count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
4	Niddamycin	CHEBI:31908	activates		CHEBI:16625	Chemical	8d8e71ea-3554-11e8-b868-001a4a160176	10863099	The putative ethylmalonyl specific AT4 from the FK520 PKS groups with the methylmalonyl-specific AT class, as does the niddamycin AT5 (Kakavas et al., 1997), which has been shown to have a preference for ethylmalonyl-CoA, but to accept methylmalonyl-CoA as well (Stassi et al., 1998).
4		UNIPROT:O31785	activates	Niddamycin	CHEBI:31908	Protein	ebea08e4-cb89-11e5-a7a8-001a4ae51246	10662693	The compounds produced by these PKSs (erythromycin, picromycin/methymycin, oleandomycin, tylosin, niddamycin and mycinamicin) are structurally similar, but each contains one or more differences when compared to any other.
1		UNIPROT:Q15904	activates	Niddamycin	CHEBI:31908	Protein	dd4ebf86-cc75-11e5-b6ad-001a4ae51246	PMC179704	Disruption of the second ORF of the PKS coding region eliminated niddamycin production, demonstrating that the cloned genes are involved in the biosynthesis of this compound.