count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
4	CACNA1	FPLX:CACNA1	activates		MESH:D001259	Phenotype	fd0ca4b4-f577-11eb-84df-001a4a160175	32534077	RMN is a hereditary model of ataxia caused mainly by mutations in the CACNA1 gene encoding the P/Q type (α1A Cav 2.1) calcium channels, as well as SCA6 (Mori et al., 2000;Oda et al., 2010).|||RMN is an animal model of hereditary ataxia (Oda, 1973), which is mainly caused by mutations in the CACNA1 gene encoding P/Q type (α1A Cav 2.1) calcium channels (Mori et al., 2000;Oda et al., 2010).
2	CACNA1	FPLX:CACNA1	activates		UNIPROT:Q12809	Protein	30a9d348-3905-11e8-9192-001a4a160175	28711494	Our result showed that in comparison with human ESCs, in rosette stage, there is a decrease in gene expression of KCNA2, KCNH1, KCNMA1, CACNA1 and an increase in KCNH2 and SCN2A.
2	CACNA1	FPLX:CACNA1	activates		UNIPROT:Q99250	Protein	30a9d348-3905-11e8-9192-001a4a160175	28711494	Our result showed that in comparison with human ESCs, in rosette stage, there is a decrease in gene expression of KCNA2, KCNH1, KCNMA1, CACNA1 and an increase in KCNH2 and SCN2A.
2	CACNA1	FPLX:CACNA1	activates		FPLX:Calcium:channels	ProteinFamily	fd0ca4b4-f577-11eb-84df-001a4a160175	32534077	RMN is an animal model of hereditary ataxia (Oda, 1973), which is mainly caused by mutations in the CACNA1 gene encoding P/Q type (α1A Cav 2.1) calcium channels (Mori et al., 2000;Oda et al., 2010).
1	CACNA1	FPLX:CACNA1	activates		UNIPROT:Q13698	Protein	9aa984bc-bc27-11e5-8abe-001a4ae51246	10.1016/j.clinph.2006.07.059	HypoPP is caused by mutations in the CACNA1 channel that links the t-tubule to Ca2+release.
1	CACNA1	FPLX:CACNA1	activates		UNIPROT:O00555	Protein	1860400e-c8ed-11e5-b79b-001a4ae51246	PMC2658038	SCA6 is caused by an expansion in the α1Acalcium channel gene (CACNA1), which functions as a voltage-dependent Ca2+channel protein that normally resides in the plasma membrane (1).
1	CACNA1	FPLX:CACNA1	activates		UNIPROT:O00555	Protein	72e10c08-374e-11e8-8f56-001a4a160175	28927531	An interesting example of a disease-causing splicing site mutation is a single nucleotide change in the CACNA1 gene, which causes Episodic ataxia type 2 (EA2).
1	CACNA1	FPLX:CACNA1	activates		MESH:D001259	Phenotype	6a9ef744-ae96-11ec-ae7b-0050569a1f61	PMCPMC8469797	In this regard, some hints can perhaps be drawn from the observation that LoF CACNA1 variants, impairing Purkinje cell firing, cause ataxia and neurodevelopmental symptoms [30].
1	CACNA1	FPLX:CACNA1	activates		MESH:D001259	Phenotype	72e10c08-374e-11e8-8f56-001a4a160175	28927531	An interesting example of a disease-causing splicing site mutation is a single nucleotide change in the CACNA1 gene, which causes Episodic ataxia type 2 (EA2).
1		CHEBI:29108	activates	CACNA1	FPLX:CACNA1	Chemical	a742ca10-c8ea-11e5-a801-001a4ae51246	18404672	Cal72-shSlo cells exhibited a drastic reduction in Slo mRNA levels without considerable alteration of other ion channels mRNAs expressed in human osteoblasts like the intermediate conductance calcium-activated potassium channel (KCNN4) and the L-type calcium channel (CACNA1).
1		MESH:D051379	increases	CACNA1	FPLX:CACNA1	Phenotype	0c87ff6c-9a1b-11ee-bde4-0050569a1f61	PMC8492879	While juvenile male mice treated with ISO increased expression of ADCY9 and CACNA1, expression of the other genes were unchanged in response to ISO.
1		PF:PF11640	inhibits	CACNA1	FPLX:CACNA1	ProteinFamily	2960916e-bbf6-11e5-8abe-001a4ae51246	PMC3483864	TAN decreases the gene expression of intracellular calcium pathways-related genes at an early stage after ischemic injury, for example, voltage-dependent calcium channel alpha 1 (CACNA1).