count	source_label	source_id	relationship	target_label	target_id	entity_type	solr_id	publication_id	sentences
4	1,4-naphthoquinones	CHEBI:132142	activates		UNIPROT:P40347	Protein	aa8f4350-bc2f-11e5-ac4e-001a4ae51246	10.1016/j.febslet.2006.02.048	In order to test the hypothesis that PTPase inactivation by menadione and other 1,4-naphthoquinones is mainly by arylation, the inactivation of an isolated PTPase known to associate with and to regulate phosphorylation of EGFR and other receptor tyrosine kinases[19,20], the fragment containing the catalytic domain of recombinant human PTP-1B (residues 1–322) was incubated with menadione and two other 1,4-naphthoquinone derivatives, 2,3-dimethoxy-1,4-naphthoquinone (DMNQ) and NSC95397.
4	1,4-naphthoquinones	CHEBI:132142	inhibits		UNIPROT:P40347	Protein	aa8f4350-bc2f-11e5-ac4e-001a4ae51246	10.1016/j.febslet.2006.02.048	In order to test the hypothesis that PTPase inactivation by menadione and other 1,4-naphthoquinones is mainly by arylation, the inactivation of an isolated PTPase known to associate with and to regulate phosphorylation of EGFR and other receptor tyrosine kinases[19,20], the fragment containing the catalytic domain of recombinant human PTP-1B (residues 1–322) was incubated with menadione and two other 1,4-naphthoquinone derivatives, 2,3-dimethoxy-1,4-naphthoquinone (DMNQ) and NSC95397.
4	1,4-naphthoquinones	CHEBI:132142	activates		UNIPROT:P47989	Protein	28e6568a-c730-11ee-b346-0050569a791b	10.1016/j.foodchem.2023.136264	Conclusion In summary, the SAR profiles of 1,4-naphthoquinones for activating human and rat XO were firstly studied.|||For RLS9, addition of 1,4-naphthoquinones decreased the Hill coefficient and increased the Vmax/S50values, except compound 3 and 14 whose Vmax/S50values were basically remain unchanged (Table S2), suggesting the positive modulation of XO activity.|||For example, there were several mutations such as the Arg607Gln variant in the Moco domain that participates in the catalytic process of XO (Kudo et al., 2008), and possibly affects the XO-activating activity of 1,4-naphthoquinones.|||In addition, the results of the current study showed a good correlation between the XO-activating activity of 1,4-naphthoquinones with the HOMO-LUMO gap values by DFT analysis, as well as the binding free energy values by molecular docking simulation (Fig. 4).
2	1,4-naphthoquinones	CHEBI:132142	activates		MESH:D008024	Phenotype	aa8f4350-bc2f-11e5-ac4e-001a4ae51246	10.1016/j.febslet.2006.02.048	These findings imply that other 1,4-naphthoquinones that may get in contact with human skin could cause the same ligand-independent activation of ErbB receptors that is found with menadione.
2	1,4-naphthoquinones	CHEBI:132142	inhibits		FPLX:Phosphatase	ProteinFamily	aa8f4350-bc2f-11e5-ac4e-001a4ae51246	10.1016/j.febslet.2006.02.048	Tyrosine phosphatase inhibition by 1,4-naphthoquinones Menadione is capable of inhibiting PTPases in cell-free systems[17]as well as in cell culture[8,18].
2	1,4-naphthoquinones	CHEBI:132142	activates		FPLX:ERBB	ProteinFamily	aa8f4350-bc2f-11e5-ac4e-001a4ae51246	10.1016/j.febslet.2006.02.048	These findings imply that other 1,4-naphthoquinones that may get in contact with human skin could cause the same ligand-independent activation of ErbB receptors that is found with menadione.
1	1,4-naphthoquinones	CHEBI:132142	activates		UNIPROT:P08922	Protein	96bf56a4-7c27-11e6-9c3b-001a4ae51246	PMC5021346	One potential liability of 1,4-naphthoquinones is the fact that they can promote the generation of reactive oxygen species (ROS) with resulting cytotoxicity, as has been demonstrated for menadione, chimaphilin, and 2-methoxy-1,4-naphthoquinone [22–24].
1	1,4-naphthoquinones	CHEBI:132142	activates		GO:0046323	Phenotype	08fe8f16-3b4c-11e8-b868-001a4a160176	PMC5822505	The mechanism of glucose uptake enhancement by 1,4-naphthoquinones of RRE may be via an insulin-independent tyrosine kinase pathway, which is previously reported for shikonin, a 1,4-naphthoquinone ofLithospermum erythrorhizon.
1	1,4-naphthoquinones	CHEBI:132142	activates		MESH:D017382	Phenotype	96bf56a4-7c27-11e6-9c3b-001a4ae51246	PMC5021346	One potential liability of 1,4-naphthoquinones is the fact that they can promote the generation of reactive oxygen species (ROS) with resulting cytotoxicity, as has been demonstrated for menadione, chimaphilin, and 2-methoxy-1,4-naphthoquinone [22–24].
1	1,4-naphthoquinones	CHEBI:132142	activates		MESH:D009285	Phenotype	7011e562-3be1-11ef-908f-0050569a1f61	10.1016/j.tetlet.2017.12.055	The substituents at the 2-position of the naphthoquinone counterpart have significant influence on the reaction outcome: 2-substituted 1,4-naphthoquinones led to the formation of dihydronaphthoquinones bearing a quaternary stereogenic center, while unsubstituted naphthoquinone reactants afforded the naphthoquinone products through a subsequent oxidation reaction (Scheme 4).6 Rueping and co-workers developed a secondary amine-catalyzed Michael addition-cyclization cascade reaction of 2-hydroxy-1,4-naphthoquinone andα,β-unsaturated aldehydes (enals), providing pyranonaphthoquinone derivatives7in good yields with excellent enantioselectivities.
1	1,4-naphthoquinones	CHEBI:132142	activates		FPLX:Protease	ProteinFamily	e17299b6-8040-11ee-add2-0050569a791b	10.1007/s11030-023-10600-2	Development of 1,4-naphthoquinones as dual inhibitors of cruzain and rhodesain by synthesis and computer-aided drug design has been described to moderately inhibit the proteases with IC50values in the single-digit micromolar range [41].
1		CHEBI:27418	activates	1,4-naphthoquinones	CHEBI:132142	Chemical	f3a7f168-bbdf-11e5-8abe-001a4ae51246	PMC4352476	Chemicals and Antibodies The 1,4-naphthoquinones Q7 and Q9 were synthesized by amination of 1,4-naphthoquinone with the respective arylamines, under aerobic conditions using CeCl3·
1		UNIPROT:P47989	activates	1,4-naphthoquinones	CHEBI:132142	Protein	28e6568a-c730-11ee-b346-0050569a791b	10.1016/j.foodchem.2023.136264	In combination with the reports that humans have relatively low activity of XO in the plasma, adipose tissue, heart and corneal epithelium than rodents (Kudo et al., 2008), the XO activation of 1,4-naphthoquinones might be underestimated when the rat is used as an experimental model.
1		MESH:D013454	inhibits	1,4-naphthoquinones	CHEBI:132142	Phenotype	5d07b9e9-f588-11eb-8b15-001a4a160175	30871965	Therefore, in order to reduce the toxicity of 1,4-naphthoquinones and increase their antitumor activity, we oxidized the sulfhydryl group to sulfoxide by MCPBA oxidation in the final step of the synthesis to reduce the toxicity of the compound.
1		CHEBI:42820	activates	1,4-naphthoquinones	CHEBI:132142	Chemical	e4887523-f7e6-11e9-a36d-001a4a160175	PMC6833478	Kawaguchi et al. [56] developed an asymmetric epoxidation of 1,4-naphthoquinones catalyzed by guanidine−urea bifunctional organocatalysts with TBHP as an oxidant, resulting in the desired epoxides with 85:15−95:5 er in 71%−98% yields (Scheme 5).