count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
12	Nicotyrine	CHEBI:7564	inhibits		UNIPROT:P11509	Protein	8c8cefe8-c476-11e5-85e4-001a4ae51246	26100465	The mouse models also suggest that nicotine toxicity can develop with lower nicotine exposure when CYP2A enzymes are impaired by nicotyrine.|||Smokers with low CYP2A13 activity should show little change during the transition from smoking to vaping, but nicotine consumption and metabolite excretion should decline and shift away from CYP2A products as nicotyrine accumulates in e-liquids and inhibits CYP2A6.|||•Smokers with low CYP2A13 activity should show little change during the transition from smoking to vaping, but nicotine consumption and metabolite excretion should decline and shift away from CYP2A products as nicotyrine accumulates in e-liquids and inhibits CYP2A6.
8	Nicotyrine	CHEBI:7564	activates		MESH:D009538	Phenotype	d00bfb70-3746-11e8-87fd-001a4a160176	26243705	The former contained a wealth of compounds including nicotine and related products such as nicotyrine, 7-methyl-1H-indole, myosmine, isonicoteine.|||In addition the smoke of the e-cigarettes contained nicotine and related products such as miosmine and nicotyrine.
4	Nicotyrine	CHEBI:7564	inhibits		UNIPROT:Q16696	Protein	8c8cefe8-c476-11e5-85e4-001a4ae51246	26100465	We are investigating the effects of nicotyrine on primary human tracheal epithelium to test whether nicotyrine inhibits CYP2A13 function in these cells: inhibition should lead to higher concentrations of nicotine relative to cotinine and 3-OH-cotinine in cell media if the hypothesis is correct.
4	Nicotyrine	CHEBI:7564	activates		MESH:D008107	Phenotype	8c8cefe8-c476-11e5-85e4-001a4ae51246	26100465	Nicotyrine could increase risks of liver injury following various liver diseases or in hyperbilirubinemia.
4	Nicotyrine	CHEBI:7564	inhibits		MESH:D009538	Phenotype	8c8cefe8-c476-11e5-85e4-001a4ae51246	26100465	A 1982 report found that nicotyrine inhibits the metabolism of nicotine without increasing its toxicity in albino mice[31].
4	Nicotyrine	CHEBI:7564	increases		MESH:D009538	Phenotype	0043d02a-3c70-11f0-afc2-0050569a791b	10.1016/j.phrs.2022.106315	Recent evidence shows that the lower temperature reached by e-cigs compared to those reached by tobacco combustion (~690 °C) appears to promote the dehydrogenation of nicotine into nicotyrine, which could, in turn, increase the plasma level of nicotine by the inhibition of some cytochrome P450 isoforms, such as cytochrome P450 2A6, and cytochrome P450 2A13, both involved in nicotine metabolism.
4	Nicotyrine	CHEBI:7564	inhibits		GO:0008152	Phenotype	8c8cefe8-c476-11e5-85e4-001a4ae51246	26100465	A 1982 report found that nicotyrine inhibits the metabolism of nicotine without increasing its toxicity in albino mice[31].
4	Nicotyrine	CHEBI:7564	activates		MESH:D006932	Phenotype	8c8cefe8-c476-11e5-85e4-001a4ae51246	26100465	Nicotyrine could increase risks of liver injury following various liver diseases or in hyperbilirubinemia.
4	Nicotyrine	CHEBI:7564	activates		GO:0018933	Phenotype	8c8cefe8-c476-11e5-85e4-001a4ae51246	26100465	Nicotyrine also may be a minor product of CYP2A6 nicotine metabolism, so that nicotine inhibits its own metabolism[35].
3	Nicotyrine	CHEBI:7564	activates		MESH:D009538	Phenotype	e9ee40e0-352d-11e8-9fbf-001a4a160176	PMC6018193	Nicotyrine, a minor tobacco alkaloid, may increase exposure to nicotine by slowing nicotine clearance rates.|||Nicotyrine A hypothesis has been put forth by Abramovitz, suggesting that nicotine delivery and withdrawal-suppressing effects of e-cigarettes are optimized in the presence of nicotyrine, which may increase aerosolized nicotine absorption through the airways and slow the process of nicotine clearance (by the liver) leading to higher and more sustained nicotine levels [158].
2	Nicotyrine	CHEBI:7564	activates		MESH:D009538	Phenotype	d4c3028a-bc50-11e5-8abe-001a4ae51246	PMC2978920	This confirms that nicotyrine is a pyrolysis product of nicotine.|||To verify the observation that nicotyrine is a pyrolysis product of nicotine, a sample of isotopically labeled (2,4,5,6)-d4-R/S-nicotine was subjected to online pyrolysis GC/MS.
1	Nicotyrine	CHEBI:7564	inhibits		UNIPROT:P11509	Protein	e9ee40e0-352d-11e8-9fbf-001a4a160176	PMC6018193	Nicotyrine inhibits CYP2A enzymes, known to be central to the metabolism of nicotine into cotinine and trans 3-hydroxycotinine [159,162].
1	Nicotyrine	CHEBI:7564	activates		MESH:D009538	Phenotype	dffe9842-ae95-11ec-8b2e-0050569a1f61	PMCPMC8835719	Research has shown that relative to tobacco leaf cigarettes, e-cigarettes expose users to distinct nicotine concentrations, chemical additives (e.g., salt, flavorings), and chemical reaction products (e.g., nicotyrine) that enhance nicotine’s rewarding properties and promote a transition to tobacco leaf cigarette use in individuals with no history of smoking [7,8,9,10].
1	Nicotyrine	CHEBI:7564	inhibits		MESH:D009538	Phenotype	e9ee40e0-352d-11e8-9fbf-001a4a160176	PMC6018193	Nicotyrine A hypothesis has been put forth by Abramovitz, suggesting that nicotine delivery and withdrawal-suppressing effects of e-cigarettes are optimized in the presence of nicotyrine, which may increase aerosolized nicotine absorption through the airways and slow the process of nicotine clearance (by the liver) leading to higher and more sustained nicotine levels [158].