed and subsequent laparoscopy confirmed the intussusception (Figure 4) at 60 cm from the ileo-cecal valve caused by a submucosal ileal lipoma (Figure 5).
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	1fccc7a8-04b7-11f0-8fe6-0050569a1f61	10.1016/j.ijscr.2024.110242	We report a case of a 62-year-old man with no medical history as an example of an unusual colonic intussusception caused by a lipoma.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	3130b2fa-390f-11e8-8636-001a4a160175	27179156	There was a comparative case of colocolic intussusception induced by lipoma in our hospital.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	e45f231e-3529-11e8-9fbf-001a4a160176	25304152	Lipomas of the gastrointestinal system larger than 2cm in size may cause bleeding, abdominal pain, intestinal obstruction or intussusception[1].
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	796eef68-c780-11ee-ae05-0050569a1f61	PMC10469518	In children, intussusception caused by lipomas is rare.
1		MESH:D008067	activates	Intussusception	MESH:D007443	Phenotype	0d693660-ea18-11ee-b346-0050569a791b	PMC9577860	We report a cecal lipoma causing colo-colonic intussusception involving the entire length of the proximal colon and the overall mass prolapsed into the pelvis that could be palpated in rectal examination.
1		MESH:D018279	activates	Intussusception	MESH:D007443	Phenotype	cafb4868-bc08-11e5-8abe-001a4ae51246	PMC4315006	In the present study, a rare case of descending colo-colonic intussusception caused by a primary signet ring cell carcinoma of the colon was described.
1		CHEBI:37136	inhibits	Intussusception	MESH:D007443	Chemical	7a66e5d2-3911-11e8-87fd-001a4a160176	20825908	A radiology US confirmed the diagnosis, and the patient underwent a barium enema that successfully reduced the intussusception.
1		CHEBI:37136	inhibits	Intussusception	MESH:D007443	Chemical	73b6d068-bbfe-11e5-9b9d-001a4ae51247	PMC4324269	On the first day of hospitalization, because of possibility of intestinal intussusception, which was evident from the abdominal ultrasound (Figure 1), a barium enema was administered in an attempt to reduce the possible intussusception, but it was not successful.
1		CHEBI:37136	inhibits	Intussusception	MESH:D007443	Chemical	5d5cb5ca-ef86-11ee-9133-0050569a1f61	10.1016/j.surg.2003.12.002	The patient I was assigned was a young child with an intussusception that had been reduced by means of a barium enema (a technique that had been popularized at Hopkins by pediatric surgeon Dr Mark Ravitch).
1		MESH:D006470	activates	Intussusception	MESH:D007443	Phenotype	afbd03e2-bbe1-11e5-8abe-001a4ae51246	PMC3624648	The rapidity of volumetric doubling of this neoplasm frequently leads to an acute abdomen presentation that may mimic other diseases (bowel obstruction secondary to ileocecal intussusception caused by tumor growth, obstruction or bleeding; some presentations may mimic acute appendicitis) [3,12].
1		MESH:D014777	activates	Intussusception	MESH:D007443	Phenotype	b97188de-394f-11e8-a34b-001a4a160175	19944222	Viral infections of the intestinal tract are believed to cause intussusception either by inducing hypertrophy of Peyer's patches or by inducing enlargement of mesenteric lymph nodes[15-17].
1		MESH:D014777	activates	Intussusception	MESH:D007443	Phenotype	a0b19286-7c41-11ee-ae93-0050569a1f61	PMC9106268	Intussusception may be caused by anatomical causes, associated diseases and viral infections.
1		MESH:D014777	activates	Intussusception	MESH:D007443	Phenotype	2aa1b6fa-c472-11e5-a92e-001a4ae51246	19549670	"A number of viral infections have been hypothesized to
                      cause intussusception, namely rotavirus and adenovirus."
1		MESH:D003560	activates	Intussusception	MESH:D007443	Phenotype	5f79ef4c-c70b-11ee-9aaa-0050569a1f61	10.1016/j.ijscr.2023.108935	Small duplication cysts can cause intussusception or volvulus, while large cysts can compress nearby organs and cause obstruction or ischemia [11].
1		MESH:D003560	activates	Intussusception	MESH:D007443	Phenotype	563d23fc-b984-11ee-a19b-0050569a791b	PMC6838286	Duodenal cyst can cause other complications such as pancreatitis, infection, weight loss, and GI bleeding from ulceration of the ectopic gastric mucosa within the cyst; jejune duplication cyst can cause abdominal bloating, constipation, intussusception, volvulus, and partial small bowel obstruction; ileal duplication cyst may be asymptomatic or present with abdominal pain, small bowel obstruction, a palpable abdominal mass, or hematochezia [44].
1		MESH:D012008	inhibits	Intussusception	MESH:D007443	Phenotype	e29fb480-c88a-11ee-b346-0050569a791b	10.1016/j.epsc.2023.102606	There was a recurrence when we tried to reduce intussusception.
1		MESH:D010212	activates	Intussusception	MESH:D007443	Phenotype	db9ecfa4-bc54-11e5-9b9d-001a4ae51247	10.1016/j.etp.2008.10.008	Nevertheless these animals also showed pre-existing gastric squamous cell papillomas, which could have impaired the normal peristaltic movements of the digestive tract and cause intussusception.
1		UNIPROT:Q13950	activates	Intussusception	MESH:D007443	Protein	db1f93de-c8e7-11e5-9ad8-001a4ae51247	17587218	CCD allowed a diagnosis of intussusception in 22/43 patients (Figure5); introital ultrasound confirmed the diagnosis in most (95%, 20/22) of the cases.
1		MESH:D004715	activates	Intussusception	MESH:D007443	Phenotype	6f6d504a-bc03-11e5-8abe-001a4ae51246	PMC3015819	The treatment of intussusception caused by ileal endometriosis consists of surgical resection of the affected intestinal part with termino-terminal anastomosis, which is often done on an emergency basis, as was the case with our patient.
1		MESH:D004715	activates	Intussusception	MESH:D007443	Phenotype	8b10908c-bc03-11e5-8abe-001a4ae51246	PMC3021310	In the reported case, we illustrate the synchronous genital and intestinal localization of endometriosis causing ileo-colic and colonic intussusception, and we discuss the diagnostic and therapeutic approach for this rare occurrence.
1		MESH:D004715	activates	Intussusception	MESH:D007443	Phenotype	b07bec50-c7c0-11ee-b346-0050569a791b	10.1007/s00384-019-03242-0	Appendiceal endometriosis can imitate symptoms of acute or chronic appendicitis, and is also known to cause cyclic and chronic right lower quadrant pain, melena, lower intestinal hemorrhage, cecal intussusception, and intestinal perforation [6].
1		MESH:D011695	inhibits	Intussusception	MESH:D007443	Phenotype	0de32e08-bc30-11e5-9b9d-001a4ae51247	PMC2698160	The clinically important medical histories included recent ileocolic intussusception that was reduced by either air enema (n = 2) or surgical manipulation (n = 1), Henoch-Schonlein purpura (HSP, n = 2), nephrotic syndrome (n = 2), and post-chemotherapy state of lymphoma (n = 1).
1		MESH:D020047	activates	Intussusception	MESH:D007443	Phenotype	477ecc0e-351d-11e8-bf76-001a4a160175	28577170	Functional consideration Laparoscopic VMR for ODS caused by rectocele and/or intussusception can ease defecation disorders and improve faecal incontinence, as demonstrated by several studies [1,3,12].
1		MESH:D009078	activates	Intussusception	MESH:D007443	Phenotype	dcdc653c-3553-11e8-a34b-001a4a160175	19059256	Answer to the Clinical Challenges and Images in GI Question: Image 2: Cecocolic Intussusception Caused by an Appendiceal Mucocele The plain film revealed an intracolic mass in the ascending colon that seemed to be connected to the terminal ileum (long arrow), which was surrounded by the mesenteric fat.
1		MESH:D009078	activates	Intussusception	MESH:D007443	Phenotype	8bedd6da-391b-11e8-9fbf-001a4a160176	21515271	Answer to the Clinical Challenges and Images in GI Question: Image 1 (page 1881): Cecal Intussusception up to the Splenic Flexure Caused by a Calcified Mucocele of the Appendix The CT images with colonic contrast showed a benign, noncalcified renal cyst (FigureA,asterisk) and a 5-cm spherical “one-eyed” calcified mass (black arrows) in the splenic flexure (FiguresAandB).
1		UNIPROT:Q9ZHD4	activates	Intussusception	MESH:D007443	Protein	02d1ea0e-bc3a-11e5-ac4e-001a4ae51246	PMC4457091	Our report aims to present the surgical management of the intussusception caused by this solitary PJP by SILS.
1		MESH:D008467	activates	Intussusception	MESH:D007443	Phenotype	35520588-3530-11e8-a51f-001a4a160176	20006230	Adult jejunojejunal intussusceptions are extremely rare and usually caused by benign leading points: lipomas, leiomyomas, inflammatory polyps, and Meckel diverticulum.
1		MESH:D008467	activates	Intussusception	MESH:D007443	Phenotype	5bc407d6-bc04-11e5-8abe-001a4ae51246	PMC4640028	[1] Although Meckel's diverticulum (MD) may cause intussusception and small bowel obstruction, it is usually asymptomatic and found incidentally during surgery.
1		MESH:D008467	activates	Intussusception	MESH:D007443	Phenotype	8d0efbb8-bc2f-11e5-8d2d-001a4ae51247	PMC4094970	Meckel's diverticulum, intestinal polyps, enteric duplication cysts, intramural hematoma, and lymphoma may also cause intussusception.
1		MESH:D008467	activates	Intussusception	MESH:D007443	Phenotype	c407c630-ed6e-11ee-b22c-0050569a1f61	10.1016/j.epsc.2013.03.013	In our case Meckel's diverticulum was the cause of intussusception but it was not identified during laparoscopy.
1		MESH:D008467	activates	Intussusception	MESH:D007443	Phenotype	3be6c888-3761-11e8-bf76-001a4a160175	21034940	However, Meckel diverticulum was indeed the cause of the recurrent intussusception in these 2 patients.
1		MESH:D008467	activates	Intussusception	MESH:D007443	Phenotype	6ad9c3bc-cb25-11ee-b346-0050569a791b	10.1016/j.fjs.2015.10.002	Introduction A small bowel intussusception is rare and can be caused by infection, polyp, lymphoma, vasculitis, Meckel's diverticulum, intestinal duplication, cystic fibrosis, and intramural hematoma.
1		MESH:D008467	activates	Intussusception	MESH:D007443	Phenotype	e1de0b04-c994-11ee-b22c-0050569a1f61	10.1016/j.epsc.2022.102529	In this case, intussusception was likely caused by the Meckel's diverticulum as the lead point.
1		MESH:D008467	activates	Intussusception	MESH:D007443	Phenotype	4dada9d2-3532-11e8-87fd-001a4a160176	24998882	In one case, Dujardin et al.[14]reported the CT and MRI diagnosis of an inverted Meckel's diverticulum causing ileoileal intussusception.
1		MESH:D018291	activates	Intussusception	MESH:D007443	Phenotype	7cfd6eca-bc03-11e5-9b9d-001a4ae51247	PMC3016800	Only one report   exists of laparoscopic ileocolic resection for intussusception caused by mucinous cystadenoma of the appendix.
