count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
2		CHEBI:26020	inhibits	vitamin D3 biosynthetic process	GO:1901755	Chemical	a75bc7e0-cd3c-11ee-b346-0050569a791b	10.1007/s00240-018-01103-z	It has been postulated that excess loss of phosphate and vitamin D-binding protein in the urine leads to secondary increased vitamin D3 synthesis [54].
1		GO:0043473	inhibits	vitamin D3 biosynthetic process	GO:1901755	Phenotype	7c05e530-351c-11e8-87fd-001a4a160176	28569361	An increase in pigmentation has been shown to decrease the amount of vitamin D3 synthesis in the skin [57].
1		UNIPROT:Q9UBM7	inhibits	vitamin D3 biosynthetic process	GO:1901755	Protein	4d0cd242-ab1c-11e6-807f-001a4ae51247	PMC5050582	DHCR7 coverts 7-dehydrocholesterol to cholesterol and, thus, reduces the substrate for vitamin D3 synthesis [47].
1		MESH:D016572	activates	vitamin D3 biosynthetic process	GO:1901755	Phenotype	b2bd4d54-bbf5-11e5-8abe-001a4ae51246	PMC3397418	A similar mechanism has been found to be employed by the immunosuppressant cyclosporine, which upregulates vitamin D3 synthesis via 1-α-hydroxylase (Overbergh et al, 2000).
1		UNIPROT:Q9GZV9	inhibits	vitamin D3 biosynthetic process	GO:1901755	Protein	85c31268-7478-11ee-add2-0050569a791b	10.1007/s11906-023-01246-4	High fibroblast growth factor 23 levels prevent 1-α hydroxylase activity and reduce vitamin D3 synthesis [60].
1		MESH:D005632	inhibits	vitamin D3 biosynthetic process	GO:1901755	Phenotype	d9a9c2a6-ae94-11ec-840e-0050569a791b	PMCPMC8625451	Excessive fructose intake can inhibit 1,25(OH)2 vitamin D3 synthesis.
1		MESH:D007654	inhibits	vitamin D3 biosynthetic process	GO:1901755	Phenotype	5591eed6-bc4b-11e5-ac4e-001a4ae51246	10.1016/j.jaci.2009.12.933	Consequently, HBD2 induction was restored when vitamin D3 synthesis was inhibited by ketoconazole.